• 한국위성정보통신학회논문지
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• 제7권3호
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• pp.86-93
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• 2012

본 논문에서는 시맨틱 웹에서 온톨로지와 메타데이터를 기술하는 OWL 문서를 대상으로 하는 키워드 검색 기법과 랭킹 기법을 제안한다. 제안한 키워드 검색 기법은 OWL 문서에 대한 키워드 검색 결과의 단위를 정보 리소스로 정의하고 질의 키워드의 범위를 클래스와 프로퍼티의 이름은 물론 리터럴 데이터까지 확장하였다. 그리고 클래스나 프로퍼티의 계층 관계, 동등 관계 등 OWL 문서에 정의되어 있는 기본적인 추론 요소들을 고려하여 직접 기술되어 있지 않지만 새롭게 유도되는 정보도 키워드 검색에 반영하였다. 또한 키워드를 통해 간접적으로 의미적 관계를 맺고 있는 정보 리소스에 대한 검색이 가능하기 때문에 질의 키워드와 관련이 있는 많은 수의 정보 리소스들을 검색할 수 있다. 제안한 랭킹 기법은 OWL 문서의 특성을 고려하여 다양한 요소를 순위 결정에 참여시킴으로써 사용자의 검색 만족도를 높일 수 있다. 본 논문에서 제안한 키워드 검색 기법과 랭킹 기법은 방송 프로그램과 같은 디지털 콘텐츠의 검색 등 다양한 분야에서 활용될 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1361-1365
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• 2015

Background: We aimed to discover potential gene biomarkers for gastric cancer (GC) diagnosis. Materials and Methods: Genechips of 10 GC tissues and 10 gastric mucosa (GM, para-carcinoma tissue, normal control) tissues were generated using an exon array of Affymetrix containing 30,000 genes. The differentially expressed genes (DEGs) between GC tissues and normal control were identified by the Limma package and analyzed by hierarchical clustering analysis. Gene ontology (GO) and pathway enrichment analyses were performed for investigating the functions of DEGs. Receiver operating characteristics (ROC) analysis was performed to measure the effects of biomarker candidates for diagnosis of GC. Results: Totals of 896 up-regulated and 60 down-regulated DEGs were identified to be differentially expressed between GC samples and normal control. Hierarchical clustering analysis showed that DEGs were highly differentially expressed and most DEGs were up-regulated. The most significantly enriched GO-BP term was revealed to be mitotic cell cycle and the most significantly enriched pathway was cell cycle. The intersection analysis showed that most significant DEGs were cyclin B1 (CCNB1) and cyclin B2 (CCNB2). The sensitivities and specificities of CCNB1 and CCNB2 were both high (p<0.0001). Areas under the ROC curve for CCNB1 and CCNB2 were both greater than 0.9 (p<0.0001). Conclusions: CCNB1 and CCNB2, which were involved in cell cycle, played significant roles in the progression and development of GC and these genes may be potential biomarkers for diagnosis and prognosis of GC.

• 한국정보과학회논문지:데이타베이스
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• 제35권3호
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• pp.231-242
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• 2008

W3C에서 OWL을 웹 온톨로지 기술을 위한 표준으로 채택함으로써 OWL 웹 온톨로지를 효과적으로 저장할 수 있는 저장 모델에 대한 필요성이 제기되었다. 지금까지 Jena, Sesame, DLDB 등과 같은 관계형 모델 기반의 저장 시스템이 개발되었나 여전히 여러 가지 문제점을 지니며, 특히 비효율적인 질의 처리 성능을 제공한다. 질의 처리 성능이 저하되는 구조적인 문제점을 하면 다음과 같다. Jena의 경우, 정규화가 이루어지지 않은 매우 단순한 구조를 지니며 단일 테이블에 대부분의 정보를 저장한다. 이는 단순 검색은 물론 조인 연산이 요구되는 질의 처리시 불필요한 정보까지 비교함으로써 성능을 급격하게 저하시킨다. Sesame와 같은 저장소는 지나치게 정규화 된 구조를 지니기 때문에 질의 처리시 많은 조인 연산이 요구된다. 심지어 단순한 특정 클래스를 검색할 경우에도 많은 조인 연산이 요구된다. 이 논문에서는 이러한 기존 저장모델의 비정규화 혹은 지나친 정규화로 인해 발생하는 질의 처리 성능 저하 문제를 해결할 수 있는 저장 모델을 제안한다. 이를 위해 OWL 요소와 질의 패턴과의 관계를 분석하고 기존 저장 모델의 구조적인 문제점을 분석한다. 이러한 분석 결과를 통해 정의된 제안 모델은 적정 수준의 정규화 된 구조를 지니며 조인 연산이나 불필요한 정보에 대한 비교를 최소할 수 있는 구조를 제공한다. 질의 처리 성능 실험을 위해 LUBM 데이타 셋을 이용하며, 검색 대상 및 대상의 계층 관계를 고려한 질의 유형을 정의한다. 추가적으로, 제안된 저장모델의 데이타 손실 여부를 확인하기 위해 질의 결과의 정확성 및 완전성에 대해 실험하고 그 결과를 기술한다. 비교 평가 결과에서, 제안 모델이 기존 저장 모델보다 나은 성능을 보였다.

