• Title/Summary/Keyword: Heterogeneous joint

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Integrated Network Management with TINA manager and TMN agent (통합 통신망 관리를 위한 TINA manager와 TMN agent의 연동방안 연구)

  • 김호철;김영탁
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.25 no.5A
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    • pp.751-762
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    • 2000
  • In the forthcoming next generation highspeed networks, the provisioning of broadband mobile multimedia services is the most important issue while an efficient network management architecture, which can manage the network resources efficiently, is essential. The next generation highspeed networks will be composed of the ATMand SDH-based transport network systems and the H-based interworking systems. The management functions of these network systems are implemented various technologies, such as TMN and SNMP. In order to integrate these network resources efficiently with heterogeneous management functions, the distributed network management architecture such as TINA is most appropriate. In this pape, we propose an interworking architecture for TINA manager and TMN agent. where the TINA-based EML subnetwork management operations mapped into the related management operations of the TMN NE agent. The proposed interworking architecture is simpler than JIDM, and the processing overhead is minimized.

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User Bandwidth Demand Centric Soft-Association Control in Wi-Fi Networks

  • Sun, Guolin;Adolphe, Sebakara Samuel Rene;Zhang, Hangming;Liu, Guisong;Jiang, Wei
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.2
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    • pp.709-730
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    • 2017
  • To address the challenge of unprecedented growth in mobile data traffic, ultra-dense network deployment is a cost efficient solution to offload the traffic over some small cells. The overlapped coverage areas of small cells create more than one candidate access points for one mobile user. Signal strength based user association in IEEE 802.11 results in a significantly unbalanced load distribution among access points. However, the effective bandwidth demand of each user actually differs vastly due to their different preferences for mobile applications. In this paper, we formulate a set of non-linear integer programming models for joint user association control and user demand guarantee problem. In this model, we are trying to maximize the system capacity and guarantee the effective bandwidth demand for each user by soft-association control with a software defined network controller. With the fact of NP-hard complexity of non-linear integer programming solver, we propose a Kernighan Lin Algorithm based graph-partitioning method for a large-scale network. Finally, we evaluated the performance of the proposed algorithm for the edge users with heterogeneous bandwidth demands and mobility scenarios. Simulation results show that the proposed adaptive soft-association control can achieve a better performance than the other two and improves the individual quality of user experience with a little price on system throughput.

A Study on Open API Security Protocol based on Multi-Channel (다중 채널 기반 오픈 API 보안 프로토콜에 관한 연구)

  • Kim, Sang-Geun
    • Journal of Convergence for Information Technology
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    • v.10 no.11
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    • pp.40-46
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    • 2020
  • Safe security technology is required for the startup ecosystem according to the construction and service of a joint open platform in the financial sector. Financial industry standard open API recommends that payment-related fintech companies develop/apply additional security technologies to protect core API authentication keys in the mutual authentication process. This study proposes an enhanced API security protocol using multiple channels. It was designed in consideration of the compatibility of heterogeneous platforms by further analyzing the problems and weaknesses of existing open API related research. I applied the method of concealment to remove the additional security channels into a single channel of the existing security protocols. As a result of the performance analysis, the two-way safety of the communication session of the multi-channel and the security of the man-in-the-middle attack of the enhanced authentication key were confirmed, and the computational performance of the delay time (less than 1 second) in the multi-session was confirmed.

Giant Cell Tumor of the Rib: A Case Report and Review of the Literature (늑골에서 발생한 거대세포종: 1예 보고 및 문헌 고찰)

