• Journal of Oral Medicine and Pain
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• 제44권3호
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• pp.118-122
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• 2019

Paraneoplastic pemphigus (PNP) is a rare and often fatal autoimmune blistering disease accompanied by both benign and malignant neoplasms. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by PNP patients. Oral ulcers are initial lesions in various autoimmune diseases like pemphigus, bullous pemphigoid, erythema multiforme, graft-versus-host, lichen planus, it does not improved despite of high-dose steroid therapy. We report a-35-year-old female who presented oral ulceration, lip crust and skin lesions. By doing several examinations, such as enzyme-linked immunosorbent assay, incisional biopsy with indirect immunofluorescence, she was diagnosed PNP with non-Hodgkin's lymphoma on pancreas.

• 한국동물생명공학회지
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• 제36권4호
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• pp.220-229
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• 2021

Lonicera caerulea (Honey berry, HB) has been used in medical treatment in Russia, Japan, China and Korea. It has high level of vitamin C and polyphenolics. Polyphenolics can improve anti-inflammatory effect and prevent cancer, diabetes mellitus type 2. Also, Vitamin C is a representative anti-oxidant. however, it is still unknown what effect it will have on the oxidation stress of the reproductive system. In previous studies, ROS can be produced when it is exposed to heat stress and has negative effect on sperm's maturation, capacitation, hyperactivation, acrosome reaction and fusion of egg and sperm. Therefore, the purpose of this study is to investigate the antioxidant effects of L. Caerulea on the sperm and mice. At first, it conducted using ICR mouse (n = 20) for 4 weeks. There are four groups of mice (n = 5 per group). Also, L. Caerulea was taken by oral gavage. Group I (control) kept at 23℃-27℃ and administer D.W (0.5 mL/day), Likewise, Group II (HB) kept at room temperature but gave HB (250 mg/kg, 0.5 mL/day), Group III (HB + HS) received heat stress (40℃) using hyperthermia induction chamber and gave HB at same dose. and Group IV (HS) exposed heat stress only. Mainly, we showed degree of gene expression using Western blot in SOD, HSP 70, 17β-HSD and Real-time PCR. It can find correlation between intracellular activity like steroid hormone, apoptosis under ROS and antioxidant activity of L. Caerulea.

• Tuberculosis and Respiratory Diseases
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• 제66권6호
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• pp.477-481
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• 2009

Leflunomide는 항류마티스 약제로 최근 류마티스 관절염 치료에 효과적으로 사용되고 있다. 최근 본 약제로 인한 간질성 폐렴이 일본과 한국에서 서구에서보다 많이 보고되고 있으며 종종 사망하는 경우도 보고되고 있다. 저자들은 25세 여자에서 Methotrexate와 Leflunomide의 병합요법 중 발생한 간질성 폐렴을 진단하였고 Methylprednisolone과 Cholestyramine을 조기 투여하여 효과적으로 치료하였기에 문헌 고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제19권2호
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• pp.176-179
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• 2015

Rituximab (RTX), a monoclonal antibody against the B-cell marker CD20, is commonly used as a treatment for antibody-mediated diseases or B-lymphocyte-mediated diseases. Destruction of B cells may reverse the disease course in many conditions; however, patients who are treated with RTX cannot respond appropriately to de novo infection due to lack of B lymphocytes. Here, we report one such case. A 7-year-old renal allograft recipient presented with severe anemia due to parvovirus infection after RTX treatment. The patient had focal segmental glomerulosclerosis and had received cadaveric kidney transplantation 6 months previously. She was treated with high-dose steroid for acute rejection and RTX for Epstein Barr Virus infection 3 months previously. At presentation, her hemoglobin level was 5.4 g/dL and leukocyte and platelet counts were normal. She had microcytic normochromic anemia and high viral load of parvovirus B19(70,578 copies/mL). Intravenous immunoglobulin ($200mg/kg{\cdot}d$) treatment controlled the progression of anemia and parvovirus infection. De novo parvovirus infection during the B lymphocyte-depletion period may have precipitated the severe anemia in this case. Close monitoring of infection is required after RTX therapy.

