• Title/Summary/Keyword: High control margin

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Long-Term Treatment Results in Soft Tissue Sarcomas of the Thoracic Wall Treated with Pre-or-Postoperative Radiotherapy - a Single Institution Experience

  • Oksuz, Didem Colpan;Ozdemir, Sevim;Kaydihan, Nuri;Dervisoglu, Sergulen;Hiz, Murat;Tuzun, Hasan;Mandel, Nil Molinas;Koca, Sedat;Dincbas, Fazilet Oner
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.22
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    • pp.9949-9953
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    • 2014
  • Objective: To evaluate the long term results among patients with soft tissue sarcoma of the thoracic wall. Materials and Methods: Twenty-six patients who were treated with pre-or postoperative radiotherapy between December 1980-December 2007, with a diagnosis of soft tissue sarcoma of the thoracic wall were retrospectively evaluated. Results: The median age was 44 years (14-85 years) and 15 of them were male. A total of 50% of patients were grade 3. The most common histologic type of tumor was undifferentiated pleomorphic sarcoma (26.9%). Tumor size varied between 2-25 cm (median 6.5 cm). Seventeen of the cases had marginal and 9 had wide local resection. Four cases received preoperative radiotherapy and 22 postoperative radiotherapy. Six of the patients with large and high grade tumors received chemotherapy. Median follow-up time was 82 months (9-309 months). Local recurrence and metastasis was detected in 34.6% and 42.3% of patients, respectively. Five-year local control (LC), disease-free survival (DFS), overall survival (OS), and disease-specific survival (DSS) were 62%, 38%, 69%, and 76% respectively. On univariate analysis, the patients with positive surgical margins had a markedly lower 5-year LC rate than patients with negative surgical margin, but the difference was not significant (43% vs 78%, p=0.1). Five-year DFS (66% vs 17%) and DSS (92% vs 60%) rates were significantly worse for the patients who had high grade tumors (p=0.01, p=0.008 respectively). Conclusions: Tumor grade and surgical margin are essential parameters for determining the prognosis of thoracic wall soft tissue sarcoma both in our series and the literature.

Treatment of Salivary Duct Carcinoma: A Case Report (타액선관 상피암의 치험례)

  • Moon, Suk Ho;Yoo, Gyeol;Choi, Yun Seok;Lim, Jin Soo;Han, Ki Taik
    • Archives of Craniofacial Surgery
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    • v.9 no.1
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    • pp.23-26
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    • 2008
  • Salivary duct carcinoma is a high-grade adenocarcinoma arising from the ductal epithelium and has very low prevalence. We report a case of salivary duct carcinoma in high risk group with satisfactory result. A 65-year-old male was referred to our clinic complaining of mass on Rt. cheek. Preoperative CT and MRI shows $2.0{\times}1.9cm$ sized multilobulated, cystic mass on the superficial lobe of Rt. parotid gland and multiple lymph node enlargement thorough the Rt. internal jugular chain. Total parotidectomy and modified radical neck dissection with adjuvant radiation therapy was performed. Pathologic result was salivary duct carcinoma and resection margin was free. Postoperative radiation therapy with 6400 cGy($200cGy{\times}12fx$) was performed. During the 24-months of follow up periods, recurrence or complications associated with operation and radiation therapy was not observed. Salivary duct carcinoma is rare disease with very poor prognosis. Lymph node metastasis is commonly accompanied at the time of diagnosis. Distant metastasis is the most common cause of death. Total parotidectomy, radical neck disssection and adjuvant radiation therapy can be the appropriate modality for the control of the salivary duct carcinoma especially in high risk group.

