• Proceedings of the KSRS Conference
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• 2000.04a
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• pp.9-9
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• 2000

For the planning of future land use for economic activities, an essential component is the identification of the vulnerable areas for natural hazard and environmental impacts from the activities. Also, exploration for mineral and energy resources is carried out by a step by step approach. At each step, a selection of the target area for the next exploration strategy is made based on all the data harnessed from the previous steps. The uncertainty of the selected target area containing undiscovered resources is a critical factor for estimating the exploration risk. We have developed not only spatial prediction models based on adapted artificial intelligence techniques to predict target and vulnerable areas but also validation techniques to estimate the uncertainties associated with the predictions. The prediction models will assist the scientists and decision-makers to make two critical decisions: (i) of the selections of the target or vulnerable areas, and (ii) of estimating the risks associated with the selections.

• Journal of Industrial Convergence
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• v.9 no.1
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• pp.1-13
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• 2011

The purpose of this study was to analysis and improve working posture using hazard factor analyzing tools. SI(The Strain Index) came up with the conclusion that RWDR1 and RWDR3 was a dangerous job, but not as dangerous as RWDR2. According to REBA. RWDR3 required some improvements; A mat to prevent fatigue(WIRE/PRESS 2), electric bogie(RWDR1), and waist/wrist protector(RWDR3). Additionally a correct sitting posture m WIRE/PRESS1 and stretching on a regular basis in RWDR2 were recommended.

• Proceedings of the Korean Society of Disaster Information Conference
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• 2022.10a
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• pp.227-228
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• 2022

전통적인 HRA(Human Reliability Analysis)방법은 특정 애플리케이션 또는 산업을 염두에 두고 있으며. 또한 이러한 방법은 종종 복잡하며, 시간이 많이 걸리고 적용하는 데 비용이 많이 들며 직접 비교하기에는 적합하지 않다. 제안된 HFHM(Human Factors Hazard Model: 인적 요인 위험 모델)은 기검증되고 시간 테스트를 거친 FTA(Fault Tree Analysis:결함 트리 분석)및 ETA(Event Tree Analysis:이벤트 트리 분석)의 확률 분석 도구 및 새로 개발된 HEP(Human Error Probability:인적 오류 확률)예측 도구와 통합되고, 인간과 관련된 PSF(Performance Shaping Factors:성능 형성 요인)를 중심으로 새로운 접근 방식으로 개발되었다. 인간-시스템은 상호작용으로 인한 재난사고 가능성을 모델링하는 위험분석 접근법 HFHM은 다음과 같은 상용 소프트웨어 도구 내에서 예시되고 자동화된다. HFHM에서 생성된 데이터는 SE 분석가 및 설계에 대한 표준화된 가이드로 사용될 수 있다. 본 연구에서는 인적 위험을 예측하는 이 새로운 접근 방식을 통해, 전체 시스템에 대한 포괄적인 재난안전 분석을 가능하게 한다.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.25 no.4
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• pp.525-533
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• 2015

Objectives: Alongside smoking, occupational exposure is an important risk factor for chronic obstructive pulmonary disease. The purpose of this study was to evaluate factors associated with occupational pulmonary function decline that can be used to create guidelines for the health management of shipyard workers Materials: This study analyzed spirometry from 10,597 male shipbuilding workers. Functional decline in spirometry was defined as FEV1/FVC <70% and logistic regression for work duration and occupational hazard exposure was performed Results: Among the subjects, 4.2% showed an obstructive pattern in pulmonary function. The odds ratios for hazard exposure were 1.67(indirect) and 3.54(direct), and for work duration 1.97(10-18 years), 2.29(19-27), and 5.02(28+). After adjusting for smoking and work-related factors, the odds ratios for work durations of over 10 years were 1.73(10-18 years), 1.99(19-27), and 4.09(28+), but for hazards exposure was 1.71(direct) alone after adjustment. Conclusions: Occupational COPD is insidious and chronic, and thus long-term hazard exposed(especially over 10 years) shipyard workers with functional decline in spirometry need to prevent and manage COPD. This study is important for establishing guidelines to manage hazard exposure among shipyard workers and prevent COPD.

