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Radiotherapy for Early Glottic Carinoma (조기 성문암 환자에서의 방사선치료)

  • Kim, Won-Taek;Nam, Ji-Ho;Kyuon, Byung-Hyun;Wang, Su-Gun;Kim, Dong-Won
    • Radiation Oncology Journal
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    • v.20 no.4
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    • pp.295-302
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    • 2002
  • Purpose : The Purpose of this study was to establish general guidelines for the treatment of patients with early glottic carcinoma (T1-2N0M0), by assessing the role of primary radiotherapy and by analyzing the tumor-related and treatment-related factors that have an influence on the treatment results. Materials and Methods : This retrospective study was composed of 80 patients who suffered from early glottic carcinoma and were treated by primary radiotherapy at Pusan National University Hospital, between August 1987 and December 1996. The distribution of patients according to T-stage was 66 for stage T1 and 14 for stage T2. All of the patients were treated with conventional radical radiotherapy using a 6MV photon beams, a total tumor dose of $60\~75.6\;Gy$ (median 68.4 Gy), administered in 5 weekly fractions of $1.8\~2.0\;Gy$. The overall radiation treatment time was from 40 to 87 days, median 51 days. All patients were followed up for at least 3 years. Univariate and multivariate analysis was done to identify the prognostic factors affecting the treatment results. Results : The five-years survival rate was $89.2\%$ for all patients, $90.2\%$ for T1 and $82.5\%$ for T2. The local control rate was $81.3\%$ for all patients, $83.3\%$ for T1 and $71.4\%$ for T2. However, when salvage operations were taken into account, the ultimate local control rate was $91.3\%,\;T1\;94.5\%,\;T2\;79.4\%$, reprosenting an increase of $8\~12\%$ in the local control rate. The voice preservation rate was $89.2\%,\;T1\;94.7\%,\;T2\;81.3\%$. Fifteen patients suffered a relapse after radiotherapy, among whom 12 patients underwent salvage surgery. We included T-stage, tumor location, total radiation dose, fraction size, field size and overall radiation treatment time as potential prognostic factors. T-stage and overall treatment time were found to be statistically significant in the univariate analysis, but in the multivariate analysis, only the over-all treatment time was found to be significant. Conclusion : The high cure and voice preservation rates obtained when using a procedure, comprising a combination of radical radiotherapy and salvage surgery, may make this the treatment of choice for patients with early glottic carcinoma. However, the prognostic factors affecting the treatment results must be kept in mind, and more accurate treatment planning and further optimization of the radiation dose are necessary.

Breeding and characterization of 'Creamy', a new interspecific hybrid between Pleurotus ferulae and P. tuoliensis (아위느타리와 백령느타리의 종간교잡 품종 '크리미'의 육성 및 특성)

  • Oh, Min-Ji;Shin, Pyung-Gyun;Lim, Ji-Hoon;Oh, Youn-Lee;Jang, Kab-Yeul;Kong, Won-Sik
    • Journal of Mushroom
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    • v.17 no.4
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    • pp.224-229
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    • 2019
  • The two most common mushroom species grown in Korea are pearl oyster mushroom (Pleurotus ostreatus) and king oyster mushroom (P. eryngii). In recent years, the production of king oyster mushroom greatly increased due to the automation of the cultivation facilities, and it became a major export mushroom owing to its excellent shelf life. However, the increase in the production of king oyster mushroom led to a decline in its market price; thus, necessitating the development of new mushroom species that could replace king oyster mushroom, to diversify the mushroom market for the benefit of both, the producers and the consumers. The Mushroom division at the National Institute of Horticultural & Herbal Science (NIHHS) reported the development of a new interspecific hybrid between P. ferulae and P. tuoliensis, referred to as 'Creamy.' Two parental strains KMCC00430 (Bisan2ho, P. ferulae) and KMCC00461 (P. tuoliensis) were selected based on the results of genetic resource analysis, and their monokaryons were collected. About 1,000 Mon-Mon crosses were performed and 73 of them were selected. Following repeated cultivation tests and strain analyses, we selected strain 7773, which had a bright creamy pileus and a thick straight stipe, and named it 'Creamy.' Optimum temperature for mycelial growth of Creamy was 25-30℃, and that for fruiting body growth was 16℃. The pileus, which had a brighter creamy color, was small in size with a diameter of 61.2 mm. Although it was cultivated in suboptimal conditions, such as low temperature and high CO2 concentration, Creamy was characterized by its straight and smooth stipe. Field production tests and further analyses indicated that the yield of Creamy was 5% higher than that of Baekhwang. It is expected that Creamy, the new interspecific hybrid with a bright creamy pileus and a pleasant flavor, will help create new opportunities for mushroom farmers and diversify the mushroom market.

