• Journal of Ginseng Research
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• 제48권2호
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• pp.129-139
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• 2024

Liver diseases are a significant global health burden and are among the most common diseases. Ginssennoside Rg3 (Rg3), which is one of the most abundant ginsenosides, has been found to have significant preventive and therapeutic effects against various types of diseases with minimal side effects. Numerous studies have demonstrated the significant preventive and therapeutic effects of Rg3 on various liver diseases such as viral hepatitis, acute liver injury, nonalcoholic liver diseases (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC). The underlying molecular mechanism behind these effects is attributed to apoptosis, autophagy, antioxidant, anti-inflammatory activities, and the regulation of multiple signaling pathways. This review provides a comprehensive description of the potential molecular mechanisms of Rg3 in the development of liver diseases. The article focuses on the regulation of apoptosis, oxidative stress, autophagy, inflammation, and other related factors. Additionally, the review discusses combination therapy and liver targeting strategy, which can accelerate the translation of Rg3 from bench to bedside. Overall, this article serves as a valuable reference for researchers and clinicians alike.

• Child Health Nursing Research
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• 제13권4호
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• pp.444-453
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• 2007

Purpose: The purpose of this study was to develope a tool to assess mothers' behavior related to healt promotion if their preschool children had disabillties. Method: The research design was a methodological study. This tool was developed in 4 stages: first, a content matrix as a conceptual framework was developed using Gordon's 11 functional health promotion patterns and 5 categories (Lee, Jung & An, 1996); second,40 preliminary items were selected through references and interviews with 9 mothers of children with disabilities; third, 2 items were discarded after content validity was done by 3 experts; fourth, reliability and validity were tested with a sample of 243 mothers of children with disabilities who were of preschool age. Results: The final tool consisted of 19 items and Cronbach's alpha coefficient for internal consistency was .82. Five factors were extracted by factor analysis and they explained 55.58% of the total variance. Conclusions: This tool was identified to have a high degree of reliability and validity. So it can be utilized to assess mothers' behavior in providing health promotion for their children who have disabilities.

• 대한간호학회지
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• 제29권6호
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• pp.1419-1433
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• 1999

Little is known about the impact of family caregiving for the demented elderly in Korea. The purpose of this study was to identify the current state of development of family caregiving research for the demented elderly in Korea and to identify correlates of caregiver or health problems and burdens within the socio-political contexts of Korea. A critical review of 17 family caregivers was carried out. The review revealed that various caregiving impacts and correlates of caregiver burden or health problems have been studied in relation to demented elderly family caregiving. Family caregiving for the demented elderly is a very complex phenomenon and various factors were related to caregiver burden, or their emotional and physical health. Findings from studies reviewed have shown inconsistent, inconclusive, and contradictory results. Furthermore, several conceptual and methodological problems were identified in the studies reviewed: restricted conceptualization, unrepresentative study samples, inadequate sample size, inappropriate study design, absence of comparison groups, inappropriate psychometric properties, and uncontrolled confounding factors. More research, as well as directions for further research, is recommended to identify family caregiving the impact of for the demented elderly, and to clarify the factors that explain results.

• Safety and Health at Work
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• 제11권1호
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• pp.109-117
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• 2020

Background: Ammonia and hydrogen sulfide are harmful gases generated during aerobic/anaerobic bacterial decomposition of livestock manure. We evaluated ammonia and hydrogen sulfide concentrations generated from workplaces at livestock farms and determined environmental factors influencing the gas concentrations. Methods: Five commercial swine farms and five poultry farms were selected for monitoring. Real-time monitors were used to measure the ammonia and hydrogen sulfide concentrations and environmental conditions during the manure-handling processes. Monitoring was conducted in the manure storage facility and composting facility. Information on the farm conditions was also collected through interview and walk-through survey. Results: The ammonia concentrations were significantly higher at the swine composting facilities (9.5-43.2 ppm) than at other manure-handling facilities at the swine and poultry farms, and high concentrations of hydrogen sulfide were identified during the manure agitation and mixing process at the swine manure storage facilities (6.9-19.5 ppm). At the poultry manure-handling facilities, the ammonia concentration was higher during the manure-handling processes (2.6-57.9 ppm), and very low hydrogen sulfide concentrations (0-3.4 ppm) were detected. The air temperature and relative humidity, volume of the facility, duration of manure storage, and the number of animals influenced the gas concentrations. Conclusion: A high level of hazardous gases was generated during manure handling, and some levels increased up to risk levels that can threaten workers' health and safety. Some of the farm operational factors were also found to influence the gas levels. By controlling and improving these factors, it would be possible to protect workers' safety and health from occupational risks.