• Korean journal of food and cookery science
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• v.21 no.5
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• pp.703-708
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• 2005

The purposes of this study were to establish washing conditions for vegetable salad to reduce the microbial hazard by using sodium hypochlorite solution and eventually to implement HACCP for salad processing. By using the salad production line of Shinkeum Co. located in Gwacheon, Gyunggi-do, salad samples were washed under several washing conditions (chlorine dip period, chlorine concentration, rinse time, etc.) to determine the most effective conditions. The original washing line consisted of 3 baths (100 ppm chlorine water dip, water rinse, and water rinse), each with a capacity of 100 L of tap water and 5 kg of salad. First, the salad samples were washed with 100 ppm of sodium hypochlorite solution for various dip times (3, 6, 9, 12 min); however, only a 1 log- or less-reduction in total microbial counts was achieved in all groups and the time of chlorine water dip was not a significant factor in reducing the microbial hazard. When another water bath was added before the chlorine water dip (4-bath washing), a 2 log-reduction in total microbial counts was achieved. This result suggested the importance of pre-dipping salad materials in water before chlorine treatment to reduce the organic load on the surface of the vegetables. Coliforms were not detected at all after washing. As the concentration of chlorine $(50{\sim}150\;ppm)$ and rinse time $(0.5{\sim}2\;min)$ increased, greater microbial reduction was achieved; however, physical damage of the salad was observed. Finally, the optimum washing conditions for salad were determined as 3 min-water dip, 3 min-chlorine (100 ppm) dip, 2 min-rinse, and 2 min-rinse.

• Molecules and Cells
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• v.44 no.9
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• pp.647-657
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• 2021

As a pancreatic inflammatory marker, regenerating islet-derived protein 3A (Reg3A) plays a key role in inflammation-associated pancreatic carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer cell migration and invasion. This study aimed to reveal a novel immuno-regulatory mechanism by which Reg3A modulates tumour-promoting responses during pancreatic cancer (PC) progression. In an in vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs) and Reg3A-overexpressing/ silenced human PC cells, PC cell-derived Reg3A was found to downregulate CD80, CD83 and CD86 expression on educated DCs, increase DC endocytic function, inhibit DC-induced T lymphocyte proliferation, reduce IL-12p70 production, and enhance IL-23 production by DCs. The positive effect of tumour-derived Reg3A-educated human DCs on PC progression was demonstrated in vivo by intraperitoneally transferring them into PC-implanted severe combined immunodeficiency (SCID) mice reconstituted with human T cells. A Reg3A-JAK2/STAT3 positive feedback loop was identified in DCs educated with Reg3A. In conclusion, as a tumour-derived factor, Reg3A acted to block the differentiation and maturation of the most important antigen-presenting cells, DCs, causing them to limit their potential anti-tumour responses, thus facilitating PC escape and progression.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.4
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• pp.47-52
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• 2008

Important factor in designing a breakaway sign support is the velocity change of the impact vehicle. It is measured from the crash test or can be calculated by 3-D Finite Element Analysis. It can also be calculated with relative ease utilizing energy and momentum conservation. In this paper a formula to calculate the velocity change of a car during the time of impact against a small sign is derived utilizing the energy and momentum balance. Using the formula, parametric studies were conducted to find that impact speed, separation force and Breakaway Fracture Energy(BFE) of the posts which represent the degree of fixedness to the foundation are the important factor to vehicle's speed change. It is shown that speed change is larger in the lower speed impact and to the posts with large separation force and BFE.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.6
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• pp.111-117
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• 2009

The RUSLE(Revised Universal Soil Loss Equation) has been most widely used to estimate sediment yield in Korea. However RUSLE factors have not been verified based on measured data of sediment yield. The analysis of characteristics for the rainfall erosivity factor R was performed in this study. The R factor of RUSLE is expressed as multiple of total rainfall energy and maximum 30 min rainfall intensity. In this study, the characteristics of 10 rainfall energy equations were investigated using data measured in Gangneung experimental watershed, and applicability of each equations was reviewed based on results of the correlation analysis between measured sediment yield and total rainfall, between measured sediment yield and maximum intensity, and between measured sediment yield and total rainfall energy yield. Also, the relationship of I30 and I60 was proposed using 10-min rainfall data during 9 years.

