• Proceedings of the Korean Information Science Society Conference
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• 2005.11a
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• pp.718-720
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• 2005

반짝이는 물체를 촬영하면 이미지에 하이라이트(highlight)와 반짝거림(specularity)이 발생한다. 하이라이트가 발생한 이미지에서 하이라이트를 제거하고 원색으로 복원하는 방법 중에 하나가 하이라이트 색 복원(inpainting)이다. 하이라이트 색을 복원하는 과정은 다음 두 단계로 구성된다. 첫 단계로 하이라이트의 위치를 알고 있다고 가정하aus 하이라이트의 주변 영역을 찾고 CL-projection을 이용해 주변 영역의 색에서 하이라이트나 반짝거림의 영향을 제거한다. 두 번째 단계로 하이라이트 주변 영역의 색을 기반으로 upper mean을 이용하여 distance transform을 수행한다. Upper mean을 이용한 distance transform의 가장 큰 장점은 하이라이트 주변을 보정하고 그 정보를 이용하기 때문에 하이라이트 색을 복원할 뿐만 아니라 반짝거림에 대한 보정도 된다.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1597-1602
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• 2012

In this study, we determined the 3D-structure of Arabidopsis thaliana KAPAS by homology modeling. We then investigated the binding mode of compounds obtained from in-house library using computational docking methods. From the flexible docking study, we achieved high dock scores for the active compounds denoted in this study as compound $\mathbf{3}$ and compound $\mathbf{4}$. Thus, we highlight the flexibility of specific residues, Lys 312 and Phe 172, when used in active sites.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.2174-2181
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• 2011

The purpose of this article is to highlight the relationships among market orientation, environmental turbulence, marketing capabilities, and organizational performance in railway industry(616 participants). Major findings are: 1) market orientation showed a significant effect on marketing capabilities, and organizational performance, 2) environmental turbulence functioned as a moderator not to organizational performance, but to marketing capabilities, 3) and marketing capabilities showed a strong effect on organizational performance. These findings imply that market orientation, as well as marketing capabilities, are so essential for creating a supreme performance in the railway industry.

• Geomechanics and Engineering
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• v.2 no.2
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• pp.71-88
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• 2010

Soil nailing technique is being widely used for stabilization of vertical cuts because of its economic, environment friendly and speedy construction. Global stability and lateral displacement are the two important stability criteria for the soil nail walls. The primary objective of the present study is to evaluate soil nail wall stability criteria under the influence of in-situ soil variability. Finite element based numerical experiments are performed in accordance with the methodology of $2^3$ factorial design of experiments. Based on the analysis of the observations from numerical experiments, two regression models are developed, and used for reliability analyses of global stability and lateral displacement of the soil nail wall. A 10 m high prototype soil nail wall is considered for better understanding and to highlight the practical implications of the present study. Based on the study, lateral displacements beyond 0.10% of vertical wall height and variability of in-situ soil parameters are found to be critical from the stability criteria considerations of the soil nail wall.

• BMB Reports
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• v.48 no.5
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• pp.266-270
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• 2015

Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors. [BMB Reports 2015; 48(5): 266-270]

• Korean Journal of Biological Psychiatry
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• v.22 no.2
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• pp.29-33
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• 2015

The brain maintains homeostasis and normal microenvironment through dynamic interactions of neurons and neuroglial cells to perform the proper information processing and normal cognitive functions. Recent post-mortem investigations and animal model studies demonstrated that the various brain areas such as cerebral cortex, hippocampus and amygdala have abnormalities in neuroglial numbers and functions in subjects with mental illnesses including schizophrenia, dementia and mood disorders like major depression and bipolar disorder. These findings highlight the putative role and involvement of neuroglial cells in mental disorders. Herein I discuss the physiological roles of neuroglial cells such as astrocytes, oligodendrocytes, and microglia in maintaining normal brain functions and their abnormalities in relation to mental disorders. Finally, all these findings could serve as a useful starting point for potential therapeutic concept and drug development to cure unnatural behaviors and abnormal cognitive functions observed in mental disorders.

• ETRI Journal
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• v.35 no.5
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• pp.757-766
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• 2013

This paper deals with the estimation of the time of arrival (TOA) of ultra-wideband signals under IEEE 802.15.4a channel models. The proposed approach is based on a randomness test and consists of determining whether an autoregressive (AR) process modeling an energy frame is random or not by using a distance to measure the randomness. The proposed method uses a threshold that is derived analytically according to a preset false alarm probability. To highlight the effectiveness of the developed approach, simulation setups as well as real data experiments are conducted to assess the performance of the new TOA estimation algorithm. Thereby, the proposed method is compared with the cell averaging constant false alarm rate technique, the threshold comparison algorithm, and the technique based on maximum energy selection with search back. The obtained results are promising, considering both simulations and collected real-life data.

• Molecules and Cells
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• v.38 no.9
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• pp.750-758
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• 2015

Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that fine-tune metabolism in response to DNA damage will enhance our understanding of molecular mechanisms of tumorigenesis and have profound implications for the development of strategies for cancer therapy. Sirtuins have been established as critical regulators in cellular homeostasis and physiology. Here, we review the emerging data revealing a pivotal function of sirtuins in genome maintenance and cell metabolism, and highlight current advances about the phenotypic consequences of defects in these critical regulators in tumorigenesis. While many questions should be addressed about the regulation and context-dependent functions of sirtuins, it appears clear that sirtuins may provide a promising, exciting new avenue for cancer therapy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.2
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• pp.646-663
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• 2014

Scrum is one of the most popular and efficient agile development methods. However, like other agile methods such as Extreme Programming (XP), Feature Driven Development (FDD), and the Dynamic Systems Development Method (DSDM), Scrum has been criticized because of lack of support to develop secure software. Thus, in 2011, we published research proposing the idea of a security backlog (SB). This paper represents the continuation of our previous research, with a focus on the evaluation in industry-based case study. Our findings highlight an improved agility in Scrum after the integration of SB. Furthermore, secure software can be developed quickly, even in situations involving requirement changes of software. Based on our experimental findings, we noticed that, when integrating SB, it is quite feasible to develop secure software using an agile Scrum model.

• Restorative Dentistry and Endodontics
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• v.37 no.3
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• pp.170-174
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• 2012

The objective of this article was to present two nonodontogenic conditions that may mimic odontogenic toothache: trigeminal neuralgia and burning mouth syndrome. Two cases are presented in which one is related to the upper left second premolar and the other is related to the upper left first molar. Both showed pain when chewing. These two cases highlight the complexities involved in diagnosing nonodontogenic toothache. This article demonstrates the importance of having a thorough knowledge of both odontogenic and nonodontogenic toothache, as well as the need for careful evaluation of the nature of the pain and history, clinical and radiographic examinations.