• BMB Reports
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• v.36 no.2
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• pp.154-158
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• 2003

Collagen is a family of proteins which consists of several genetically distinct molecular species and is intimately involved in tissue organization, function, differentiation and development. The purpose of this study was to investigate the concentration of different hydroxyproline (Hyp) fractions viz., total, free, peptide-bound, protein-bound, soluble- and insoluble-collagen hydroxyproline (Hyp) in various bovine tissues. Results showed that liver had the highest concentration of free Hyp followed by kidney, brain, spleen, lungs, muscle and heart. Liver also had the highest concentration of peptide-bound collagen Hyp followed by kidney, heart, spleen, lungs, brain and muscle. The concentration of protein-bound collagen Hyp was highest in the liver, followed by kidney, spleen, lungs, muscle, brain and heart. Total Hyp was highest in the liver, followed by kidney, spleen, brain, heart, muscle and lungs. Liver also had significantly high concentration of collagen as compared to other tissues examined (P<0.001). Spleen had the significantly higher concentration of soluble-collagen Hyp when compared to other tissues (P<0.001). This was followed by heart, muscle, lungs, brain, kidney and liver. Heart had the highest concentration of insoluble-collagen Hyp followed by lungs, kidney, liver, muscle, spleen and brain. The variation among the insoluble-collagen Hyp concentration of heart and muscle, spleen and brain was significant (P<0.001). We speculate that these differences could be due to the variation in turn over of rate of collagen metabolism in this species.

• Journal of People, Plants, and Environment
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• v.22 no.2
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• pp.219-229
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• 2019

This study was carried out to verify the accuracy of fitness tracking devices in monitoring heart rate and energy consumption and to contribute to the development of a forest exercise program that can recommend the intensity and amount of forest exercises based on personal health-related data and provide monitoring and feedback on forest exercises. Among several commercially available wearable devices, Fitbit was selected for the research, as it provides Open API and data collected by Fitbit can be utilized by third parties to develop programs. Fitbit provides users with various information collected during forest exercises including exercise time and distance, heart rate, energy consumption, as well as the altitude and slope of forests collected by GPS. However, in order to verify the usability of the heart rate and energy consumption data collected by Fitbit in forest, the accuracy of heart rate and energy consumption were verified by comparing the data collected by Fitbit and reference. In this study, 13 middle-aged women were participated, and it was found that the heart rate measured by Fitbit showed a very low error rate and high correlation with that measured by the reference. The energy consumption measured by Fitbit was not significantly different from that measured in the reference, but the error rate was slightly higher. However, there was high correlation between the results measured by Fibit and the reference, therefore, it can be concluded that Fitbit can be utilized in developing actual forest exercise programs.

• Journal of Chest Surgery
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• v.20 no.3
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• pp.458-472
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• 1987

A heart supplies bloods of about 15, 000 liters to each human organ in a day. A normal function of heart valves is necessary to this act of heart. The disease of heart valve develops to a narrowness of a closure, resulting in an abnormal circulation of bloods. In an attempt to eliminate the affliction of heart valves, the operation method to repair with artificial heart valves has been developed and saved numerous patients over past 30 years. This replacement operation has been performed since early 1960`s in Korea, but all the artificial heart valves used are imported from abroad with very high costs until recent years. The artificial heart valve using pyrolytic carbon has been developed at KAIST, which was proved to be stable in the mechanical performance and durability. Therefore, the in viva performance of this valve was examined through animal tests. The artificial heart valves used in this study are tilting disc type valves, in which the disc were made of graphite coated with pyrolytic carbon and the cages were made of titanium. In viva testings of these valves were performed in 12 dogs, in which right ventriculo-pulmonary arterial [Croup I] or inter-aortic [Croup IV] valved conduit was implanted using polytetrafluoroethylene conduits containing KAIST valve and aortic valve [Group II] or pulmonary valve [Croup III] was replaced by a KAIST valve with a 21mm or 19mm tissue annulus diameter. In group I and II, pre-and post-operative transvalvular pressure gradient was measured and compared with other prosthetic valves. During post operative period laboratory examination was performed including hemoglobin, hematocrit, red cell count, white cell, lactic acid dehydrogenase and platelet. The eight surviving dogs were sacrificed and autopsy was performed at 2, 6, and 8 weeks. KAIST valve has low transvalvular gradient and relatively high orifice area. Average ventriculo-aortic peak systolic transvalvular gradient was 14 mmHg in 21 mm valve and 19 mmHg in 19 mm valve. The valve has slight intravascular hemolysis effect. Thrombogenic effect of low polishing quality and eddy currents around small orifice is high. The valve has vulnerability of disc movement. These animal tests suggest that the improvement of the heart valve design, surface polishing state and prescription methods.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.845-851
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• 2003

