• 제목/요약/키워드: Health research and development

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착상전기(着床前期)에 있어서 ICR Mouse의 태아(胎兒)에 대한 방사선(放射線) 개체(個體) Level 영향(影響)의 연구(硏究) (The Developmental Effects of Radiation on ICR Mouse Embryos in Preimplantation Stage)

  • 구연화
    • Journal of Radiation Protection and Research
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    • 제21권4호
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    • pp.273-284
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    • 1996
  • 착상전기(着床前期}의 태아(胎兒)는 방사선(放射線)을 비롯한 많은 환경요인(環境要因)에 대하여 감수성(感受性)이 높은 개체(個體)임에도 불구하고 특히 이 시기는 임신부(姙娠婦)가 자각(自覺)적으로 임신을 감지할 수 없는 시기이기에 이러한 여러 환경유해요인으로부터 의도적으로 피할 수가 없다. 그러므로 착상전기의 영향을 충분히 검토한 후에 의료행위를 취할 것이며 이에 대한 방어(防禦)대책도 검토할 필요가 있다. 종래 까지 방사선에 대한 태아영향에 관한 많은 연구결과에 의하면 방사선 및 그 외의 유해요인에 대한 착상전기의 영향은 배사망(胚死亡)(유산(流産))만이 일어나며 기형(奇形)은 유발(誘發)하지 않는다고 하여 발생학(發生學)등 여러 교과서에서 기형은 기관형성기(器官形戚期)만이 국한(局限)해서 일어나는 영향이라고 단정되어 왔었다. 그러나 이 연구결과 착상전기에 있어서도 기형이 유발하여 오히려 기관형성기((器官形成期)보다도 감수성이 높다는 것이다. 또한 착상전기에서도 기형유발의 시기특이성을 가지며 여러 종류의 기형이 발생한다는 것이 본 연구로부터 밝혀졌다. 실험동물은 ICR Mouse를 사용했다. ICR Mouse는 일반적으로 태아사망 및 기형실험에 널리 사용되는 것이다. 사육조건은 Conventional 한 조건하에서 사육했으며 Mating 방법(方法)은 Female 마우스의 발정기(Sexual Excitement period)에 있는 mouse 질(膣)을 육안 적으로 관찰하여 $AM 6:00{\sim}AM 9:00$시까지 3시간만 mate시켰다. AM9:00시에 Vaginal Plug를 관찰하여 임신을 확인했다. Plug가 확인 된 마우스는 AM8:00시에 수정(Conception)된 것으로 가정하고 이 시점을 임신 0일 0시로 수정 난의 태아연령을 산정했다. 방사선조사는 $^{135}Cs\;{\gamma}-$선을 사용하였으며 임신 마우스의 전신조사를 실시하고 조사한 시기는 각 2, 48, 72, 96hpc이며 조사한 방사선 선량 군은 $0.1{\sim}2.5Gy$이다. 태아영향 관찰지표는 태아 연령은 mate일 오전 8:00시를 임신 0일 0시로 환산하여 태아연령 18일에 임신마우스를 Cervical vertebral dislocation에 의해 도살했다. 도살 후 해부하여 각 임신 마우스별로 관찰했다. 착상 율을 관찰하기 위하여 황체수를 세었고, 태아사망과 생존태아를 구별했다. 자궁 내 사망의 분류는 태아사망을 1) preimplantation death 2) Embryonic death 3) Fetal death로 분류했다. 착상전사망은 수정후 $0{\sim}4.5$일(1세포기${\sim}$배반포후기 부화까지)까지의 사망으로써 난소의 황체수(배란 수)와 착상태아(생존태아, 착상흔, 태반유잔, 흡수태아, 침연태아의 합계)로부터 구할 수 있다. Embonic death는 수정 후 $4.5{\sim}13$일까지의 사망으로써 Implantation sites, Placental remnants, Resorption of fetus로 관찰된 것이다. Fetal death는 수정후 $14{\sim}18$일까지의 사망으로써 Maceration of fetus로 관찰되는 것이다. 통계학적 분석은 각 Group의 착상 을과 자궁 내 사망 율을 산출할 때에는 각 임신마우스에 따라 발생빈도가 크게 다르기 때문에 통계처리에는 Non parametric 검정인 Kluskal Wallis 검정을 사용하여 분석하였다. 또한 개체 Level 영향인 착상을, 태아사망, 기형의 threshold dose의 산정에 대해서는 SAS-Logistic 검정에 따라 통계 분석을 하여 $5%(Ld_5,\;ED_5)$$10%{\times}2/3$점을 threshold dose로 판단했다. 태아체 중에 대해서는 parametric검정인 t-test검정에 의하여 분석했다. 그 결과 착상전기에서도 기형이 유발하며 특히 시기에 따라 일어나는 때와 일어나지 않는 때가 있음을 본 연구로부터 밝혀졌다. 또한 착상전기의 영향으로써 유발되는 기형은 여러 종류의 기형이 발생함이 밝혀졌다. 특히 이시기는 착상전 사망 및 배(胚)사망은 방사선 선량에 따라 크게 일어나나 태아사망(Fetal death) 및 태아체중은 유의차(有意差)가 없었다.

