• Journal of Periodontal and Implant Science
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• v.35 no.1
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• pp.1-8
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• 2005

Bacterial heat shock protein has been one of the components that are responsible to induce autoimmune disease mechanisms in the pathogenesis of atherosclerosis due to high level of homology in sequence with human counterpart. This mechanism may explain how bacterial infectious disease, such as periodontal disease, might contribute to the acceleration of the disease process of atherosclerosis. Porphyromonas gingivalis which is a major periodontal pathogenic bacterial species, has been implicated as one of the pathogenic bacteria playing the role in this context. The present study has been performed to evaluate the anti-atherosclerotic effect of adoptive transfer of Porphyromonas gingivalis heat shock protein epitope-specific T cell lines into severe combined immunodeficiency (SCID) mice. Peptide no. 15 with amino acid sequence VKEVASKTND-specific T cell line was selected for the transfer. When experimental atherosclerosis was induced in SCID mice adoptively transferred either by the T cell lines (experimental group) or by non-specific mouse T cells (control group), there was no significant difference in the severity and extent of the atherosclerosis induced by hypercholesterol diet.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.3
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• pp.540-541
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• 2008

The aim of the present study is to determine clinical efficacy and adverse reaction of yugan-tang. We compared symptoms and liver function test results of 160 patients with damp-heat type liver disease in before and after taking yugan-tang. The patients took 200ml yugan-tang two times daily for three months. Then we analyzed these datas statistically. The overall therapeutic effect was "markedly improved" in 70 of 160 patients (43.75%) and "improved" in 75 of 160 patients (46.88%). yugan-tang markedly improved damp-heat type liver disease, especially jaundice, abdominal distention, hypochondriac pain, nause, vomiting and anorexia. Alanine aminotransferase (ALT) level and total bilirubin (TBIL) level were within normal limits at baseline. But albumin-globulin ratio (A/G) level was not changed markedly. I think that yugan-tang is worth applying widely to clinic.

• The Journal of Internal Korean Medicine
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• v.45 no.3
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• pp.415-428
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• 2024

Objective and Methods: This study examined Cheng Guopeng (程國彭)'s understanding of Shanghan Disease (傷寒病) through <Yixue xinwu (醫學心悟)>, created tables based on this, and these tables were compared with <Shiyong zhongyi neike biaodian (實用中醫內科表典)>'s table on Six Meridian Pattern Identification (六經辨證). Results and Conclusion: 1. <Yixue xinwu> and <Shiyong zhongy neike biaodian> were mostly similar regarding the pathology and the Six Meridian Pattern Identification of Shanghan Disease. However, <Shiyong zhongyi neike biaodian> selected terms that encompass internal medical diseases rather than terms that refer only to infectious diseases. 2. About Taiyang meridian disease (太陽 經病), <Yixue xinwu> recognized the existence of Wen bing (溫病) and Re bing (熱病), but did not regard them as True Shanghan Disease (正傷寒), and differentially diagnosed them as Similar Shanghan Disease (類傷寒). 3. About Yangming meridian disease (陽明 經病), <Yixue xinwu> understood this as a meridian transmitted heat-syndrome in the interior (傳經 裏熱證), and created a new Radix Puerariae Decoction (葛根湯). This prescription has the same name as the <Shanghanlun (傷寒論)>, but it has a different drug composition and indications. 4. About three-In meridian disease (3陰 經病), <Yixue xinwu> always divided it into two categories: meridian transmitted heat-syndrome in the interior (傳經 裏熱證) and meridian stroked cold-syndrome in the interior (直中 裏寒證). However, <Shiyong zhongyi neike biaodian> described Taiin disease (太陰病) as Spleen-stomach deficiency cold-syndrome (脾胃虛寒證). This means that meridian transmitted heat-syndrome in the interior (傳經 裏熱證) does not exist among Taiin disease.