The objective is to establish the standard of criteria for differential diagnosis of signs and symptoms. This study selected signs and symptoms related to heart which stands for Fire(火) as a kind of five phase(五行). Eleven experts was asked to evaluate the adequateness of criteria which was developed by Korea Institute of Oriental Medicine(KIOM) and to suggest the amendment of them. To implement the study, we used the questionnaire which asks about the diagnosis criteria for an insufficiency of the heart-qi(心氣虛證), deficiency of the heart blood(心血氣證), deficiency of the heart-yin(心陰虛證), insufficiency of the heart-yang(心陽虛證), exuberant fire due to hyperactivity of the heart(心火亢盛證), stagnation of the heart blood(心血瘀阻證), heart disturbed by phlegm-fire(痰火擾心證), attack of the heart by retainedfluid(水氣凌心證). Every criteria consists of primary symptoms, secondary symptoms, tongue findings. and pulse findings. In perspectives of the classification of patterns for signs and symptoms and criteria for diagnosis, the result shows that the previous standard doesn't have so many problem. So many of experts were agree with the criteria which was suggested but the trend is that they use, in their actual practice, less than the criteria. Additionally, they pointed that every element in a criterion should have the different weight value, criteria for the overlapped pattern should be added, and, in future, criteria which are based on clinical investigation should be established.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10a
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• pp.762-767
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• 1991

To make electromechanical total artificial heart implantable inside the body, transcutaneous energy transmission system was designed and simulated by using PSPICE program. The fabricated system was evaluated by using Mock circulation system and showed comparable performance with the D.C power supply

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.06a
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• pp.323-324
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• 2007

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.38 no.5
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• pp.59-69
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• 2001

Recently many researches concerning heart sound analysis are being processed with development of digital signal processing and electronic components. But there are few researches about recognition of heart sound, especially full cardiac cycled heart sound, In this paper, a new recognition methods about. full cardiac cycled heart sound was proposed. For the first, the database was built by principal components analysis on training heart sound set. This database is used to recognize new input of heart sound, Ilear sounds were classified into seven classes such as normal(NO) class, pre-systolic murmurr(PS) class, early systolic murmur(ES) class, late systolic murmurr(LS) class, early diastolic murmur(EI) class, late diastolic murmur(LD) class and continuous murmuru(CM) class. As a result, we could verify that our new method has better efficiencies for the recognition the characteristics of heart sound than any precedent research. The maximum recognition rates of the new method are 71% for NO, 80% for PS and ES, 78% for LS, 87% for ED, 60% for LD and 20% for CM. Although the present results aren't practically sufficient to use our new method in recognizing heart sound, the importance of this paper is for recognition of heart sound within full cardiac cycle. We can get a better result by building a more efficient database.

• The Korean Journal of Rehabilitation Nursing
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• v.4 no.1
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• pp.73-83
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• 2001

