• Nutrition Research and Practice
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• 제17권5호
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• pp.959-968
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• 2023

BACKGROUND/OBJECTIVES: Few studies have provided evidence of the association between diet quality and dental caries. This study aimed to examine the association between diet quality and untreated dental caries in a Korean representative population. SUBJECTS/METHODS: The study population included a sample of 13,815 participants, aged ≥ 19 from the Korea National Health and Nutrition Examination Survey during 2013-2015. The explanatory variable was diet quality and the outcome variable was untreated dental caries. Untreated dental caries were defined by the number of decayed teeth recorded according to the criteria established by the World Health Organization. Diet quality was defined by using the Korean Healthy Eating Index (KHEI) through the 24-h recall methods. We assessed the association between diet quality and untreated dental caries while adjusting for age, sex, education, income, smoking status, dental visits, toothbrushing frequencies, obesity, and diabetes mellitus. RESULTS: The mean overall KHEI scores in the untreated dental caries group were significantly lower than those in the group without untreated dental caries. Significant differences were observed in the untreated dental caries group based on the KHEI quartiles (P < 0.001). After adjusting for potential confounders, the quartiles of KHEI scores showed an association with untreated dental caries, demonstrating a dose-effect trend (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.35-1.84 for 1st quartile; OR, 1.38; 95% CI, 1.19-1.59 for 2nd quartile; OR, 1.32; 95% CI, 1.14-1.53 for 3rd quartile; reference quartile highest]). CONCLUSIONS: The findings indicated an inverse association between diet quality and untreated dental caries in Korean adults. Healthcare providers should take into account the significant role of diet quality in preventing and managing oral health.

• 대한임상독성학회지
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• 제21권2호
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• pp.143-150
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• 2023

Purpose: This study aimed to compare the clinical features of methanol and ethylene glycol poisoning. Methods: This single-center retrospective observational study included patients with toxic alcohol poisoning who visited a regional emergency medical center. Patients with methanol and ethylene glycol poisoning from January 2004 to June 2023 were selected for the study using diagnostic codes. Results: Twenty-two patients with toxic alcohol poisoning visited during the study period, with 11 patients for each category. Compared to methanol poisoning, ethylene glycol poisoning patients were more likely to have consumed alcohol for suicidal purposes (n=4 [36.36%] vs. n=8 [72.73%]) and were more likely to be drowsy (n=0 vs. n=6 [54.55%], p=0.016). The anion gap (25.43±8.35 mmol/L vs. 13.22±6.23 mmol/L, p=0.001) and lactic acid levels (1.785 [1.3-2.785] mmol/L vs. 9.90 [4.20-11.81] mmol/L, p=0.007) were higher in ethylene glycol poisoning patients than in methanol poisoning patients. Among alcohol dehydrogenase blockers, oral ethanol was administered to 10 patients (45.45%) (n=4 [36.36%] vs. n=6 [54.55%]), and intravenous ethanol was administered to six patients (n=4 [36.36%] vs. n=2 [18.18%]). Fomepizole was administered to two patients (9.09%) each, and renal replacement therapy was non-significantly more common in patients with ethylene glycol poisoning (n=8 [72.73%] vs. n=3 [27.27%], p=0.128). Three patients had delays in diagnosis and treatment, and while there were no fatalities, one patient was left with permanent vision damage. Conclusion: Because these are uncommon types of poisoning and the clinical presentation is difficult to recognize early, healthcare providers should be familiar with toxic alcohol types and screen for them to ensure proper diagnosis and treatment.

• The Korean Journal of Pain
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• 제37권1호
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• pp.41-50
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• 2024

Background: Recognizing the seriousness of the misuse and abuse of medical narcotics, the South Korean government introduced the world's first narcotic management system, the Narcotics Information Management System (NIMS). This study aimed to explore the recent one-year opioid prescribing patterns in South Korea using the NIMS database. Methods: This study analyzed opioid prescription records in South Korea for the year 2022, utilizing the dispensing/administration dataset provided by NIMS. Public data from the Korean Statistical Information Service were also utilized to explore prescription trends over the past four years. The examination covered 16 different opioid analgesics, assessed by the total number of units prescribed based on routes of administration, type of institutions, and patients' sex and age group. Additionally, the disposal rate for each ingredient was computed. Results: In total, 206,941 records of 87,792,968 opioid analgesic units were analyzed. Recently, the overall quantity of prescribed opioid analgesic units has remained relatively stable. The most prescribed ingredient was oral oxycodone, followed by tapentadol and sublingual fentanyl. Tertiary hospitals had the highest number of dispensed units (49.4%), followed by community pharmacies (40.2%). The highest number of prescribed units was attributed to male patients in their 60s. The disposal rates of the oral and transdermal formulations were less than 0.1%. Conclusions: Opioid prescription in South Korea features a high proportion of oral formulations, tertiary hospital administration, pharmacy dispensing, and elderly patients. Sustained education and surveillance of patients and healthcare providers is required.

