• Journal of the Korean Magnetic Resonance Society
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• 제22권4호
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• pp.119-124
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• 2018

Although the transcription factor CP2c has been recently validated as a promising target for development of novel anticancer therapy, its structure has not been solved yet. In the present study, the purified recombinant protein corresponding to the tetramerization domain of CP2c appeared to be well folded, whereas the Elf-1 domain showed a largely unfolded conformation. Particularly, the Elf-1 domain, which contains the putative DNA-binding region, showed a conformational equilibrium between relatively less-ordered and well-ordered conformers. Interestingly, addition of zinc shifted the equilibrium to the relatively more structured conformer, whereas zinc binding decreased the overall stability of the protein, leading to a promoted precipitation. Likewise, a dodecapeptide that has been suggested to bind to the Elf-1 domain also appeared to shift the conformational equilibrium and to destabilize the protein. These results constitute the first structural characterization of the CP2c domains and newly suggest that zinc ion might be involved in the conformational regulation of the protein.

• Molecules and Cells
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• 제46권9호
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• pp.558-572
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• 2023

Chronic obstructive pulmonary disease (COPD) will be the third leading cause of death worldwide by 2030. One of its components, emphysema, has been defined as a lung disease that irreversibly damages the lungs' alveoli. Treatment is currently unavailable for emphysema symptoms and complete cure of the disease. Hyaluronan (HA) and proteoglycan link protein 1 (HAPLN1), an HA-binding protein linking HA in the extracellular matrix to stabilize the proteoglycan structure, forms a bulky hydrogel-like aggregate. Studies on the biological role of the full-length HAPLN1, a simple structure-stabilizing protein, are limited. Here, we demonstrated for the first time that treating human alveolar epithelial type 2 cells with recombinant human HAPLN1 (rhHAPLN1) increased TGF-β receptor 1 (TGF-β RI) protein levels, but not TGF-β RII, in a CD44-dependent manner with concurrent enhancement of the phosphorylated Smad3 (p-Smad3), but not p-Smad2, upon TGF-β1 stimulation. Furthermore, rhHAPLN1 significantly increased sirtuins levels (i.e., SIRT1/2/6) without TGF-β1 and inhibited acetylated p300 levels that were increased by TGF-β1. rhHAPLN1 is crucial in regulating cellular senescence, including p53, p21, and p16, and inflammation markers such as p-NF-κB and Nrf2. Both senile emphysema mouse model induced via intraperitoneal rhHAPLN1 injections and porcine pancreatic elastase (PPE)-induced COPD mouse model generated via rhHAPLN1-containing aerosols inhalations showed a significantly potent efficacy in reducing alveolar spaces enlargement. Preclinical trials are underway to investigate the effects of inhaled rhHAPLN1-containing aerosols on several COPD animal models.

• Journal of the Korean Society of Food Culture
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• 제12권3호
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• pp.331-339
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• 1997

With increases in senior citizens and changes in family structure, the need for long-term care system for elderly is increasing, however, the capacity and environment of Korean facilities are very limited. Health and nutritional status of long-term care residents are worse than free-living elderly. In this study, general food service management and health care practices in long-term care systems were investigated. Questionnaire were sent to the directors of all 162 long-term care facilities in Korea and 81 returned the complete answers. The results showed 1) There are slow but steady increase in long-term care systems in Korea, however, the capacity is far from adequate. Less than 10,000 elderly were resided in the facilities. Most of the systems were free-nursing homes and supported by the goverment. Staffing structure revealed that most of the facilities had a director, a secretary, nurses, but only 21% of the systerm hired a dietitian. It showed the shortage of nurses, physical therapists, and dietitians. Therefore, food purchasing, menu planning, food delivery, and the other food service management processes are handled by non-professionals, such as director, secretary, or cooks. Modified fool frequency questionnaire were used to get the frequencies of each food items used in menu and a menu-analysis was made on the one-day menu provided by the facilities. The results showed relatively satisfactory in nutrients content and food frequencies., however, this was about what was used in menu, not what was eaten by the residents. Therefore this results did not tell that the food intake status of individuals. In most facilities general health checkup was done on a regular basis, and had residents with various chronic degenerative diseases, such as hypertension, neuralgia, stroke, arthritis, diabetes. But the items checked on health checkup included weight, height, blood and urine tests, X-ray test, which suggested that the checkup lists should be revised to accomodate the health problem of the aged today.