• Genomics & Informatics
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• 제5권1호
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• pp.10-18
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• 2007

Numerous studies have reported that genes with similar expression patterns are co-regulated. From gene expression data, we have assumed that genes having similar expression pattern would share similar transcription factor binding sites (TFBSs). These function as the binding regions for transcription factors (TFs) and thereby regulate gene expression. In this context, various analysis tools have been developed. However, they have shortcomings in the combined analysis of expression patterns and significant TFBSs and in the functional analysis of target genes of significantly overrepresented putative regulators. In this study, we present a web-based A Functional Clustering Analysis Tool for Predicted Transcription Regulatory Elements and Gene Ontology Terms (FCAnalyzer). This system integrates microarray clustering data with similar expression patterns, and TFBS data in each cluster. FCAnalyzer is designed to perform two independent clustering procedures. The first process clusters gene expression profiles using the K-means clustering method, and the second process clusters predicted TFBSs in the upstream region of previously clustered genes using the hierarchical biclustering method for simultaneous grouping of genes and samples. This system offers retrieved information for predicted TFBSs in each cluster using $Match^{TM}$ in the TRANSFAC database. We used gene ontology term analysis for functional annotation of genes in the same cluster. We also provide the user with a combinatorial TFBS analysis of TFBS pairs. The enrichment of TFBS analysis and GO term analysis is statistically by the calculation of P values based on Fisher’s exact test, hypergeometric distribution and Bonferroni correction. FCAnalyzer is a web-based, user-friendly functional clustering analysis system that facilitates the transcriptional regulatory analysis of co-expressed genes. This system presents the analyses of clustered genes, significant TFBSs, significantly enriched TFBS combinations, their target genes and TFBS-TF pairs.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제6권6호
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• pp.285-292
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• 2017

전장공간은 다양한 무기체계가 유기적으로 활용되고 있으며, 자원의 성능 및 통신환경이 제약되고 환경의 가변성이 높은 특징이 있다. 이러한 전장환경에서 운용되는 자원의 접근성과 통합성의 한계를 극복하고 유연한 조합을 통해 임무를 수행할 수 있는 방안으로 서비스 지향 구조 기반의 기술을 접목시키는 연구들이 진행되고 있다. 본 연구에서는 지휘관이 전장 환경에서 임무에 필요한 다양한 SW를 서비스 기반으로 운용하기 위해 서비스 기반의 임무 계획 및 수행을 지원하는 계층형 임무서비스 모델을 제안한다. 또한 워크플로우 기술과 시맨틱 능력기반 추천을 활용한 개발도구를 구현하고 전투 임무 시나리오에 적용하여 실효성을 보이고자 한다.

• 영어영문학
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• 제64권3호
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• pp.329-345
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• 2018

Sun Yung Shin's poetry collection Skirt Full of Black (2007) brings the author's personal history as a Korean female adoptee to bear upon poetic language in daring formal experiments, instantiating the liminal state of being shuttled across borders to land in an in-between state of marginalization. Other Korean American poets have also drawn on the experience of transnational adoption and racialization explore the literary potential of English to materialize haunting memories or the untranslatable yet persistent echoes of a lost home that gestures across linguistic boundaries, as seen in the case of Lee Herrick or Jennifer Kwon Dobbs. Shin however dismantles the referential foundation of English as a language she was transplanted into through formal transgressions such as frazzled syntax, atypical typography, decontextualized punctuation marks, and phonetic and visual play. The power to signify and thereby differentiate one entity or meaning from another dissipates in the cacophonic feast of signs in Skirt Full of Black; the word fragments of identificatory markers that turn racialized, gendered, and culturally contained subjects into exotic things lose the power to define them as such, and instead become alterities by departing from the conventional meaning-making dynamics of language. Expanding on the avant-garde legacy of Korean American poets Theresa Hak Kyung Cha and Myung Mi Kim to delve further into the liminal space between Korean and American, referential and representational, or spoken and written words, Shin carves out a space for discreteness that does not subscribe to the hierarchical ontology of differential value assignment.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.245-252
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• 2022

