• The Korean Journal of Physiology and Pharmacology
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• v.11 no.3
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• pp.89-95
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• 2007

Polygala tenuifolia (PT) is one of the most well-known traditional herbal medicines in Korea which is commonly used for the treatment of cardiovascular symptoms. The anti-ischemic effects of PT in isolated rat heart was investigated by analyzing changes in blood pressure, aortic flow, coronary flow, and cardiac output. And, its underlying mechanism was examined by quantitating intracellular calcium content in rat neonatal cardiomyocytes. Rats were divided into two groups: an ischemia-induced group without any treatment, and an ischemia-induced group treated with PT. Ischemia of isolated heart was induced by stopping the supply of oxygen and buffer for 10 min. The isolated heart was exposed to PT for the first 5 min of 10 min ischemia. PT treatment significantly prevented the decreases of perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions. In addition, hemodynamics (except heart rate) of the PT-treated group was significantly recovered 60 min after reperfusion compared to the control group (systolic aortic pressure: 83.3% vs. 64.9%, aortic flow volume: 69.5% vs. 48.7%, coronary flow volume: 77.7% vs. 58.4%, and cardiac output: 71.6% vs. 51.2%, p < 0.01). As for the underlying mechanism, PT significantly prevented intracellular calcium increase which was induced by isoproterenol (p < 0.01), suggesting that the anti-ischemic effect of PT is mediated by inhibition of intracellular calcium increase.

• Journal of Integrative Natural Science
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• v.14 no.3
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• pp.95-98
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• 2021

By far, studies on the effect of oral administration of peppermint essential oil on blood pressure are not consistent, increasing or decreasing. And the effect of inhalation of peppermint essential oil on blood pressure was not reported. This study was designed to clarify the effect of peppermint essential oil inhalation on the blood pressure and autonomic nervous system. Blood pressure and heart rate variability (HRV) as an indicator of autonomic nervous system activity were measured. The systolic and diastolic blood pressure was not changed significantly by inhalation of peppermint essential oil. Standard deviation of normal to normal (SDNN), a parameter of total activity of autonomic nervous system also was not changed significantly. High frequency (HF) power level, an indicator of parasympathetic nervous system activity was not changed by peppermint. These results indicate that action mechanism of peppermint essential oil on blood pressure is different by the method of administration, oral or inhalation.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.6
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• pp.605-613
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• 1999

The purpose of the present study was to evaluate cardiovascular regulation during passive standing (PS) after ethanol ingestion by spectral analysis of heart rate variability (HRV) in flushed and nonflushed subjects. Of 24 young male subjects, 8 belonged to flushed group (F) and 16 to nonflushed group (NF). Two sessions of 10-min PS were performed before and after ethanol (0.5 g/kg) ingestion. Powers of R-R interval variability in very low frequency $(VLF,\;0{\sim}0.05\;Hz),$ low frequency $(LF,\;0.05{\sim}0.15\;Hz)$ and high frequency $(HF,\;0.15{\sim}0.50\;Hz)$ bands, normalized powers (LFn and HFn) and LF/HF ratio were obtained. After ethanol ingestion, F showed higher heart rate than NF. PS increased LFn $(+22.9{\pm}3.6\;in\;NF,\;+12.8{\pm}4.7$ in F, in normalized units) and LF/HF $(+3.10{\pm}0.57\;in\;NF,\;+3.00{\pm}1.08\;in\;F)$ and decreased HFn powers. Ethanol ingestion increased LFn and LF/HF and decreased HFn. PS after ethanol resulted in higher LFn and LF/HF and lower HFn than the prior PS. F showed a greater and more sustained HRV change than NF after ethanol. In conclusion, PS or ethanol ingestion increased LFn and LF/HF and decreased HFn. Flushed subjects showed an accentuated HRV response to ethanol.

• The Korean Journal of Physiology
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• v.9 no.1
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• pp.39-43
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• 1975

The effects of histamine on cardiovascular system in 6 dogs were analyzed. Mongrel dogs, 10 to 16 kg in body weight, were anesthetized with Nembutal (30 mg/kg) and arterial blood pressure, heart rate, central venous pressure, electrocardiogram were recorded and measured plasma potassium concentration. Histamine $(100{\mu}g/ml)$ was infused slowly at the rate of 0.25 ml/min through the external jugular vein until BP was 80/60 and maintained restored BP for more than 5 min. The process repeated $4{\sim}5$ times. At each time before and after infusion every items were recorded and measured. 1. Arterial blood pressure was 142/105 (mean 117) mmHg in control and decreased to 90/60 68) after histamine infusion. 2. Heart rate changed from 175 beat/min to 150 and central venous pressure from 6.2 to 5.2 cm $H_2O$. 3. Plasma potassium concentration was 4.3 mEq/L and slightly increased to 4.7 mEq/L but it was not significant statistically. 4. Most characteristic changes revealed in EKG especially in T-waves. Height, Width, Steepness, and Slimness were increased $1.5{\sim}3.7$ times than control level and Pointedness decresed 0.5 times than before.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.115-124
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• 2006