  • Kim, Hyun-Soo;Kim, Dae-Hyun;Lim, Sung-Jig;Park, Yong-Koo
    • The Journal of the Korean bone and joint tumor society
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    • v.15 no.1
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    • pp.52-58
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    • 2009
  • Giant cell tumor (GCT) of the rib may present as a posterior mediastinal mass when it involves the posterior arc. Only 4 cases of GCT of the rib presenting as a posterior mediastinal mass have been reported. We report a case of a 38-year-old man with GCT of the rib. Computed tomography revealed a well-defined, multi-lobulated, heterogeneous mass in the right superoposterior mediastinum, which appeared to invade the right third rib and thoracic vertebra. It was thought to be a posterior mediastinal ganglioneuroma or its malignant transformation. Grossly, the tumor mass arose in the posterior arc and showed substantial growth out of the rib. Microscopically, the tumor consisted of interspersed multi-nucleated giant cells and stromal mononuclear cells, compatible with GCT. For GCT, a wide excision with elective radiotherapy should be considered. GCT must be differentiated from posterior mediastinal ganglioneuroma that can be treated by surgical excision alone.

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Lessons From the Success and Failure of Targeted Drugs for Rheumatoid Arthritis: Perspectives for Effective Basic and Translational Research

  • Mingyo Kim;Yong-ho Choe;Sang-il Lee
    • IMMUNE NETWORK
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    • v.22 no.1
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    • pp.8.1-8.20
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    • 2022
  • Rheumatoid arthritis (RA) is a representative autoimmune disease that is primarily characterized by persistent inflammation and progressive destruction of synovial joints. RA has a complex and heterogeneous pathophysiology, involving interactions among various immune and joint stromal cells and a diverse network of cytokines and intracellular signaling pathways. With improved understanding of RA, over the past decades, therapeutic strategies have become considerably advanced and now included targeted molecular therapies, such as tumor necrosis factor inhibitors, IL-6 blockers, B-cell depletion agents, as well as inhibitors of T-cell co-stimulation and Janus kinases. However, a considerable proportion of RA patients experience refractory disease and interrupted treatment owing to the associated risk of developing serious infections and cancers. In contrast, although IL-1β, IL-17A, and p38α play significant roles in RA pathogenesis, several drugs targeting these factors have not been approved because of their low efficacy and severe adverse effects. In this review, we provide an overview of the working mechanism, advantages, and limitations of the currently available targeted drugs for RA. Additionally, we suggest potential mechanistic causes for clinically approved and failed drugs. Thus, this review provides perspectives on approaches for basic and translational studies that hold promise for identifying future next-generation therapeutics for RA.

Survival Results and Prognostic Factors in T4 N0-3 Non-small Cell Lung Cancer Patients According to the AJCC 7th Edition Staging System

  • Arslan, Deniz;Bozcuk, Hakan;Gunduz, Seyda;Tural, Deniz;Tattli, Ali Murat;Uysal, Mukremin;Goksu, Sema Sezgin;Bassorgun, Cumhur Ibrahim;Koral, Lokman;Coskun, Hasan Senol;Ozdogan, Mustafa;Savas, Burhan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2465-2472
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    • 2014
  • Background: The American Joint Committee on Cancer (AJCC) published a new staging system ($7^{th}$ edition) in 2009. In our study, we evaluated the survival results and prognostic factors among T4 local advanced non-small cell lung cancer (LA-NSCLC) patients in a large heterogeneous group, in accordance with this new system. Materials and Methods: We retrospectively evaluated the files of 122 T4 N0-3 M0 LA-NSCLC patients, identified according to the new staging system, treated at two centers between November 2003 and June 2012. Variables correlating with univariate survival at p<0.20 were later included in multivariate Cox regression analysis. Here, selection of relevant predictors of survival was carried out in accordance with the likelihood ratio formula with p<0.05 regarded as significant. Results: The median age was 60 and the median follow-up period was 17.4 months. Median overall survival (OS) was 18.3 months, the 1 year overall survival (OS) rate was 72%, and the 5 year OS rate was 28%. Statistically significant predictors of survival were (p<0.20) ECOG-PS (Eastern Cooperative Oncology Group Performance Status), age, T4 factor subgroup, stage and primary treatment in OS univariate analysis. On multivariate analysis for OS ECOG-PS (p=0.001), diagnostic stage (p=0.021), and primary treatment (p=0.004) were significant. In the group receiving non-curative treatment, the median OS was 11.0 months, while it was 19.0 months in the definitive RT group and 26.6 months in the curative treatment group. There was a significant difference between the non-curative group and the groups which had definitive RT and curative operations (respectively p<0.001 and p=0.001) in terms of OS, but not between the groups which had definitive RT and curative operations. The median event free survival (EFS) rate was 9.9 months, with rates of 46% and 19% at 3 and 5 years, respectively. On univariate analysis of EFS rate with ECOG-PS, weight loss and staging, statistical significance was found only for thorax computerized tomography (CT)+18F-fluorodeoxy-glucose positron emission tomography-CT (PET-CT) use, stage and primary treatment (p<0.20). In multivariate analysis with EFS, only the primary treatment was statistically significant (p=0.001). In the group receiving non-curative treatment, the median EFS was 10.5 months while in the curative operation group it was 14.7 months. When all the primary treatment groups were taken into consideration, grade III/IV side effect swas observed in 57 patients (46.6%). Esophagitis was most prominent among those that received definitive radiotherapy. Conclusions: Independent prognostic factors among these 122 heterogeneous LA-NSCLC T4 N0-3 M0 patients were age at diagnosis, ECOG-PS, stage and primary treatment, the last also being a significant prognostic indicator of EFS. Our findings point to the importance of appropriate staging and a multidisciplinary approach with modern imaging methods in this patient group. In those with T4 lesions, treatment selection and the effective use of curative potential should be the most important goal of clinical care.