Genetic diversity of Clostridium perfringens form food-poisoning outbreak in Gyeonggi-do, 2013-2014 (경기도 식중독에서 분리된 Clostridium perfringens의 유전적 특성 분석)

  • Park, Sung-Hee;Choi, Ok-Kyung;Jeong, Jin-A;Kim, Woon-Ho;Lee, Yea-Eun;Park, Kwang-Hee;Yoon, Mi-Hye
    • Korean Journal of Microbiology
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    • v.52 no.3
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    • pp.286-297
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    • 2016
  • Clostridium perfringens is both a ubiquitous environmental bacterium and a major cause of human gastrointestinal disease, and C. perfringens food poisoning ranks among the most common gastrointestinal diseases in developed countries. 120 isolates of C. perfringens were obtained from food-poisoning outbreaks in 2013~2014, Gyeonggi-do. Using PCR, all 120 isolates were identified as C. perfringens type A. Of the tested isolates, 49 isolates carried the cpe gene, 71 isolates carried the cpb2 gene. The outbreak cases of cpb2 and cpe /cpb2 genes were 7 and 7, whereas the outbreak cases of cpe-gene were 2. The epidemiological relationship between C. perfringens isolates has previously been investigated chiefly by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The genetics relatedness of the isolates raged from 53.5-100% and 75 district PFGE type were observed. The PFGE results revealed a wide genetic diversity among the 64 cpb2 carrying isolates (except 7 isolates), while 46 cpe-carrying isolates (except 3 isolates) showed a high genetic similarity. The MLST analysis revealed that 14 cpe isolates (cpe-chromosomal isolates) belong to a distinct cluster that is significantly distant from all the other cpb2 isolates (cpe-plasmid carrying and cpe-negative isolates). The isolates carrying a cpb2 appear to be rarely related, and are more variable than chromosomal cpe isolates. The results suggest that the cpe-positive outbreak isolates showed close genetic relation, whereas the cpb2-positive isolates revealed a wide genetic diversity.

Impact of Recent Weather Variation on Yield Components and Growth Stages of Winter Barley in Korea (최근의 기상환경 변화에 따른 가을보리의 수량구성요소 및 생육단계 변화)

  • 심교문;윤성호;정영상;이정택;황규홍
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.4 no.1
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    • pp.38-48
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    • 2002
  • This study examines the relationships between atmospheric influences and grain yields including yield components as well as growth stages. Data used in this study were collected from the long-term field experiment at Suwon for the period between 1974 and 2000. Mean grain yield of barley cultivar, Olbori, for the recent 14 years(1987∼2000) with warm winters was higher by 0.42 ton per hectare than that for 27 years(1974∼2000) at Suwon as a result of the higher numbers of spikes per unit land area and grains per spike. However, the 1000-grain weight decreased by about 0.6 gram. Mean first day of regrowth for the recent 14 years was earlier by five days than that for 27 years. Also, beginning date of regrowth was positively correlated with that of heading and ripening. Mean period of ripening for the years of 1987 through 2000 was similar to that for 27 years, but mean period of overwintering was shorter by nine days than that for 27 years. On the other hand, mean periods of seedling and tillering were longer by three days than those for 27 years. Meteorological elements at various growth stages affecting grain yield of winter barley were air temperature (positive correlation) and sunshine hour (negative correlation) of overwintering stage, precipitation (negative correlation) of tillering stage, and potential evapotranpiration (positive correlation) of tillering stage. The 1000-grain weight was not significantly correlated with the meteorological elements. Culm length was negatively influenced by high temperature and dry weather situations during the ripening period, but spike length was positively influenced. Overall, it was found that grain yield of barley, cultivar Olbori, was iufluenced by meteorological elements of overwintering, tillering, and ripening stages.