• Childhood Kidney Diseases
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• 제23권1호
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• pp.53-57
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• 2019

Renal cortical necrosis (RCN) is patchy or diffuse ischemic destruction of the renal cortex caused by significantly reduced renal arterial perfusion. It is a rare cause of acute kidney injury (AKI) and is associated with high mortality. Here, we review the case of RCN in a 15-year-old boy who developed AKI. A 15-year-old boy was referred to our hospital from a local hospital due to a sharp decrease in his renal function. He presented with acute flank pain, nausea with vomiting, and oliguria for the past two days. He had taken a single dose of antihistamine for nasal congestion. At our hospital, his peak blood pressure was 148/83 mmHg and he had a high body mass index of $32.9kg/m^2$. The laboratory data showed a blood urea nitrogen (BUN) of 28.4 mg/dL, a creatinine of 4.26 mg/dL, and a glomerular filtration rate estimated from the serum cystatin C of $20.2mL/min/1.73m^2$. Proteinuria (spot urine protein to creatinine ratio 1.66) with pyuria was observed. Kidney sonography showed parenchymal swelling and increased renal echogenicity. Due to rapidly progressing nephritis, steroid pulse therapy (750 mg/IV) was done on the second day of his admission and the patient showed complete recovery with normal renal function. However, the kidney biopsy findings revealed renal cortical hemorrhagic necrosis. Multifocal, relatively well-circumscribed, hemorrhagic necrotic areas (about 25%) were detected in the tubulointerstitium. Although RCN is an unusual cause of AKI, especially in children, pediatricians should consider the possibility of RCN when evaluating patients with rapidly decreasing renal function.

• Journal of Korean Neurosurgical Society
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• 제65권6호
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• pp.861-867
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• 2022

Objective : High-dose radiation is well known to induce and modulate the immune system. This study was performed to evaluate the correlation between clinical outcomes and changes in natural killer cell activity (NKA) after Gamma Knife Radiosurgery (GKS) in patients with brain cancer. Methods : We performed an open-label, prospective, cross-sectional study of 38 patients who were treated with GKS for brain tumors, including metastatic and benign brain tumors. All of the patients underwent GKS, and blood samples were collected before and after GKS. NKA was measured using an enzyme-linked immunosorbent assay kit, to measure interferon-gamma (IFNγ) secreted by ex vivo-stimulated NK cells from whole blood. We explored the correlations between NK cell-produced IFNγ (NKA-IFNγ) levels and clinical parameters of patients who were treated with GKS for brain tumors. Results : NKA-IFNγ levels were decreased in metastatic brain tumor patients compared to those with benign brain tumors (p<0.0001). All the patients who used steroid treatment to reduce brain swelling after GKS had an NKA-IFNγ level of zero except one patient. High NKA-IFNγ levels were not associated with a rapid decrease in brain metastasis and did not increase after GKS. Conclusion : The activity of NK cells in metastatic brain tumors decreased more than that in benign brain tumors after GKS.

• Tuberculosis and Respiratory Diseases
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• 제39권6호
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• pp.536-541
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• 1992

본 증례에서와 같이 BOOP는 임상상 및 조직소견에서의 특징과 좋은 예후를 갖는 미만성 침윤성 폐질환의 한 아형이며 원발성 폐섬유화증과는 달리 부신피질스테로이드에 의해 완치될 수 있다는 점에서 이 질환에 대한 인식은 매우 중요하다. 저자들은 부신피질스테로이드를 사용한후 1개월후부터 임상적으로 뚜렷한 호전을 보였으며, 2개월후부터는 흉부 X선 및 폐기능검사상 현저한 호전을 보였으며, 치료 3개월 후 부터는 prednisolne 요량 감소를 시작하였다. 경과도중 증상의 재발없이 일시적으로 흉부 X선상 새로운 병소가 나타났으나 용량을 증가시켜 곧 소실되었다. 치료 1년뒤 Prednisolone 중단 후에도 재발없이 안정상태를 유지하고 있다.

• Childhood Kidney Diseases
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• 제8권1호
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• pp.33-42
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• 2004

