• Food Science and Biotechnology
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• v.14 no.3
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• pp.323-327
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• 2005

The effects of commercial marinades were evaluated for their influence on heterocyclic aromatic amine (HAA) formation and overall mutagenicity in fried beef steaks. Three different commercial marinades A, B, and C tested individually reduced the total HAA formation in fried beef steaks by 44, 38, and 40%, respectively. Three different commercial marinades were also effective in reducing the overall mutagenicity in fried beef steaks. There was, however, no significant difference in the inhibition achieved with three different commercial marinades. Reduction of overall mutagenicity was related to the decrease in HAA formation in fried beef steaks.

• Bulletin of the Korean Chemical Society
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• v.18 no.5
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• pp.484-488
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• 1997

The angular and planar heterocyclic compounds containing nitrogen, sulfur and oxygen were synthesized by reaction of 6,7-dichloro-5,8-quinoxalinedione with aromatic and aliphatic dinucleophiles. Nucleophilic reactivity was somewhat different between 2,3-dichloro-1,4-naphthoquinone and 6,7-dichloro-5,8-quinolinedione with dinucleophiles. The distribution of electron in heterocycle appeared to contribute to this difference. The intercalation comple of planar heterocyclic compound between GC/GC base pairs showed the optimum intercalation but the intercalation of angular heterocyclic compound was not good. Thus, the planar compound was expected to have antitumor activity.

• Food Science of Animal Resources
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• v.31 no.4
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• pp.563-569
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• 2011

Heterocyclic amines (HCAs) are food mutagens and carcinogens that are found in cooked fish, meat, and protein-rich foods. This study examined the inhibitory effect of marinades containing a Nelumbo nucifera leaf fraction on HCA formation in cooked beef steak. As a result of the Ames assay, cooked beef marinated with the N. nucifera leaf butanol fraction (2.0 g) cooked at $190^{\circ}C$ showed a 61.5% reduction in overall mutagenicity. However, these data revealed no significant difference in mutagenicity in the ethanol, ethyl acetate, or water fractions. Formation of MeIQx (2-amino-3,8 dimethylimidazo[4,5-f]-quinoxalin) and PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine) was inhibited 60.7-63.5%. Cooked beef marinated with the water fraction of the N. nucifera leaf significantly (p<0.05) reduced the formation of MeIQx, PhIP, and DiMeIQx (2-amino-3,4,8 trimethylimidazo[4,5-f]-quinoxaline) by 65.3, 67.6, and 73.9%, respectively. These results show that marinades containing the N. nucifera leaf fraction could be an alternative method for reducing HCA formation in cooked beef steak.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1794-1796
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• 2012

• Bulletin of the Korean Chemical Society
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• v.33 no.10
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• pp.3430-3432
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• 2012

• Journal of the Korean Chemical Society
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• v.52 no.5
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• pp.511-514
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• 2008

• Bulletin of the Korean Chemical Society
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• v.28 no.10
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• pp.1877-1880
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• 2007

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.100-100
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• 2002

2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a heterocyclic amine, significantly inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophages. The decrease in NO production was found to correlate well with a decrease in iNOS mRNA expression as demonstrated by Northern blot analysis.(omitted)

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.37-40
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• 1998

Aromatic polybenzoxazoles have been known since 1964 as a class of aromatic heterocyclic polymers that exhibit excellent thermal stability. Polyhydroxyamides (PHA), precursor polymers to PBO, can cyclize to farm stable heterocyclic polymers with the simultaneous release of small molecules, which can be expected to act as a fire quencher. (omitted)

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.116-116
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• 1993

전 세계적으로 문제가 되고 있는 질병인 AIDS의 원인 virus인 HIV에 활성이 있는 nucleoside 유도체를 개발하기 위해, 일반적으로 HIV에 활성이 있는 3'-deoxythymidine 유도체의 일종으로써 3'-위치에 hydroxy기 대신에 heterocyclic thio기가 치환된 3'-deoxy-3' -(pyrimidin-2-yl)thio thymidine 및 3'-deoxy-3'-(1-methyltetrazol-5-yl) thiothymidine을 thymidine을 출발물질로 각각 합성하였다. 그러나 이 두 화합물은 항 HIV-1 (CEM cell line)에 대하여 활성이 없었다.