• Journal of Korean Medical classics
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• v.19 no.2 s.33
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• pp.248-265
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• 2006

Impulse of ki refers to palpitation around the navel, it is mostly caused by impairment of yang due to erroneous sweating, deficiency of the spleen yang. Behcet's syndrome caused by prolonged damp-heat and pathogenic germs. Its symptoms are characterized by conjunctival congestion, blue canthus and ulceration of the oral cavity, restlessness all the time, etc. It is advisable to follow the therapeutic principles of clearing away heat and drying damp, detoxicating and sterilizing. Lily disease is one of the emotional disease. It caused by yin deficiency of the heart and lung, found in mental depression or convalescence after a critical disease. Its symptoms are characterized by restlessness, reticence, insomnia, failure to walk, poor appetite, a subjective hot or cold, bitter taste and dark urine. It is advisable to follow the therapeutic principle of nourishing yin to clear away heat. Cholera refers to the disease marked by sudden severe vomiting and diarrhea, and colic of the heart and the abdomen. It is mostly caused by deficiency of the ki in the middle-energizer, emotional stress, etc. It is characterized by such symptoms as sudden severe vomiting and diarrhea, restlessness, etc. It is advisable to follow the therapeutic principles of warming yang and removing toxic substances, and strengthening the spleen and stomach. Heat invasion of blood chamber due to affection of the exterior pathogens, pathogenic heat invading the blood in deficiency and fighting with the blood. Its symptoms are marked by fever, feeling of the fullness, etc. There are deficiency of blood, hot blood and stasis of blood. The different therapeutic treatment should be taken according to different types thereof.

• Journal of Preventive Medicine and Public Health
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• v.38 no.3
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• pp.283-290
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• 2005

Objectives : The aim of this paper was to examine the relationship between the summertime (June to August) heat index, which quantifies the bioclimatic apparent temperature in sultry weather, and the daily disease-related mortality in Seoul for the period from 1991 to 2000. Methods : The daily maximum (or minimum) summertime heat indices, which show synergetic apparent temperatures, were calculated from the six hourly temperatures and real time humidity data for Seoul from 1991 to 2000. The disease-related daily mortality was extracted with respect to types of disease, age and sex, etc. and compared with the time series of the daily heat indices. Results : The summertime mortality in 1994 exceeded the normal by 626 persons. Specifically, blood circulation-related and cancer-related mortalities increased in 1994 by 29.7% (224 persons) and 15.4% (107 persons), respectively, compared with those in 1993. Elderly persons, those above 65 years, were shown to be highly susceptible to strong heat waves, whereas the other age and sex-based groups showed no significant difference in mortality. In particular, a heat wave episode on the 22nd of July 2004 ($>45^{\circ}C$ daily heat index) resulted in double the normal number of mortalities after a lag time of 3 days. Specifically, blood circulation-related mortalities, such as cerebral infraction, were predominant causes. Overall, a critical mortality threshold was reached when the heat index exceeded approximately $37^{\circ}C$, which corresponds to human body temperature. A linear regression model based on the heat indices above $37^{\circ}C$, with a 3 day lag time, accounted for 63% of the abnormally increased mortality (${\geq}+2$ standard deviations). Conclusions : This study revealed that elderly persons, those over 65 years old, are more vulnerable to mortality due to abnormal heat waves in Seoul, Korea. When the daily maximum heat index exceeds approximately $37^{\circ}C$, blood circulation-related mortality significantly increases. A linear regression model, with respect to lag-time, showed that the heat index based on a human model is a more dependable indicator for the prediction of hot weather-related mortality than the ambient air temperature.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.4
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• pp.634-639
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• 2020

Objective: This study was conducted to investigate the effect of heating of foot-and-mouth disease (FMD) vaccine before injection, on the incidence of lesions at the injection site (pork butt), amount of discarded meat, and economical benefit. Methods: In total, 101,086 piglets raised in 30 farms, were vaccinated in the neck with 2 mL of FMD vaccine at 56 d and 84 d of age using a commercial syringe. The heat treatment group (48,511 pigs) was injected with the FMD vaccine after it had been heated in a water bath at 40℃ for 20 min. After slaughter, the incidence of lesions on the pork butt was inspected, and the subsequent amount of discarded meat was recorded. Results: Heat treatment of FMD vaccine reduced the incident rate of lesions on the pork butt (p<0.01). Overall, 17.81% of the pigs in the heat treatment group had lesions, while the incident rate in the control group was 21.70%. The amount of discarded meat per head of total pigs and per head of pigs with lesions were significantly lower in the heat treatment group than the control group (p<0.01). Thus, the proportion of discarded meat to dressed carcass was lower in the heat treatment group (0.249%) compared with the control group (0.338%) (p<0.01). Farms that rear 1,000 sows can gain 1,863,289 KRW (1,600 USD) in one year when they adopt heat treatment of FMD vaccine before injection. Conclusion: Heat treatment of FMD vaccine using simple heat equipment (water bath) can be effective in reducing lesions caused by FMD vaccination and increase the economic benefits in pig farms.