Risk identification for bridge projects is a knowledge-based and labor-intensive task involving several procedures and stakeholders. Presently, risk information of bridge projects is unstructured and stored in different sources and formats, hindering knowledge sharing, reuse, and automation of the risk identification process. Consequently, there is a need to develop structured and formalized risk information for bridge projects to aid effective risk identification and automation of the risk management processes to ensure project success. This study proposes a semantic risk breakdown structure (SRBS) to support risk identification for bridge projects. SRBS is a searchable hierarchical risk breakdown structure (RBS) developed with python programming language based on a semantic modeling approach. The proposed SRBS for risk identification of bridge projects consists of a 4-level tree structure with 11 categories of risks and 116 potential risks associated with bridge projects. The contributions of this paper are threefold. Firstly, this study fills the gap in knowledge by presenting a formalized risk breakdown structure that could enhance the risk identification of bridge projects. Secondly, the proposed SRBS can assist in the creation of a risk database to support the automation of the risk identification process for bridge projects to reduce manual efforts. Lastly, the proposed SRBS can be used as a risk ontology that could aid the development of an artificial intelligence-based integrated risk management system for construction projects.

• 한국환경과학회지
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• 제24권5호
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• pp.623-631
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• 2015

Microarray technology provides a unique tool for the determination of gene expression at the level of messenger RNA (mRNA). This study, the mRNA expression profiles provide insight into the mechanism of action of cadmium in Fleshy shrimp (Fenneropenaeus chinensis). The ability of genomic technologies was contributed decisively to development of new molecular biomarkers and to the determination of new possible gene targets. Also, it can be approach for monitoring of trace metal using oligo-chip microarray-based in potential model marine user level organisms. 15K oligo-chip for F. chinensis that include mostly unique sets of genes from cDNA sequences was developed. A total of 13,971 spots (1,181 mRNAs up- regulated and 996 down regulated) were identified to be significantly expressed on microarray by hierarchical clustering of genes after exposure to cadmium for different conditions (Cd24-5000 and Cd48-1000). Most of the changes of mRNA expression were observed at the long time and low concentration exposure of Cd48-1000. But, gene ontology analysis (GO annotation) were no significant different between experiments groups. It was observed that mRNA expression of main genes involved in metabolism, cell component, molecular binding and catalytic function. It was suggested that cadmium inhibited metabolism and growth of F. chinensis.

• 한국수정란이식학회지
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• 제30권2호
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• pp.99-107
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• 2015

The aim of the present study was to identify coat color associated genes that are differentially expressed in mature Korean brindle cattle (KBC) with different coat colors and in Hanwoo cows. KBC calves, before and after coat color appearance, were included. Total cellular RNA was isolated from the tail hair cells and used for microarray. The number of expressed coat color associated genes/probes was 5813 in mature KBC and Hanwoo cows. Among the expressed coat color associated genes/probes, 167 genes were the coat color associated genes listed in the Gene card database and 125 genes were the pigment and melanocyte genes listed in the Gene ontology_bovine database. There were 23 genes/probes commonly listed in both databases and their expressions were further studied. Out of the 23 genes/probes, MLPH, PMEL, TYR and TYRP1 genes were expressed at least two fold higher (p<0.01) levels in KBC with brindle color than either Hanwoo or KBC with brown color. TYRP1 expression was 22.96 or 19.89 fold higher (p<0.01) in KBC with brindle color than either Hanwoo or KBC with brown color, respectively, which was the biggest fold difference. The hierarchical clustering analysis indicated that MLPH, PMEL, TYR and TYRP1 were the highly expressed genes in mature cattle. There were only a few genes differentially expressed after coat color appearance in KBC calves. Studies on the regulation and mechanism of gene expression of highly expressed genes would be next steps to better understand coat color determination and to improve brindle coat color appearance in KBC.

• 인터넷정보학회논문지
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• 제12권4호
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• pp.119-133
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• 2011

웹 2.0의 등장과 함께 RESTful 웹 서비스의 활용이 전통적인 SOAP 기반 웹 서비스에 비해 크게 증가되고 있다. 최근 웹상에 이용 가능한 RESTful 웹 서비스들의 수가 급격하게 증가됨에 따라 사용자들이 적합한 웹 서비스를 찾는 것은 매우 중요한 이슈로 대두되었다. 그러나 기존의 키워드 기반 검색 방법은 나쁜 재현율과 나쁜 정확률 때문에 문제가 많다. 본 논문에서는 연관규칙 기반 클러스터링 기법에 패턴 기반 시맨틱 분석 기법을 추가한 하나의 새로운 시맨틱 온톨로지 구축 방법을 제안한다. 이를 통해 온톨로지를 자동 구축하여 시맨틱 정보의 주석처리 부담을 줄일 수 있고, 보다 효율적인 웹 서비스 검색을 지원한다. 본 논문에서 제안된 방법은 ProgrammableWeb 사이트로부터 168개의 RESTful 웹 서비스를 다운로드 받아 실험 분석을 수행한 결과, 기존의 키워드 기반 검색 방법에 비해 재현율과 정확률 두 측면에서 각각 35%, 18%의 성능 향상을 보였다.