• KIISE Transactions on Computing Practices
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• v.22 no.1
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• pp.56-60
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• 2016

Peptide identification in tandem mass spectrometry is usually done by searching the spectra against target databases consisting of reference protein sequences. To control false discovery rates for high-confidence peptide identification, spectra are also searched against decoy databases constructed by permuting reference protein sequences. In this case, a peptide of the same sequence could be included in both the target and the decoy databases or multiple entries of a same peptide could exist in the decoy database. These phenomena make the protein identification problem complicated. Thus, it is important to minimize the number of such redundant peptides for accurate protein identification. In this regard, we examined two popular methods for decoy database generation: 'pseudo-shuffling' and 'pseudo-reversing'. We experimented with target databases of varying sizes and investigated the effect of the maximum number of missed cleavage sites allowed in a peptide (MC), which is one of the parameters for target and decoy database generation. In our experiments, the level of redundancy in decoy databases was proportional to the target database size and the value of MC, due to the increase in the number of short peptides (7 to 10 AA). Moreover, 'pseudo-reversing' always generated decoy databases with lower levels of redundancy compared to 'pseudo-shuffling'.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.12B
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• pp.2359-2368
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• 1999

In this paper we propose a 2D FLIR image-based 3D target recognition system which performs group-to-ground vehicle recognition using the target contour and its degree of reliability extracted from FLIR image. First we extract target from background in FLIR image. Then we define contour points of the extracted target which have high edge gradient magnitude and brightness value as reliable contour point and make reliable contour by grouping all reliable contour points. After that we extract corresponding reliable contours from model contour image and perform comparison between scene and model features which are calculated by DST(discrete sine transform) of reliable contours. Experiment shows that the proposed algorithm work well and even in case of imperfect target extraction it showed better performance then conventional 2D contour-based matching algorithms.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.1
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• pp.59-66
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• 2000

In a previous paper, we have examined the effects of nozzle configuration and jet to jet spacing on the heat transfer of 1 row of circular water jets. In this paper, experiments have been conducted to obtain the effects of nozzle to target plate distances on the heat transfer of 1 row of 3 jets and 1 row of 5 jets. The nozzle configurations are Cone type, Reverse cone type and Vertical circular type. Nozzle to target plate distance H was varied from 16 mm(H/D=2) to 80mm(H/D=10). For fixed value of mass flow rate and nozzle to target plate distance, larger values of average Nusselt number were obtained for the smaller jet to jet spacing. For the array of water jets, the average heat transfer was decreased slightly with increasing nozzle to target plate distance at low jet velocity of $\textrm{V}_{o}$=3 m/s. However, except for $\textrm{V}_{o}$=8 m/s of 1 row of 5 jets, it was increased with increasing nozzle to target plate distance at high jet velocity of $\textrm{V}_{o}$$\geq$6m/s. We proposed to apply the nozzle configuration of maximum average heat transfer to each nozzle to target plate distance for 1 row of 3 jets, and, it was Reverse cone type nozzle for 1 row of 5 jets(Reynolds number$\geq$36000).

• Genomics & Informatics
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• v.20 no.2
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• pp.20.1-20.13
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• 2022

Recent studies have focused on the early detection of ovarian cancer (OC) using tumor materials by liquid biopsy. The mechanisms of microRNAs (miRNAs) to impact OC and signaling pathways are still unknown. This study aims to reliably perform functional analysis of previously validated circulating miRNAs' target genes by using pathfindR. Also, overall survival and pathological stage analyses were evaluated with miRNAs' target genes which are common in the The Cancer Genome Atlas and GTEx datasets. Our previous studies have validated three downregulated miRNAs (hsa-miR-885-5p, hsa-miR-1909-5p, and hsa-let7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques. The predicted target genes of these miRNAs were retrieved from the miRDB database (v6.0). Active-subnetwork-oriented Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was conducted by pathfindR using the target genes. Enrichment of KEGG pathways assessed by the analysis of pathfindR indicated that 24 pathways were related to the target genes. Ubiquitin-mediated proteolysis, spliceosome and Notch signaling pathway were the top three pathways with the lowest p-values (p < 0.001). Ninety-three common genes were found to be differentially expressed (p < 0.05) in the datasets. No significant genes were found to be significant in the analysis of overall survival analyses, but 24 genes were found to be significant with pathological stages analysis (p < 0.05). The findings of our study provide in-silico evidence that validated circulating miRNAs' target genes and enriched pathways are related to OC and have potential roles in theranostics applications. Further experimental investigations are required to validate our results which will ultimately provide a new perspective for translational applications in OC management.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.434-439
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• 1993

This paper present a sensor based obstacle avoidance method which is based on a VFH(Vector Field Histogram) method. The basic idea of obstacle avoidance is to find a minimum obstacle direction and distance. From the minimum sonar index and the target direction high level system determine steering angle of mobile robot. The sonar sensor system consists of 12 ultra sonic sensor, and each sensor have its direction and safety value. This method has advantage on calculation speed and small memory. This method is implemented on indoor autonomous vehicle'ALiVE-2'.

