• Korean Journal of Head & Neck Oncology
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• v.18 no.2
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• pp.150-156
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• 2002

Objectives: Most of human cancers may result from exposure to environmental carcinogens, and individual effectiveness in the detoxification of these chemicals will influence susceptibility to malignant disease. Glutathione S-Transferases(GSTs) enzymes are involved in the detoxification of active metabolites of many carcinogens from tobacco smoke and may be important in modulating susceptibility to smoke-related cancer. The purpose of this study is to determine the polymorphism of GSTM1, GSTT1, and GSTP1 in control group and head and neck squamous cell carcinoma group of Korean, and to investigate the effect of GSTs polymorphism on the risk of head and neck cancer. Materials and Methods: A hospital-based case-control study was performed with a group of 133 control individual and 136 head and neck squamous cell carcinoma patients. The polymorphisms of GSTs were analysed using polymerase chain reaction in GSTM1 and GSTTl, and polymerase chain reaction-restriction fragment length polymorphism in GSTP1. Results: The relative risk (odds ratio) of GSTM(-) genotype was 1.14(95% CI, 0.70-1.85) compared to GSTM1(+). The odds ratio of GSTTl(-) genotype was 0.91(95% CI, 0.55-1.50). In old age($65$) group, the odds ratio of GSTT1(-) genotype was 5.2(95% CI, 1.53-17.89). The GSTP1 Val/Val genotype conferred a 1.7-fold risk(95% CI, 0.40-7.34) of head and neck cancer compared with GSTP1 Ile/Ile genotype. Among the combined genotypes of GSTs, GSTM1(-)/GSTT1(+)/GSTP1 Val/Val and GSTM1(-)/GSTTl(-)/GSTP1 Ile/Val genotypes conferred a 2.6-fold and 1.3-fold risk(95% CI, 0.24-14.15 and 0.43-3.14) compared with the GSTM1(+)/GSTTl(+)/GSTP1 Ile/Ile genotype, respectively. Conclusion: Polymorphism of GSTs might modulate susceptibility to head and neck cancer in Korean population. The genotype of GSTP1 Val/Val and combined genotypes of GSTM1(-)/GSTT1(+)/GSTP1 Val/Val, and GSTM1(-)/GSTT1(-)/GSTP1 Ile/Val might be important risk factors to determine the individual susceptibility to head and neck squamous cell carcinoma.

• Journal of Biosystems Engineering
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• v.16 no.2
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• pp.148-158
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• 1991

This study was undertaken to develop the feed rate control system for the head feed thresher by making use of the microprocessor and to evaluate the response of the system to a various threshing conditions. It was verified the performance of the control system through experiments. Control conditions were determined based on the simulation results of control system. The control system set at RH=500rpm, RL=480rpm for the bundle feed was considered optimum to give a high threshing capability and still to stabilize the feeding seed regardless of the bundle size. The control system for the continuous spread feed set at the range of LH=15mm, and LL=12mm gave a high control performance for the feeding mass of 1.1Kg/m and lower tested. In addition, the feed rate proportionality constant should be set lower than one in order to keep the rotational speed of threshing cylinder within the range of 500~520rpm.

• Korean Journal of Head & Neck Oncology
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• v.27 no.2
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• pp.177-182
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• 2011

Backgrounds : Head and neck cancer is one of the most prevalent cancers in the world. It tends to remain localized at the primary site and regional lymph nodes, but if distant metastasis occurs, it has a poor prognosis. This study was performed to evaluate the prevalence of distant metastasis and to determine the risk factor in locally advanced head and neck cancer after induction chemotherapy followed locoregional control therapy. Methods : A retrospective review was performed in 420 patients with locally advanced head and neck cancer who treated with induction chemotherapy followed locoregional control therapy from January 2001 to December 2010. Among them, 31 patients who had distant metastasis as first relapse within 2 years after termination of therapy were analyzed for clinical features and the risk factors of distant metastasis. Results : The overall incidence of distant metastasis was 7.3%. The bone, lung, and liver were the most frequent metastatic organs. In univariate analysis, nodal stage, nasopharyngeal cancer, laryngeal cancer, G3/G4 neutropenia during induction chemotherapy, and concurrent chemoradiotherapy were the influencing factors for distant metastasis. In multivariate analysis, advanced N stage and nasopharynx were the risk factors of distant metastasis, and grade 3/4 neutropenia during induction chemotherapy was considered to decrease distant metastasis. Conclusion : This study suggests that the advanced N stage is the risk factor of distant metastasis and Grade 3/4 neutropenia during induction chemotherapy can be beneficial against distant metastasis in locally advanced head and neck cancer patients treated with induction chemotherapy followed locoregional control therapy.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.26 no.2
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• pp.122-126
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• 2015