The purpose of this study is to investigate the relationships between the biological base of coping strategy and the different constitutions. First of all, subjects were divided in to 3 groups dy Questionnaire for the Sasang Constitution Classification II and Yin-Yang Property Analysis. Then each group was assigned into two experimental coping conditions, active and passive condition, in turn. The SDNN(The Standard Deviation of the NN Intervals) of HRV(Heart rate variability) index was estimated from two conditions after giving a aversive pain stimulus. The results of the study were as follows 1. The interaction between constitution and coping condition is significant(p<0.05). 2. The SDNNs of Shaoyangren are higher than those of Taiyinren under passive condition but it was opposite under active condition(p<0.05). 3. The main effect of constitution is also significant but that of coping condition is not significant. 4. Thee Shaoyangren is higher than Shaoyinren in multiple comparisons(p<0.05). 5. The interaction between Yin-Yang constitution and coping condition is significant and the main effect of only constitution is significant(p<0.05). According to these results, different constitution can respond differently to coping condition and It is highly related to biological mechanism associated with two basic coping strategies.

• Journal of Oriental Physiology
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• v.14 no.2 s.20
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• pp.179-187
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• 1999

To investigate how Jagamchotang provent cellular injury by a certain starting point on reperfusion injury after ischemia in myocardial cell, conducted MTT assay, LM stydy and measured LDH secretion, heart rate and nitric oxide(NO), and got the following results. 1. Jagamchotang did not injure cells even in $20{\mu}g/ml$. 2. Jaganchotang repressed the toxicity of mitochondria and cell membrane in reperfusing after ischemia and repressed the contraction of promontory of myocardial cell and reduction of the number of cells. Also maintained regular heart rate and reduced the number of heart rate. 3. Synthesis of NO by Jagamchotang in ischemia increased 1.9 times than a control. 4. When reperfusing with sodium nitropruside (SNO), NO donor in ischemia repressed the toxicity of mitochondria as the case of reperfusing with Jagamchotang in ischemia. Therefore, putting these findings together, it. can be said the effect of Jagamchotang in ischemia will be closely related with generation of NO.

• The Korean Journal of Physiology
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• v.5 no.2
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• pp.29-40
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• 1971

Oxygen consumption, pulmonary ventilation, heart rate, and breathing frequency were measured on 8 men walking on a treadmill carrying load of 9 kg on hand, back, or head. Besides measurements were made on subjects carrying loads of 2.6 kg each on both feet. The speed of level walking was 4, 5, and 5.5km/hr and a fixed speed off km/hr with grades of 0, 3, 6, and 9%. Comparisons were made between free walking without load and walking with various types of loads. The following results were obtained. 1. In level or uphill walking the changes in oxygen consumption, pulmonary ventilation, breathing frequency and heart rate were smallest in back load walking, and largest in hand load walking. The method of back load was most efficient and hand load was the least efficient. The energy cost in head load walking was smaller than that of in hand load walking. It was assumed that foot load costed more energy than hand load. 2. In level walking the measured parameters increased abruptly at the speed of 5.5 km/hr. Oxygen consumption in a free walking at 4 km/hr was 11.4ml/kg b.wt., and 13.1 ml/kg b.wt. 5.5 km/hr, and in a hand load walking at 4 km/hr was 13.9, and 18.8 ml/kg b. wt. at 5.5 km/hr. 3. In uphill walking oxygen consumption and other parameters increased abruptly at the grade of 6%. Oxygen consumption at 4 km/hr and 0% grade was 11.4 ml/kg b. wt., 13.6 at 6% grade, and 16.21/kg b. wt. at 9% grade in a free walking. In back load walking oxygen consumption at 4km/hr and 0% grade was 12.3 ml/kg b.wt.,14.9 at 6% grade, and 18.7 ml/kg b.wt. In hand load walking the oxygen consumption was the greatest, namely, 13.9 at 0% grade, 17.9 at 6%, and 20.0 ml/kg b. wt. at 9% grade. 4. Both in level and uphill walking the changes in pulmonary ventilation and heart rate paralleled with oxygen consumption. 5. The changes in heart rate and breathing frequency in hand load were characteristic. Both in level and uphill walk breathing frequency increased to 30 per minute when a load was held on hand and showed a small increase as the exercise became severe. In the other method of load carrying the Peak value of breathing frequency was less than 30 Per minute. Heart rate showed 106 beats/minute even at a speed of 4 km/hr when a load was held on hand, whereas, heart rate was between, 53 and 100 beats/minute in the other types of load carriage. 6. Number of strides per minute in level walking increased as the speed increased. At the speed floater than 5 km/hr number of strides per minute of load carrying walk was greater than that of free walking. In uphill walk number of strides per minute decreased as the grade increased. Number of strides in hand load walk was greatest and back load walk showed the same number of strides as the free walk.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.4
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• pp.207-210
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• 2003