• Asian-Australasian Journal of Animal Sciences
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• 제27권9호
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• pp.1360-1367
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• 2014

Triplicate groups of fed and starved olive flounder, Paralichthys olivaceus (body weight: $119.8{\pm}17.46$ g), were examined over 42 days for physiological changes using hematological, biochemical, and non-specific immune parameters. No significant differences in concentrations of blood hemoglobin and hematocrit and plasma levels of total cholesterol, aspartate aminotransferase, alanine aminotransferase, glucose, and cortisol were detected between fed and starved groups at any sampling time throughout the experiment. In contrast, plasma total protein concentrations were significantly lower in starved fish than in fed fish from day 7 onwards. Moreover, plasma lysozyme concentrations were significantly higher in starved flounder from day 21 onwards. This result confirms that the response of olive flounder to short-term (less than about 1.5 months) starvation consists of a readjustment of metabolism rather than the activation of an alarm-stress response. The present results indicate that starvation does not significantly compromise the health status of fish despite food limitation.

• Archives of Plastic Surgery
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• 제49권5호
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• pp.663-667
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• 2022

Finger dorsum defects are a challenging situation. Many reconstruction methods are used in these defects. Extended reverse dorsal metacarpal artery (RDMA) flap is used in dorsal finger reconstruction. Venous congestion in this flap is most important cause of flap failure. In this case, we presented a case in which we used heparin cream due to development of venous congestion in our patient who underwent an extended RDMA flap. A 24-year-old female patient presented to the emergency department with a defect of dorsal of left-hand fourth finger. Defect was covered with an extended RDMA flap. On postoperative first day, venous congestion was observed, and heparin cream was applied three times a day on flap. The signs of venous congestion were regressed. Tissue healed as a result of superficial epidermolysis and skin grafting. No functional limitation was observed in sixth-month postoperative control. Venous congestion is the most important cause of flap failure of extended RDMA flaps. Generally, subcutaneous heparin administration and leech therapy are used. In our case, heparin was applied as a cream instead of subcutaneously, and flap healing was observed as a result of superficial epidermolysis. Heparin cream application can also be used as a treatment option in flaps with venous congestion.

• Structural Monitoring and Maintenance
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• 제3권1호
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• pp.33-49
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• 2016

Structural Health Monitoring (SHM) has been attracting numerous research efforts around the world because it targets at monitoring structural conditions and performance to prevent catastrophic failure, and to provide quantitative data for engineers and infrastructure owners to design a reliable and economical asset management strategy. In the past decade, with supports from Australian Research Council (ARC), Cooperative Research Center for Infrastructure and Engineering Asset Management (CIEAM), CSIRO and industry partners, intensive research works have been conducted in the School of Civil, Environmental and Mining Engineering, University of Western Australia and Centre for Infrastructural Monitoring and Protection, Curtin University on various techniques of SHM. The researches include the development of hardware, software and various algorithms, such as various signal processing techniques for operational modal analysis, modal analysis toolbox, non-model based methods for assessing the shear connection in composite bridges and identifying the free spanning and supports conditions of pipelines, vibration based structural damage identification and model updating approaches considering uncertainty and noise effects, structural identification under moving loads, guided wave propagation technique for detecting debonding damage, and relative displacement sensors for SHM in composite and steel truss bridges. This paper aims at summarizing and reviewing the recent research advances on SHM of civil infrastructure in Western Australia.