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병원 간호행정 개선을 위한 연구 (A Study for Improvement of Nursing Service Administration)

  • 박정호
    • 대한간호학회지
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    • 제3권1호
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    • pp.13-40
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    • 1972
  • Much has teed changed in the field of hospital administration in the It wake of the rapid development of sciences, techniques ana systematic hospital management. However, we still have a long way to go in organization, in the quality of hospital employees and hospital equipment and facilities, and in financial support in order to achieve proper hospital management. The above factors greatly effect the ability of hospitals to fulfill their obligation in patient care and nursing services. The purpose of this study is to determine the optimal methods of standardization and quality nursing so as to improve present nursing services through investigations and analyses of various problems concerning nursing administration. This study has been undertaken during the six month period from October 1971 to March 1972. The 41 comprehensive hospitals have been selected iron amongst the 139 in the whole country. These have been categorized according-to the specific purposes of their establishment, such as 7 university hospitals, 18 national or public hospitals, 12 religious hospitals and 4 enterprise ones. The following conclusions have been acquired thus far from information obtained through interviews with nursing directors who are in charge of the nursing administration in each hospital, and further investigations concerning the purposes of establishment, the organization, personnel arrangements, working conditions, practices of service, and budgets of the nursing service department. 1. The nursing administration along with its activities in this country has been uncritical1y adopted from that of the developed countries. It is necessary for us to re-establish a new medical and nursing system which is adequate for our social environments through continuous study and research. 2. The survey shows that the 7 university hospitals were chiefly concerned with education, medical care and research; the 18 national or public hospitals with medical care, public health and charity work; the 2 religious hospitals with medical care, charity and missionary works; and the 4 enterprise hospitals with public health, medical care and charity works. In general, the main purposes of the hospitals were those of charity organizations in the pursuit of medical care, education and public benefits. 3. The survey shows that in general hospital facilities rate 64 per cent and medical care 60 per-cent against a 100 per cent optimum basis in accordance with the medical treatment law and approved criteria for training hospitals. In these respects, university hospitals have achieved the highest standards, followed by religious ones, enterprise ones, and national or public ones in that order. 4. The ages of nursing directors range from 30 to 50. The level of education achieved by most of the directors is that of graduation from a nursing technical high school and a three year nursing junior college; a very few have graduated from college or have taken graduate courses. 5. As for the career tenure of nurses in the hospitals: one-third of the nurses, or 38 per cent, have worked less than one year; those in the category of one year to two represent 24 pet cent. This means that a total of 62 per cent of the career nurses have been practicing their profession for less than two years. Career nurses with over 5 years experience number only 16 per cent: therefore the efficiency of nursing services has been rated very low. 6. As for the standard of education of the nurses: 62 per cent of them have taken a three year course of nursing in junior colleges, and 22 per cent in nursing technical high schools. College graduate nurses come up to only 15 per cent; and those with graduate course only 0.4 per cent. This indicates that most of the nurses are front nursing technical high schools and three year nursing junior colleges. Accordingly, it is advisable that nursing services be divided according to their functions, such as professional, technical nurses and nurse's aides. 7. The survey also shows that the purpose of nursing service administration in the hospitals has been regulated in writing in 74 per cent of the hospitals and not regulated in writing in 26 per cent of the hospitals. The general purposes of nursing are as follows: patient care, assistance in medical care and education. The main purpose of these nursing services is to establish proper operational and personnel management which focus on in-service education. 8. The nursing service departments belong to the medical departments in almost 60 per cent of the hospitals. Even though the nursing service department is formally separated, about 24 per cent of the hospitals regard it as a functional unit in the medical department. Only 5 per cent of the hospitals keep the department as a separate one. To the contrary, approximately 12 per cent of the hospitals have not established a nursing service department at all but surbodinate it to the other department. In this respect, it is required that a new hospital organization be made to acknowledge the independent function of the nursing department. In 76 per cent of the hospitals they have advisory committees under the nursing department, such as a dormitory self·regulating committee, an in-service education committee and a nursing procedure and policy committee. 