• Journal of the Korea Society for Simulation
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• v.12 no.4
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• pp.25-40
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• 2003

With the growing usage of the networks, the world-wide Internet has become the main means to exchange data and carry out transactions. It has also become the main means to attack hosts. To solve the security problems which occur in the network such as Internet, we import software products of network security elements like an IDS (Intrusion Detection System) and a firewall. In this paper, we have designed and constructed the general simulation environment of network security model composed of multiple IDSes and a firewall which coordinate by CNP (Contract Net Protocol) for the effective detection of the intrusion. The CNP, the methodology for efficient integration of computer systems on heterogeneous environment such as distributed systems, is essentially a collection of agents, which cooperate to resolve a problem. Command console in the CNP is a manager who controls the execution of agents or a contractee, who performs intrusion detection. In the network security model, each model of simulation environment is hierarchically designed by DEVS(Discrete Event system Specification) formalism. The purpose of this simulation is that the application of rete pattern-matching algorithm speeds up the inference cycle phases of the intrusion detection expert system and we evaluate the characteristics and performance of CNP architecture with rete pattern-matching algorithm.

• Proceedings of the KAIS Fall Conference
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• 2003.11a
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• pp.197-206
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• 2003

With the growing usage of the networks, the world-wide Internet has become the main means to exchange data and carry out transactions. It has also become the main means to attack hosts. To solve the security problems which occur in the network such as Internet, we import software products of network security elements like an IDS (Intrusion Detection System) and a firewall. In this paper, we have designed and constructed the General Simulation Environment of Network Security model composed of multiple IDSes and a firewall which coordinate by CNP (Contract Net Protocol) for the effective detection of the intrusion. The CNP, the methodology for efficient integration of computer systems on heterogeneous environment such as distributed systems, is essentially a collection of agents, which cooperate to resolve a problem. Command console in the CNP is a manager who controls tie execution of agents or a contractee, who performs intrusion detection. In the Network Security model, each model of simulation environment is hierarchically designed by DEVS (Discrete EVent system Specification) formalism. The purpose of this simulation is to evaluate the characteristics and performance of CNP architecture with rete pattern matching algorithm and the application of rete pattern matching algorithm for the speeding up the inference cycle phases of the intrusion detection expert system.

• Journal of Intelligence and Information Systems
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• v.14 no.1
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• pp.47-66
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• 2008

This study is aimed at proposing a new type of ubiquitous decision support system (u-DSS) portal which is embedded with two important mechanisms like an intelligent ontology management module (i-OMM) and multi-agent coordination mechanism (MACM). The proposed portal provides timely decision support to the involved decision entities (represented as agents) by taking advantage of the two mechanisms embedded on the portal. The most important virtue of the proposed portal is that it can resolve two problems such as semantic discordance and data confliction which are occurring very often in an ubiquitous computing environment. Frequent requests of revising the already established decision information due to the rapid changes in decision entities' requirements require the extremely flexible and intelligent u-DSS vehicle like theproposed mechanism. In this sense, the i-OMM is designed to provide support to solving the semantic discordance in the way that the i-OMM virtually integrates ontology view (IOV) to integrate heterogeneous ontology among the agents engaged inubiquitous commerce situations. Then the i-OMM sends the IOV to the MACM to resolve the conflicts among the involved agents. The proposed u-DSS portal was applied to the u-fulfillment problem in which all the involved decisionagents need their own requirements to be satisfied seamlessly and timely. The experimental results show that the proposed u-DSS portal is very robust and promising in the field of u-DSS and context modeling.

• Korean Journal of Cognitive Science
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• v.11 no.1
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• pp.67-80
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• 2000

Distributed cooperative information system is the one that has various knowledge sources as well as problem solving capabilities to get information in a distributed and heterogeneous data environment. In a distributed cooperative information system. a control mechanism to facilitate the available information is very important. and usually the role of the control mechanism determines the behavior of the total system In this research. we proposed a model of the distributed cooperative information system which is based on the multi-agent paradigm. We also implemented a test system to show l its feasibility. The proposed system makes the knowledge sources into agents and a special agent called 'facilitator' controls the cooperation between the knowledge agents The facilitator uses the knowledge granularity level to determine the sequence of the activation of the agents. In other words. the knowledge source with simple but fast processing mechanism activates first while more sophisticated but slow knowledge sources are activated late. In an environment in which we have several knowledge sources for the same topic. the proposed system will simulate the focusing mechanism of human cognitive process.

• Korean Journal of Cognitive Science
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• v.12 no.1_2
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• pp.55-63
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• 2001

Speaking generally, agent-based technology is a kind of technology to handle the flood of information resulted from the popularization of the internet. Agent system is a multi-distributed system which consists of both homogeneous and heterogeneous agents. Generally there is a coordination agent in between which is in charge of control and m message flow among the application agents. The purpose of this thesis is to propose a coordination method among agents, some of which provide informations and some of which request them. In multi-agent system, the Information Providing Agent(IPA) registers its capabilities to Coordination Agent(CA) and the Information Requesting Agent(lRA) requests CA what it needs. To coordinate them with satisfactory results the coordination agent ought to have an ability to return a relatively proper data to the requester which is supposed to be similar even though it is not so exact as was intended. For this, this thesis proposes a scheme for an coordination agent to find an IPA which provides an information which correlates most closely with that of IRA.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1693-1698
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• 2015

The heterogeneous nature of lung cancer has become increasingly apparent since introduction of molecular classification. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations. In light of the tsunami of new biomarkers and targeted agents, next generation sequencing testing strategies will be more appropriate in identifying the patients for each therapy and enabling personalized patients care. The challenge now is how best to interpret the results of these genomic tests, in the context of other clinical data, to optimize treatment choices. In genomic era of cancer treatment, the traditional one-size-fits-all paradigm is being replaced with more effective, personalized oncologic care. This review provides an overview of lung cancer genomics and personalized treatment.