• Korean Journal of Clinical Oncology
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• v.14 no.2
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• pp.128-134
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• 2018

Purpose: Previous studies have addressed the role of the hypercoagulable state in the pathogenesis of cancer progression and metastasis. In this study, we investigated the association between coagulation factors, including tissue factor (TF) expression, platelet count, and fibrinogen level, and disease recurrence in patients with non-metastatic colorectal cancer. Methods: Patients who underwent curative resection for stage II or III colorectal cancer between 2000 and 2007 were included in this study. Data from a prospectively maintained database were retrospectively reviewed. TF expression was determined by immunohistochemistry using an anti-TF monoclonal antibody. The Kaplan-Meier method was used to estimate 5-year disease-free survival. Results: TF was highly expressed in 257 of 297 patients (86.5%). TF expression was not significantly associated with the platelet counts (P=0.180) or fibrinogen level (P=0.281). The 5-year disease-free survival rate was lower in patients with high TF expression than in patients with low TF expression (72.3% vs. 83.9%, P=0.074). In Cox hazard analysis, high TF expression was an independent risk factor for tumor recurrence (hazard ratio [HR] 2.446; 95% confidence interval [CI], 1.054-5.674; P=0.037). Undifferentiated histologic type (HR, 2.911; 95% CI, 1.308-6.481; P=0.009), venous invasion (HR, 2.784; 95% CI, 1.431-5.417; P=0.003), and lymph node metastasis (HR, 2.497; 95% CI, 1.499-4.158; P<0.001), were also significantly associated with disease recurrence. Conclusion: TF expression is associated with a recurrence in patients with non-metastatic colorectal cancer. However, further studies are required to clarify the underlying mechanisms relating TF expression with oncologic outcomes and its potential role as a therapeutic target.

• Journal of the Korean Geotechnical Society
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• v.36 no.2
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• pp.5-15
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• 2020

The liquefaction phenomenon that occurred during the Pohang earthquake (M_L=5.4) brought new awareness to the people about the risk of liquefaction caused by the earthquake. Liquefaction hazard maps with 2 km grid made in 2014 used more than 100,000 borehole data for the whole country, and regions without soil investigation data were produced using interpolation. In the mapping of macro liquefaction hazard for the whole country, the site amplification effect and the ground water level 0 m were considered. Recently, the Ministry of Public Administration and Security (2018) published a new site classification method and amplification coefficient of the common standard for seismic design. Therefore, it is necessary to rewrite the liquefaction hazard map reflecting the revised amplification coefficient. In this study, the results of site classification according to the average shear wave velocity in soils before and after revision were compared in the whole country. Also, liquefaction assessment results were compared in Gangseo-gu, Busan. At this time, two ground accelerations corresponding to the 500 and 1,000 years of return period and two ground water table, 5 m for the average condition and 0 m the extreme condition were applied. In the drawing of liquefaction hazard map, a 500 m grid was applied to secure a resolution higher than the previous 2 km grid. As a result, the ground conditions that were classified as S_C and S_D grounds based on the existing site classification standard were reclassified as S₂, S₃, and S₄ through the revised site classification standard. Also, the result of the Liquefaction assessments with a return period of 500 years and 1,000 years resulted in a relatively overestimation of the LPI applied with the ground amplification factor before revision. And the results of this study have a great influence on the liquefaction assessment, which is the basis of the creation of the regional liquefaction hazard map using the amplification factor.