Seepage Behaviors of Enlargement Levee Containing Box Culvert Constructed on Soft Ground (연약지반에 설치된 배수통문을 포함하는 하천 보축제체의 수문 위치에 따른 침투 거동)

  • Yang, Hak-Young;Kim, Young-Muk
    • Journal of the Korean Geotechnical Society
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    • v.34 no.3
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    • pp.29-41
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    • 2018
  • In the case of the enlargement levee on the soft foundation, the existing levee and the enlargement levee connection can be damaged due to heterogeneous subsidence such as differential settlement at the joint of the box culvert passing through the levee. This study selected the downstream region of the Geum River and then confirmed the influence of the piping possibility on the levee by performing a 2D seepage analysis and analyzing the seepage tendency according to the position of the box culvert's gate. As a result, the flow velocity and the hydraulic gradient are larger in the upper breakage than the lower breakage, and the upper leak was more vulnerable to the piping than the lower leak. If leaks occur in the gate located on the riverside land, the risk of piping is increased when the water level rises and is maintained highly. In the case of the gate located on the inland, it could be predicted that the leakage could damage the stability of levee by increasing the water pressure inside the levee. As a result, if leakage occurs at any position in the box culvert, the pore water pressure is increased or decreased compared with the case when no leakage occurs. Therefore, if the pore water pressure is drastically reduced or increased compared with the normal case, leakage may occur. However, the result of this study is based on a 2D seepage analysis, and it is likely to be different from actual cases. Therefore, more detailed analysis by 3D analysis is recommended.

A Sensitivity Analysis of JULES Land Surface Model for Two Major Ecosystems in Korea: Influence of Biophysical Parameters on the Simulation of Gross Primary Productivity and Ecosystem Respiration (한국의 두 주요 생태계에 대한 JULES 지면 모형의 민감도 분석: 일차생산량과 생태계 호흡의 모사에 미치는 생물리모수의 영향)

