• The Korean Journal of Physiology
• /
• v.9 no.2
• /
• pp.33-39
• /
• 1975

Changes of urinary aldosterone excretion, concurrent sodium and potassium excretion following furosemide administration were studied in normotensive young Korean with high sodium intake, moderate sodium restriction and marked sodium depletion. After intravenous injection of furosemd 40mg, plasma and urine samples were collected at every thirty minutes for two hours. Plasma-and urinary aldosterone, electrolyte concentration and urine flow rate were measured by means of radioimmunoassay or flamephotometry. Relations of urinary aldosterone to concurrent sodium or potassium/sodium ratio, and of urinary aldosterone to concurrent plasma aldosterone activity were studied. Following were the results: 1. Furosemide administration resulted in a increased urinary aldosterone concentration and unchanged or somewhat decreased sodium concentration in course of time after the injection. 2. Urinary potassium concentration showed initial decrease and subsequent increase in course of time after furosemide administration and it resulted in a gradual increase in urinary potassium/sodium ratio. 3. Studying the relations between urinary aldosterone excretion and potassium/sodium excretion ratio, or sodium excretion were meaningless because of the urinary flow rate after the injection was decreased with time course. 4. Furosemide administration showed a good relationship of urinary aldosterone concentration to concurrent potassium/sodium ratio rather than concurrent sodium concentration in subjects with sodium restriction, but no meaningful relationship was detected in subjects with high sodium intake because increasing rate of the ratio was not so wide. 5. Furosemide also resulted a reasonable relation of plasma aldosterone concentration to concurrent urinary aldosterone concentration especially during low sodium intake. 6. Above results suggested that relation of urinary aldosterone concentration to K/Na ratio following furosemide administration during sodium restriction is significant and has a benefit to reduce the variation induced by kalemic change showing in the diragram for daily aldosterone to sodium excretion.

• Archives of Pharmacal Research
• /
• v.24 no.3
• /
• pp.240-248
• /
• 2001

The present study was attempted to investigate the effect of quinine on secretion of catecholamines (CA) etroked by cholinergic stimulation and membrane depolarization from the isolated perfused rat adrenal gland. The perfusion of quinine (15-150${\mu}$M) into an adrenal vein for 60 min produced dose- and time-dependent inhibition in CA secretion evoked by ACh ($5.32{\times}10^{-3}M$), high $K^{+}5.6{\times}10^{-2}M$, DMPP ($10^{-4}M$ for 2 min), McN-A-343 ($10^{-4}M$ for 2 min), cyclopiazonic acid ($10^{-5}$ for 4 min) and Bay-K-8644 ($10^{-5}$ M for 4 min). Also, under the presence of pinacidil ($10^{-4}$ M), which is also known to be a selective potassium channel activator, CA secretory responses evoked by ACh, high potassium, DMPP McN-A-343, Bay-K-8644 and cyclopiazonic acid were also greatly reduced. When preloaded along with quinine ($5{\times}10^{-5}M$) and glibenclamide ($10^{-6}$ M), a specific blocker of ATP-regulated potassium channels, CA secretory responses evoked by ACh, high potassium, DMPP McN-A-343, Bay-K-8644 and cyclopiazonic acid were recovered as compared to those of quinine-treatment only. taken together, these results demonstrate that quinine inhibits CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization through inhibiting influx of extracellular calcium and release in intracellular calcium in the rat adrenmodullary chromaffin cells. These findings suggest that activation of potassium channels may be involved at least in inhibitory action of quinine on CA secretion from the rat adrenal gland.

