• 제목/요약/키워드: Hospital Solution

검색결과 747건 처리시간 0.026초

개심술중 심폐우회 충전용객속에서의 10% 펜타스타치와 20% 알부민의 임상 비교 (The Clinical Comparisons of 10% Pentastarch and 20% Albumin in Priming Solutions for Cardiopulmonary Bypass in Cardiac Operations)

  • 백만종
    • Journal of Chest Surgery
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    • 제27권2호
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    • pp.99-113
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    • 1994
  • Pentastarch is a new synthetic hydroxyethyl starch similar to hetastarch. We report on the clinical comparisons the clinical efficacy and safety of 10% pentastarch in prime solutions for CPB in cardiac operations with that of 20% serum albumin. During CPB, group P [n = 20] received 500ml of 10% pentastarch and group A [n = 20] received 100ml of 20% albumin in prime solutions The postoperative time of ICU stay in group P and the day and amount of chest drain, hospital stay in group A were longer [p<0.05]. Fresh whole blood and PRBC were added only in group A and a higher amount of hartman solution was added in group A during CPB [p<0.05]. Prothrombin time was prolonged preoperatively and 2 days postoperatively in group A and 7 days postoperatively in group P [p<0.05] but there were no significant differences in bleeding time or fibrinogen level. Platelet count was higher immediately postoperatively in group A and preoperatively and 1, 2, and 7 days postoperatively in group P [p<0.05].Total protein and albumin level were higher 1 day postoperatively in group A and 2 and 7 days postoperatively in group P [p<0.05]. BUN was increased 2 days postoperatively in group A and Cr was increased 1 day postoperatively in group P [p<0.05]. CPK was higher preoperatively and 1, 2, and 7 days postoperatively in group A and plasma hemoglobin level was also higher 2 and 7 days postoperatively in group A [p<0.05]. There were no significant differences in arterial blood gas analysis but higher pO2 and lower pCO2 levels were maintained in group P and ejection fraction was higher 7 days postoperatively in group P [p<0.05]. Both groups were improved postoperatively in NYHA class and the hemodynamic parameters such as MAP, CO, CI, SV, LVSWI were well maintained in group P [p<0.05]. The amount of blood products used was higher in group A and urine output was higher immediately postoperatively in group A and 1, 2 days postoperatively in group P and the chest output was higher in group A. The complications were developed in 7 patients in group A and 5 patients in group P and mortality was not present in both groups.In conclusion, 10% pentastarch is as safe and effective as 20% albumin in prime solutions for cardiopulmonary bypass in cardiac operations.

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인체의 위 조직 시료에서 자기공명영상장치를 이용한 확산계수 측정에 대한 기초 연구 (Ex Vivo MR Diffusion Coefficient Measurement of Human Gastric Tissue)

  • 문치웅;최기승;;;양영일;장희경;은충기
    • 대한의용생체공학회:의공학회지
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    • 제27권5호
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    • pp.203-209
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    • 2006
  • The aim of this study is to investigate the feasibility of ex vivo MR diffusion tensor imaging technique in order to observe the diffusion-contrast characteristics of human gastric tissues. On normal and pathologic gastric tissues, which have been fixed in a polycarbonate plastic tube filled with 10% formalin solution, laboratory made 3D diffusion tensor Turbo FLASH pulse sequence was used to obtain high resolution MR images with voxel size of $0.5{\times}0.5{\times}0.5mm^3\;using\;64{\times}32{\times}32mm^3$ field of view in conjunction with an acquisition matrix of $128{\times}64{\times}64$. Diffusion weighted- gradient pulses were employed with b values of 0 and $600s/mm^2$ in 6 orientations. The sequence was implemented on a clinical 3.0-T MRI scanner(Siemens, Erlangen, Germany) with a home-made quadrature-typed birdcage Tx/Rx rf coil for small specimen. Diffusion tensor values in each pixel were calculated using linear algebra and singular value decomposition(SVD) algorithm. Apparent diffusion coefficient(ADC) and fractional anisotropy(FA) map were also obtained from diffusion tensor data to compare pixel intensities between normal and abnormal gastric tissues. The processing software was developed by authors using Visual C++(Microsoft, WA, U.S.A.) and mathematical/statistical library of GNUwin32(Free Software Foundation). This study shows that 3D diffusion tensor Turbo FLASH sequence is useful to resolve fine micro-structures of gastric tissue and both ADC and FA values in normal gastric tissue are higher than those in abnormal tissue. Authors expect that this study also represents another possibility of gastric carcinoma detection by visualizing diffusion characteristics of proton spins in the gastric tissues.

