• Journal of Chest Surgery
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• v.19 no.1
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• pp.160-164
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• 1986

Tetralogy of Fallot with absent pulmonic valve is a rare cardiac malformation. The most significant symptoms during early infancy are secondary to bronchial compression resulting from the dilated pulmonary arteries. The clinical diagnosis was confirmed by echocardiography, cardiac catheterization and cardioangiography. A case of TOF with absent pulmonic valve was successful operated upon without insertion of the pulmonic valve. The narrow pulmonic valve annulus was enlarged with a transannular pericardial patch graft. The postoperative course was uneventful.

• The Korean Journal of Ecology
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• v.24 no.6
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• pp.341-348
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• 2001

Population dynamics of the oldest relic stand of Pinus densiflora for. erecta which remains as a status of patch in Sokwang-Ri area, Uljin-Gun, was studied to provide the basic data for conservation of the oldest pine stand in Korea. The upper slope site and ridge site including total 12 plots mainly represented Pinus densiflora for. erecta and Quercus mongolica. These two tree species showed reverse J-shaped distribution. From this information, it was concluded that intensive interspecific competition between two species could be occurring. Age distribution of P. densiflora for. erecta on the sites above middle slope area was indicated bi-modal type or tri-modal type which was known as an age structure of climax forest. Therefore, it was estimated that Pinus densiflora for. erecta population could be continuously maintained in the each patch above middle slope area. In the valley sites, hardwood species such as Q. mongolica, Q. variabilis, Styrax obassia and Acer pseudosieboldianum occupied most part of the under crown-cover area and their seedlings and saplings were developing into the closed upper layer crown because the height of upper layer crown reached about 35 meters and such a high crown height was more suitable for light utilization by plants of under layer. The growth patterns were mainly fluctuated for the entire life time of the oldest tree caused by frequent disturbance. And the initial growth curves of the mature trees and suppressed juvenile trees showed different tendencies along the sites.

• Toxicological Research
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• v.29 no.2
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• pp.87-90
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• 2013

The potential role of topical valproate (VPA) in hair regrowth has been recently suggested. However, safety reports of VPA as a topical formulation are lacking. Therefore, in the present study, we investigated whether VPA causes skin irritation in humans. We first performed a cell viability test and showed that VPA did not exhibit toxicity toward HaCaT keratinocytes, fibroblasts, and RBL-3H mast cells. We then performed clinical patch test and skin irritation test through transdermal drug delivery with the help of microneedle rollers. No significant findings were obtained in the clinical patch test. In the skin irritation test, only 1 patient showed erythema at 1 hr, but the irritation reaction faded away within a few hours. Erythema and edema were not observed at 24 hr. We concluded that VPA has minimal potential to elicit skin irritation. Therefore, we consider that VPA can safely be applied to human skin.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.542-545
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• 2005

This paper is concerned wi th the generation of the Lamb waves in a non­ferromagnetic plate by a recently-developed orientation-adjustable patch-type magnetostrictive transducer (OPMT) and the dispersion analysis from the measured Lamb waves. OPMT is capable of adjusting wave-propagation orientation only with a single installation on a plate. The mechanics behind the wave generation and measurement by the magnetostrictive phenomenon, the working principle of OPMT is explained and the actual generation and measurement of the Lamb waves were conducted in a 3 mm-thick aluminum plate. For the accurate analysis of the dispersion characteristics of the measured Lamb waves, a modified version of the short-time Fourier transform, known as the dispersion-based short-time Fourier transform, was employed. The results presented in this work would serve as the underlying research for an advanced non-destructive evaluation based on ultrasonic waves.

• Journal of Chest Surgery
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• v.18 no.2
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• pp.299-304
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• 1985

The partial A-V canal defect consist of ostium primum type atrial septal defect with a cleft mitral anterior leaflet. The clinical findings depend upon the site and size of the left-to-right shunt, the degree of A-V valvular regurgitation, and the degree of resultant pulmonary artery hypertension. We experienced 3 cases of similar condition. The data were as follow: 1. Chest P-A showed increased pulmonary vascularity and moderate cardiomegaly with left atrial enlargement. 2. E.K.G. showed left axis deviation, left atrial enlargement, and left ventricular hypertrophy. 3. Right heart catheterization showed significant 02 step up of SVC-RA and left-to-right shunt. 4. Left ventriculogram showed mitral regurgitation and filling of both atrium. Operative findings were as follow: 1. Primum type atrial septal defect [2x2 cm]. 2. Cleft in the anterior leaflet of the mitral vave. 3. No evidence of ventricular septal defect and tricuspid anomaly. Through a right atriotomy with moderate hypothermia, the mitral cleft was approximated with interrupted sutures. The interatrial communication was closed by a patch of Dacron/pericardium. The patch was attached to junction of the mitral and tricuspid valves along the crest of the ventricular septum using interrupted sutures and the other site using continuous sutures. Postoperative course was uneventful and discharged in good general condition except postoperative bleeding in case 3.