  • Jang, Ji-Hyeon;Hong, Jin-Kyu;Byun, Young-Hwa;Kwon, Hyo-Jung;Chae, Nam-Yi;Lim, Jong-Hwan;Kim, Joon
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.12 no.2
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    • pp.107-121
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    • 2010
  • We conducted a sensitivity test of Joint UK Land Environment Simulator (JULES), in which the influence of biophysical parameters on the simulation of gross primary productivity (GPP) and ecosystem respiration (RE) was investigated for two typical ecosystems in Korea. For this test, we employed the whole-year observation of eddy-covariance fluxes measured in 2006 at two KoFlux sites: (1) a deciduous forest in complex terrain in Gwangneung and (2) a farmland with heterogeneous mosaic patches in Haenam. Our analysis showed that the simulated GPP was most sensitive to the maximum rate of RuBP carboxylation and leaf nitrogen concentration for both ecosystems. RE was sensitive to wood biomass parameter for the deciduous forest in Gwangneung. For the mixed farmland in Haenam, however, RE was most sensitive to the maximum rate of RuBP carboxylation and leaf nitrogen concentration like the simulated GPP. For both sites, the JULES model overestimated both GPP and RE when the default values of input parameters were adopted. Considering the fact that the leaf nitrogen concentration observed at the deciduous forest site was only about 60% of its default value, the significant portion of the model's overestimation can be attributed to such a discrepancy in the input parameters. Our finding demonstrates that the abovementioned key biophysical parameters of the two ecosystems should be evaluated carefully prior to any simulation and interpretation of ecosystem carbon exchange in Korea.

The Impact of the Internet Channel Introduction Depending on the Ownership of the Internet Channel (도입주체에 따른 인터넷경로의 도입효과)

  • Yoo, Weon-Sang
    • Journal of Global Scholars of Marketing Science
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    • v.19 no.1
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    • pp.37-46
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    • 2009
  • The Census Bureau of the Department of Commerce announced in May 2008 that U.S. retail e-commerce sales for 2006 reached $ 107 billion, up from $ 87 billion in 2005 - an increase of 22 percent. From 2001 to 2006, retail e-sales increased at an average annual growth rate of 25.4 percent. The explosive growth of E-Commerce has caused profound changes in marketing channel relationships and structures in many industries. Despite the great potential implications for both academicians and practitioners, there still exists a great deal of uncertainty about the impact of the Internet channel introduction on distribution channel management. The purpose of this study is to investigate how the ownership of the new Internet channel affects the existing channel members and consumers. To explore the above research questions, this study conducts well-controlled mathematical experiments to isolate the impact of the Internet channel by comparing before and after the Internet channel entry. The model consists of a monopolist manufacturer selling its product through a channel system including one independent physical store before the entry of an Internet store. The addition of the Internet store to this channel system results in a mixed channel comprised of two different types of channels. The new Internet store can be launched by the independent physical store such as Bestbuy. In this case, the physical retailer coordinates the two types of stores to maximize the joint profits from the two stores. The Internet store also can be introduced by an independent Internet retailer such as Amazon. In this case, a retail level competition occurs between the two types of stores. Although the manufacturer sells only one product, consumers view each product-outlet pair as a unique offering. Thus, the introduction of the Internet channel provides two product offerings for consumers. The channel structures analyzed in this study are illustrated in Fig.1. It is assumed that the manufacturer plays as a Stackelberg leader maximizing its own profits with the foresight of the independent retailer's optimal responses as typically assumed in previous analytical channel studies. As a Stackelberg follower, the independent physical retailer or independent Internet retailer maximizes its own profits, conditional on the manufacturer's wholesale price. The price competition between two the independent retailers is assumed to be a Bertrand Nash game. For simplicity, the marginal cost is set at zero, as typically assumed in this type of study. In order to explore the research questions above, this study develops a game theoretic model that possesses the following three key characteristics. First, the model explicitly captures the fact that an Internet channel and a physical store exist in two independent dimensions (one in physical space and the other in cyber space). This enables this model to demonstrate that the effect of adding an Internet store is different from that of adding another physical store. Second, the model reflects the fact that consumers are heterogeneous in their preferences for using a physical store and for using an Internet channel. Third, the model captures the vertical strategic interactions between an upstream manufacturer and a downstream retailer, making it possible to analyze the channel structure issues discussed in this paper. Although numerous previous models capture this vertical dimension of marketing channels, none simultaneously incorporates the three characteristics reflected in this model. The analysis results are summarized in Table 1. When the new Internet channel is introduced by the existing physical retailer and the retailer coordinates both types of stores to maximize the joint profits from the both stores, retail prices increase due to a combination of the coordination of the retail prices and the wider market coverage. The quantity sold does not significantly increase despite the wider market coverage, because the excessively high retail prices alleviate the market coverage effect to a degree. Interestingly, the coordinated total retail profits are lower than the combined retail profits of two competing independent retailers. This implies that when a physical retailer opens an Internet channel, the retailers could be better off managing the two channels separately rather than coordinating them, unless they have the foresight of the manufacturer's pricing behavior. It is also found that the introduction of an Internet channel affects the power balance of the channel. The retail competition is strong when an independent Internet store joins a channel with an independent physical retailer. This implies that each retailer in this structure has weak channel power. Due to intense retail competition, the manufacturer uses its channel power to increase its wholesale price to extract more profits from the total channel profit. However, the retailers cannot increase retail prices accordingly because of the intense retail level competition, leading to lower channel power. In this case, consumer welfare increases due to the wider market coverage and lower retail prices caused by the retail competition. The model employed for this study is not designed to capture all the characteristics of the Internet channel. The theoretical model in this study can also be applied for any stores that are not geographically constrained such as TV home shopping or catalog sales via mail. The reasons the model in this study is names as "Internet" are as follows: first, the most representative example of the stores that are not geographically constrained is the Internet. Second, catalog sales usually determine the target markets using the pre-specified mailing lists. In this aspect, the model used in this study is closer to the Internet than catalog sales. However, it would be a desirable future research direction to mathematically and theoretically distinguish the core differences among the stores that are not geographically constrained. The model is simplified by a set of assumptions to obtain mathematical traceability. First, this study assumes the price is the only strategic tool for competition. In the real world, however, various marketing variables can be used for competition. Therefore, a more realistic model can be designed if a model incorporates other various marketing variables such as service levels or operation costs. Second, this study assumes the market with one monopoly manufacturer. Therefore, the results from this study should be carefully interpreted considering this limitation. Future research could extend this limitation by introducing manufacturer level competition. Finally, some of the results are drawn from the assumption that the monopoly manufacturer is the Stackelberg leader. Although this is a standard assumption among game theoretic studies of this kind, we could gain deeper understanding and generalize our findings beyond this assumption if the model is analyzed by different game rules.