Ref-1 protects against FeCl3-induced thrombosis and tissue factor expression via the GSK3β-NF-κB pathway

  • Lee, Ikjun;Nagar, Harsha;Kim, Seonhee;Choi, Su-jeong;Piao, Shuyu;Ahn, Moonsang;Jeon, Byeong Hwa;Oh, Sang-Ha;Kang, Shin Kwang;Kim, Cuk-Seong
    • The Korean Journal of Physiology and Pharmacology
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    • 제25권1호
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    • pp.59-68
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    • 2021
  • Arterial thrombosis and its associated diseases are considered to constitute a major healthcare problem. Arterial thrombosis, defined as blood clot formation in an artery that interrupts blood circulation, is associated with many cardiovascular diseases. Oxidative stress is one of many important factors that aggravates the pathophysiological process of arterial thrombosis. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ref-1) has a multifunctional role in cells that includes the regulation of oxidative stress and anti-inflammatory function. The aim of this study was to investigate the therapeutic effect of adenovirus-mediated Ref-1 overexpression on arterial thrombosis induced by 60% FeCl3 solution in rats. Blood flow was measured to detect the time to occlusion, thrombus formation was detected by hematoxylin and eosin staining, reactive oxygen species (ROS) levels were detected by high-performance liquid chromatography, and the expression of tissue factor and other proteins was detected by Western blot. FeCl3 aggravated thrombus formation in carotid arteries and reduced the time to artery occlusion. Ref-1 significantly delayed arterial obstruction via the inhibition of thrombus formation, especially by downregulating tissue factor expression through the Akt-GSK3β-NF-κB signaling pathway. Ref1 also reduced the expression of vascular inflammation markers ICAM-1 and VCAM-1, and reduced the level of ROS that contributed to thrombus formation. The results showed that adenovirus-mediated Ref-1 overexpression reduced thrombus formation in the rat carotid artery. In summary, Ref-1 overexpression had anti-thrombotic effects in a carotid artery thrombosis model and could be a target for the treatment of arterial thrombosis.

페퍼민트, 그레이프후룻 에센셜 오일을 이용한 족욕 또는 스프레이 적용이 하지부종, 통증 및 피로에 미치는 효과 (Effects of Foot Bath and Spray Application of Peppermint and Grapefruit Essential Oils on Lower Extremity Edema, Pain, and Fatigue)

  • 한아리;김주리;허명행
    • 한국융합학회논문지
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    • 제13권1호
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    • pp.375-386
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    • 2022
  • 오랫동안 서 있거나 걷는 등의 작업 후에 흔히 중력으로 인한 체내순환이 영향을 받아 하지의 부종, 통증, 피로 등이 발생할 수 있다. 본 연구는 보완대체요법으로 아로마테라피 에센셜 오일을 이용하여 족욕 또는 스프레이로 적용하였을 때 하지부종 및 하지통증, 피로에 미치는 효과를 확인하기 위한 연구이다. 본 연구는 무작위통제연구이며, 연구 참여자는 2018년 8월 15일부터 2018년 10월 11일까지 D광역시 소재 E 대학교병원에서 연구 참여자 모집공고에 자원한 간호사 78 명을 대상으로 동질성을 유지하기 위한 낮번 근무를 하는 간호사로 하였다. 실험 중재는 그레이프후룻과 페퍼민트를 1:1로 블렌딩한 에센셜 오일을 0.5ml 넣은 9L의 물에 족욕을 하거나 3%로 희석하여 분사하는 스프레이 방법을 적용하였다. 자료는 ANOVA, Repeated Measures ANOVA로 분석하였다. 아로마 테라피 족욕군과 스프레이군의 종아리 둘레가 대조군에 비해 유의하게 감소하였다(F = 14.053, p <.001). 하지 통증 (F = 42.497, p <.001)과 피로 (F = 20.641, p <.001)도 실험 중재 후 아로마테라피 족욕군과 스프레이군에서 대조군보다 유의하게 감소하였다. 하지의 부종과 통증을 완화하기 위해 족욕을 권장하며, 적용 수월성을 고려할 때 아로마 스프레이를 적극 권장한다.

