• 대한약침학회지
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• 제8권1호
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• pp.41-44
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• 2005

Objectives : This experiment was conducted to reevaluate $LD_{50}$ of Korean bee venom acupuncture as many changes have occurred over the years. Methods : ICR mice were used as the experiment animals and bee venom acupuncture was manufactured under the protocols of Korean Institute of herbal Acupuncture. Based on the previous reports, experiment was divided into pre and main sections. Results : 1. Presumed $LD_{50}$ value is at 5.25mg/kg 2. Deaths of experiment animals occurred within 48 hours. 3. Reduced toxicity of the bee venom acupuncture is likely to be the results of more refined manufacturing process and production. Conclusion : Comparing with the values of the previous results, toxicity of the bee venom acupuncture showed significant changes and more accurate findings on $LD_{50}$ value must be accomplished to lead further studies on the bee venom acupuncture.

• Journal of Acupuncture Research
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• 제33권3호
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• pp.207-218
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• 2016

Objectives : The purpose of this study is to report the clinical effect of Korean Medical Treatment and acupuncture based on M-test theory & herbal medicine for treating systemic sclerosis. Methods : We treated a patient diagnosed with systemic sclerosis. We used general acupuncture & acupuncture based on M-test theory, herbal medicine, moxibustion, and physical therapy. The outcomes were evaluated by using peripheral body temperature measurement, numeric rating scale(NRS), visual analog scale(VAS), and an activities of daily living(ADL) questionnaire for systemic sclerosis. Results : The average peripheral body temperature increased from $36.16^{\circ}C$ to $36.38^{\circ}C$. The NRS showed no difference, but VAS decreased from 7.43 to 5.43. The ADL questionnaire score decreased from 17 to 12. Conclusion : This case study suggests that Korean Medical Treatment and acupuncture based on M-test theory & herbal medicine could be effective for treating systemic sclerosis. However, further studies are needed to confirm this result.

• Journal of Acupuncture Research
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• 제20권6호
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• pp.45-62
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• 2003

Objective: This study was designed to investigate effects of Nokyongsageunhwan and Nokyongsageunhwan aquapuncuture on body weight, body length, intellectual development Methods: We observed body weight, body length, intellectual development after feeding Nokyongsageunhwan and Nokyongsageunhwan aquapuncuture for thirty three days, and mRNA expressions of GHRF, Somatostatin, IGF-1, NPY were analyzed by RT-PCR method. Results: The results were summarized as follows. 1. Body length was significantly increased in Nokyongsageunhwan herbal acupuncture group compared to normal group and normal saline injection group on 4th week, 2. Lower part of hind leg length was significantly increased in Nokyongsageunhwan oral administration group compared to normal group on 3rd week, and it was significantly increased in Nokyongsageunhwan herbal acupuncture group and Nokyongsageunhwan oral administration group compared to that of normal group on 4th week. 3. As results of observing memory aquisition using Morris water maze system, there was significantly difference in Nokyongsageunhwan oral administration group compared to that of normal group on 4th week. 4. As results of observing retention using Morris water maze system, staying time was significantly increased in Nokyongsageunhwan herbal acupuncture group compared to that of normal group. 5. The somatostatin mRNA expression in the hypothalamus was significantly decreased in Nokyongsageunhwan oral administration group compared to that of normal group. 6. The IGF-1 mRNA expression in the hypothalamus is significantly increased in Nokyongsageunhwan herbal acupuncture group and Nokyongsageunhwan oral administration group compared to that of normal group. 7. The NPY mRNA expression in the hypothalamus was significantly increased in Nokyongsageunhwan oral administration group compared to that of normal group, and it was increased in Nokyongsageunhwan herbal acupuncture group compared to that of normal group, but there was no significant difference. Conclusions: According to the above results, it appears that Nokyongsageunhwan oral administration and Nokyongsageunhwan herbal acupuncture on acupoint GB34 and GB39 showed effects on the growth and the intellectual development of rats.

