• 한국정밀공학회지
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• 제31권4호
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• pp.287-295
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• 2014

Smart manufacturing (SM) considered as a new trend of modern manufacturing helps to meet objectives associated with the productivity, quality, cost and competiveness. It is characterized by decentralized, distributed, networked compositions of autonomous systems. The model of SM is inherited from the organization of the living systems in biology and nature such as ant colony, school of fish, bee's foraging behaviors, and so on. In which, the resources of the manufacturing system are considered as biological organisms, which are autonomous entities so that the manufacturing system has the advanced characteristics inspired from biology such as self-adaptation, self-diagnosis, and self-healing. To prove this concept, a cloud machining system is considered as research object in which internet of things and cloud computing are used to integrate, organize and allocate the machining resources. Artificial life tools are used for cooperation among autonomous elements in the cloud machining system.

• 약학회지
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• 제37권5호
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• pp.532-537
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• 1993

Angiogenesis refers to the formation of new capillary blood vessels, or neovascularization occurring under various physical conditions, such as development of the embryo, formation of corpus luteum, wound healing and pathological conditions including tumor growth and metastases, hemangiomas, diabetic retinopathy, rheumatoid arthritis. There are many evidences that angiogenesis is important for the progressive growth of solid tumors and also permits the shedding of metastatic tumors from the primary site. Thus, treatment of angiogenesis inhibitors might be a novel strategy for tumor growth inhibition. Normal vascular endothelial cells are in a state of differentiation and angiogenic endothelial cells migrate and proliferate, and they subsequently differentiate into vessel-forming quiescent phenotype cells, Therfore, it was speculated that a modifier of cell differentiation could also affect angiogenesis. In order to identify new antiangiogenic factors, the research was conducted to estimate the inhibitory activities of cell differentiation agents by means of chick embryo chorioallantoic membrane(CAM) assay. Hence, we have established the CAM assay for the screening of antiangiogenic agents. Using the CAM assay, we found that ursolic acid, a tumor cell differentiation-inducing agent, showed a markedly inhibitory effect on chick embryonic angiogenesis.

• Biomolecules & Therapeutics
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• 제1권1호
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• pp.20-25
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• 1993

DA-125, a new anthracycline derivative, shows significant anticancer activities. We conducted a study to examine the local irritating effect of DA-125 using mice and rabbits. In the skin test in mice, intradermal injection of 0.4 mg of DA-125, compared to a dosage of 0.2 mg of adriamycin, had weak irritating potentials to induce skin ulceration and erythematous induration. A dosage of 0.6 mg of DA-125 produced similar degree of lesions in perivascular irritation model to that of 0.2 mg of adriamycin, but the healing time was shorter in the case of mice treated with DA-125. In ocular irritation study in rabbit, the highest M.O.I.(mean ocular irritation index) of 0.5% DA-125 solution was 0.67, therefore DA-125 could be considered as a practically non-irritating anticancer agent. These results suggest that substitution of DA-125 for Adriamycin would reduces the possibility of outbreaks of local irritation and the severity of the lesions.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
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• pp.169-172
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• 2003

Manufacturing process for autonomic microcapsules was introduced and autonomic microcapsules were manufactured by varying with various manufacturing process variables. Urea-formaldehyde resin was used for the wall of microcapsules and DCPD (dicyclopentadiene) was used for the self-healing agent. The characteristics of these microcapsules was evaluated through a particle size analyaer, an optical microscope, and a TGA. The various manufacturing process variables, such as pH and agitation speed of the emulsified solution, were considered to focus in this study. According to the results, the particle size distributions were affected on the agitation speed of the emulsified solution, and the thermal stability was influenced by pH of the emulsified solution.

• Archives of Pharmacal Research
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• 제21권1호
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• pp.1-5
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• 1998

Rebamipide, 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinone-4-yl]-propionic acid, a novel antipeptic ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and to accelerate the healing of chronic ulcers. Therapeutic effect of rebamipide was investigated with regard to the inhibitory effect on xanthine oxidase activity and type conversion of the enzyme which play a profound role in oxygen radicals generation system. Intraperitoneal administration of rebamipide at 60 mg/kg body weight reduced the xanthine oxidase activity, lipid peroxide content in ammonia induced hemorrhagic lesion. These results suggest that the therapeutic effect of rebamipide on gastric mucosal lesion may be in part due to the inhibitory activity of xanthine oxidase and type conversion rate of the enzyme.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2004년도 추계학술대회
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• pp.259-268
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• 2004

유비쿼터스환경으로 발전하기 위하여 네트웍을 구성하는 시스템들의 문제나 장애의 자가 진단 및 치유에 대한 요구가 높아지고 있다. 본 논문에서는 이러한 유비쿼터스환경에서 여러 시스템들이 스스로 자신의 오류나 문제를 관찰, 진단하고 치유할 수 있는 자가치유 시스템을 제안한다. 특히, 제안 시스템은 기존의 자가 치유시스템에서 연구되어왔던 일률적인 치유가 아닌 각각의 시스템의 상황을 인식하고 그것에 맞추어서 치유전략을 달리하는 상황인식 기능과 치유 결과 분석을 통해 치유전략을 자발적으로 개선해 나가는 기능을 제공한다. 구체적인 주요 기능은 다음과 같다: 치유대상들의 의존성 점검을 통한 근원적인 문제 해결, 자가치유를 위한 효율적인 리소스 사용, 벤더의 웹서버를 검색하여 치유정보를 수집, 벤더 의존성의 경감등, 치유프로세스의 개선은 물론 치유를 위한 관리자의 작업 부담을 상당 부분 경감할 수 있게 된다. 제안 시스템은 시뮬레이션을 통하여 그 유효성을 입증하고 있다.