• Journal of Preventive Medicine and Public Health
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• 제57권2호
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• pp.148-156
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• 2024

Objectives: Understanding patterns of quality of life in people who inject drugs (PWID) can help healthcare providers plan and manage their health problems in a more focused manner. Therefore, the current study aimed to identify patterns of health-related quality of life in PWID in southeast Iran. Methods: This cross-sectional study was conducted in southeast Iran on men who had injected drugs at least once during the last year. We used convenience sampling in 2 drop-in centers and venue-based sampling at 85 venues. Demographic characteristics, high-risk behaviors, and health-related quality of life were evaluated using the 5-level EQ-5D version (EQ-5D-5L) questionnaire. Latent profile analysis was used to identify patterns of quality of life. Results: This study enrolled 398 PWID, who had a mean age of 34.1±11.4 years. About 47.9% reported a prison history in the last 10 years, 59.2% had injected drugs in the last month, and 31.6% had a history of sharing syringes. About 46.3% reported having 2 or more sexual partners in the last 6 months, and 14.7% had a history of sex with men. Out of the 5 EQ-5D-5L profiles, the fifth profile had the most people (36.6%). Most variations in quality of life were related to pain and discomfort. Conclusions: We showed that the pain and discomfort dimension of EQ-5D-5L had more variation in PWID. This finding will be useful for allocating appropriate interventions and resources to promote health-related quality of life in this population.

• 한국산학기술학회논문지
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• 제16권1호
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• pp.490-497
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• 2015

본 연구는 신체적 기능장애를 지닌 국가유공자의 삶의 질 수준을 확인하고 삶의 질에 영향을 미치는 관련 요인들을 알아보기 위하여 실시하였다. 연구대상자는 서울, 부산, 대구, 광주와 대전에 위치한 보훈병원에서 신체적 기능장애로 치료를 받고 있는 국가유공자 412명을 대상으로 하였다. 대상자의 삶의 질은 SF-36을 이용하여 평가하였고, 일상생활동작은 수정된 바델지수로, 통증수준은 4항목 시각적 상사척도로, 우울증 척도는 노인우울척도를 이용하여 평가하였다. 연구 결과, 삶의 질은 연령이 높을수록, 주관적 건강상태가 나쁠수록, 경제수준이 낮을수록, 와병기간이 길수록, 통증수준, 우울증 점수가 높을수록 유의하게 낮아지는 것으로 나타났다. 회귀분석 결과 삶의 질에 가장 크게 영향을 미치는 변수는 우울증(B=-.969)이었으며, 주관적 건강상태(B=-5.098), 일상생활동작 수행(B=.140), 통증수준(B=-.163) 순으로 나타났다. 따라서 본 연구의 결과는 신체적 기능장애를 지닌 국가유공자의 삶의 질 향상을 위해 심리적 접근 뿐 아니라 일상생활동작 수행정도 등 신체적 증상의 완화, 통증감소를 개선시킬 수 있는 의학적 중재 및 프로그램 개발의 기초자료로 활용될 수 있을 것이다.

• 감성과학
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• 제22권3호
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• pp.77-90
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• 2019

본 연구는 기본 욕구의 개인차에 따라 메시지에 담긴 행동을 추구하는 데 효과적인 메시지 제공자가 다른지 알아보고자 하였다. Haddock, Maio, Arnold, & Huskinson (2008)에 의하면, 감성 욕구(NFA)가 높은 사람은 정서 기반의 메시지에, 인지 욕구(NFC)가 높은 사람은 인지 기반의 메시지에 더 영향을 받았다. 본 연구는 이러한 기본 욕구의 개인차가 메시지뿐 아니라 메시지 제공자에까지 적용할 수 있으리라 생각했다. 예를 들면, 감성 욕구가 높은 사람은 전문가보다 의미 있는 타인에게 전달받은 메시지를 더 잘 수용할 수 있다. 이에 따라, 본 연구는 VR에서 개인별 건강 조언에 효과적인 메시지 제공자를 파악하고자, 개인의 욕구 (2: NFA, NFC), 메시지 제공자 (3: 전문가, 의미 있는 타인, 타인) 그리고 VR 착용 (2: Text, VR)에 따른 선호도와 일상생활 스트레스 관리에 대한 자기 효능감을 측정하였다. 실험결과, 예상과 달리, 기본 욕구와 메시지 제공자의 특성에 따른 일치 효과는 발견할 수 없었다. 그러나, 감성 욕구가 높은 집단이 VR 건강 조언에 더 적합하다는 경향을 파악할 수 있었다. 본 연구의 의의는 VR 환경에서 개인의 맞춤형 메시지 제공자를 파악하고자 한 데 있다. 또한, 본 연구는 초기 단계의 연구로 추후 VR 환경의 건강 조언 연구에 기여하리라 예상한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1115-1118
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• 2016

