• 정보과학회 컴퓨팅의 실제 논문지
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• 제22권1호
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• pp.56-60
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• 2016

탠덤 질량 분석에서는 신뢰도 높은 펩타이드 동정을 위해 목표 데이터베이스의 참조 단백질 순서를 재배치한 디코이 데이터베이스가 주로 이용된다. 한편 목표 데이터베이스와 디코이 데이터베이스 사이 혹은 디코이 데이터베이스 내부에 서열이 동일한 중복 펩타이드가 존재할 수 있으며, 이는 단백질 동정을 어렵게 하는 요인이 된다. 따라서 디코이 데이터베이스의 중복성을 최소화하는 것은 중요한 문제이다. 본 논문에서는 디코이 데이터베이스 생성에 널리 사용되는 의사셔플(pseudo-shuffling)과 의사역순(pseudo-reversing) 방법이 디코이 데이터베이스의 중복성에 미치는 영향을 조사하였다. 실험 결과, 목표 데이터베이스 크기와 데이터베이스 생성 시 허용되는 'missed cleavage site'의 최대 개수는 중복성을 증가시킴을 확인하였다. 또한 동일한 조건에서는 의사역순 방법이 의사셔플보다 항상 낮은 수준의 중복성을 가지는 디코이 데이터베이스를 생성하였다.

• 한국통신학회논문지
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• 제24권12B호
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• pp.2359-2368
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• 1999

본 논문에서는 2차원 영상을 기반으로 3차원 목표물을 인식하는 기법의 한 예로서 적외선 영상으로부터 추출된 물체의 모양 정보와 모양 정보의 신뢰도를 이용해서 지상에서 지상용 차량을 인식하는 기법(ground-to-ground vehicle recognition)을 제안한다. 우선 목표물 추출과정에서 얻어진 마스크의 윤곽선 상에 있는 점들 중 에지 경사도의 크기와 밝기값이 일정한 값 이상이 되는 점들을 신뢰도가 높은 점이라고 정의하고 신뢰도가 높은 점들을 연결해서 신뢰도가 높은 부분 윤곽선(sub-contour)을 추출한다. 모델로부터 입력 영상의 신뢰도가 높은 윤곽선에 해당되는 윤곽선을 선택한 후 각각 해당되는 윤곽선들은 이산 정현 변환(Discrete Sine Transform)을 사용해서 특징값을 계산한 다음 서로 비교한다. 실험 결과 영상 분할이 불완전한 경우 신뢰도를 이용한 방법이 그렇지 않은 방법보다 더 나은 결과를 보였다.

• 설비공학논문집
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• 제12권1호
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• pp.59-66
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• 2000

In a previous paper, we have examined the effects of nozzle configuration and jet to jet spacing on the heat transfer of 1 row of circular water jets. In this paper, experiments have been conducted to obtain the effects of nozzle to target plate distances on the heat transfer of 1 row of 3 jets and 1 row of 5 jets. The nozzle configurations are Cone type, Reverse cone type and Vertical circular type. Nozzle to target plate distance H was varied from 16 mm(H/D=2) to 80mm(H/D=10). For fixed value of mass flow rate and nozzle to target plate distance, larger values of average Nusselt number were obtained for the smaller jet to jet spacing. For the array of water jets, the average heat transfer was decreased slightly with increasing nozzle to target plate distance at low jet velocity of $\textrm{V}_{o}$=3 m/s. However, except for $\textrm{V}_{o}$=8 m/s of 1 row of 5 jets, it was increased with increasing nozzle to target plate distance at high jet velocity of $\textrm{V}_{o}$$\geq$6m/s. We proposed to apply the nozzle configuration of maximum average heat transfer to each nozzle to target plate distance for 1 row of 3 jets, and, it was Reverse cone type nozzle for 1 row of 5 jets(Reynolds number$\geq$36000).