A Study on the Selection of Adaptable Tree in Air Pollution Area (大氣汚染地域 適應 樹種 選拔에 關한 硏究)

  • 朴晥澈
    • Journal of Korean Society for Atmospheric Environment
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    • v.7 no.1
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    • pp.55-65
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    • 1991
  • The study was performed to select a adaptable tree species under stressed field conditions where there are a industrial plants operating with a number of smoke stacks emitting pollutants, such as hydrogen fluoride and sulfur dioxide. As a result of the study, a tree species selected are due to construct a forest belt in a zones near industrial plants to reduce the concentrations of air pollutants. The concentrations of atmospheric hydrogen fluoride and sulfur dioxide were very higher at experimental sites near industrial plants (air-pollution sites) than at control site. The leaves of 7 tree species grown at air pollution sites contained more sulfur and, specially, fluorine than at those control site. Among the tested tree species, Ligustrum japonicum Thunb. and Euonymus japonica Thunb. grown at air pollution sites did not at all break out a foliar injury but appeared to be healthy, as well as those grown at control site. Acer pseudo-sieboldianum Kom., Pinus virginiana Mill., Larix leptolepis Gordon., Pinus koraiensis Sieb. et Zucc., Pinus strobus L., Picea abies Karst and Ligustrum obtusifolium Sieb. et Zucc., however, showed a severe fluoride-type foliar injury such as necrosis on tip or margin of leaves, etc. Fluorine found in leaves was proved to be correlated to sulfur found in leaves whereas index of foliar injury hadn't a good correlation to pollutants found in leaves. It appears that Euonymus japonica Thunb., Ligustrum japonica Thunb., Platanus acerifolia Willd, Chamaecyparis pisifera Endl., Populus tomentiglandulosa T. Lee and Sophora japonica L. grown at both experimental sites had a high value of percent survival whereas Pinus virginiana Mill., Pinus koraiensis Sib. et Zucc., Koelreuteria paniculata Laxm. and Alnus hirsuta Rupr. had an extremely low value of that. In comparison with control site, the percent tree height increments in Chamaecyparis pisifera Endl., Ligustrum japonicum Thunb., Quercus acutissima Carruth., Populus tomentiglandulosa T. Lee, Pinus thunbergii Parl and Euonymus japonica Thunb. and the percent upmost root diameters in Populus tomentiglandulosa T. Lee, Chamaecyparis pisifera Endl., Euonymus japonica Thunb., Ligustrum japonicum Thunb., Betula platyphylla var. japonica Hara and Pinus thunbergii Parl. cultivated at air polluted sites showed very high value above 90%, respectively. A significant negative correlation (r=-0.662) was recognized between the index of foliage injury and the percent collective character, which was the mean of tree characters such as percent survival, percent tree height increment and percent upmost root diameter increment which compared to those at air polluted site with those at control site. Based on the percent collective character Ligustrum japonicum Thunb., Euonymus japonica Thunb., Chamaecyparis pisifera Endl., Populus tomentiglandlosa T. Lee, Betula platyphyla var. japonica Hara and Platanus occidentalis L. have large value about 90%, respectively. Therefore, the results indicate that this tree species are adaptable species in air polluted regions. For better understanding of the adaptable tree species, furthur studies concerning the effects of various air pollutants on the tree growth are required.

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Experimental Analysis of Axial Vibration in Slim-type Optical Disc Drive (슬림형 광 디스크 드라이브의 축방향 진동에 대한 실험적 해석)

  • 박대경;전규찬;이성진;장동섭
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2002.05a
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    • pp.694-699
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    • 2002
  • As the demand for slim laptops requires ion'-height optical disc drives, vibration problems of optical disc drives are of great concern. Additionally, with the decrease of a track width and a depth of focus in high density drives, studies on vibration resonance between mechanical parts become more important. From the vibration point of view, the performance of optical disc drives is closely related with the relative displacement between a disc and an objective lens which is controlled by servo mechanism. In other words, to read and write data properly, the relative displacement between an optical disc and an objective lens should be within a certain limit. The relative displacement is dependent on not only an anti-vibration mechanism design but also servo control capability. Good servo controls can make compensation for poor mechanisms, and vice versa. In a usual development process, robustness of the anti-vibration mechanism is always verified with the servo control of an objective lens. Engineers partially modify servo gain margin in case of a data reading error. This modification cannot correct the data reading error occasionally and the mechanism should be redesigned more robustly. Therefore it is necessary to verify a mechanism with respect to the possible servo gain plot. In this study we propose the experimental verification method far anti-vibration mechanism with respect to the existing servo gain plot. This method verifies axial vibration characteristics of optical disc drives on the basis of transmissibility. Using this method, we verified our mechanism and modified the mechanism for better anti-vibration characteristics.