• Korean Journal of Plant Resources
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• v.13 no.3
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• pp.208-212
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• 2000

The effect of heat covering materials during cultivation of Shigyoku grape was examined on the effect of protection from freezing damage, labor reduction, and disease resistance during the wintering. This experimentwas accomplished using different combination of heat covering materials from the end of Nov as follows: straw and heat conservation cover B, kilding, color fabric A, and white needle punching fabric. Capacity of heat conservation was the least form white needle punching fabric, and the differences of other materials was slight. Early sprouting occurred by the treatment with heat conservation cover B, and the rate of sprouting was about 70.7% after 9 days of sprouting, showing 2.3-12.5% increase. Growth effect was not differ between heat conservation materials. Disease and insects occurred by the in dice 3.0-3.2 of crown gall from the heat conservation cover B treatment. Other damages were not observed or very little from other treatments. Demand of labor during steps of these treatments was more observed by 6% for kilding than heat conservation cover B, and those of color fabric A and white needle punching fabric were reduced by 6 and 15%, respectively.

• Journal of Korean Society for Atmospheric Environment
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• v.24 no.5
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• pp.523-537
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• 2008

In Korea, the global warming leads to more frequent high temperature region. increasing the need for research into physical damage caused by high temperature. We therefore analyzed the differences of mortality, caused by extreme heat, among gender and age. We also examined the trend of mortality from high temperature-sensitive diseases. Women are more affected by exposure to high temperature than are men; People over 65 years old have higher mortality rate (1.5 times) than under 65. As for high temperature-related diseases, cerebrovascular disease was the number one cause of death, and chronic lower respiratory disease and cardiovascular disease followed.

• Journal of Korean Medical classics
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• v.29 no.1
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• pp.139-172
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• 2016

Objectives : The purpose of research thesis is an advanced interpretation of the Name of Constitutional Disease of Dong-uisusebowon(東醫壽世保元) 1901 edition(辛丑本) evaluated to interpretation incompleted, and application of clinical diagnosis by rivised interpretation. Methods : A study on translation of sasangin(四象人)'s constitutional disease is researched the methods of documentary research on Dong-uisusebowon(東醫壽世保元) 1901 edition(辛丑本) and 1894 edition(甲午本). Results : Result of analysis of 4 meaning unit is as follows. Viscera or entrails means root or terminus of organ whom getting disease. Cold or heat based means being chilled or hot of triple energizer. Eexterior or interior means origin of disease of exterior or interior. Cold or heat means being chilled or hot of digestive system. Conclusions : In the clinical diagnosis using revised interpretaion, diagnosis of exterior or interior disease can be decided by symptoms of Taeyang syndrome(太陽病)'s fever and aversion to cold or not. Diagnosis of cold or heat disease can be decided by diarrhea or constipation.

• Journal of Korean Medical classics
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• v.25 no.4
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• pp.85-94
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• 2012

The concept of makwon(膜原) holds great importance in the texts of Seup-yeoljobyeon(濕熱條辨). Research on the concept was based on Seolsaengbaek(薛生白)'s medical theories organized by Wang Maengyeong(王孟英). The results are as follows. Seolsaengbaek describes makwon as half-exterior half-interior(半表半裏) of yang-myeong(陽明) and half-exterior half-interior of the body. The half-exterior half-interior in these definitions each hold a different meaning. In half-exterior half-interior of yang-myeong, it refers to its mediating function, focusing on the location of makwon as yang-myeong. In half-exterior half-interior of the body, it refers to an intersection where the pathological mechanism of damp-heat disease(seup-yeoljeung 濕熱證) begins, and also where the course of the disease changes. This is why treatment of the makwon is included in treating many damp-heat disease symptoms. The conditions derived from the original damp-heat disease can follow the designated prognosis, or follow a reversed course. Because of its intersecting role, treating the makwon can help prevent aggravation. In treatment, consideration of the healthygi(jeonggi 正氣), the bodily fluids(jinaek 津液) with an understanding of the various prognosis is crucial.