• 제목/요약/키워드: Health research and development

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곰팡이 노출에 따른 건강영향 및 민감 시설 내 곰팡이 분포 현황 (Health Effects of Exposure to Indoor Mold and the Levels of Mold in Facilities with Susceptible Populations in Korea)

  • 서성철
    • 한국환경보건학회지
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    • 제46권4호
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    • pp.359-367
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    • 2020
  • Objectives: Exposure to mold is strongly associated with adverse health effects (development or exacerbation of allergic diseases). We reviewed the health effects of mold exposure and explored to determine the annual distribution of indoor mold in facilities with susceptible populations. Methods: The health effects of mold exposure were mainly summarized by reviewing related papers and WHO research reports. We selected 10 facilities, including daycare centers, postpartum care centers, medical institutions, and elderly care facilities within the Seoul Metropolitan. Mold sampling was performed once every week or once every quarter from February 2016 to 2017. In addition, fungal species analyses was performed, and distribution status by month and facility was analyzed in the same manner as concentration. Results: Adverse health effects attributed to fungal exposure are largely divided into allergic symptoms, toxic effects, and infectious effects. Monthly mean concentrations of mold indoors and outdoors was 368.8 CFU/㎥ (geometric mean 213.4 CFU/㎥) and 496.0 CFU/㎥ (327.9 CFU/㎥), respectively. The indoor concentration has begun to increase in February, peaked in July, declined in August, increased again until October, and then decreased in November. About 36 genera of indoor fungal species were found in each facility. Cladosporium sp., Penicillium sp., Fusarium sp., Aspergillus sp., Alternaria sp., and Arthrinium sp. were observed as the dominant species. Conclusions: Our findings showed that the overall level of indoor mold was below the 500 CFU/㎥ level recommended by the Ministry of Environment. The development of DNA-based assessment and expanding facilities to be monitored for mold would be necessary for preventive aspects.

Effect of Lactic Acid Bacteria on D- and L-Lactic Acid Contents of Kimchi

  • Jin, Qing;Yoon, Hyang-Sik;Han, Nam-Soo;Lee, Jun-Soo;Han, Jin-Soo
    • Food Science and Biotechnology
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    • 제15권6호
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    • pp.948-953
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    • 2006
  • The D-form of lactic acid is frequently detected in fermented foods, and an excessive dietary intake of D-lactic acid may induce metabolic stress in both infants and patients. This work was carried out to determine the prevailing microorganisms relevant to the accumulation of D-lactic acid in kimchi. Leuconostoc (Leuc.) mesenteroides and Leuc. citreum primarily synthesized D-lactate with a small quantity of L-form. Leuc. gelidum and Leuc. inhae evidenced patterns similar to this. Lactobacillus (Lb.) plantarum and Lb. brevis were shown to convert glucose into a balanced mixture of D-/L-lactic acid, whereas Lb. casei principally synthesized L-lactic acid and a very small quantity of D-lactic acid. When kimchi was incubated at 8 or $22^{\circ}C$, D-lactic acid was over-produced than L-form. Leuconostoc was determined as the primary producer between the initial to mid-phase of fermentation and Lb. plantarum or Lb. brevis seemed to boost D-lactic acid content during later stage of acid accumulation.

Comparison of D- and L-Lactic Acid Contents in Commercial Kimchi and Sauerkraut

  • Yoon, Hyang-Sik;Son, Yeo-Jin;Han, Jin-Soo;Lee, Jun-Soo;Han, Nam-Soo
    • Food Science and Biotechnology
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    • 제14권1호
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    • pp.64-67
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    • 2005
  • Commercial kimchi and sauerkraut were analyzed for their D- and L-lactic acid contents. Ranges of D- and L-lactic acid contents in commercial kimchi were 17-57 (38.51 mean) and 25-87 (64.47 mean) mM, respectively. Ratio of D-lactic acid on L-lactic acid (D/L) was 0.50-0.80 (0.60 mean). Ranges of D- and L-lactic acid contents in commercial sauerkraut were 68.96-103.62 (88.97 mean) and 74.46-82.26 (78.91 mean) mM, respectively, with D/L of 0.90-1.26 (1.13 mean). Results reveal kimchi and sauerkraut contained a significant amount of D-lactic acid, with sauerkraut showing a higher content than kimchi, while L-lactic acid contents were not significantly different.