• Korean Journal of Soil Science and Fertilizer
• /
• v.10 no.3
• /
• pp.189-201
• /
• 1977

Some of basic aspects of soil potassium with special reference to soil physical properties were discussed. Data in the Official Soil Series Description(Korea) was analyzed according to soil type, land form, and soil texture to find soil potassium status which may explain different response to potassium application. Exchangeable potassium contents decreased with soil depth irrespective of soil type, land form and soil texture. Change in degree of potassium saturation within soil profile was not so clear as exchangeable potassium but the degree of potassium saturation of A horizon was highest among soil horizon. Soils of terrace and mountain foot slope showed high values both in exchangeable potassium and degree of potassium sauration and only these two soils were classified as soils having exchangeable potassium higher than 0.3 meq per 100g of soil and degree of potassium saturation higher than 5.0%. Exchangeable potassium of fine loamy and fine clayey soils is higher than 0.3 meq per 100g of soil but degree of potassium saturation is lower than 4.0%. Degree of potassium saturation of sandy soils exceeds 5.0% but exchangeable potassium is very low. Soils of rolling, hilly, unmatured and alpine land soils have lower exchangeable potassium and show lower degree of potassium saturation. The highest distribution of exchangeable potassium content irrespective of soil horizons was shown in the range of 0.1-0.2 meq per 100g of soil. The highest distribution of degree of potassium saturation was in the range of 2.0-3.0% in A horizon and 1.0-2.0% in B and C horizons. Of the soil series concerned in this analysis, 27.3% in A horizon, 11.1% in B horizon and 4.0% in C horizon had exchangeable potassium higher than 0.3 meq per 100g of soil and 18.0% in A horizon, 6.3% in B horizon, and 4.1% in C horizon showed degree of potassium saturation higher than 5.0%. The low response of potassium application only to soils in terrace and mountain foot slope may be resulted from the high exchangeable potassium content and high degree of potassium saturation. It is concluded that a great response of potassium application to soils is expected especially in dry season.

• Journal of Korean Neurosurgical Society
• /
• v.38 no.6
• /
• pp.456-464
• /
• 2005

Objective : The authors investigated whether rotenone induces cellular death also in non-dopaminergic neurons and high concentration of potassium ion can show protective effect for non-dopaminergic neuron in case of rotenone-induced cytotoxicity. Methods : Neuro 2A cells was treated with rotenone, and their survival as well as cell death mechanism was estimated using 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium[MTT] assay, Lactate dehydrogenase[LDH] release assay, fluorescence microscopy, and agarose gel electrophoresis. The changes in rotenone-treated cells was also studied after co-treatment of 50mM KCl. And the protective effect of KCl was evaluated by mitochondrial membrane potential assay and compared with the effects of various antioxidants. Results : Neuro 2A cells treated with rotenone underwent apoptotic death showing chromosome condensation and fragmentation as well as DNA laddering. Co-incubation of neuro 2A cells with 50mM KCl prevented it from the cytotoxicity induced by rotenone. Intracellular accumulation of reactive oxygen species[ROS] resulting by rotenone were significantly reduced by 50mM KCl. Potassium exhibited significantly similar potency compared to the antioxidants. Conclusion : The present findings showed that potassium attenuated rotenone-induced cytotoxicity, intracellular accumulation of ROS, and fragmentation of DNA in Neuro 2A cells. These findings suggest the therapeutic potential of potassium ion in neuronal apoptosis, but the practical application of high concentration of potassium ion remains to be settled.

• Journal of Chest Surgery
• /
• v.23 no.1
• /
• pp.9-15
• /
• 1990

This study was designed to investigate the protective effect of chlorpromazine against the reperfusion injury of myocardium after high potassium cardioplegic arrest. Langendorff`s preparations of rat heart were infused with high potassium cardioplegic solution[St. Thomas Hospital Solution] at 25oC. Chlorpromazine [10-7Ｍ] increased the recovery of myocardial contractility[dp/dt], left ventricular pressure[LVP], and coronary flow rate of the reperfused heart. Both in control and experimental groups, the restoration of myocardial activity could not reach to the level of preplegic control. These results suggest that the etiologic factors of the reperfusion injury include the influence of high potassium cardioplegic solution and/or reperfusion itself, and that chlorpromazine protects myocardium from the reperfusion injury.