Background and Objective : Laryngeal microscopic surgery (LMS) is popular method to treat for vocal polyp. There is not always the improvement of the voice after operation. Many methods have been developed for better outcome of the surgery. The purpose of this study is to investigate the effect of the triamcinolone injection at vocal cord during LMS. Materials and Methods : The medical records of 28 patients, received LMS under diagnosis of vocal polyp, were retrospectively reviewed. The patients were divided into two groups depending on whether triamcinolone injected or not (case group : Triamcinolone-injected group, control group : Triamcinolone-not injected group). The quality of voice was evaluated by GRBAS scale, fundamental frequency (Fo), jitter, shimmer and NHR (Noise to harmonic ratio) at previous operation, 4 weeks after operation, 8 weeks after operation. Each voice analysis factor was compared between case group and control group by Independent t-test. Results : The mean differences of each voice analysis factor. The mean difference of Jitter, Shimmer, NHR in case group were lower than in control group, and mean difference of GRBAS scale in case group were higher than in control group. These differences were not significant (p>0.05). Conclusion : Though there was a tendency of better voice outcome in patients of triamcinolone-injection, it may not be concluded that the triamcinolone injection is helpful for better voice outcome in surgery of vocal polyp due to statistical insignificance.

• Journal of Korean Physical Therapy Science
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• v.19 no.3
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• pp.31-38
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• 2012

Background : The purpose of this study was to evaluate the effect of the kinesio taping on the forward head posture and to reduce secondary pain and attitude transformation by applying kinesio taping. Methods : The subjects were the C university students(n = 30) in Chung-buk district without medical history. They were divided into two groups:experimental group(N = 15) and control group(N = 15). Control group was heard verbal instructions to keep right attitude and Experimental group was applied to kinesio taping. Change of an attitude, such as an angle, distance, CROM, CVA, CRA prices, before and after experiment was measured respectively. Result : The results of this study showed that in comparison of pre and post changes, experimental group noticeable changes in angle, CROMSI and CVA(p<.05). Angle, CROMSI and CVA were significant differed between groups(p<.05). Conclusion : Kinesio taping application was seemed to be effective on the improvement of forward head position. Therefore, it is suggested that Kinesio taping application should be one the potential methods to facillitate the forward head position. Comprehensive research is required about a point of time and duration for intervention in clinical approach for subjects.

• Journal of the Korea Society for Simulation
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• v.7 no.2
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• pp.125-136
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• 1998

To upgrade railway traffic density without any change of signal block length between stations on existing railway lines, a new signalling system of train control "the pattern control technique" is suggested. It needs very little change to computerize the cab signal using transponders. A computer simulation system is developed to experiment the new control method. The new signalling system shows much increase of the railway traffic efficiency. The train head-way time by the fixed signalling system and the new pattern control system is analyzed. The pattern control technique shows 35% increasement of trair operation under same condition of railway and trains.nd trains.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11a
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• pp.875-878
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• 2005

This paper presents active control of aperture type near-field storage head. In order to achieve fast and accurate control, dual servo control algorithm is applied. Based on the big difference in time constant, we seperate two actuator and control independently. With the combination of fine and coarse actuator, gap is controlled within 100nm until the disk rotates upto 10 rpm speed. From the experimental results, the feasibility and performance of active gap control is proved.

• Transactions of the Society of Information Storage Systems
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• v.4 no.1
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• pp.19-22
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• 2008

For the assembly and evaluation of solid immersion lens (SIL) optical head which is the key component of SIL based near field recording (NFR) technology, we modify the Twyman-Green interferometer. Super-hemisphere SIL optical head for the surface recording is assembled and evaluated by the modified Twyman-Green interferometer. In order to verify the optical performance of the assembled SIL optical head, we compare the measured results of the SIL optical head with the simulation ones. Finally, we show the feasibility of applying the assembled SIL optical head to near field recording system by the experiment of the dynamic gap control based on test bed.

• Transactions of the Korean Society of Automotive Engineers
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• v.24 no.4
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• pp.416-424
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• 2016

A robust design of head gasket is pursued by using FEA model of engine assembly. Engine assembly model consists of cylinder head, block, gasket, and head bolt is constructed to understand a complex behavior of this engine compound. Thermal loading is performed on the assembled engine cylinder and block to obtain temperature field. Firing load is added to the results of heat transfer analysis to simulate the engine operation condition. Temperature filed results from heat transfer analysis are mapped into the structural mesh. Contact pressure distribution along the bead has been monitored for the engine operation condition. Based on the results obtained from the analysis, Taguchi method has been adopted for a robust design process of head gasket. Among the control factors, bolt size affects most robustness of head gasket sealing.

• Korean Journal of Head & Neck Oncology
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• v.35 no.2
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• pp.57-60
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• 2019

Warthin's tumor (WT) is second most common neoplasm in the parotid gland and it can be accompanied by inflammation and necrosis. The chest wall inflammation may present a rapid and fatal clinical course and secondary to parotid abscess is extremely rare. An 81-year-old man came to emergency room complained of rapidly enlarged left parotid mass and inflammatory symptoms and signs around the upper lateral neck. We performed incision and drainage with adequate infection control. He was pathologically diagnosed as abscess. We report the unique and instructive clinical case with a literature review.