• Genomics & Informatics
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• 제20권2호
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• pp.20.1-20.13
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• 2022

Recent studies have focused on the early detection of ovarian cancer (OC) using tumor materials by liquid biopsy. The mechanisms of microRNAs (miRNAs) to impact OC and signaling pathways are still unknown. This study aims to reliably perform functional analysis of previously validated circulating miRNAs' target genes by using pathfindR. Also, overall survival and pathological stage analyses were evaluated with miRNAs' target genes which are common in the The Cancer Genome Atlas and GTEx datasets. Our previous studies have validated three downregulated miRNAs (hsa-miR-885-5p, hsa-miR-1909-5p, and hsa-let7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques. The predicted target genes of these miRNAs were retrieved from the miRDB database (v6.0). Active-subnetwork-oriented Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was conducted by pathfindR using the target genes. Enrichment of KEGG pathways assessed by the analysis of pathfindR indicated that 24 pathways were related to the target genes. Ubiquitin-mediated proteolysis, spliceosome and Notch signaling pathway were the top three pathways with the lowest p-values (p < 0.001). Ninety-three common genes were found to be differentially expressed (p < 0.05) in the datasets. No significant genes were found to be significant in the analysis of overall survival analyses, but 24 genes were found to be significant with pathological stages analysis (p < 0.05). The findings of our study provide in-silico evidence that validated circulating miRNAs' target genes and enriched pathways are related to OC and have potential roles in theranostics applications. Further experimental investigations are required to validate our results which will ultimately provide a new perspective for translational applications in OC management.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1993년도 한국자동제어학술회의논문집(국내학술편); Seoul National University, Seoul; 20-22 Oct. 1993
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• pp.434-439
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• 1993

This paper present a sensor based obstacle avoidance method which is based on a VFH(Vector Field Histogram) method. The basic idea of obstacle avoidance is to find a minimum obstacle direction and distance. From the minimum sonar index and the target direction high level system determine steering angle of mobile robot. The sonar sensor system consists of 12 ultra sonic sensor, and each sensor have its direction and safety value. This method has advantage on calculation speed and small memory. This method is implemented on indoor autonomous vehicle'ALiVE-2'.

• 유통과학연구
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• 제12권2호
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• pp.81-93
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• 2014

Purpose - Recent rapid environmental changes in the hospital industry are accelerating the spread of customer satisfaction management. Customers' desires have become diversified and advanced; in the past, customers tended to preferred popularized and standardized care, whereas they now prefer individualized and differentiated care, based on an increase in income. Specifically, this study tries to analyze the mediating effects of factors that affect the configuration portion of customer value and relationship quality (customer trust and relationship commitment) by investigating the impacts and configuration factor of customer value on relationship quality and determining how these factors impact customer loyalty directly or indirectly. Research design, data, and methodology - This study aims to determine the customer value factors that impact the perceptions of dental hospital customers, how these factors impact relationship quality and customer loyalty, and the causal relationship of these factors, and to verify the research model based on previous research. To increase the validity and reliability of the questionnaire, the authors of this study constructed basic questions using measurement tools already verified for reliability and validity in existing studies. In this study, customer value is defined as customers' recognizing value by exchanging goods or services and is measured using a five-point Likert scale using 19 questions about the 4-Ds, such as convenience value, quick service, response value, and trustworthiness. For each question, "very low" was set at 1 point and "very high" at 5 points. Customer trust, relationship commitment, and customer loyalty are also measured using a five-point Likert 5-point scale (1 = very low, 5 = very high) based on previous studies. Results - For customer value, trustworthiness and quick service are shown to have direct significant positive impacts on customer loyalty. For customer value and quality of the relationship (customer confidence and commitment), trustworthiness, response value, confidence value, and quick service are shown to have a significant positive impact on customer truth, in order of impact. For the relationship between customer value and commitment, quick service and response value are shown to have significant positive impact. Customer confidence has a very high positive influence on commitment. For the relationship between the quality of the relationship (customer confidence and commitment) and customer loyalty, customer confidence is shown to have more of an impact than commitment, in terms of a direct influence of customer loyalty. Commitment showed a positive impact on customer loyalty. For the relationship between customer confidence and customer loyalty, commitment showed a mediating effect. Conclusions - Many additional variables could apply; this study focused on customer value, quality of the relationship, and customer loyalty. In particular, there will be significant value in identifying the relationships among customer value, relationship quality, and customer loyalty by using impact factors for customer value; ensuring external validity by expanding denotation and applying the findings to other service industries; and undertaking continuous research. This study has limited generalization potential because the target for this survey was located only in the Seoul area.