• Child Health Nursing Research
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• 제25권4호
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• pp.528-540
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• 2019

Purpose: This study was conducted to design services for improving the quality of care of hospitalized children with acute diseases. Methods: The service design process had four phases: discovery, definition, development, and delivery. The participants were 23 mothers of hospitalized children with an acute disease, and seven nurses and three doctors working at a pediatric hospital. Data were collected through self-report questionnaires, in-depth interviews, and observations. The data were analyzed using content analysis and descriptive statistics. Results: The participants reported needs for explanations about the treatment, skillful nursing, and environmental improvements. The concept of the services was familiarity and enjoyment, aimed at solving the problems of unfamiliarity and boredom. A six-guideline was presented for improving the quality of care of hospitalized children with acute diseases: improvement of awareness, development of educational materials, improvement of skills, environmental improvements, play activities, and evaluations of user satisfaction. Conclusion: These findings indicate that nursing services should deliver familiarity and enjoyment to hospitalized children and their families. The findings of this study emphasize that the service design methodology can be used to improve the quality of care of hospitalized children with acute diseases.

• Safety and Health at Work
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• 제9권4호
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• pp.454-461
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• 2018

Background: Working conditions and psychosocial work factors have acquired an important role explaining the well-being and performance of professional drivers, including those working in the field of public transport. This study aimed to examine the association between job strain and the operational performance of public transport drivers and to compare the expositions with psychosocial risk at work of three different types of transport workers: taxi drivers, city bus drivers, and interurban bus drivers. Method: A sample of 780 professional drivers was drawn from three transport companies in Bogota (Colombia). The participants answered the Job Content Questionnaire and a set of sociodemographic and driving performance questions, including age, professional driving experience, work schedules, and accidents and penalties suffered in the last 2 years. Results: Analyses showed significant associations between measures of socio-labor variables and key performance indicators such road traffic accidents and penalties. Furthermore, multiple linear regression analysis contributed to explain significantly suffered accidents from key variables of the Job Demand-Control model, essentially from job strain. In addition, throughout post-hoc analyses, significant differences were found in terms of perceived social support, job strain, and job insecurity. Conclusion: Work stress is an issue that compromises the safety of professional drivers. This research provides evidence supporting a significant effect of job strain on the professional driver's performance. Moreover, the statistically significant differences between taxi drivers, city bus drivers, and interurban bus drivers in their expositions to work-related stress suggest the need for tailored occupational safety interventions on each occupational group.

• 치위생과학회지
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• 제24권1호
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• pp.9-21
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• 2024

Background: The purpose of this study was to utilize text network analysis and topic modeling to identify interconnected relationships among keywords present in patent information related to oral health, and subsequently extract latent topics and visualize them. By examining key keywords and specific subjects, this study sought to comprehend the technological trends in oral health-related innovations. Furthermore, it aims to serve as foundational material, suggesting directions for technological advancement in dentistry and dental hygiene. Methods: The data utilized in this study consisted of information registered over a 20-year period until July 31st, 2023, obtained from the patent information retrieval service, KIPRIS. A total of 6,865 patent titles related to keywords, such as "dentistry," "teeth," and "oral health," were collected through the searches. The research tools included a custom-designed program coded specifically for the research objectives based on Python 3.10. This program was used for keyword frequency analysis, semantic network analysis, and implementation of Latent Dirichlet Allocation for topic modeling. Results: Upon analyzing the centrality of connections among the top 50 frequently occurring words, "method," "tooth," and "manufacturing" displayed the highest centrality, while "active ingredient" had the lowest. Regarding topic modeling outcomes, the "implant" topic constituted the largest share at 22.0%, while topics concerning "devices and materials for oral health" and "toothbrushes and oral care" exhibited the lowest proportions at 5.5% each. Conclusion: Technologies concerning methods and implants are continually being researched in patents related to oral health, while there is comparatively less technological development in devices and materials for oral health. This study is expected to be a valuable resource for uncovering potential themes from a large volume of patent titles and suggesting research directions.