목 적 : 소아 신증후군에서 스테로이드 장기투여에 따른 대사성 골질환은 흔한 합병증 중의 하나이다. 저자들은 성인에서의 스테로이드 유발성 골다공증 치료에 유효한 bisphosphonate(alendronate)를 투여하여 소아 신증후군에서 스테로이드 유발 대사성 골질환에 대한 치료효과에 대해 전향적으로 평가하고자 하였다. 방 법 : 신증후군 이환 기간이 2년된 5-8세의 환자 58명에게 DEXA로 골밀도를 측정하여 요추 골밀도가 Z-score -1 이하인 환아 30명(51.7%)을 대상으로 선정한 후 이들을 alendronate 주 1회 투여군, calcitriol 투여군, 약제 비투여군등의 세 군으로 분류하여 1년간 연구하였다. 치료 6개월, 1년에 요추 L1-L4 골밀도를 측정하였고 치료 전과 치료 1년 후 생화학적 검사를 측정하였다. 각 군간 평균 연령, 기저 요추 골밀도, 스테로이드 축적량, 골밀도% 변화율, 요추 골밀도 Z-score를 측정 분석하였다. 결 과 : 총 30명 환자에서 기본 요추 골밀도 측정시 환아의 나이는 $7.4{\pm}1.7$세였고 신증후군 이환기간은 $2.2{\pm}1.2$년이었다. Z-score로 진단된 골밀도 감소증은 23명(76.7%), 골다공증은 7명(23.3%)이었다. 각 생화학적 변수들은 치료 전후로 차이가 없었으며, 군 간에도 유의한 차이가 없었다(P>0.05). 빈번 재발형 신증후군과 스테로이드 의존형 신증후군은 22명(73.3%)으로 드문 재발형 신증후군 8명(26.6%)에 비해 대사성 골질환의 빈도가 높았다. 골밀도 변화율은 alendronate 군에서 치료 1년에 8.56%였고, calcitriol군은 5.79% 증가를 보였으며, 비투여군은 1.9%증가를 보였다. Z-socre 변화는 alendronate 군과 calcitriol 군에서만 호전되었고, 비투여군에서는 감소하였다. 골밀도 증가율은 각 군간 유의한 차이를 보였지만(P=0.0002), alendronate 군과 비투여군, calcitriol 군과 비투여군 간에 있었고(P<0.05), alendronate 군과 calcitriol 군간에는 유의한 차이가 없었다. Alendronate 투여시 약복용을 중단할 만큼의 심각한 부작용은 발현되지 않았다. 결 론 : 소아 신증후군 환자에서 고용량의 스테로이드를 투여해야 하는 경우 대사성 골질환의 발생 위험이 높기 때문에 정기적인 골밀도 측정이 필요하며, 그 평가 도구로는 요추 골밀도 Z-score가 유용함을 알 수 있었다. 또한 신증후군 환아의 스테로이드 유발 대사성 골질환에서 alendronate 주 1회 경구투여는 요추 골밀도를 증가시키는 효과적인 치료법이었다.

• 대한안과학회지
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• 제59권11호
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• pp.1097-1102
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• 2018

목적: 클로르페나피르 음독 후 중추신경계 손상을 동반한 독성 시신경병증 1예를 보고하고자 한다. 증례요약: 44세 여자가 7일 전부터의 양안 시력저하를 주소로 내원하였다. 환자는 내원 2주 전 자살 목적으로 클로르페나피르 한 모금을 음독했고, 직후 근처 병원에서 위세척을 시행하였다. 초기 최대교정시력은 우안 안전수지 30 cm, 좌안 안전수동이었다. 양안 동공은 5.0 mm로 커져 있었고, 빛에 대한 반응은 느렸으며 좌안에는 상대구심동공운동장애가 관찰되었다. 안저검사에서 양안 시신경유두부종이 관찰되었고, 뇌자기공명영상에서 양안 시신경과 속섬유막, 뇌량, 중소뇌각, 뇌간 등 백질 신경로를 따라 양쪽에 대칭적인 고강도신호가 관찰되었다. 클로르페나피르 중독으로 인한 독성 시신경병증으로 진단 후, 고용량 스테로이드치료를 3일간 시행하였으나 양안 최대교정시력은 광각무로 악화되었다. 3개월 후, 안저검사에서 양안 시신경위축이 관찰되었고, 빛간섭단층촬영에서 망막신경섬유층 및 신경절세포-내망상세포층 두께가 감소하였다. 결론: 매우 적은 양이라도 클로르페나피르에 노출되면 적절한 치료에도 불구하고 잠복기를 거쳐 심각한 시신경손상이 발생할 수 있으므로 주의해야 하겠다.

• Tuberculosis and Respiratory Diseases
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• 제75권4호
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• pp.165-169
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• 2013

An inflammatory myofibroblastic tumor (IMT) is a rare disease entity reported to arise in various organs. It is thought to be a neoplastic or reactive inflammatory condition, controversially. The treatment of choice for myofibroblastic tumor is surgery, and recurrence is known to be rare. The optimal treatment method is not well-known for patients ineligible for surgery. We report a 47-year-old patient with aggressive recurrent IMT of the lungs. The patient had been admitted for an evaluation of back-pain two years after a complete resection of pulmonary IMT. Radiation therapy was performed for multiple bone recurrences, and the symptoms were improved. However the patient presented again with aggravated back-pain six months later. High-dose steroid and non-steroidal anti-inflammatory drugs were administered, but the disease progressed aggressively, resulting in spinal cord compression and metastasis to intra-abdominal organs. This is a very rare case of aggressively recurrent pulmonary IMT with multi-organ metastasis.