9. Personnel arrangement and working conditions of nurses 1) The ratio of nurses to patients is as follows: In university hospitals, 1 to 2.9 for hospitalized patients and 1 to 4.0 for out-patients; in religious hospitals, 1 to 2.3 for hospitalized patients and 1 to 5.4 for out-patients. Grouped together this indicates that one nurse covers 2.2 hospitalized patients and 4.3 out-patients on a daily basis. The current medical treatment law stipulates that one nurse should care for 2.5 hospitalized patients or 30.0 out-patients. Therefore the statistics indicate that nursing services are being peformed with an insufficient number of nurses to cover out-patients. The current law concerns the minimum number of nurses and disregards the required number of nurses for operation rooms, recovery rooms, delivery rooms, new-born baby rooms, central supply rooms and emergency rooms. Accordingly, tile medical treatment law has been requested to be amended. 2) The ratio of doctors to nurses: In university hospitals, the ratio is 1 to 1.1; in national of public hospitals, 1 to 0.8; in religious hospitals 1 to 0.5; and in private hospitals 1 to 0.7. The average ratio is 1 to 0.8; generally the ideal ratio is 3 to 1. Since the number of doctors working in hospitals has been recently increasing, the nursing services have consequently teen overloaded, sacrificing the services to the patients. 3) The ratio of nurses to clerical staff is 1 to 0.4. However, the ideal ratio is 5 to 1, that is, 1 to 0.2. This means that clerical personnel far outnumber the nursing staff. 4) The ratio of nurses to nurse's-aides; The average 2.5 to 1 indicates that most of the nursing service are delegated to nurse's-aides owing to the shortage of registered nurses. This is the main cause of the deterioration in the quality of nursing services. It is a real problem in the guest for better nursing services that certain hospitals employ a disproportionate number of nurse's-aides in order to meet financial requirements. 5) As for the working conditions, most of hospitals employ a three-shift day with 8 hours of duty each. However, certain hospitals still use two shifts a day. 6) As for the working environment, most of the hospitals lack welfare and hygienic facilities. 7) The salary basis is the highest in the private university hospitals, with enterprise hospitals next and religious hospitals and national or public ones lowest. 8) Method of employment is made through paper screening, and further that the appointment of nurses is conditional upon the favorable opinion of the nursing directors. 9) The unemployment ratio for one year in 1971 averaged 29 per cent. The reasons for unemployment indicate that the highest is because of marriage up to 40 per cent, and next is because of overseas employment. This high unemployment ratio further causes the deterioration of efficiency in nursing services and supplementary activities. The hospital authorities concerned should take this matter into a jeep consideration in order to reduce unemployment. 10) The importance of in-service education is well recognized and established. 1% has been noted that on the-job nurses. training has been most active, with nursing directors taking charge of the orientation programs of newly employed nurses. However, it is most necessary that a comprehensive study be made of instructors, contents and methods of education with a separate section for in-service education. 10. Nursing services'activities 1) Division of services and job descriptions are urgently required. 81 per rent of the hospitals keep written regulations of services in accordance with nursing service manuals. 19 per cent of the hospitals do not keep written regulations. Most of hospitals delegate to the nursing directors or certain supervisors the power of stipulating service regulations. In 21 per cent of the total hospitals they have policy committees, standardization committees and advisory committees to proceed with the stipulation of regulations. 2) Approximately 81 per cent of the hospitals have service channels in which directors, supervisors, head nurses and staff nurses perform their appropriate services according to the service plans and make up the service reports. In approximately 19 per cent of the hospitals the staff perform their nursing services without utilizing the above channels. 3) In the performance of nursing services, a ward manual is considered the most important one to be utilized in about 32 percent of hospitals. 25 per cent of hospitals indicate they use a kardex; 17 per cent use ward-rounding, and others take advantage of work sheets or coordination with other departments through conferences. 4) In about 78 per cent of hospitals they have records which indicate the status of personnel, and in 22 per cent they have not. 5) It has been advised that morale among nurses may be increased, ensuring more efficient services, by their being able to exchange opinions and views with each other. 6) The satisfactory performance of nursing services rely on the following factors to the degree indicated: approximately 32 per cent to the systematic nursing activities and services; 27 per cent to the head nurses ability for nursing diagnosis; 22 per cent to an effective supervisory system; 16 per cent to the hospital facilities and proper supply, and 3 per cent to effective in·service education. This means that nurses, supervisors, head nurses and directors play the most important roles in the performance of nursing services. 11. About 87 per cent of the hospitals do not have separate budgets for their nursing departments, and only 13 per cent of the hospitals have separate budgets. It is recommended that the planning and execution of the nursing administration be delegated to the pertinent administrators in order to bring about improved proved performances and activities in nursing services.

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