Long-term effects of maxillary skeletal expander treatment on functional breathing

  • Andrew Combs;Ney Paredes;Ramon Dominguez-Mompell;Martin Romero-Maroto;Boshi Zhang;Islam Elkenawy;Luca Sfogliano;Layla Fijany;Ozge Colak;Ben Wu;Won Moon
    • 대한치과교정학회지
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    • 제54권1호
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    • pp.59-68
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    • 2024
  • Objective: To investigate the long-term effects of maxillary skeletal expander (MSE) treatment on functional breathing. Methods: Objective measures of breathing, the peak nasal inspiratory flow (PNIF), and peak oral inspiratory flow (POIF), and subjective measures of breathing, the visual analog scale (VAS) and nasal obstruction symptom evaluation (NOSE) survey, were used to investigate the long-term effects of MSE in functional breathing. Seventeen patients, mean age 19.4 ± 3.9 years treated at the UCLA Orthodontics Clinic were assessed on their functional breathing at 3 timepoints: pre-expansion (T0), post-expansion (T1), and post-orthodontic treatment (T2). Results: Immediately after expansion (T1), all the objective functional breathing values were significantly increased in comparison to T0 (P < 0.05). The VAS total, VAS right and VAS left were significantly lower at T1 in comparison to T0 (P < 0.05). At 26.8 ± 3.9 months after MSE expansion (T2), PNIF total, PNIF right, PNIF left, and POIF were significantly higher when compared to T0 (P < 0.05). Also, VAS total, VAS right and VAS left were significantly lower at T2 when compared to T0 (P < 0.05). Additionally, there was a positive correlation between PNIF and the magnitude of expansion at anterior nasal spine and zygomaticomaxillary point (ZMA). There was a positive correlation between total VAS and the magnitude of expansion at the ZMA. There were no significant changes for the NOSE subjective breathing measurement at all time comparisons. Conclusions: Overall, MSE treatment produces an increased objective and subjective airway improvement that continues to remain stable in the long-term post expansion.

한국과 일본의 사망률 비교 분석을 통한 건강증진정책 함의 (A comparative study for the development of a health promotion policy through an analysis of the mortality rates in Korea and Japan, $1983{\sim}2003$)

  • Nam, Eun-Woo;Song, Yea-Li-A;Moriyama, Masaki;Ishihara, Akiko
    • 보건교육건강증진학회지
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    • 제24권5호
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    • pp.39-54
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    • 2007
  • 본 연구는 1983년부터 2003년까지 21년간의 한국과 일본의 사망통계자료를 이용하여 두 나라간의 사망원인을 비교 분석하였다. 사망률은 일본의 2003년 인구를 표준인구로 한 직접법을 통해 표준화되었다. 분석 결과, 2001/2003년에 한국과 일본의 주요사인의 순위가 크게 바뀌어 가고 있음을 알 수 있었다. 즉, 한국에서는 악성신생물, 당뇨, 신부전, 추락, 자살로 인한 사망률이 증가하였고, 일본에서는 당뇨보다는 폐렴으로 인한 사망률이 증가하고 있었다. 또한, 2001/2003년에는 만성질환으로 인한 사망률의 비율이 급성질환으로 인해 사망하는 경우가 많았다. 이상의 분석 결과, 한국의 건강증진사업은 악성신생물, 당뇨, 신부전, 추락사고, 그리고 자살의 예방과 관리에 대한 다양한 사업이 필요함을 알 수 있었다. 또한, 노인 인구가 많은 일본의 경우, 폐렴으로 인한 사망자가 증가하는 경향을 볼 때에, 한국의 경우도 노인의 경우 폐렴 관련 건강관리가 필요함을 시사하고 있다.

Genome Sequencing and Genome-Wide Identification of Carbohydrate-Active Enzymes (CAZymes) in the White Rot Fungus Flammulina fennae

  • Lee, Chang-Soo;Kong, Won-Sik;Park, Young-Jin
    • 한국미생물·생명공학회지
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    • 제46권3호
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    • pp.300-312
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    • 2018
  • Whole-genome sequencing of the wood-rotting fungus, Flammulina fennae, was carried out to identify carbohydrate-active enzymes (CAZymes). De novo genome assembly (31 kmer) of short reads by next-generation sequencing revealed a total genome length of 32,423,623 base pairs (39% GC). A total of 11,591 gene models in the assembled genome sequence of F. fennae were predicted by ab initio gene prediction using the AUGUSTUS tool. In a genome-wide comparison, 6,715 orthologous groups shared at least one gene with F. fennae and 10,667 (92%) of 11,591 genes for F. fennae proteins had orthologs among the Dikarya. Additionally, F. fennae contained 23 species-specific genes, of which 16 were paralogous. CAZyme identification and annotation revealed 513 CAZymes, including 82 auxiliary activities, 220 glycoside hydrolases, 85 glycosyltransferases, 20 polysaccharide lyases, 57 carbohydrate esterases, and 45 carbohydrate binding-modules in the F. fennae genome. The genome information of F. fennae increases the understanding of this basidiomycete fungus. CAZyme gene information will be useful for detailed studies of lignocellulosic biomass degradation for biotechnological and industrial applications.