• 대한약침학회지
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• 제5권1호
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• pp.105-112
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• 2002

Objective: This study was designed to evaluate the possibility of Hypertension by moistening Herbal-acupuncture at Blood Pressure Point(HN136). Methods: We reviewed 14 patients of Hypertension. They were hospitalized at oriental medical hospital of Sang-Ji university for 2002. 1. 2. - 2002. 5. 2. First, we divided into two groups; Group Ⅰ was administrated by moistening Herbal-acupuncture at Blood Pressure Point(HN136), and was not given any western medicine about Hypertension during the period of experiment. Group Ⅱ was administrated by moistening Herbal-acupuncture at Blood Pressure Point(HN136), and given western medicine about Hypertension during the period of experiment. we observed the change of systolic and diastolic for 2 weeks, and compared Group Ⅰ with Group Ⅱ . Results: The results obtained as follows: 1. The figure of systolic in Group Ⅰ was decreased, but there was no signification. There was a significant decrease in Group Ⅱ (p<0.05) 2. The figure of diastolic in Group Ⅰ was decreased, but there was no signification. There was a significant decrease in Group Ⅱ (p<0.05) 3. Group Ⅱ was more effective than Group Ⅰ in the results. Conclusion: The results suggest that moistening Herbal-acupuncture at Blood Pressure Point(HN136) was effective treatment of Hypertension. So further research is needed continuously.

• 대한한의학방제학회지
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• 제15권2호
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• pp.65-77
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• 2007

Objective: To review and summarize the existing evidence on acupuncture&moxibustion treatment for cancer and cancer related symptoms. Methods : We searched Pubmed and jurnal of Korean acupuncture &moxibustion. Results: We selected 17 articles. effectivness of cancer acupuncture &moxibustion treatment. 14 articles reported acupuncture &moxibustion to be effective in subjective symptoms and quality of life. Other three articles reported that acupuncture&moxibustion treatment was moderately effective but insignificant compared to sham acupuncture&moxibustion treatment. Conclusion: For the study on acupuncture&moxibustion treatments in cancer it is necessary that we conduct research on the various natures of acupuncture&moxibustion. More clinical data would be needed to prove the effects of acupuncture&moxibustion treatment in cancer.

• 대한약침학회지
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• 제6권2호
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• pp.7-27
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• 2003

Objective : The purpose of this study was to investigate acute and subacute toxicity and sarcoma-180 anti-cancer effects of herbal acupuncture with cultivated wild ginseng (distilled) in mice and rats. Method : Balb/c mice were injected intravenous with cultivated wild ginseng herbal acupuncture for $LD_{50}$ and acute toxicity test. Sprague-Dawley rats were injected intravenous with cultivated wild ginseng herbal acupuncture for subacute toxicity test. The cultivated wild ginseng herbal-acupuncture was injected at the tail vein of mice. Results : 1. In acute $LD_{50}$ toxicity test, there was no mortality thus unable to attain the value. 2. Examining the toxic response in the acute toxicity test, there was no sign of toxication. 3. In acute toxic test, running biochemical serum test couldn't yield any differences between the control and experiment groups. 4. In subacute toxicity test, there was no sign of toxication in the experimental groups and didn't show any changes in weight compared to the normal group. 5. In subacute toxicity test, biochemical serum test showed significant increase of Total albumin, Albumin, and Glucose in the experimental group I compared with the control group. Significant decrease of GOT, ALP, GPT, and Triglyceride were shown. In experiment group II, only Glucose showed significant increase compared with the control group. 6. Measuring survival rate for anti-cancer effects of Sarcoma-180 cancer cell line, all the experimental groups showed significant increase in survival rate. 7. Measuring NK cell activity rate, no significant difference was shown throughout the groups. 8. Measuring Interleukin-2 productivity rate, all the experimental groups didn't show significant difference. 9. For manifestation of cytokine mRNA, significant decrease of interleukin-10 was witnessed in the experimental group compared to the control group. Conclusion : According to the results, we can conclude cultivated wild ginseng herbal acupuncture caused negligible toxicity, and had anti-tumor effects in mice.