• Structural Engineering and Mechanics
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• v.17 no.3_4
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• pp.347-356
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• 2004

In order to extend the lifetime of buildings and civil infrastructure, patch type fibrous composite retrofitting materials are widely used. Retrofitted concrete columns and beams gain stiffness and strength, but lose toughness and show brittle failure. Usually, the cracks in concrete structures are visible to the naked eye and the status of the structure in the life cycle is estimated through visual inspections. After retrofitting of the structure, crack visibility is blocked by retrofitted composite materials. Therefore, structural monitoring after retrofitting is indispensable and self diagnosis method with optical fiber sensors is very useful. In this paper, we try to detect the peel out effect and find the strain difference between the main structure and retrofitting patch material when they separate from each other. In the experiment, two fiber optic Bragg grating sensors are applied to the main concrete structure and the patching material separately at the same position. The sensors show coincident behaviors at the initial loading, but different behaviors after a certain load. The test results show the possibility of optical fiber sensor monitoring of beam structures retrofitted by the composite patches.

• Journal of Pharmaceutical Investigation
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• v.40 no.1
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• pp.33-38
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• 2010

Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. The oral administration of sibutramine is followed by its dose-related side effects. In this study, sibutramine was formulated into drug in adhesive (DIA) patches in an attempt to overcome these problems. The effects of different formulation variables including pressure-sensitive adhesive (PSA), loading amount of drug, thickness of matrix and enhancer on the skin permeation of the drug were evaluated using excised hairless mouse skin. In the acrylic adhesive with carboxyl functional group, low release of sibutramine was observed due to the strong interaction between carboxyl group of adhesive and amine group of sibutramine. The acrylic adhesive without functional group provided good adhesion force and allowed high drug loading. Changing drug load as well as thickness of the matrix was found to alter permeation rate. $Crovol^{(R)}$ PK40 and $Crovol^{(R)}$ A40, were found to be effective enhancers for sibutramine. The optimized patch contained 20% sibutramine, and 5% $Crovol^{(R)}$ A40 as permeation enhancer, in $80\;{\mu}m$ thick Duro-$Tak^{(R)}$ 87-9301 matrix.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.5
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• pp.581-589
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• 1998

A regulating mechanism of the ATP-sensitive potassium channels $(K_{ATP}\;channels)$ is yet to fully explained. This study was carried out to investigate the effects of intracellular application of monocarboxylates (acetate, formate, lactate, and pyruvate) on $K_{ATP}$ channels in isolated rabbit ventricular myocytes. Single channel currents of $K_{ATP}$ channels were recorded using the excised inside-out or permeabilized attached (open-cell) patch-clamp technique at room temperature. Intracellular application of acetate, formate and pyruvate led to an inhibition of channel activity, whereas intracellular application of lactate increased channel activity. These effects were reversible upon washout. Analysis of single channel kinetics showed that monocarboxylates did not affect open-time constant and close-time constant. These results suggest that monocarboxylates participate in modulating $K_{ATP}$ channels activity in cardiac cells and that modulation of $K_{ATP}$ channels activity may resolve the discrepancy between the low $K_i$ in excised membrane patches and high levels of intracellular ATP concentration during myocardial ischemia or hypoxia.

• Journal of Mechanical Science and Technology
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• v.16 no.5
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• pp.599-608
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• 2002

Finite element analysis for the stress intensity factor (SIF) at the skin/stiffener structure with inclined central crack repaired by composite stiffened panels is developed. A numerical investigation was conducted to characterize the fracture behavior and crack growth behavior at the inclined crack. In order to investigate the crack growth direction, maximum tangential stress (MTS) criterion are used. Also, this paper is to study the performance of the effective bonded composite patch repair of a plate containing an inclined central through-crack. The main objective of this research is the validation of the inclined crack patching design. In this paper, the reduction of stress intensity factors at the crack-tip and prediction of crack growth direction are determined to evaluate the effects of various non-dimensional design parameter including; composite patch thickness and stiffener distance. We report the results of finite element analysis on the stiffener locations and crack slant angles and discuss them in this paper. The research on cracked structure subjected to mixed mode loading is accomplished and concludes that more work using a different approaches is necessary. The authors hope the present study will aid those who are responsible for the repair of damaged aircraft structures and also provide general repair guidelines.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.21 no.9
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• pp.1050-1055
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• 2010

In this paper, the K band $3{\times}6$ array antenna having unequal input is presented. To control the input impedance of the patch antenna, the length of inset feed is adjusted. Also, the same current in each element is excited by Kirchhoff's law. The proposed unequal impedance array antenna is a nonuniform amplitude array. The bandwidth of the proposed unequal impedance array antenna is wider by 1.5 times than that of the equal array antenna. This broad bandwidth is thought to be due to multiple resonances of patches. The unequal impedance array antennas have fractional bandwidths of 5.07 % and gains of 18.32 dBi.