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Experimental Analysis of Axial Vibration in Slim-type Optical Disc Drive (슬림형 광 디스크 드라이브의 축방향 진동에 대한 실험적 해석)

  • 박대경;전규찬;이성진;장동섭
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.12 no.11
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    • pp.833-839
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    • 2002
  • As the demand for slim laptops requires low-height optical disc drives, vibration problems of optical disc drives are of great concern. Additionally, with the decrease of a track width and a depth of focus in high density drives, studies on vibration resonance between mechanical parts become more important. From the vibration point of view, the performance of optical disc drives is closely related with the relative displacement between a disc and an objective lens which is controlled by servo mechanism. In other words, to read and write data properly, the relative displacement between an optical disc and an objective lens should be within a certain limit. The relative displacement is dependent on not only an anti-vibration mechanism design but also servo control capability. Good servo controls can make compensation for poor mechanisms, and vice versa. In a usual development process, robustness of the anti-vibration mechanism is always verified with the servo control of an objective lens. Engineers partially modify servo gain margin in case of a data reading error. This modification cannot correct the data reading error occasionally and the mechanism should be redesigned more robustly. Therefore it is necessary to verify a mechanism with respect to the possible servo gain plot. In this study we propose the experimental verification method for anti-vibration mechanism with respect to the existing servo gain plot. Thismethod verifies axial vibration characteristics of optical disc drives on the basis of transmissibility. Using this method, we verified our mechanism and modified the mechanism for better anti-vibration characteristics.

A Study on the Effects of I&C Systems by EMI Generating from Corona Discharge at Transformer Area (변압기 지역 코로나 전자파 간섭에 의한 계측제어설비 영향에 관한 연구)

  • Min, Moon-Gi;Lee, Jae-Ki;Park, Jin-Yeub;Kim, Hee-Je
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.63 no.2
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    • pp.266-271
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    • 2014
  • The Electromagnetic Interference(EMI) generating from corona discharge of transformer area can interference the digital Instrument and Control(I&C) systems located nearby transformers. When the potential gradient of the electric field around the conductor is high enough to form a conductive region but not high enough to cause electrical breakdown to nearby objects, the EMI of corona discharge emits with the conducted and radiated noise and it interferences the signals of the I&C systems. Since digital I&C systems have an efficiency and competitive price, the analog I&C systems have been upgraded and displaced with the digital I&C systems but which have less EMI Immunity. There was no assessment to I&C systems by EMI generating corona discharge nearby transformers. When the safety-related I&C systems are installed in plants, the verification of equipment EMI should be done not in site-specific test but in test facilities. There are the need to do the site-specific EMI evaluation of corona discharge nearby transformers. This paper assesses the margin between plant emission limits and the highest composite plant emission of corona. When the non safety-related I&C systems are placed in transformer area, it suggests the appropriate radiated susceptibility level to EMI of corona discharge.

Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

  • Han, Hee Ji;Kim, Ju Ree;Nam, Hee Rim;Keum, Ki Chang;Suh, Chang Ok;Kim, Yong Bae
    • Radiation Oncology Journal
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    • v.32 no.3
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    • pp.132-137
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    • 2014
  • Purpose: To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure. Materials and Methods: From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total of 320 patients were treated with breast-conserving surgery and radiotherapy. Results: The median age of patients was 48 years, and the median follow-up time was 72.8 months. Close resection margin (RM) was observed in 13 patients. The median number of dissected SNB was two, and that of total retrieved ALNs was 11. Sentinel node accuracy was 94.7%, and the overall false negative rate (FNR) was 5.3%. Eleven patients experienced treatment failure. Local recurrence, regional LN recurrence, and distant metastasis were identified in 0.9%, 1.9%, and 2.8% of these patients, respectively. Sentinel LN status were not associated with locoregional recurrence (p > 0.05). Close RM was the only significant factor for disease-free survival (DFS) in univariate and multivariate analysis. The 5-year overall survival, DFS, and locoregional DFS were 100%, 96.8%, and 98.1%, respectively. Conclusion: In this study, SNB was performed with high accuracy and low FNR and high locoregional control was achieved.