The aims of this study were to identify the mothers educational needs when they have children who have had open heart surgery in congenital heart disease, to identify the children's characteristics with this problem, and also to provide the basic information on the development of the educational program for the mothers. The subjects of the study were 101 mothers of children and their children hospitalized with congenital heart disease in pediatric wards of G. University Hospital in Inchon and S. Hospital in Puch on from June to November 2000. The study used a Likert-type questionnaire with 39 questions which was based on a previous questionnaire developed by Lee Mi-ryun(1989) for adult open heart surgery patients. The reliability of the questionnaire was Cronbach' ${\alpha}$=.9375. The data were collected directly from mothers of the patients in wards. The t-test, ANOVA was adopted for the data analysis. The key results of the study are as follows : 1) The average age of the children was 32.90 months. The majority of the children are male and weighted 3.0-3.5Kg at birth. Most of the children had VSD(29.7%), and 10.9% of children had a family history of heart disease. 2) An average score of 4.62 out of a maximum of 5.00 was recorded for the educational needs of the children's mother. The highest score of 4.69 was for home care after discharge followed by a score of 4.67 for diagnosis and prognosis on congenital heart disease. And pre-post operation care scored 4.51. The mean scores of single-question items of educational need were, in order, 4.81 for immunization after operation, 4.80 for recovery process, and 4.77 for prognosis of the disease. The score of 4.18 for measurement of intake and output was the lowest. 3) The analysis on the children's mothers educational needs by social-demographic characteristics such as sex, age of patient and mother, economical status, educational status, number of child, hospitalization times, and hospitalization cause showed no significant difference statistically, but there was a significant difference between mothers with jobs and with out jobs.

• Korean Journal of Plant Resources
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• v.36 no.5
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• pp.490-495
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• 2023

This study was conducted to investigate the growth and fruit characteristics of recently introduced or bred varieties in Korea and to review domestic adaptability. As for the sprouting rate among cultivars, 'Stella' was the highest at 91.6%, followed by 'My Heart' (78.3%), 'IFG-6' (77.3%), and 'Hongju Seedless' (73.2%). As for the flower incidence rate by cultivar, 'Stella' was the highest at 113.5%, and 'IFG-6' had a lower flower incidence at 45.3% compared to other cultivars. The diameter of shoots was less than 11.0 mm in the other three cultivars except for 'Hongju Seedless', and 'Hongju Seedless' was the thickest at 12.5 mm and 'Stella' was the thinnest at 9.6 mm. The berry weight of 'My Heart' was 11.3 g, heavier than other cultivars, followed by 'Stella', 'IFG-6' and 'Hongju Seedless'. Soluble sugar content at harvest time by cultivar was about 19.0°Bx or higher, with 'IFG-6' having the highest level of 20.2°Bx, followed by 'My Heart', 'Stella', and 'Hongju Seedless'. Acidity was the lowest in 'My Heart' at 0.39%, followed by 'IFG-6', 'Stella' and 'Hongju Seedless'. As for the coloring, in the case of 'My Heart', the skin color did not change to red even after the harvest season, therefore the grapes were irregularly colored, so it was judged that the development of cultivation technology to enhance the coloring was necessary.

• Molecules and Cells
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• v.37 no.4
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• pp.330-336
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• 2014

Thymosin beta4 (TB4) has multiple functions in cellular response in processes as diverse as embryonic organ development and the pathogeneses of disease, especially those associated with cardiac coronary vessels. However, the specific roles played by TB4 during heart valve development in vertebrates are largely unknown. Here, we identified a novel function of TB4 in endothelial-mesenchymal transformation (EMT) in cardiac valve endocardial cushions in zebrafish. The expressions of thymosin family members in developing zebrafish embryos were determined by whole mount in situ hybridization. Of the thymosin family members only zTB4 was expressed in the developing heart region. Cardiac valve development at 48 h post fertilization was defected in zebrafish TB4 (zTB4) morpholino-injected embryos (morphants). In zTB4 morphants, abnormal linear heart tube development was observed. The expressions of bone morphogenetic protein (BMP) 4, notch1b, and hyaluronic acid synthase (HAS) 2 genes were also markedly reduced in atrio-ventricular canal (AVC). Endocardial cells in the AVC region were stained with anti-Zn5 antibody reactive against Dm-grasp (an EMT marker) to observe EMT in developing cardiac valves in zTB4 morphants. EMT marker expression in valve endothelial cells was confirmed after transfection with TB4 siRNA in the presence of transforming growth factor ${\beta}$ ($TGF{\beta}$) by RT-PCR and immunofluorescent assay. Zn5-positive endocardial AVC cells were not observed in zTB4 morphants, and knockdown of TB4 suppressed TGF-${\beta}$-induced EMT in ovine valve endothelial cells. Taken together, our results demonstrate that TB4 plays a pivotal role in cardiac valve formation by increasing EMT.