• 한국식품영양학회지
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• 제12권1호
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• pp.13-19
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• 1999

To examine the relationship between the casual infection of gastric cancer and lifestyle and nutritional status we surveyed 169 persons 90 females and 79 males aged 40∼69 years from June 7 to June 14 1997 in Whachon area Kang-Won Do Korea. For this purpose we investigated Helicobacter pylori infec-tion and identified the effect of sex age, smoking alcohol consumption economic status occupation life-style and food intake on Helicobacter phlori infection. Helicobacter pylori status was evaluated using an en-zyme-linked immunosorbant assay(ELISA) for anti-Helicobacter pylori immunoglobulin G(IgG). Helicob-acter pylori infection was present in 66.3% of total subjects namely 67.7% of female and 64.4% of male and its prevalence increased with smoking low education level and low monthly income. Energy total protein calcium and vitamin C intakes in the negative Helicobacgter phlori infection group were higher than those in positive Helicobacter pylori infection group. However iron and niacin intakes were lower in the helicobacter pylori negative group than in the positive group.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5219-5223
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• 2015

Helicobacter pylori (H. pylori) infection as a serious problem in both adults and children can induce chronic gastritis, peptic ulcer disease (PUD), and possibly gastric cancer. The aim of the current study was to survey antibiotic resistance and also to determine influence of PPAR$\gamma$ polymorphism in patients with H. pylori infection. During an 11-month-period, 98 H. pylori isolates were collected from 104 biopsy specimens. In vitro susceptibility of H. pylori isolates to 4 antimicrobial agents metronidazole, clarithromycin, amoxicillin and tetracycline were assessed by quantitative method according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. PPAR$\gamma$ polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism assay. The frequency of H. pylori infection in our study was 94.2%. In vitro susceptibility data showed that highest level of resistance was related to metronidazole (66.3%), and the majority of H. pylori isolates were highly susceptible to amoxicillin and tetracycline (94.9% and 96.9%, respectively). Genotypic frequencies were 25.5% for CC (Pro12Pro), 40.8% for GC (Pro12Ala) and 33.7% for GG (Ala12Ala). In our study, CG genotype had highest distributions among infected patients with H. pylori. The study suggests that the PPAR-$\gamma$ Pro12Ala polymorphism could be evaluated as a potential genetic marker for susceptibility to gastric cancer in the presence of H. pylori infection.

• 한국식품영양학회지
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• 제10권3호
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• pp.330-338
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• 1997

위암발증 원인을 밝히기 위하여 농촌지역 일반 주민들의 Helicobater pylori의 감염율과 생활습관 및 영양섭취 실태와의 상관관계를 검토하기 위하여 강원도 춘천시 인근 농촌 지역 주민들을 조사하였다. 조사 대상자는 40대 이상인 지역 주민 183명으로 남자 81명, 여자 102명에 대하여 설문조사와 식사량 조사, 혈액 생화학적 분석 및 혈청 ELISA법에 의한 Helicobater pylori의 감염 정도를 분석하였다. 그 결과를 요약하면 다음과 같다. 1. 조사 대상자의 학력은 74.3%가 국졸이하였고, 월수입은 80.3%가 100만원 이하였다. 2. 조사 대상자의 직업은 75.3%가 농업에 종사하였으며, 가족형태는 62.8%가 핵가족이었다. 3. 출산 자녀수는 75.9%가 2명에서 5명의 자녀를 출산하였고, 음주자는 46.4%이며 매일 술을 마시는 사람이 12%였다. 흡연자는 21.9%였으며, 비흡연자는 78.1%였다. 4. 평균신장은 157.4cm였고 여자의 평균 신장은 151.9cm, 남자의 평균 신장은 164.4cm였고 남녀간에 유의차가 있었다(p<0.001). 5. Helicobater pylori의 감염율은 총 조사 대상자 중 64.5%였으며, 남자가 65.4%, 여자가 63.7%였다. 감염율은 흡연자, 학력 수준이 낮을수록, 월수입이 적을수록, 출산 자녀수가 많을수록, 50대의 연령에서 많은 것으로 나타났다. 6. Helicobater pylori의 감염 음성자와 양성자간의 영양소 섭취실태를 보면 음성자가 에너지, 총지질(p<0.05), 동물성 지질(p<0.05), 철분 섭취량(p<0.001), 비타민 A의 섭취량(p<0.01), 비타민 C 섭취량(p<0.05)에 있어서 유의적으로 높은 섭취량을 나타내었다. 그러나 칼슘 섭취량은 음성인자가 낮았다.

• Journal of Preventive Medicine and Public Health
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• 제41권6호
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• pp.373-379
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• 2008

Objectives ; The objective of this study was to evaluate the prevalence of atrophic gastritis and intestinal metaplasia according to gender, age and Helicobacter pylori infection in a rural population in Korea. Methods: Between April 2003 and January 2007, 713 subjects (298 men and 415 women, age range: 18-85) among the 2,161 adults who participated in a population-based survey received gastrointestinal endoscopy. All the subjects provided informed consent. Multiple biopsy specimens were evaluated for the presence of atrophic gastritis and intestinal metaplasia. The presence of Helicobacter Pylori was determined using CLO and histology testing. Results ; The age-adjusted prevalence of atrophic gastritis was 42.7% for men and 38.1% for women and the prevalence of intestinal metaplasia was 42.5% for men and 32.7% for women. The prevalence of atrophic gastritis and intestinal metaplasia increased significantly with age for both men and women (p for trend<0.001). The age-adjusted prevalence of Helicobacter pylori was similar for men (59.0%) and women (56.7%). The subjects with Helicobacter pylori infection showed a significantly higher prevalence of intestinal metaplasia (44.3%) compared with that (26.8%) of the noninfected subjects (p<0.001). However, the prevalence of atrophic gastritis was not statistically different between the Helicobacter pylori-infected subjects and the noninfected individuals. Conclusions : Our findings suggest that the prevalence of atrophic gastritis and intestinal metaplasia is higher for a Korean rural population than that for a Western population; this may be related to the high incidence of gastric cancer in Koreans. Especially, the prevalence of intestinal metaplasia was high for the subjects with Helicobacter pylori infection. The multistep process of gastric carcinogenesis and the various factors contributing to each step of this process need to be determined by conducting future follow-up studies.