Background: There is controversy about ablation efficacy of low or high doses of radioiodine-131 (RAI) in patients with differentiated thyroid cancers (DTC). The purpose of this prospective study was to determine efficacy of 30 mCi and 100 mCi of RAI to achieve successful ablation in patients with low to intermediate risk DTC. Materials and Methods: This prospective cross sectional study was conducted from April 2013 to November 2015. Inclusion criteria were patients of either gender, 18 years or older, having low to intermediate risk papillary and follicular thyroid cancers with T1-3, N0/N1/Nx but no evidence of distant metastasis. Thirty-nine patients were administered 30 mCi of RAI while 61 patients were given 100 mCi. Informed consent was acquired from all patients and counseling was done by nuclear physicians regarding benefits and possible side effects of RAI. After an average of 6 months (range 6-16 months; 2-3 weeks after thyroxin withdrawal), these patients were followed up for stimulated TSH, thyroglobulin (sTg) and thyroglobulin antibodies, ultrasound neck (U/S) and a diagnostic whole body iodine scan (WBIS) for ablation outcome. Successful ablation was concluded with stimulated Tg< 2ng/ml with negative antibodies, negative U/S and a negative diagnostic WBIS (triple negative criteria). ROC curve analysis was used to find diagnostic strength of baseline sTg to predict successful ablation. Results: Successful ablation based upon triple negative criteria was 56% in the low dose and 57% in the high dose group (non-significant difference). Based on a single criterion (follow-up sTg<2 ng/ml), values were 82% and 77% (again non-significant). The ROC curve revealed that a baseline sTg level ${\leq}7.4ng/ml$ had the highest diagnostic strength to predict successful ablation in all patients. Conclusions: We conclude that 30 mCi of RAI has similar ablation success to 100 mCi dose in patients with low to intermediate risk DTC. A baseline $sTg{\leq}7.4ng/ml$ is a strong predictor of successful ablation in all patients. Low dose RAI is safer, more cost effective and more convenient for patients and healthcare providers.

• 한국컴퓨터정보학회논문지
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• 제16권12호
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• pp.71-81
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• 2011

스마트폰 기반 개인 전자의료기록 관리 서비스는 병원과 의사와 환자가 병력을 공유하고 조회하여 환자의 병력을 효과적으로 관리하여 진단 효율을 높이는 서비스이다. 그러나 이런 전자의료기록 관리 서비스에서 발생되는 데이터는 도시와 같은 큰 범위의 모든 환자들의 병력 데이터를 전통 데이터베이스 관리시스템(DBMS)을 사용해 처리할 경우 빈번하게 발생하는 질의 처리 요청 등의 원인으로 병목현상이 발생 할 수 있어 실시간 데이터 스트림의 처리를 지원하는 데이터 스트림 관리시스템(Data Stream Management System)에 대한 연구가 진행되고 있다. 본 논문에서는 시스템 구조 및 연속 질의 처리기와 CCR 데이터 구조를 포함한 CCR 데이터 스트림 서버 시스템을 제안한다. 제안 시스템은 실시간적으로 발생하는 CCR 데이터 스트림을 처리 및 모니터링 하기 위한 시스템으로 사용자의 CCR 데이터 이력데이터에 대한 조회 및 실시간으로 발생하는 CCR 데이터에 대한 연속질의를 지원한다. 또한 개인 건강 정보는 지리적으로 떨어져 있는 헬스케어 프로바이더 사이에서 공유되어 환자의 병원이력정보를 관리한다. 또한 본 논문에서는 제안시스템에 기반한 아이폰 헬스케어 응용어플리케이션을 설계 및 개발하여 제안 시스템의 설계와 구축과정 및 성능을 보여준다.