Lipids play many structural and metabolic roles, and dietary fat has great impact on metabolism and health. Fatty acid oxidation rate is dependent on tissue types. However there has been no report on the relationship between the rate of fatty acid oxidation and carnitine transport system in outer mitochondrial membrane of many tissues. In this study, the rate of fatty acid oxidation and carnitine palmitoyltransferase (CPT) I activity in the carnitine transport system were measured to understand the metabolic characteristics of fatty acid in various tissues. Palmitic acid oxidation rate and CPT I activity in various tissues were measured. Tissues were obtained from the white and red skeletal muscles, heart, liver, kidney and brain of rats. The highest lipid oxidation rate was demonstrated in the cardiac muscle, and the lowest oxidation rate was in brain. Red gastrocnemius muscle followed to the cardiac muscle. Lipid oxidation rates of kidney, white gastrocnemius muscle and liver were similar, ranging from 101 to 126 DPM/mg/hr. CPT I activity in the cardiac muscle was the highest, red gastrocnemius muscle followed by liver. Brain tissue showed the lowest CPT I activity as well as lipid oxidation rate, although the values were not significantly different from those of kidney and white gastrocnemius muscle. Therefore, lipid oxidation rate was highly (p＜0.001) related to CPT I activity. Lipid oxidation rate is variable, depending on tissue types, and is highly (p＜0.001) related to CPT I activity. CPT I activity may be a good marker to indicate lipid oxidation capacity in various tissues.

• The Korean Journal of Physiology
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• v.5 no.2
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• pp.71-78
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• 1971

Anesthetized dogs were tilted from horizontal to the upright and head down position. Tilting to the upright position was followed by an increase in heart rate. In the head down position a decreased heart rate was obtained. The arterial blood pressure was decreased in the upright position and was decreased markedly in the head down position. The central venous pressure was decreased in the upright position and was markedly decreased down to the negative pressure in the head down position. The respiratory rate was slightly increased in the upright position comparing to that in the horizontal position. No remarkable changes were noted in the head down position. From the above results the following factors were discussed The decreased arterial blood pressure during the upright position was supposed to be the secondary effect from the diminished venous return that was suggested by the decreased central venous pressure. The decreased arterial blood pressure in the head down position was also supposed as the above reason as the diminished central venous pressure during the tilt. In addition the cardioinhibitory effects originated from the baroreceptors might have been operated during head down tilting. In the heart rate there was slight tachycardia in the upright position this was assumed as the abolished cardioinhibitory impulses from the baroreceptor in the upright position. On the contrary, despite of the decrease of arterial blood pressure in the head down position as well as in the upright, the bradycardia have been appeared. This was suggestive of cardioinhibitory impulses from the baroreceptors which was stretched during head down tilting. From the above findings there is a possibility of continous cardioinhibitory responses during head down tilting for this kind of the short period of 10 minutes which was chosed in this study.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.5
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• pp.745-752
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• 2012

This study aims to show the change of Heart Rate Variability(HRV) and Pulse wave velocity(PWV) on menstruation in women at college. Heart Rate Variability(HRV) and Pulse wave velocity(PWV) of 122 women at college were measured at their menstruation and ordinary period. SDNN, RMSSD, SDSD, HRV Index(%), stress resistance and cardiac activity were significantly higher at their menstruation than ordinary period, but Total Power and pNN50(%) were opposite. The automatic nervous system balance and physical stress were decreased in groups without dysmenorrhea than with one. PWV(E-R) and PWV(E-L) were much higher at menstruation than ordinary period. PTT(F-R) and PTT(F-L) were decreased in groups without dysmenorrhea than with severe one. We demonstrated that menstruation can effect on Heart Rate Variability and Pulse wave velocity and dysmenorrhea can cause the imbalance of autonomic nervous system.