필수의료 정책 패키지, 내실화가 관건이다 (The Policy Package Related to Essential Medical Service: The Key Is Elaboration and Solidification)

  • 이선희
    • 보건행정학회지
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    • 제34권1호
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    • pp.1-3
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    • 2024
  • 최근 필수의료에 대한 접근성 문제가 중요한 사회적 현안이 되고 있다. 정부는 필수의료 제공체계를 강화하기 위해 '필수의료 정책 패키지'를 종합적 대안으로 제시하고 2028년까지 10조 원 이상의 재원을 투입하겠다고 천명하였다. 의료체계의 틀을 바꾸는 중요한 내용을 담고 있는 만큼, 정책 추진 시 고려해야 할 몇 가지 논점을 제시하고자 한다. 첫째, 의사인력양성시스템 설계 시 정쟁화를 막는 기전이 강구되어야 한다. 둘째, 전공의 의존도를 줄이고 전문의 중심 병원으로 전환하는 것은 전공의 양성비용을 사회가 부담하는 한편, 전문의 서비스에 대한 대가로 고비용을 지불한다는 것을 의미한다. 이러한 변화로 인한 비용을 사회가 지불할 용의가 있는지를 숙고하고 적절하게 예산이 마련되어야 한다. 셋째, 세부 정책수단들 중 공유형 진료체계나 지역네트워크사업 등은 개념적 논의 수준에 있기 때문에 다양한 쟁점들이 내실 있게 검토되어야 하며, 국내 의료체계의 여건에 적합하도록 중장기적으로 검토해갈 필요가 있다.

작업환경실태조사 및 작업환경측정자료(2018~2022) 결과를 활용한 우리나라 전자산업에서의 고위험물질 노출 특성 -디클로로메탄, 트리클로로메탄, 수산화테트라메틸암모늄 중심으로- (Characteristics of Exposure to High-Risk Substances in the Electronics Industry Using the Work Environment Survey and Work Environment Measurement Database (2018~2022) in South Korea -Dichloromethane, Trichloromethane, and Tetramethylammonium Hydroxide-)

  • 황성호;함승헌;김형렬;류현철;안진수;윤진하;윤충식;이나은;이상만;이재환;권세영;장재필;하권철
    • 한국환경보건학회지
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    • 제50권3호
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    • pp.221-228
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    • 2024
  • Background: Social interest is increasing due to frequent accidents caused by chemicals in the electronics industry. Objectives: The purpose of this study is to present a management plan by evaluating the exposure characteristics of dichloromethane (DCM), trichloromethane (TCM), and tetramethyl ammonium hydroxide (TMAH), which are high-risk substances to which people may be exposed in the electronics industry in South Korea. Methods: To investigate the handling companies and status of the hazardous chemicals DCM, TCM, and TMAH, the handling status of the three substances was classified based on electronics industry-related codes from the 2019 Work Environment Survey (Chemical Handling and Manufacturing) data with work environment measurement results for five years. Results: DCM, TCM, and TMAH are commonly used as cleaning agents in the electronics industry. For DCM, it was found that all work environment measurement results from 2018 to 2021 but not 2022 exceeded the exposure standard. Conclusions: Identifying the distribution channels of hazardous chemicals is an intervention point that can reduce exposure to hazardous chemicals. It requires management through tracking systems such as unique verification numbers at the import and manufacturing stages, and proper cultivation of and related support for handling chemicals by business managers.