• Child Health Nursing Research
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• 제19권2호
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• pp.120-129
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• 2013

목적 지속적인 의료기술의 발달로 미숙아의 치료, 양육 방법이 변화되어지고 있으며, 정보통신기술의 발달로 교육매체 역시 다양화 되어지는 시점에서 미숙아 부모를 위한 미숙아 돌봄 교육과 관련된 국내 연구 논문을 통합적으로 고찰하여 그 구성요소를 파악하고 각각에 대해 논의함으로써 향후 교육방법의 방향을 모색하고자 하였다. 방법 연구는 Whittemore와 Knafle (2005)이 제시한 통합적 고찰(integrative review) 방법으로 연구목적규정, 문헌검색, 데이터평가, 데이터 분석의 과정에 따라 체계적으로 탐색하고 논의하여 그 의미 있는 결과를 도출하였다. 엄격한 선정기준과 제외기준을 적용하여 4개의 국내 논문데이터베이스에서 1990년부터 2012년 10월까지 국내에서 발표된 논문 중 최종적으로 본 연구에 사용된 연구는 16편으로 확정하였다. 결과 통합적 고찰결과 미숙아 부모를 위한 미숙아 돌봄 교육의 구성요소로는 '교육자로서의 간호사와 학습자로서의 부모', '교육 내용과 교육 효과', 그리고 교육 매체, 시기, 장소를 포함한 '교육 환경'으로 분류되었다. 결론 미숙아 돌봄 교육을 위하여 부모와 가족교육을 전담하는 간호사 역할의 인정과 기관과 정부의 지속적인 관리와 지원과 함께 다학제적인 접근으로 각 양육자에 따른 맞춤형 교육이 되어야할 것이다. 향후 미숙아 돌봄 교육에서는 다양한 측면에서 교육의 효과를 측정할 수 있는 평가도구와 효율적인 교육매체의 개발과 효과적인 교육환경에서 미숙아 돌봄을 향상시킬 수 있는 프로그램의 개발을 제언한다.

• 한국임상약학회지
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• 제19권1호
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• pp.1-17
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• 2009

Adverse drug reactions (ADR) caused by inappropriate prescription are responsible for major socioeconomic loss. Drug-drug interactions (DDI) has been recognized as a major part of ADRs and, therefore, healthcare professionals should prevent possible DDIs to minimize preventable ADRs. This study aimed to examine DDI information in drug information references and Korea Food & Drug Administration (KFDA) drug labeling information. Drug ingredients from the formulary of Health Insurance Review and Assessment Service in Korea (HIRA) were included for the study. DDI information source used for the study were Micromedex Drugdex and Drug Information Facts (DIF) with the DDI severity level of "moderate" or more. The DDI information in KFDA drug labeling were collected and compared. Drug ingredients were classified with KFDA Drug Classification and ATC Classification of WHO for the analysis. Among the total 1,355 drug ingredients satisfying inclusion criteria, 738 ingredients involved at least one DDI, which was described in Micromedex and/or DIF. Drug Ingredients of 176 involved DDI only described in KFDA drug labeling, but not Micromedex nor DIF. Drug ingredients of 35 which DDIs were described in Micromedex or DIF did not have DDI based on KFDA drug labeling. Micromedex and DIF retrieved 7,582 and 3,071 DDIs, respectively 57.6% and 58.5% of DDIs were also described in KFDA drug labeling. Central nervous system (CNS) drugs, cardiovascular system (CVS) drugs and the antiinfectives appeared to have higher frequency of DDIs among all drug classes. The highest number of DDIs with high severity level ("contraindicated" or "major") were the DDIs of CNS drugs. The antiinfectives are the second drug group having serious DDIs. The DDI pairs of the CNS drug and the antiinfective had the highest contraindication risk (13.6%). DDI information from Micromedex and DIF were not consistent with the result that only 465 ingredients' DDIs are common in both literature (total DDI numbers were 715 vs 488, respectively). And 1,652 DDI information are common in both references among 7,582 vs 3,071 DDIs, respectively. Only 55.2% of DDI information in the database contained in the KFDA drug labeling. Prescribers and pharmacists should pay attention to the drugs for CV system, CNS and infections because of higher risk of possible DDIs compared to other drug classes. KFDA drug labeling is not likely to be recommended as a good information source for DDI due to significant inconsistency of information. Drug information providers should be aware that DDI information from different sources are not consistent and therefore multiple references should be used.