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Solitary Plasmacytoma of the Bone: Radiologic Findings (골단일 형질세포종 : 방사선학적 소견)

  • Yoon, Choon-Sik;Kim, Myung-Joon;Ahn, Chang-Soo;Suh, Jin-Suck;Shin, Kyoo-Ho
    • The Journal of the Korean bone and joint tumor society
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    • v.6 no.2
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    • pp.61-68
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    • 2000
  • Purpose : We examined the patients to evaluate the radiologic findings of solitary plasmacytoma of the bone. Materials and Methods : We retrospectively reviewed radiologic findings of 9 cases with solitary plasmacytoma of the bone (SPB) for recent 5 years, but 2 cases were not included this study due to an abnormal finding of bone marrow and another 2 cases were not included due to an abnormal manifestations of computed tomography (n=1) and MRI (n=1). Results : Among 5 cases, 4 cases had an osteolytic bone destruction and 1 case had an osteosclerotic bone destruction on the plain radiograph. Computed tomography and MRI showed more informations about trabeculated bone destruction and the soft-tissue extension of the lesion comparing to plain radiographs. The MRI finding of SPB in 4 cases showed a relatively high signal intensity on T1-weighted image and intermediate signal intensity on T2-weighted image, on which the signal intensity of the lesion is slightly higher than that of the muscle. One case had an extensive soft-tissue involvement and multiple necrosis, which presented iso to low signal intensity on T1-weighted image and high heterogeneous signal intensity on T2-weighted image. The Gadolinium-enhanced T1-weighted images of 5 cases showed diffusely strong enhancement of the lesion except on the necrosis areas. Conclusion : Computed tomography and MRI may present some characteristics of SPB and demonstrate another foci of plasma cell infiltrates, so these can be helpful for the diagnosis and treatment of SPB.

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