소방활동방해죄의 의미와 구성요건 개선에 관한 검토 -119구급활동 방해를 중심으로- (A Review on the Improvement of the Meaning and Composition Requirements of Interference with Fire Protection Activities - Focusing on Interference with 119 EMS Activities -)

  • 홍영표
    • 의료법학
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    • 제24권3호
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    • pp.105-124
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    • 2023
  • 현대 사회는 뜻밖의 사고와 위험 상황으로 불안정한 환경에 직면하고 있다. 예를 들어 분당 다리 붕괴사고와 이태원 압사사고 등이 그 예가 될 것이다. 이와 함께 급성심정지나 뇌졸중과 같은 중대한 응급상황이 발생하였을 때, 신속한 조치와 전문 의료 기관으로의 원활한 이송이 필요한 경우 또한 빈번하게 발생하고 있다. 이러한 위험 요소에 대응하기 위해 국가는 국민의 생명과 안전을 보호하기 위한 다양한 시스템을 구축하고 있는데, 119구급대는 응급 의료 시스템 중 핵심적인 역할을 수행한다. 중대한 외상 환자나 중증 질환 환자의 응급 상황에 즉각적으로 대응하여 손상을 최소화하고, 응급의료 기관으로 신속하게 이송하여 전문적인 치료를 제공함으로써 환자의 생명과 안전을 보호하는 것이 그 목표이다. 이와 관련된 핵심 활동이 구급활동인 것이다. 특히, 119구급시스템은 응급 환자의 병원 이송을 책임지는 핵심 기관이나, 구급대원들은 업무수행 중 구급활동 방해 사례에 여전히 직면하고 있다. 이러한 방해 사례는 경찰의 협조 노력에도 불구하고 줄어들지 않고 있고, 구급활동은 공무집행 방해죄와 유사한 특성을 지니며, 응급의료 시스템 내에서 근무하는 응급의료 종사자에 대한 폭행 및 장비 파손과 같은 사례와도 유사한 형태를 보인다. 따라서 119구급시스템을 포함한 응급 의료 활동을 수행하는 과정에서 발생하는 방해 문제에 대한 심층적인 이해와 개선 노력이 필요하다. 이러한 문제에 대한 해결책은 "소방기본법"과 "119구조·구급에 관한 법률"을 중심으로 구급활동 방해죄의 조건을 정립하고 개선하는 것이다.

사인으로부터 추출한 정유와 용매 추출물의 휘발성 물질 및 금속성분 분석 (Analysis of volatile compounds and metals in essential oil and solvent extracts of Amomi Fructus)