Study on Development of Embedded Source Depth Assessment Method Using Gamma Spectrum Ratio (감마선 스펙트럼 비율을 이용한 매립 선원의 깊이 평가 방법론 개발 연구)

  • Kim, Jun-Ha;Cheong, Jea-Hak;Hong, Sang-Bum;Seo, Bum-Kyung;Lee, Byung Chae
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.18 no.1
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    • pp.51-62
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    • 2020
  • This study was conducted to develop a method for depth assessment of embedded sources using gamma-spectrum ratio and for the evaluation of field applicability. To this end, Peak to Compton and Peak to valley ratio changes were evaluated according to 137Cs, 60Co, 152Eu point source depth using HPGe detector and MCNP simulation. The effects of measurement distance of PTV and PTC methods were evaluated. Using the results, the source depth assessment equation using the PTC and PTV methods was derived based on the detection distance of 50 cm. In addition, the sensitivity of detection distance changes was assessed when using PTV and PTC methods, and error increased by 3 to 4 cm when detection distance decreased by 20 cm based on 50 cm. However, it was confirmed that if the detection distance was increased to 100 cm, the effects of detection distance were small. And PTV and PTC methods were compared with the two distance measurement method which evaluates the depth of source by the change of net peak counting rate according to the detection distance. As a result of source depth assessment, the PTV and PTC showed a maximum error of 1.87 cm and the two distance measurement method showed maximum error of 2.69 cm. The results of the experiment confirmed that the accuracy of the PTV and PTC methods was higher than two distance measurement. In addition, Sensitivity evaluation by horizontal position error of source has maximum error of less than 25.59 cm for the two distance measurement method. On the other hand, PTV and PTC method showed high accuracy with maximum error of less than 8.04 cm. In addition, the PTC method has lowest standard deviation for the same time measurement, which is expected to enable rapid measurement.

The Neutralization Treatment of Waste Mortar and Recycled Aggregate by Using the scCO2-Water-Aggregate Reaction (초임계이산화탄소-물-골재 반응을 이용한 폐모르타르와 순환골재의 중성화 처리)

  • Kim, Taehyoung;Lee, Jinkyun;Chung, Chul-woo;Kim, Jihyun;Lee, Minhee;Kim, Seon-ok
    • Economic and Environmental Geology
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    • v.51 no.4
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    • pp.359-370
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    • 2018
  • The batch and column experiments were performed to overcome the limitation of the neutralization process using the $scCO_2$-water-recycled aggregate, reducing its treatment time to 3 hour. The waste cement mortar and two kinds of recycled aggregate were used for the experiment. In the extraction batch experiment, three different types of waste mortar were reacted with water and $scCO_2$ for 1 ~ 24 hour and the pH of extracted solution from the treated waste mortar was measured to determine the minimum reaction time maintaining below 9.8 of pH. The continuous column experiment was also performed to identify the pH reduction effect of the neutralization process for the massive recycled aggregate, considering the non-equilibrium reaction in the field. Thirty five gram of waste mortar was mixed with 70 mL of distilled water in a high pressurized stainless steel cell at 100 bar and $50^{\circ}C$ for 1 ~ 24 hour as the neutralization process. The dried waste mortar was mixed with water at 150 rpm for 10 min. and the pH of water was measured for 15 days. The XRD and TG/DTA analyses for the waste mortar before and after the reaction were performed to identify the mineralogical change during the neutralization process. The acryl column (16 cm in diameter, 1 m in length) was packed with 3 hour treated (or untreated) recycled aggregate and 220 liter of distilled water was flushed down into the column. The pH and $Ca^{2+}$ concentration of the effluent from the column were measured at the certain time interval. The pH of extracted water from 3 hour treated waste mortar (10 ~ 13 mm in diameter) maintained below 9.8 (the legal limit). From XRD and TG/DTA analyses, the amount of portlandite in the waste mortar decreased after the neutralization process but the calcite was created as the secondary mineral. From the column experiment, the pH of the effluent from the column packed with 3 hour treated recycled aggregate kept below 9.8 regardless of their sizes, identifying that the recycled aggregate with 3 hour $scCO_2$ treatment can be reused in real construction sites.