• 한국콘텐츠학회논문지
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• 제18권7호
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• pp.590-599
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• 2018

한정된 자원을 가진 전장 환경에서 다수의 표적을 효과적으로 제압하는 사격 계획을 수행하기 위한 기반정보로써, 표적에 대한 분석을 통해 표적의 위협도를 정량적으로 산출하여 높은 위협도를 가지는 표적에 대해 우선순위를 부여하는 과정이 필수적이다. 그러나 대지표적에 대한 위협 평가 알고리즘에 대한 연구는 아직 초기 수준에 머무르고 있다. 이를 고려하여, 본 논문에서는 다수의 대지표적을 위한 위협 평가 알고리즘을 제안한다. 제안하는 알고리즘에서는 표적 및 보호자산의 형태를 고려하여 근접도 연산을 수행한 후, 무장 및 보호 자산의 중요도에 따른 가중치를 설정하여 표적 성질을 고려한 표적의 위협도를 산출하는 것을 핵심으로 한다. 본 논문에서는 제안하는 알고리즘의 시뮬레이션 및 가시화를 통해 성능 평가 및 검증을 수행하였다. 성능 평가 결과 제안하는 알고리즘은 무장 및 보호자산의 위치가 다양한 환경에서 무장 및 보호자산의 중요도를 나타내는 가중치에 따라서 위협도 평가를 효과적으로 수행함으로써, 실제 대지 무기 체계에 적용할 시에 높은 효용성 및 효과가 기대된다.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.III
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• pp.662-669
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• 2000

Based on the viscous flow characteristics of gas through capillary tube, a simple and low cost system was developed for controlling gas concentration for use in C.A experiments. The gas flow rate through capillary tube had a linear relationship with pressure, $(length)^{-1}$ and $(radius)^4$ of capillary tube, which agreed well with Hagen-Poiseuille's law. The developed system could control the gas concentration in storage chamber within ${\pm}0.3%$ deviation compared to the preset concentration. The required time for producing target gas concentration in storage chamber was exactly predicted by the model used in this study, and it required much longer time than the calculated time which divided the volume of chamber by flow rate. Therefore, for producing target gas concentration as quickly as possible, it needs to supply higher flow rate of gas during the initial stage of experiment when gas concentration in storage chamber has not reached at target value. It appeared that the developed system was very useful for C.A experiments. Because one could decide a desired flow rate by the prediction model, control flow rate freely and easily by changing pressure in the pressure-regulating chamber and the accuracy was high.

• 한국의학물리학회지:의학물리
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• 제28권4호
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• pp.144-148
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• 2017

When a high density metallic implant is placed in the path of the proton beam, spatial heterogeneity can be caused due to artifacts in three dimensional (3D) computed tomography (CT) scans. These artifacts result in range uncertainty in dose calculation in treatment planning system (TPS). And this uncertainty may cause significant underdosing to the target volume or overdosing to normal tissue beyond the target. In clinical cases, metal implants must be placed in the beam path in order to preserve organ at risk (OARs) and increase target coverage for tumors. So we should introduce Ti-mesh. In this paper, we measured the lateral dose profile for proton beam using an EBT3 film to confirm dosimetric impact of Ti-mesh when the Ti-mesh plate was placed in the proton beam pathway. The effect of Ti-mesh on the proton beam was investigated by comparing the lateral dose profile calculated from TPS with the film-measured value under the same conditions.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.675-675
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• 2013

CIGS thin films have received a great attention as a promising material for solar cells due to their high absorption coefficient, appropriate bandgap, long-term stability, and low cost production. CIGS thin films have been deposited by various methods such as co-evaporation, sputtering, spray pyrolysis and electro-deposition. In this study, Cu(In,Ga)Se2(CIGS) thin films were prepared using a single quaternary target by rf magnetron sputtering. The effect of sulfurization on the structural, compositional and electrical properties of the films was examined in order to develop the deposition process. An optimal sulfurization process will be selected for the preparation of CIGS thin films with good structural, optical and electrical properties by applying various sulfurization processes. In addition, the electrical properties of CIGS thin films were investigated by post-deposition annealing process. The carrier concentration of CIG(SSe) thin films after sulfurization was increased from $10^{14}cm^{-3}$ to $10^{16}cm^{-3}$ and the resistivity was increased from 10 ${\Omega}cm$ to $10^3$ ${\Omega}cm$. It is confirmed that CIG(SSe) thin films prepared at optimal deposition condition have similar atomic ratio to the target value after sulfurization.