• Journal of Korean Academy of Nursing
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• 제53권3호
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• pp.359-369
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• 2023

Purpose: This study evaluated the internal structure (structural validity, internal consistency, and measurement invariance) of the Health-Related Quality of Life Instrument with Eight Items (HINT-8), developed to measure Korean people's health-related quality of life. Methods: A secondary analysis was conducted using data from the Korea National Health and Nutrition Examination Survey, involving 6,167 adults aged over 18 years. The structural validity of the HINT-8 was assessed using exploratory graph analysis and confirmatory factor analysis. Internal consistency and measurement invariance were analyzed using McDonald's omega (ω) and multigroup confirmatory factor analysis, respectively. Results: The HINT-8 had a single dimension and good internal consistency (ω =.804). The one-dimension HINT-8 exhibited matric invariance but not scalar invariance across sociodemographic groups (sex, age, education, and marital status). Further, it exhibited scalar or partial scalar invariance across medical condition groups (hypertension, diabetes, depressive symptoms, and cancer). Conclusion: The study finds that the HINT-8 demonstrated satisfactory structural validity and internal consistency, indicating its suitability for practice and research. However, the HINT-8 scores cannot be compared across different groups regarding sex, age, education, and marital status, as the interpretation varies within each sociodemographic category. Conversely, interpretation of the HINT-8 is consistent for individuals with and without hypertension, diabetes, depressive symptom, and cancer.

• Journal of the Korea Safety Management & Science
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• 제18권1호
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• pp.179-190
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• 2016

Awareness about health is still in short supply, sufficient research and investment is falling mothayeo made, the development of image and health technology for health compared to productivity enhancement technology behind the relative reality. Through the analysis and study of special measures and health education in the country catering to propose measures and methods for this. Current analyzed and summarized to find a special health and safety training relevant provisions appear in the national legislation. By analyzing the characteristics and to leverage to workers unearthed an in-depth awareness and issues for the institutions and laws. Survey research methods to analyze the documents and government publications and research through an Internet search. Survey Research conducted a self - survey on new knowledge and attitude toward the concessionaires to sanitation target, the attitude of the sanitary administration, attitudes to hygiene education and hygiene practice Conditions received health education carried out by catering Federation regularly. Health education is a systematic settlement system for the external reality of professional education. Health and health administrators to establish an organizational structure strengthening phase. Employers and health care workers are raising awareness. Employers have a responsibility to prevent industrial accidents. Consequently, special health education targeted construction workers changed to fit the content-driven information on the species and the proper arrangement of time "based health education" currently being conducted.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제18권5호
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• pp.1087-1095
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• 2014

A recent major development in computer technology is the advent of the wearable computer system that is based on human-centric interface technology trends and ubiquitous computing environments. Wearable computer systems can use the wireless universal serial bus (WUSB) that refers to USB technology that is merged with WiMedia PHY/MAC technical specifications. In this paper, we focus on an integrated system of the wireless USB over the IEEE 802.15.6 wireless body area networks (WBAN) for wireless wearable computer systems supporting U-health services. And a communication structure that can differentiate QoS of U-health WBAN and WUSB traffic with different priorities is proposed for WUSB over IEEE 802.15.6 hierarchical protocol. In our proposal and performance evaluation, throughputs of U-health WBAN and WUSB traffic are analyzed under single and multiple QoS classes to evaluate the effectiveness of proposed QoS differentiating structure in WUSB over IEEE 802.15.6.