• Journal of Distribution Science
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• v.12 no.2
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• pp.81-93
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• 2014

Purpose - Recent rapid environmental changes in the hospital industry are accelerating the spread of customer satisfaction management. Customers' desires have become diversified and advanced; in the past, customers tended to preferred popularized and standardized care, whereas they now prefer individualized and differentiated care, based on an increase in income. Specifically, this study tries to analyze the mediating effects of factors that affect the configuration portion of customer value and relationship quality (customer trust and relationship commitment) by investigating the impacts and configuration factor of customer value on relationship quality and determining how these factors impact customer loyalty directly or indirectly. Research design, data, and methodology - This study aims to determine the customer value factors that impact the perceptions of dental hospital customers, how these factors impact relationship quality and customer loyalty, and the causal relationship of these factors, and to verify the research model based on previous research. To increase the validity and reliability of the questionnaire, the authors of this study constructed basic questions using measurement tools already verified for reliability and validity in existing studies. In this study, customer value is defined as customers' recognizing value by exchanging goods or services and is measured using a five-point Likert scale using 19 questions about the 4-Ds, such as convenience value, quick service, response value, and trustworthiness. For each question, "very low" was set at 1 point and "very high" at 5 points. Customer trust, relationship commitment, and customer loyalty are also measured using a five-point Likert 5-point scale (1 = very low, 5 = very high) based on previous studies. Results - For customer value, trustworthiness and quick service are shown to have direct significant positive impacts on customer loyalty. For customer value and quality of the relationship (customer confidence and commitment), trustworthiness, response value, confidence value, and quick service are shown to have a significant positive impact on customer truth, in order of impact. For the relationship between customer value and commitment, quick service and response value are shown to have significant positive impact. Customer confidence has a very high positive influence on commitment. For the relationship between the quality of the relationship (customer confidence and commitment) and customer loyalty, customer confidence is shown to have more of an impact than commitment, in terms of a direct influence of customer loyalty. Commitment showed a positive impact on customer loyalty. For the relationship between customer confidence and customer loyalty, commitment showed a mediating effect. Conclusions - Many additional variables could apply; this study focused on customer value, quality of the relationship, and customer loyalty. In particular, there will be significant value in identifying the relationships among customer value, relationship quality, and customer loyalty by using impact factors for customer value; ensuring external validity by expanding denotation and applying the findings to other service industries; and undertaking continuous research. This study has limited generalization potential because the target for this survey was located only in the Seoul area.

• The Journal of the Korea Contents Association
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• v.18 no.7
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• pp.590-599
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• 2018

As a basic information to implement the fire plan that dominates multiple targets effectively under the battle environment with limited resources, such a process is mandatory that gives a priority order to a target with the high level of threat by quantitatively computing the threat level of an individual target through the analysis on the target. However, the study has still remained in the initial level on an evaluation algorithm for the threat level of the ground target. Considering this fact, the present paper proposes the evaluation algorithm for the threat by multiple ground targets. The proposed algorithm has a core point to consider the type of target and protected asset to implement the computation of proximity; set the additional value based on the weights indicating the significance of weapon and protected asset; and compute the threat level of a target that considers the characteristics of the target. The evaluation and verification of performances have been implemented through the simulation and visualization of an algorithm proposed in the present paper. From the performance result, as the proposed algorithm has been able to perform effectively the threat assessment according to the weights indicating the significance of weapons and protected assets under diverse environments where weapons and protected assets are located, high utility and effect are expected when applied to an actual ground weapon system.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2000.11c
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• pp.662-669
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• 2000

Based on the viscous flow characteristics of gas through capillary tube, a simple and low cost system was developed for controlling gas concentration for use in C.A experiments. The gas flow rate through capillary tube had a linear relationship with pressure, $(length)^{-1}$ and $(radius)^4$ of capillary tube, which agreed well with Hagen-Poiseuille's law. The developed system could control the gas concentration in storage chamber within ${\pm}0.3%$ deviation compared to the preset concentration. The required time for producing target gas concentration in storage chamber was exactly predicted by the model used in this study, and it required much longer time than the calculated time which divided the volume of chamber by flow rate. Therefore, for producing target gas concentration as quickly as possible, it needs to supply higher flow rate of gas during the initial stage of experiment when gas concentration in storage chamber has not reached at target value. It appeared that the developed system was very useful for C.A experiments. Because one could decide a desired flow rate by the prediction model, control flow rate freely and easily by changing pressure in the pressure-regulating chamber and the accuracy was high.

• Progress in Medical Physics
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• v.28 no.4
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• pp.144-148
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• 2017

When a high density metallic implant is placed in the path of the proton beam, spatial heterogeneity can be caused due to artifacts in three dimensional (3D) computed tomography (CT) scans. These artifacts result in range uncertainty in dose calculation in treatment planning system (TPS). And this uncertainty may cause significant underdosing to the target volume or overdosing to normal tissue beyond the target. In clinical cases, metal implants must be placed in the beam path in order to preserve organ at risk (OARs) and increase target coverage for tumors. So we should introduce Ti-mesh. In this paper, we measured the lateral dose profile for proton beam using an EBT3 film to confirm dosimetric impact of Ti-mesh when the Ti-mesh plate was placed in the proton beam pathway. The effect of Ti-mesh on the proton beam was investigated by comparing the lateral dose profile calculated from TPS with the film-measured value under the same conditions.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.675-675
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• 2013

CIGS thin films have received a great attention as a promising material for solar cells due to their high absorption coefficient, appropriate bandgap, long-term stability, and low cost production. CIGS thin films have been deposited by various methods such as co-evaporation, sputtering, spray pyrolysis and electro-deposition. In this study, Cu(In,Ga)Se2(CIGS) thin films were prepared using a single quaternary target by rf magnetron sputtering. The effect of sulfurization on the structural, compositional and electrical properties of the films was examined in order to develop the deposition process. An optimal sulfurization process will be selected for the preparation of CIGS thin films with good structural, optical and electrical properties by applying various sulfurization processes. In addition, the electrical properties of CIGS thin films were investigated by post-deposition annealing process. The carrier concentration of CIG(SSe) thin films after sulfurization was increased from $10^{14}cm^{-3}$ to $10^{16}cm^{-3}$ and the resistivity was increased from 10 ${\Omega}cm$ to $10^3$ ${\Omega}cm$. It is confirmed that CIG(SSe) thin films prepared at optimal deposition condition have similar atomic ratio to the target value after sulfurization.