• Natural Product Sciences
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• 제25권2호
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• pp.92-102
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• 2019

Centella asiatica (Linn.) Urban (Umbelliferae) which is also known as 'pegaga' is highly consumed and eaten raw as 'ulam' in Malaysia. C. asiatica is used in traditional medicines to treat various health conditions such as rheumatism, inflammation, syphilis, skin diseases and diarrhoea. Various reports exhibited that the crude extracts and isolated bioactive compounds of C. asiatica possessed a broad range of pharmacological activities such as anti-oxidant, anti-diabetic, anti-tumor, wound healing, anti-microbial, anti-inflammatory, immunomodulatory, hepatoprotective and memory enhancing properties. The pharmacological validation on anti-microbial and immunomodulatory of C. asiatica is very limited and several existence review papers related for this plant had not been focused for both activities. This review therefore attempts to combine the existing literature to offer immense scope for researchers engaged in validation of the traditional claims and bioactivities of this plant related with anti-microbial and immunomodulatory potential.

• 셀메드
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• 제11권1호
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• pp.5.1-5.2
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• 2021

The aim of this article is to argue that BanLyeo music (companion music) is much better than medicine. A companion who shares thoughts or actions, or a metaphorical description of an object that is always close or carried. Isn't the music that we share in our daily lives a BanLyeo music (companion music)? Music stays with us forever as long as we choose. Therefore, it is music that can go with us until the end, so I think we should call it BanLyeo music (companion music). Music can be with us whenever and wherever we want, soothing sadness and pain and cheering us up. Here is a person who is living a second life happily because of BanLyeo music. Beyond the passive listening to music, direct and active music performance is a great power to save one person. As a more effective healing agent than medicine, BanLyeo music is a great power to stay together for the rest of your life and cheer you up. So, I think music is much better than medicine.

• Journal of Periodontal and Implant Science
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• 제25권1호
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• pp.1-13
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• 1995

Chlorhexidine and Listerine are widely used in dentistry due to its effectiveness on plaque control and bactericidal action. The effects of these agent on chronic gingivitis and wound healing following surgical periodontal therapy in human has been favorable. Understanding the effects of chlorhexidine and Listerine on human gingival fibroblast will provide the rationale for its use during the healing process of periodontal surgery. The purpose of this study was to compare the effects of chlorhexidine and Listerine on human gingival fibroblast. Human gingival fibroblasts were cultured from the healthy gingiva on the extracted premolar of orthodontic patients. Human gingival fibroblast were trypsinized and cultured in growth medium added range of 0.0012-0.12% chlorhexidine and 1-100% Listerine mouth wash solution. The cell used in this study were between fifth to eighth passage number. The cell morphology were examined by inverted microscope and the cell activity were measured by MIT assay. The Morphology of gingival fibroblast added Chlorhexidine and Listerine at the concentration of all range were became globular and lost their cytoplasmic process. Our results indicate that a 0.0012 concentration of chlorhexidine and 1% concentration of Listerine were shows minimal cytotoxicity, but above these concentraion, there was a significant difference between the cell activity in the experimental group and control group(p

• KSBB Journal
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• 제16권3호
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• pp.237-240
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• 2001

본 연구에서는 keratinocytes 세포를 이용하여 VEGF가 세포의 증식, MMP-2 및 plasmin 분비에 미치는 영향을 조사하였다. 그 결과 VEGF는 keratinocytes의 세포증식을 약 2.5배 상승시켜 내피세포 뿐반 아니라 상피세포에서도 강력한 mitogen임을 확인하였으며 submaximal effect를 보이는 농도는 10 ng/mL이었다. VEGF의 농도 증가에 따른 MMP-2의 분비에 미치는 효과 역시 10 ng/mL에서 최대 효과를 나타냈으며 VEGF 처리 후 1시간만에 확인 가능한 MMP-2 밴드가 나타났다. 한편, MMP-2의 분비 증가와 함께 plasmin의 분비 증가가 수반되는지를 확인한 결과 VEGF를 첨가했을 때 약 3배 정도 plasmin의 분비량이 증가함을 알 수 었었다. 이러한 결과는 VEGF의 성장촉진 효과와 관련자어 볼 때 MMP-2와 plasmin이 keratinocytes 세포의 성장과 이동에 부분적으로 관여할 것임을 시사하고 있다.