• Health Policy and Management
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• 제18권2호
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• pp.19-38
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• 2008

Financial ratios are key indicators of an organization's financial and business conditions. Among various financial indicators, profitability, financial structure, financial activity and liquidity ratios are frequently used and analyzed. Using the structural equation modeling(SEM) technique, this study examines the structural causal relationships among key financial indicators. Data for this study are taken from complete financial statements from 142 hospitals that passed the standardization audit undertaken by the Korean Hospital Association from 1998 to 2001 for the purpose of accrediting teaching hospitals. In order to improve comparability, ratio values are standardized using the Blom's normal distribution. The final model of the SEM has four latent constructs: financial activity(total asset turnover, fixed asset turnover), liquidity(current ratio, quick ratio, collection period), financial structure(total debt to equity, long-term debt to equity, fixed assets to fund balance), and profitability(return on assets, normal profit to total assets, operating margin to gross revenue, normal profit to gross revenue). While examining several model fit indices(Chi-square (df) = 178.661 (40), likelihood ratio=4.467, RMR=.11, GFI=.849, RMSEA=.157), the final SEM we employed shows a relatively good fit. After examining the path coefficient of the constructs, the financial structure of the hospital affects the hospital's profitability in a statistically significant way. A hospital which utilizes its liabilities, more specifically fixed liabilities, and makes a stable investment decision for fixed assets was found to have a higher profitability than other hospitals. Then, the standard path coefficients were examined to directly compare the influence of variables. It was found that there were no statistically significant path coefficients among constructs. When it comes to variables, however, statistically significant relationships were found. between. financial activity and. fixed. asset turnover, and between profitability and normal profit to gross revenue. These results show that the observed variables of fixed asset turnover and normal profit to gross revenue can be used as indicators representing financial activity and profitability.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제18권4호
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• pp.839-847
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• 2014

A recent major development in computer technology is the advent of the wearable computer system that is based on human-centric interface technology trends and ubiquitous computing environments. Wearable computer systems can use the wireless universal serial bus (WUSB) that refers to USB technology that is merged with WiMedia PHY/MAC technical specifications. In this paper, we focus on an integrated system of the wireless USB over the wireless body area networks (WBAN) for wireless wearable computer systems supporting U-health services. To construct the WUSB over WBAN communication systems, we propose a WBAN beaconing structure to assign WUSB communication periods. In the proposed structure, WUSB uses private periods of WBAN. In our performance evaluations, we compare theoretical results and simulation results about throughputs of WUSB under various WBAN channel occupations to evaluate the effectiveness of proposed structure in WUSB over WBAN communications.

• Journal of the Society of Naval Architects of Korea
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• 제61권2호
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• pp.115-124
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• 2024

To detect and prevent structural damage caused by various loads on marine structures and ships, structural health monitoring procedure is essential. Estimating loads acting on the structures which are measured by sensors that are mounted properly are crucial for structural health monitoring. However, attaching an excessive number of sensors to the structure without consideration can be inefficient due to the high costs involved and the potential for inducing structural instability. In this study, we introduce a method to determine the optimal number of sensors and their optimized locations for strain measurement sensors, allowing for accurate load estimation throughout the structure using model expansion method. To estimate the loads exerted on the entire structure with minimal sensors, we construct a strain-load interpolation matrix using the strain mode shapes of the finite element (FE) model and select the optimal sensor locations by applying D-Optimal Design and the row exchange algorithm. Finally, we estimate the loads exerted on the entire structure using the model expansion method. To validate the proposed method, we compare the results obtained by applying the optimal sensor placement and model expansion method to an FE model subjected to arbitrary loads with the loads exerted on the entire FE model, demonstrating efficiency and accuracy.

• Smart Structures and Systems
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• 제5권4호
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• pp.469-482
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• 2009

The emerging sensor-based structural health monitoring (SHM) technology has a potential for cost-effective maintenance of aging civil infrastructure systems. The author proposes to integrate continuous and global monitoring using on-structure sensors with targeted local non-destructive evaluation (NDE). Significant technical challenges arise, however, from the lack of cost-effective sensors for monitoring spatially large structures, as well as reliable methods for interpreting sensor data into structural health conditions. This paper reviews recent efforts and advances made in addressing these challenges, with example sensor hardware and health monitoring software developed in the author's research center. The hardware includes a novel fiber optic accelerometer, a vision-based displacement sensor, a distributed strain sensor, and a microwave imaging NDE device. The health monitoring software includes a number of system identification methods such as the neural networks, extended Kalman filter, and nonlinear damping identificaiton based on structural dynamic response measurement. These methods have been experimentally validated through seismic shaking table tests of a realistic bridge model and tested in a number of instrumented bridges and buildings.