• 대한약침학회지
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• 제6권1호
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• pp.76-94
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• 2003

Objectives : The purpose of this study was to investigate Acute$\cdot$Subacute Toxicity and Anti-cancer Effect of K-Herbal-acupuncture in mice and rats. Methods : Balb/c mice were injected intraperitoneally with K-herbal-acupuncture for $LD_{50}$ and acute toxicity test. Sprague-Dawley rats were injected intraperitoneally with K-herbal-acupuncture for subacute toxicity test. K-Herbal-acupuncture was injected on abdomen of mice with S-180 cancer cell line. Result : 1. $LD_{50}$ of K-Herbal-acupuncture was limited $4{\times}10^{-3}$ml/kg~$2{\times}10^{-3}$ml/kg by the test. 2. In acute toxicity test, all of mice were down to the moving reflex, but the weight of mice was increased in treatment group, compared with the normal group. (P<0.05) 3. In acute toxicity test of serum biochemical values of mice, glucose was increased in treatment II group, total cholesterol was increased both treatments.(P<0.05) 4. In subacute toxicity test, the clinical signs of toxication was down to the moving reflex, but it is not severe like acute toxicity test, and observed weight loss at the treatments. 5. In subacute toxicity test, liver weight was decreased compared with the normal group. (P<0.05) 6. In subacute toxicity test of complete blood count test (CBC) of rat, HCT was decreased in treatments, compared with the normal group.(P<0.05) 7. In subacute toxicity test of serum biochemical values of rat, uric acid and triglyceride were decreased, and glucose was increased in treatment groups compared with the control group. (P<0.05) 8. Median survival time was increased about $45\%$ in treatment groups compared with the control group.(P<0.05) 9. Natural killer cell activity was increased in B16F10 lung cancer model, but it was not in sarcoma-180 abdomen cancer. 10. In interleukin-2 productivity test, treatment groups didn't show significant change in lung cancer and abdomen cancer, compared with the normal group.(P<0.005) 11. In making an examination of metastatic cancer with the naked eye, melanoma metastasized in the Lung of C57BL/6 mice. The treated group showed more Melanoma than the control in the numbers and volume. Conclusion : According to the result, K-herbal-acupuncture need further study to know the function and effect in cancer.

• Korean Journal of Acupuncture
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• 제26권1호
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• pp.139-159
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• 2009

Objective & Methods : The purpose of this study is to observe the effects of herbal-acupuncture with Lycii Fructus (LF-HA) at KI10 (Eumgok) on osteoporosis in ovariectomized (OVX) ddy mice. We carried out several experimental items which were known to be related with osteoporosis. Results : 1. Tibial BMD was significantly increased in the LF-HA group. 2. Tibial Ca level was significantly increased in the LF-HA group. 3. Osteoclast like cell in tibia was significantly decreased in the LF-HA group. 4. Histological change of tibia was improved, the trabecular bone thickness was significantly increased and the growth plate length was significantly decreased in the LF-HA group. Conclusion : These results suggest that LF-HA at KI10 has therapeutic effects on osteoporosis especially by way of suppressing osteoclast cells in ovariectomized ddy mice.

• 혜화의학회지
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• 제22권1호
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• pp.225-233
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• 2013

Objective : The objective of this study is to observe the effect of anti-inflammatory herbal acupuncture, acupuncture, physical theraphy, external treatment, therapeutic exercise on the osteochondritis dissecans. Methods : Anti-inflammatory herbal acupuncture and acupuncture were used to treat knee pain and gait disturbance. We evaluated the patient through VAS(visual analogue scale) daily and symptoms. Results & Conclusions : After 31 days of treatment, right knee pain was decreased from VAS 10 to VAS 4, redness, burning sensation, edemaright of right knee were decreased. And the patient could walk. Oriental medicine treatment is proved to be helpful to imporve the symptoms of the osteochondritis dissecans.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.191-195
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• 2006

This article presents a case report of complex regional pain syndrome (CRPS) involving the ankle and foot; the bee-venom herbal acupuncture (BVH) was performed as part of a pain management program. An 46-year-old man presented with CRPS in the left lower extremity that was inadequately controlled with typical oral medication. Sympathetic block the extremity did not provide significant pain relief. However, BVH resulted in significant pain relief and improvement in patient's attitude. This case report showed that BVH may be efficacious in treating patients with CRPS. Further study is needed to determine the effects of BVH on symptoms related to CRPS.