• Journal of the Korean Chemical Society
• /
• v.55 no.3
• /
• pp.486-489
• /
• 2011

Potassium dihydrogen phosphate was found to be an efficient catalyst for the Pechmann condensation of phenols with ethyl acetoacetate, leading to the formation of coumarins under microwave-irradiation and solvent-free condition. This procedure offers several advantages, including the low loading of catalysts, high yields, clean reactions, short reaction time for the synthesis of coumarins.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.35 no.6
• /
• pp.497-503
• /
• 1990

A field experiment was conducted to find out the effects of nitrogen and potassium rates on the growing characters, yield and quality of burley tobacco (1988 : Burley 21, 1989: Burley 21 and KB101) during successive two years. The effect of added nitrogen fertilizer on the growth characters at topping stage was different according to growing years. Potassium rate had no effect on the growth characters. The effects of nitrogen and potassium rates on the nitrogen conteut of leaf during growth stage were great, while the effects on the potassium content were not large, relatively. As compared with Burley 21, KB101 showed high yield, and the productivity in nitrogen-reduced condition was high. The yield and quality were increased when nitrogen applied to 22.75kg/l0a, but the yield was not increased and the quality was decreased when nitrogen applied above 22.75kg/l0a. Neither potassium rate nor potassium/nitrogen application ratio had effects on the yield and quality, while the quality was somewhat decreased when potassium/nitrogen ratio was small. When the nitrogen fertilizer being applied above 22.75kg/l0a, there were no advantageous effects on the yield and quality, It is sufficient that the potassium application is about 35.0kg/l0a, and the scheme of reducing of potassium rate may be considerable.

• Applied Chemistry for Engineering
• /
• v.30 no.3
• /
• pp.384-388
• /
• 2019

In winter season, the snow and ice accretion on the bottom of the high speed railway rolling stock and boogie part has fallen at a high speed from the ballast section (gravel section for the transmission of the rolling stock load received by sleepers and fixing sleepers), causing the gravel to be scattered, thereby damaging the railway rolling stock structures and facilities. In order to solve these problems, the gravel scattering prevention net, manual de-icing, and movable hot air machine were used, but their efficiency was low. For the more efficient de-icing than ever before, an optimum material for de-icing fluid for high speed railway rolling stock was developed by evaluating the ice melting capacity, kinematic viscosity, evaporation of the material used as a chemical de-icing fluid. Four kinds of organic acid salts (sodium formate, sodium acetate, potassium formate and potassium acetate) and two different alcohols (propylene glycol, glycerol) were used as evaluation materials. Potassium formate, potassium acetate, and propylene glycol had similar ice melting capacities in the indoor test, but the propylene glycol showed the best ice melting capacity in spraying the system simulation test. This is because the kinematic viscosity of propylene glycol was 2.989029 St, which is higher than those of other materials therefore, it could stay longer on the ice and de-icing. In addition, potassium formate and potassium acetate were difficult to be used since the crystals precipitated and adversely affected the appearance of the rolling stock. The propylene glycol is the most optimum as an de-icing fluid for the high speed railway rolling stock.

• Asian Journal of Turfgrass Science
• /
• v.9 no.4
• /
• pp.285-292
• /
• 1995

To elucidate the mineral cycles of potassium in a dynamic grassland ecosystem in a steady state condition, this investigation was cunducted along the northwest side on Mt. Kwanak. The exper-imental results may he summarized on communities of Z. japonica and M. sinensis as follows. As compared with some pronerties of the surface soils among two semi-natural grasslands, the levels of exchangeahle potassium were high in M. sinensis and low in Z. japonica. Contents of potassium for the litters of Z. japonica and M. sinensis were 1.69% and 2.51%, re-spectively. The annual production of potassium was 1.32 g /m$m^2$ in the Z. japonica grassland and 3. 08 g /m$m^2$in the M. sinensis grassland. For a case of steady production and release, the ratio of annual min- eral production to the amount accumulated on top of the mineral soil in a steady state provides estimates of the release constant k. The models of the release, accumulation and annual cycle of potassium in a grassland ecosystem are determined by the equation (1) to (3), respectively (Table 3). Since it requires a period of about each 0.693 /r, 3 /r and 5 /r years for the release and accumu-lation of 50, 95 and 99% of its steady-state level, the estimates for potassium in a dynamic grass-land ecosystem of Mt. Kwanak were 1.5, 6.6 and 11.0 years in the Z. japonica grassland, and were 2.7, 11.9 and 19.8 years in the M. sinensis grassland. The amounts of annual cycles for potassium in a grassland ecosystem under the steady-state conditions were 1.32 g /m$^2$ in the Z. japonica grassland and 3.08 g /$m^2$ in the M. sinensis grassland. Key words : ZQvsia japonica Ahscanthus sinensis, Mt. Kwanak, Potassium cycles.