  • 이삼근;음철헌;손창규
    • 분석과학
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    • 제28권6호
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    • pp.436-445
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    • 2015
  • 한약재 중 항산화 작용이 있다고 알려진 사인(Amomi Fructus)을 SDE (simultaneous distillation extraction) 방법으로 정유(essential oil)를 추출하고 GC-MS (gas chromatography-mass spectrometry)를 이용하여 39개의 성분을 규명하였으며, 주요 성분은 camphor, borneol acetate, borneol, D-limonene 및 camphene이었다. 유기용매 3가지(헥세인, 다이에틸 에터 및 다이클로로메테인)를 이용하여 얻은 용매 추출물에서 정유성분 이외에 추가로 4개의 성분을 규명하였으며, 주요 5개 성분은 동일하였으나 상대적인 면적 비율은 차이가 있었다. 특정온도와 휘발 조건에서 정유와 용매 추출물에서 휘발하는 물질들의 종류와 상대적인 비율을 측정하기 위하여 dynamic headspace를 이용하여 특정 조건에서 휘발하는 물질들을 트랩에 포집한 후 GC-MS로 분석하였다. 사인으로부터 SDE 방법에 의해 정유를 추출하는 방법의 회수율을 장뇌(camphor)를 이용하여 측정하였으며, 장뇌의 회수율은 82.0% 이었다. 사인에서 Hg의 함량은 수은 분석기로 측정하였으며, Cd, Pb, Cr, Mn, Co, Ni, Cu 와 Zn은 ICP-MS (Inductively coupled plasma-mass spectrometer)로 측정하였다. 사인에서 Pb, Cd 및 Hg이 각각 0.72 mg/kg, <0.10 mg/kg 및 0.0023 mg/kg 검출되었으며, 이는 순도시험 허용기준치 이하의 값들이었다. 사인에서 Cr, Mn, Co, Ni, Cu와 Zn의 함량을 조사한 결과 Mn (213 mg/kg), Cu (8.29 mg/kg) 및 Zn (31.0 mg/kg)등이 비교적 높은 함량으로 검출되었으며, 정유와 용매 추출물에서도 Mn (0.65~9.08 mg/kg), Cu (1.16~4.40 mg/kg) 및 Zn (1.10~3.80 mg/kg)이 검출되었다. 이들 금속성분이 사인에서 기인하는 것인지 아니면 유통과정이나 취급과정에서 오염된 것인지의 여부 규명이 필요하며, 또한 이런 금속들이 생물학적 활성 연구에 어떤 영향 주는지도 규명할 필요가 있다.

리포다당질에 의한 급성폐손상에서 Ethyl Pyruvate의 효과 (The Effects of Ethyl Pyruvate on Lipopolysaccharide-induced Acute Lung Injury)

  • 이승현;윤대위;정진용;이경주;김세중;이은주;강은해;정기환;이승룡;이상엽;김제형;신철;심재정;인광호;강경호;유세화
    • Tuberculosis and Respiratory Diseases
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    • 제61권4호
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    • pp.374-383
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    • 2006
  • 연구배경: 급성폐손상에서 활성산소종에 의한 산화 손상은 주요한 역할을 한다. Ethyl pyruvate (EP) 는 체내에서 생성되는 pyruvate의 유도체로 항산화 및 항염증 효과가 있음이 알려졌다. 저자들은 리포다당질에 의한 급성폐손상 모델에서 EP가 염증반응에 미치는 영향을 연구하고자 하였다. 방 법: 5주 령의 BALB/c 생쥐를 이용하여 리포다당질을 기관 내로 투여하여 급성폐손상을 유도하였다. 대조군, LPS군, EP+LPS군, LPS+EP군으로 나누어 기관지폐포세척액에서 TNF-$\alpha$, IL-6 및 myeloperoxidase (MPO)의 활성을, 폐조직에서 급성폐손상 지수와 NF-$\kappa$B의 농도를 측정하였다. 결 과: EP+LPS군에서 TNF-$\alpha$ 및 IL-6의 농도는 LPS군과 비교하여 감소하였고 (p<0.05) 이들 염증성 시토카인의 농도의 변화는 NF-$\kappa$B의 농도의 변화와 상관 관계를 보였다 (p<0.01). 급성폐손상 지수는 EP+LPS군 및 LPS+EP군에서 LPS군과 비교하여 낮았고 (p<0.05) MPO활성은 EP+LPS군에서 LPS군에 비해 낮았다 (p<0.05). 결 론: EP는 LPS로 인한 급성폐손상에 있어서 예방 및 치료 효과가 있는 것으로 판단된다.