Studies on the Effects of Hydrogen Fluoride Gas in Paddy Rice and Weeds at Fluorine Damaged Site (불화수소(弗化水素)가스에 의(依)한 수도(水稻) 및 잡초(雜草)의 피해(被害) 조사연구(調査硏究))

  • Kim, Bok-Young;Cho, Jae-Kyu
    • Korean Journal of Environmental Agriculture
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    • v.2 no.2
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    • pp.98-102
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    • 1983
  • The hydrogen fluoride gas generated from making the cement hardener injured the plants growing at the neighbour field. This investigation was conducted on sample analysis of hydrogen fluoride gas damage plants which included the ratios of destroyed leaves, damage symptoms, and nutrient elements in paddy rice and weeds. The results obtained were as follows; 1) The ratio of destroyed leaves at near HF source was very high reaching about 95% at 100m, 65% at 500m, 5% at 2㎞, respectively. 2) The necrosis was the characteristic symptom of fluoride injury on rice plant and occurred predominantly at the tip and margins of damage leaf. It developed along the tip and margins of leaves with a dull, gray-green, water soaked discoloration. 3) The fluorine content of tip and margins of damaged rice leaves were 1,600 ppm, 3 to 20 times higher than that of center part and it ranged from 130 to 242.5 ppm in weed leaves, but from 10 to 15 ppm in normal weed leaves. 4) The contents of calcium, potassium, silicon, iron and manganese were higher in tip and margins than in the center of rice damage leaves. 5) The Cocculus trilolous. D.C was the most resistant plant to HF gas than any other plant growing in this site, while wild berry and aralia tree belong to most sensitive plant group.

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Studies on Dry Matter Yield s, Chmical Composition And Net Energy Accumlation in Three Leading Temperate Grass Species III. Seasonal changes of chemical components under dfferent cutting managements (주요북방형 목초의 건물수량 , 화학성분 및 Net Energy 축적에 관한 연구 III. 예취관리에 화학성분의 계절적 변화)

  • 김정갑;양종성;한흥전
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.6 no.3
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    • pp.157-163
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    • 1986
  • Synthesis and accumulation pattern of Weender components in orchardgrass (Dactylis glomerata L.) cv. Potomac and Baraula, perennial ryegrass (Lolium perenne L.) cv. Reveille and Semperweide and meadow fescue (Festuca pratensis Huds.) cv. Cosmos 11 and N.F.G. were studied under different growth environments and cutting managements. The field experiments were conducted as a split plot design with three cutting regimes of 6-7 cuts at grazing stage, 4-5 cuts at silage and 3 cuts at hay stage from 1975 to 1979 in Korea and West Germany. The results obtained are summarized as follows: 1. Air temperature, rainfalls and solar radiation were found to be an important meteorological factors influenced to synthesis and accumulation of Weender components. Under high temperature and strong solar radiation during summer season in Korea, accumulation of crude fiber and cell-wall constituents (NDF) in the plants, as average of all grass species and cutting regimes, were increased to about 30.1% and 48.7% from 27,9% and 42.9% in spring, respectively, while total nonstructural carbohydrates (TNC) were decreased to 1.52% in summer from 4.01% in spring. In West Germany, the concentration of Weeder components showed little seasonal variation. 2. Crude fiber and neutral detergent fiber (NDF) were shown higher concentration in orchardgrass than those of perennial ryegrass and meadow fescue, but N-free extractions and TNC as well as net energy value were less accumulated in orchardgrass. Orchardgrass contained lower net energy contents with 534 StE. 431 StE and 575 StE/kg for Suweon, Cheju and Freising, respectively, as compared with 624 StE (Suweon), 491 StE (Cheju) and 657 StE/kg (Freising) in meadow fescue.