• Korean Journal of Soil Science and Fertilizer
• /
• v.10 no.3
• /
• pp.103-134
• /
• 1977

The physiological and biochemical role of potassium for upland crops according to recent research reports and the nutritional status of potassium in Korea were reviewed. Since physical and chemical characteristics of potassium ion are different from those of sodium, potassium can not completely be replaced by sodium and replacement must be limited to minimum possible functional area. Specific roles of potassium seem to keep fine structure of biological membranes such as thylacoid membrane of chloroplast in the most efficient form and to be allosteric effector and conformation controller of various enzymes principally in carbohydrate and protein metabolism. Potassium is essential to improve the efficiency of phoro- and oxidative- phosphorylation and involve deeply in all energy required metabolisms especially synthesis of organic matter and their translocation. Potassium has many important, physiological functions such as maintenance of osmotic pressure and optimum hydration of cell colloids, consequently uptake and translocation of water resulting in higher water use efficiency and of better subcellular environment for various physiological and biochemical activities. Potassium affects uptake and translocation of mineral nutrients and quality of products. potassium itself in products may become a quality criteria due to potassium essentiality for human beings. Potassium uptake is greatly decreased by low temperature and controlled by unknown feed back mechanism of potassium in plants. Thus the luxury absorption should be reconsidered. Total potassium content of upland soil in Korea is about 3% but the exchangeable one is about 0.3 me/100g soil. All upland crops require much potassium probably due to freezing and cold weather and also due to wet damage and drought caused by uneven rainfall pattern. In barley, potassium should be high at just before freezing and just after thawing and move into grain from heading for higher yield. Use efficiency of potassium was 27% for barley and 58% in old uplands, 46% in newly opened hilly lands for soybean. Soybean plant showed potassium deficiency symptom in various fields especially in newly opened hilly lands. Potassium criteria for normal growth appear 2% $K_2O$ and 1.0 K/(Ca+Mg) (content ratio) at flower bud initiation stage for soybean. Potassium requirement in plant was high in carrot, egg plant, chinese cabbage, red pepper, raddish and tomato. Potassium content in leaves was significantly correlated with yield in chinese cabbage. Sweet potato. greatly absorbed potassium subsequently affected potassium nutrition of the following crop. In the case of potassium deficiency, root showed the greatest difference in potassium content from that of normal indicating that deficiency damages root first. Potatoes and corn showed much higher potassium content in comparison with calcium and magnesium. Forage crops from ranges showed relatively high potassium content which was significantly and positively correlated with nitrogen, phosphorus and calcium content. Percentage of orchards (apple, pear, peach, grape, and orange) insufficient in potassium ranged from 16 to 25. The leaves and soils from the good apple and pear orchards showed higher potassium content than those from the poor ones. Critical ratio of $K_2O/(CaO+MgO)$ in mulberry leaves to escape from winter death of branch tip was 0.95. In the multiple croping system, exchangeable potassium in soils after one crop was affected by the previous crops and potassium uptake seemed to be related with soil organic matter providing soil moisture and aeration. Thus, the long term and quantitative investigation of various forms of potassium including total one are needed in relation to soil, weather and croping system. Potassium uptake and efficiency may be increased by topdressing, deep placement, slow-releasing or granular fertilizer application with the consideration of rainfall pattern. In all researches for nutritional explanation including potassium of crop yield reasonable and practicable nutritional indices will most easily be obtained through multifactor analysis.