선천성심질환(先天性心疾患)의 심폐기(心肺器) 개심수술(開心手術) - 4례(例) 보고(報告) - (Open Heart Surgery of Congenital Heart Diseases -Report of Four Cases-)

  • 김근호;박영관;지행옥;김영태;이종배;정윤채;오철수
    • Journal of Chest Surgery
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    • 제9권1호
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    • pp.1-9
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    • 1976
  • The present. study reports four cases of congenital heart diseases, who received open heart surgery by the Sarn's Heart-Lung-Machine in the department of Thoracic Surgery, Hanyang University Hospital during the period between July 1975 and May 1976. The Heart-Lung-Machine consisted of the Sarn's five head roller pump motor system (model 5000), heat exchanger, bubble trap, the Rygg-Kyvsgaard oxygenator, and monitors. The priming of pump oxygenator was carried out by the hemodilution method using Hartman's solution and whole blood. Of the four cases of the heart diseases, three whose body weight were below 30kg, received the partial hemodilution priming and the remaining one whose body weight was 52kg received the total hemodilution priming with Hartman's solution alone. The rate of hemodilution was in the average of 60.5ml/kg. Extracorporeal circulation was performed at the perfusion flow rate of the average 94.0ml/kg/min, and at the moderate hypothermia between 35'5"C and 30'5"C of the rectal temperature. In the total cardiopulmonary bypass, arterial blood pressure was anged between 30 mmHg and 85 mmHg, generally maintaining over 60 mmHg and venous pressure was measured between 4 and $23cmH_2O$, generally maintaining below $10cmH_2O$. The first case: The patient, a nine year old girl having the symptoms and physical signs typical to cardiac anomaly was definitely diagnosed as isolated pulmonary stenosis through the cardiac catheterization. There was, however, no cyanosis, no pathological finding by X-ray and E.C.G. tracings. The valvulotomy was performed through the arteriotomy of pulmouary artery under the total cardiopulmonary bypass. Postoperative course of the patient was uneventful, and murmur and the clinical symptoms disappeared. The second case: A 12 year old boy with congenital heart anomaly was positively identified as having ventricular septal defect through the cardiac catheterization. As in the case with the first case, the patient exhibited the symptoms and physical signs typical to cardiac anomaly, but no pathological abnormality by X-ray and E.C.G. tracings. The septal defect was localized on atrioventricular canal and was 2 by 10 mm in size. The septal defect was closed by direct simple sutures under the cardiopulmonary bypass. Postoperative hemodynamic study revealed that the pressure of the right ventricle and pulmonary artery were decreased satisfactory. Postoperative course of the patient was uneventful, and murmur and the clinical symptoms disappeared. The third case: The patient, a 19 year old girl had been experienced the clinical symptoms typical to cardiac anomaly for 16 years. The pink tetralogy of Fallot was definitey diagnosed through the cardiac catheterization. The patient was placed on an ablolute bed rest prior to the operation because of severe exertional dyspnea, fatigability, and frequent syncopal attacks. However, she exhibited very slight cyanosis. Positive findings were noted on E.C.G. tracings and blood picture, but no evidence of pathological abnormality on X-ray was observed. All of the four surgical approaches such as Teflon patch closure (3 by 4cm in size) of ventricular septal defect, myocardial resection of right ventricular outflow tract, valvulotomy of pulmonary valvular stenosis, and pericardial patch closing of ventriculotomy wound were performed in 95 minutes under the cardiopulmonary bypass. Postoperative hemodynamic study revealed that the pressure of the right ventricle was decreased and pulmonary artery was increased satisfactorily. Postoperative course of the patient was uneventful, and murmur and the clinical symptoms disappeared. The fourth case: The patient, a 7 1/4 year old girl had the symptoms of cardiac anomaly for only three years prior to the operation. She was positively identified as having acyanotic tetralogy of Fallot by open heart surgery. The patient showed positive findings by X-ray and E.C.G. tracings, but exhibited no cyanosis and normal blood picture. All of the three surgical approaches, such a myocardial resection of hypertrophic sight ventricular outflow tract, direct suture closing of ventricular septal defect and pericardial patch closing of ventriculotomy wound were carried out in 110 minutes under the cardiopulmonary bypass. Postoperative hemodynamic study revealed that the pressure of the right ventricle was decreased and pulmonary artery was increased satisfactorily. Postoperative course of the patient was uneventful, and the symptoms disappeared.

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