KSR-III 김발엔진 구동장치 서보필터 설계

  • Sun, Byung-Chan;Jung, Ho-Lac
    • Aerospace Engineering and Technology
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    • v.1 no.2
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    • pp.105-112
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    • 2002
  • In this paper, a servo filter design for the gimbal engine actuator system of KSR-III(Korea Sounding Rocket-III) is considered. A reasonable filter structure is determined based on the actuator analytic models. The servo filter consists of a 2-nd order lowpass filter and a 1-st order compensator. The lowpass filter is required to protect the actuator from high frequency vibration, and the compensator to enhance the resulting stability. A Butterworth type servo filter is considered as the simplest one. The final servo filter type is determined by evaluating simultaneously both high frequency gain reduction performance and the corresponding KSR-III stability margin. Consequently it is revealed that a notch type servo filter located on the error between command signal and feedback signal in the control loop is very effective. Later, based on the proposed servo filter type, an onboard servo filter hardware of KSR-III will be designed and tested.

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Postoperative Radiotherapy for Parotid Gland Malignancy (귀밑샘 악성 종양의 수술 후 방사선 치료)

  • Eom Keun-Yong;Wu Hong-Gyun;Kim Jae-Sung;Park Charn Il;Kim In-Ah;Kim Kwang Hyun;Lee Chae Seo
    • Radiation Oncology Journal
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    • v.23 no.3
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    • pp.131-136
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    • 2005
  • Purpose: The aim of this study was to evaluate the clinical results of postoperative radiotherapy for parotid gland malignancy, and determine prognostic factors for locoregional control and survival. Materials and Methods: Between 1980 and 2002, 130 patients with parotid malignancy were registered In the database of the Department of Radiation Oncology, Seoul National University Hospital. The subjects of this analysis were the 72 of these 130 patients who underwent postoperative Irradiation, There were 42 males and 30 females, with a median age of 46.5 years. The most common histological type was a mucoepidermoid carcinoma. There were 6, 23, 23 and 20 patients in Stages I, II, III and IV, respectively. The median dose to the tumor bed was 60 Gy, with a median fraction size of 1.8 Gy. Results: The overall 5 and 10 year survival rates were 85 and $76\%$, respectively, The five-year locoregional control rate was $85\%$, which reached a plateau phase after 6 years. Sex and histological type were found to be statistically significant for overall survival from a multivariate analysis. No other factors, Including age, facial nerve palsy and stage, were related to overall survival. For locoregional control, nodal involvement and positive resection margin were associated with poor local control. Histological type, tumor size, perineural invasion and type of surgery were not significant for locoregional control. Conclusion: A high survival rate of parotid gland malignancies, with surgery and postoperative radiotherapy, was confirmed. Sex and histological type were significant prognostic factors for overall survival. Nodal Involvement and a positive resection margin were associated with poor locoregional control.

Control of Annual Bluegrass(Poa annua L.) by Bispyribac-sodium (Bispyribac-sodium 처리에 의한 새포아풀(Poa annua L.) 방제)

  • Park, Nam-Il;Lee, In-Yong;Park, Jae-Eup;Kim, Ho-Jun;Chun, Jae-Chul;Ogasawara, Masaru
    • Asian Journal of Turfgrass Science
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    • v.20 no.2
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    • pp.157-165
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    • 2006
  • This study was initiated to investigate herbicidal selectivity margin with annual bluegrass and bentgrass according to growth stages through herbicidal spectrum of bispyribac-sodium and therefore to examine application possibility to prevent annual bluegrass selectively. The herbicidal efncacy by pre-emergence application was generally low. But a high herbicidal efficacy was observed over 90% for Shehpherd's purse. Foliar treatment resulted in a higher herbicidal efficacy in all tested plants except dallisgrass, lovegrass, curled dock and bentgrass as compared with pre-emergence application. We found bispyribac-sodium could be used as a selective weeding chemical between annual bluegrass and bentgrass. In regard to dose-responses to the growth stage, annual bluegrass was more susceptible to bispyribac-sodium than bentgrass for the same dosage. Particularly, bispyribac-sodium application in inflorescence emergence stage showed a greater herbicidal selectivity margin of 6.8 times with annual bluegrass over creeping bentgrass after 28 days from the application. These data demonstrated that annual bluegrass was more sensitive to bispyribac-sodium over creeping bentgrass.