산후우울의 영향요인과 모성 정체성과의 관련성 (Factors associated with Postpartum Depression and Its Influence on Maternal Identity)

  • 정연이;김혜원
    • 여성건강간호학회지
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    • 제20권1호
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    • pp.29-37
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    • 2014
  • Purpose: This study aimed to examine the factors associated with postpartum depression and its influence on maternal identity of postpartum women. Methods: Research design was a cross sectional descriptive study with a total of 89 women within the six month postpartum period. Associations of eating habits, overall sleep quality and other factors with postpartum depression utilizing the Korean Beck Depression Inventory (K-BDI) were done. The influence of postpartum depression on maternal identity was analyzed. Variables yielding significant associations (p<.05) were included in an adjusted logistic regression and a stepwise multiple regression. Results: Mean scores of postpartum depression was $9.42{\pm}6.08$ and 31.5% (n=28) for mild depression, 11.2% (n=10) was moderate and 4.5% (n=4) was severe depression on the K-BDI scale. Perceived health status and overall sleep quality were predictors of postpartum depression. Postpartum depression and the husband's love were predictors of maternal identity. Conclusion: Awareness of poor health perception and sleep quality will be helpful to detect for postpartum depression. Strategies to increase maternal identity during the postpartum period would be tailored by level of depression.

건설업 위험성 평가 최적화를 위한 운영 주체간 안전보건 인식도 조사 연구 (A Study on the Perception Level of Health and Safety among the Participants for Optimization of Risk Assessment in Construction Industry)

  • 백충현;조을룡
    • 대한안전경영과학회지
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    • 제17권3호
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    • pp.23-32
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    • 2015
  • Recently, the Ministry of Labour, published clause 2 of Article 41 (Risk Assessment) of the Act "Industrial Safety and Health" dated 12 June 2013 in connection with continuous increase of accidents at construction sites in order to prevent accidents in industrial safety and health in new construction in accordance with the risk assessment on construction projects are realized after March 13, 2014. In this paper, positive method of calculating risk discussed by performing research the awareness of general contractors and sub-contractors with presenting risky situation is considered. The purpose will be a positive method of calculating risk and would be a sufficient base and give a positive direction in the development of new systems currently working in the construction and risk assessment which consider the characteristics of sufficient risk assessment system for future research.

보행 장애인의 승차감 개선을 위한 휠체어용 능동형 서스펜션 시스템 개발 (Development of Active Suspension System for Wheelchairs to Improve Riding Comfort of Gait Disorders)

  • 허영준;전금상;이상훈;최성대;장익규
    • 대한의용생체공학회:의공학회지
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    • 제41권5호
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    • pp.203-209
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    • 2020
  • As the number of people with gait disorders increases, the demand for using wheelchairs increases and the area of a ctivity for people with disabilities expands, thereby they increasing the demand for riding comfortability in various driving environments. Therefore, this study is to develop an entry-level active suspension system that apply to wheelchairs and to evaluate its usability. The suspension applied in this paper consists of a coil spring, a shock absorber, a control module to control the strength of the shock absorber, and a road surface condition monitoring system. A wheelchair occupant secures the riding comfort by adjusting the coil strength of the shock absorber in 12 steps according to various road conditions. Therefore, the mechanical properties were evaluated through the structural analysis of the suspension system, and the tendency toward the magnitude of the road surface vibration attenuated according to the rigidity of the suspension through the vibration test was attempted. In conclusion, as a result of structural analysis of the suspension system, stress in a range lower than the yield strength of the material was generated, and the vibration test showed the effect of attenuating the vibration generated from the road surface when the stiffness of the suspension was adjusted.

Status and Prospects of the Utilization of Medicinal Plants in the Philippines

  • Waje, Catherine K.
    • 한국자원식물학회:학술대회논문집
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    • 한국자원식물학회 2005년도 International Symposium & conference of the Plant Resources Society of Korea
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    • pp.11-16
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    • 2005
  • Utilization of herbal medicine has been an intrinsic part of Philippine culture for many centuries. In spite of tremendous development in the field of modern medicine, traditional and alternative medicine will continue to flourish and take an important role in meeting the basic health needs of the people. The National Integrated Research Program on Medicinal Plant (NIRPROMP), the lead government institution for herbal medicinal research had already validated ten medicinal plants and is currently studying new batch of medicinal plants. Five of the ten clinically-tested medicinal plants have been elevated to herbal medicinal drugs that are now being commercially manufactured in the different parts of the country. Research on medicinal plants takes longer time as the nature of medical research dictates it to be. It must adhere to the internationally accepted standards of medicinal research in the Philippines was observed making alternative medicine an effective health delivery system to the people.

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