• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.363-369
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• 2014

Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally under street names such as "Spice" and "Smoke". Many countries including Korea have started to schedule some of the JWH series compounds as controlled substances, but there are a number of JWH series chemicals that remain uncontrolled by law. In this study, three synthetic CBs with different binding affinities to the $CB_1$ receptor (JWH-073, 081, and 210) and ${\Delta}^9$-tetrahydrocannabinol (${\Delta}^9$-THC) were evaluated for their potential for psychological dependence. The conditioned place preference test (unbiased method) and self-administration test (fixed ratio of 1) using rodents were conducted. $K_i$ values of the three synthetic cannabinoids were calculated as supplementary data using a receptor binding assay and overexpressed $CB_1$ protein membranes to compare dependence potential with $CB_1$ receptor binding affinity. All mice administered JWH-073, 081, or 210 showed significantly increased time spent at unpreferred space in a dose-dependence manner in the conditioned place preference test. In contrast, all tested substances except ${\Delta}^9$-THC showed aversion phenomenon at high doses in the conditioned place preference test. The order of affinity to the $CB_1$ receptor in the receptor binding assay was JWH-210 > JWH-081 >> JWH-073, which was in agreement with the results from the conditioned place preference test. However, no change in self-administration was observed. These findings suggest the possibility to predict dependence potential of synthetic CBs through a receptor binding assay at the screening level.

• Korean Journal of Environmental Biology
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• v.28 no.3
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• pp.133-142
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• 2010

This study was performed to investigate the community structure of the macrobenthic invertebrates around Ui Island, Sinan-gun, Jeollanam-do, Korea. Benthic invertebrates were collected during May and September 2008 at seven stations. A total of 63 macrobenthic species was collected. The overall average macrobenthos density and biomass were 268 inds. $m^{-2}$ and 11.54 gWWt $m^{-2}$, respectively. Based on abundance data, there were 5 dominant species accounting for approximately 72.00% of total individuals. The polychaetes Notomastus latericeus, Scolelepis sagittaria, Amaeana occidentalis, Glycera chirori and the amphipoda Mandibulophoxus mai were found in high densities. The conventional multi-variate statistics (cluster analysis and non-metric multidimensional scaling) applied to assess spatial variation in macrobenthic assemblages. As a result, three communities could be distinguished: a sand dominated, a mixed sediment and a third community in the mud dominated station. The community in the sand dominated station was characterized by high abundance of the polychaetes S. sagittaria and the amphipods M. mai, Monoculodes sp. and Grandifoxus malipoensis. However, the most common species within the mixed sediment station were the polychaetes N. latericeus, A. occidentalis and amphipoda Urothoe sp.. Finally the mud dominated station was numerically dominated by the polychaetes Scolelepis sp., Heteromastus filiformis and Sigambra tentaculata. In conclusion, the sediment composition may be important factors controlling of the macrobenthic community structure in the study area.

• Journal of The Korean Society of Grassland and Forage Science
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• v.41 no.2
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• pp.96-101
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• 2021

This study was conducted to determine the effect of horse manure compost application on Italian ryegrass (IRG) yield and volcanic ash soil characteristics. Because the number of horses in Korea is growing, the amount of horse manure is growing. Jeju island, where about 55 % of the horses live, is composed of volcanic ash soil. This study was conducted for about 7 months. Sowing was conducted on October 2019. Harvesting was conducted at heading stage(2020.5.). Five treatments were established based on the horse manure compost composition. These were 100 % chemical fertilizer (CF), the combination of 50 % horse manure and 50 % chemical fertilizer (combination), horse manure with 50 % nitrogen (HM 50 %), horse manure with 100 % nitrogen (HM 100 %), and horse manure with 150 % nitrogen (HM 150 %). The plant height and dry matter yield were investigated to determine the forage yield and the soil characteristics of pH, total nitrogen, available phosphate, and organic matter were analyzed. The plant heights in the CF, combination, and HM 150 % treatments were 147.8 cm, 144.3 cm, and 147.1 cm respectively (Table 2). Dry matter yield in the CF treatment was about 23,807 kg/ha, which tended to be the highest dry matter yield. HM 150 % and the combination treatment were about 18,804 and 18,455 kg/ha, respectively, which tended to be the highest dry matter yield of the treatments amended with horse manure compost. The dry matter yield of the HM 100 % and HM 50 % treatments was about 15,801 kg/ha and 14,446 kg/ha, respectively (Table 2). The pH of the surface soil tended to increase after the experiment. The soil pH of the HM 150 % treatment was significantly higher than the soil pH of the other treatments. The pH was affected by the amount of horse manure compost, with a pH of 8.1. The available phosphate in the treatments in which horse manure compost was added was higher than the available phosphate in the CF treatment. And the available phosphate in the HM 150 % treatment was significantly higher than the available phosphate in the other treatments (p < 0.05)(Table 3). These results suggest that 50 % horse manure should be applied to IRG as the basal fertilizer and the remaining 50 % should be chemical fertilizer as the top fertilizer. This can provide the proper IRG dry matter yield with less effect on volcanic ash soil.

• Radiation Oncology Journal
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• v.27 no.4
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• pp.201-209
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• 2009

Purpose: To investigate the care patterns for radiation therapy and to determine inter-hospital differences for patients with laryngeal carcinoma in Korea. Materials and Methods: A total of 237 cases of laryngeal carcinoma (glottis, 144; supraglottis, 93) assembled from 23 hospitals, who underwent irradiation in the year of 1998 and 1999, were retrospectively analyzed to investigate inter-hospital differences with respect to radiotherapy treatment. We grouped the 23 hospitals based on the number of new patients annually irradiated in 1998; and designated them as group A (${\geq}$900 patients), group B (${\geq}$400 patients and <900 patients), and group C (<400 patients). Results: The median age of the 237 patients was 62 years (range, 25 to 88 years), of which 216 were male and 21 were female. The clinical stages were distributed as follows: for glottis cancer, I; 61.8%, II; 21.5%, III; 4.2%, IVa; 11.1%, IVb; 1.4%, and in supraglottic cancer, I; 4.3%, II; 19.4%, III; 28.0%, IVa; 43.0%, IVb; 5.4%, respectively. Some differences were observed among the 3 groups with respect to the dose calculation method, radiation energy, field arrangement, and use of an immobilization device. No significant difference among 3 hospital groups was observed with respect to treatment modality, irradiation volume, and median total dose delivered to the primary site. Conclusion: This study revealed that radiotherapy process and patterns of care are relatively uniform in laryngeal cancer patients in Korean hospitals, and we hope this nationwide data can be used as a basis for the standardization of radiotherapy for the treatment of laryngeal cancer.