• Proceedings of the Korean Information Science Society Conference
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• 2002.04a
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• pp.817-819
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• 2002

최근 컴퓨터 바이러스와 해킹 기법의 기술적인 향상으로 인하여 바이러스로 인한 피해가 확산되고 있다. 이에 따른 바이러스와 해킹 피해들로부터 시스템과 사용자 데이터를 보호하기 위한 다양한 방법들이 연구 및 적용되어 있다. 하지만 기존의 연구는 이기종으로 구성된 서로 이질적인 네트워크 환경에 적용하고 사용하기 위해서는 많은 수동적인 노력과 시간을 필요로 하고 있다. 본 논문에서는 이기종으로 구성된 네트워크상에서 이동 에이전트를 이용한 바이러스 탐색 기법에 대해 연구하였다. 제시한 방법은 사용자들에게 바이러스 탐색 에이전트와 관련된 해당 호스트상에서의 탐색업무 수행 투명성을 제공하여 호스트의 부하에 큰 영향을 주지 않는 방안으로써 자바 언어 특성인 플랫폼의 독립성이라는 이점을 지원하고 있는 자바 기반의 바이러스 탐색 시스템을 설계하였다. 이는 중앙 집중 관리 형태의 서버기반 방식으로 등록된 지역 네트워크 내의 이질적인 호스트에서 각 호스트의 부하를 고려하여 바이러스 탐색 업무를 수행함으로써 사용자로 하여금 능동성과 자율성, 바이러스 탐색 업무에 있어서의 투명성을 제공할 수 있는 컴퓨터 바이러스 탐색 업무를 수행하는 이동 에이전트 기반의 탐색 시스템을 새롭게 제안한다.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10b
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• pp.93-95
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• 1998

본 논문에서는 기존의 파일 시스템을 이용한 모빌 에이전트가 아나라, 분산된 서로 다른 데이터베이스 환경에서 효과적인 데이터 탐색을 위한 디렉토리와 옐로우 페이지를 모빌 에이전트를 이용하여 설계하고 구현하였다. 그리고 개발 환경은 서로 다른 Windows NT와 유닉스 시스템을 혼용하였고, 플랫폼에 독립적인 Java 언어와 통합 모질 에이전트 환경을 지원하는 ASDK를 사용하였다. 이러한 기능을 전투 상황이라는 시나리오에 적용하였다. 신속하게 여러 부대 가용자산 정보를 수집해야 하는 긴박한 상황 속에서 이미 Traffic Jam 상태에 있는 제한되어있는 통신망은 요구하는 속도를 충족시키기 곤란할 것이다. 이러한 상황 속에서 모빌 에이전트의 활발한 활동은 필요한 데이터를 지속적으로 갱신, 탐색 할 것이며, 특히 모빌 컴퓨팅 환경과 결합되어 더욱 효율적인 결과를 나타낼 것이다.

• Journal of Technology Innovation
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• v.11 no.2
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• pp.283-314
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• 2003

The transformation of sector system in Information and Communications Technology (ICT), a prominent character in sector system, has been paid much attention in innovation theory with rapid change in information technologies and technological environment. In this context, we explore how Sectoral Innovation System (SIS) in ICT has been transformed since 1970 by employing US patent data and Proxy variables which measures the basic elements for SIS and its technological characteristics. By utilizing patent data, it is demonstrated that technological regimes, key links and Schumpeterian patterns of innovation in overall ICT sector have drastically transformed over the last three decades. We also reviewed how changes of knowledge bases and technological characteristics driving forces of dynamics in ICT help heterogeneous agents interact with environmental factors (Industrial structure and institutions), leading to industrial or economic growth and its dynamics in the historical perspective over ICT sector (Telecommunication, Computer and Semiconductor). Consequently, our research shows clearly that Schumpeterian patterns of innovation have shifted from Mark I to Mark II in ICT. Our study also provides a glimpse picture of dynamics patent data.

• Korean Journal of Biological Psychiatry
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• v.23 no.1
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• pp.1-11
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• 2016

Development of various antidepressants such as monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and noradrenergic and specific serotonergic antidepressant has led to a tremendous progression of pharmaceutical treatment for depression, but still there are some limitations of current antidepressants, such as treatment-resistant depression and delayed onset of antidepressants. The pathogenesis of depression is unclear because depression is a heterogeneous disease state, and the mechanisms of antidepressants remain uncertain as well. Nevertheless, in an attempt to develop novel antidepressants, some trials have been conducted based on the potential biological mechanism discovered in the numerous research results. This review will provide information about the potential novel antidepressants and the current states of clinical studies using them. In particular, some potential novel antidepressants anti-inflammatory agents, antioxidants, anticholinergics, modulators of Hypothalamic Pituitary Adrenal Axis, glutamate, and opioid systems, as well as some neuropeptides such as susbstance P, neuropeptide Y, and galanin will be discussed.