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Influence of Growth Location And Cutting Managements on Macro-And Microelements in Temperate Grasses (주요 화본과 목초에 있어서 재배지역 및 예취관리가 다량 및 미량요소 함량에 미치는 영향)

  • 김정갑;황석중
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.6 no.3
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    • pp.145-150
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    • 1986
  • The experiments were conducted to study the influence of growth location and cutting microelements macro-and on managements in temperate grasses in Korea and West Germany from 1975 to 1979. The field trials were designed as split plot with three grass species of Dactylis glomerata L., Lolium perenne L. and Festuca pratensis Huds under three cutting regimes at grazing stage, silage stage and hay stage. The results obtained are summarized as follows: 1. Concentrations of macro-and microelements in temperate grasses showed a different response to growth location and growing season. P concentration in the plants was decreased under hot stress in summer, whereas Mg and Na tended to be increased. The seasonal changes in K and Zn were not significant. 2. Morphological growth stage was to be found as an important factors influenced to mineral components. P and K contents in temperate grasses tended to be decreased as morphological development especially under high temperature in Suweon and Cheju. Ca and Mg were less affected by morphological stage and cutting managements. 3. Mean value of Ca/P ratio in the plants were 1.58, 1.33 and 1.21 for meadow fescue, perennial ryegrass and orchardgrass, respectively. Ca/P ratio in grasses tended to be increased as morphological development. 4. Zn deficiency in the plants occured in all grass species and experimental sites. Mean Zn concentration of the plant were 34.2%, 31.2% and 37.8% for Suweon, Cheju and Taekwalyong, respectivelly. Na deficiency occured in orchardgrass and meadow fescue, especially in taekwalyong. Cool temperature resulted in a decrease of Na absorption and accumulation.

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Studies on the improvement and Utilization of Pasture on the Forest III. Seasonal herbage production and utilization of pasture on the forest (임간초지의 개량 및 이용에 관한 연구 III. 임간초지에서 계절별 목초생산성 및 이용성)

  • 이형석;이인덕
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.9 no.1
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    • pp.7-14
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    • 1989
  • This experiment was carried out to determine the seasonal herbage production and utilization during the growing season of pasture on the forest (shading 30%). Plant height, leaf area index(LAl), dry matter(DM) production and distribution, chemical composition, in vitro dry matter digestibility(IVDMD), herbage utilization percentage and chewing efficiency were investigated using the Corridale sheep. Experimental field was treated by one plot design(3 rep.) and performed from 1987 to 1988 at Chungnam National University, Daejon. The results obtained are summarized as follows: 1. The highest plant height and LA1 were observed in May(35.0 cm, 4.89), followed by April(28.0 cm, 4.23), while the plant height and LA1 in October (13.0 cm, 0.49) showed very low. 2. During the growing season, about 58.3 % of annual DM production (7240 kg/ha) was produced during the spring (April, May and June) and the highest DM production was obtained in May (2040 kg/ha), which was more than 28.2 % of total DM production. However, DM production in July and August was about 24.2 % and those in September and October (17.5 %) was very low, but the difference of DM production from June to September was small. 3. The maximum DM production per day (65.8 kg/ha) was observed in May, followed by June (28.7 kglha), while DM production per day in October (16.5 kg/ha) showed very low (p <0.01). 4. Crude protein content and IVDMD of herbage samples during the spring (April, May and June) were higher, while crude fiber, ADF, and NDF content were lower in an summer growth herbage samples (July and August), but autumn growth herbage samples was intermediate. Crude ash content and IVDMD of collected herbage samples were slightly more, while crude fiber, ADF and NDF content were slightly less than offered and residued herbage samples during the growing season. 5. The maximum DM intake per metabolic body size was observed in May(68.9 g), followed by October (66.7 g), while very low in August (52.5 g). Significant positive correlation (p <0.05) was found between DM intake and IVDMD. 6. Herbage utilization percentage was very high in April (83.4 %), while very low in August (64.0 %). The percentage of annual herbage utilization was about 75.5 %. 7. The maximum ruminating and chewing efficiency of herbage samples were observed in May, followed by October, while very low in August.

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