• Imaging Science in Dentistry
• /
• 제31권3호
• /
• pp.181-184
• /
• 2001

Thirteen-year-old girl complaining of the swelling and pain on the left midface visited our dental hospital. On the radiographic examination, well-defined radiolucent lesion with hyperostotic border was found in the left maxilla accompanying with the external root resorption of the involved teeth and the displaced second molar. CT showed calcified bodies, thinning of hard palate, inferior orbital wall and lateral wall of nasal fossa, and thinning and perforation of the buccal plate of the maxilla. Enucleation and curettage of the lesion and nasoantrostomy was carried out and histopathologic examination mainly showed a solid tumor tissue composed of odontogenic epithelium and pulp tissues admixed with dentin and enamel formation. And some part of reduced follicular epithelium of tooth germ showed a change mimicking calcifying odontogenic cyst. Taken together, we concluded the lesion is an ameloblastic fibro-odontoma with a change of calcifying odontogenic cyst.

• International Journal of Oral Biology
• /
• 제39권4호
• /
• pp.187-192
• /
• 2014

Nonthermal atmospheric pressure plasma has attracted great interest for biomedical applications. The plasma consists of charged particles, radicals, and a strong electric field as the fourth state of matter. This study evaluated the change in the surface roughness after tooth bleaching by plasma in combination with a low concentration (15%) of carbamide peroxide, specifically whether the application of plasma produced detriments, such as demineralization and structural change, with the goal of efficient and safe tooth bleaching. After being combined with plasma and 15% carbamide peroxide, the hydroxyapatite surface was significantly smoother with a low roughness average value. Tooth bleaching with 15% carbamide peroxide alone produced an irregular surface and increased the surface roughness with high roughness average value. Tooth bleaching with plasma resulted in no significant variations in hydroxyapatite in terms of change in surface roughness and surface topography. The application of tooth bleaching with plasma is not deleterious to dental hard tissue, implicating it as a safe tooth bleaching technique.

• Journal of Korean Dental Science
• /
• 제9권2호
• /
• pp.55-62
• /
• 2016

Purpose: Alveolar bone develops with tooth eruption and is absorbed following tooth extraction. Various ridge preservation techniques have sought to prevent ridge atrophy, with no superior technique evident. Collagen has a long history as a biocompatible material. Its usefulness and safety have been amply verified. The related compound, atelocollagen, is also safe and displays reduced antigenicity since telopeptides are not present. Materials and Methods: The current study evaluated whether the $Rapiderm^{(R)}$ atelocollagen plug (Dalim Tissen, Seoul, Korea) improves tissue healing of extraction sockets and assessed the sequential pattern of bone regeneration using histology and microcomputed tomography in six beagle dogs. To assess the change of extraction socket, hard tissues were examined 2, 4, 6, and 8 weeks after tooth extraction. Result: The experimental groups showed better bone fill with slow remodeling process compared to the control groups although there was no statistical difference between groups. Conclusion: The atelocollagen seems to have a tendency to slow bone remodeling in the early phase of healing period and maintain remodeling capacity until late phase of remodeling. Also, use of atelocollagen increased the bone-to-tissue ratio compared to healing of untreated extraction socket.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제34권5호
• /
• pp.343-348
• /
• 2012

Treatment of hemifacial atrophy is a challenge for oral & maxillofacial surgeons. The surgical approach basically focused on skeletal correction so that the overlying soft tissues can be improved by the osseous change of the skeleton. However, the treatment ends up with insufficient soft tissue mophology in most cases even after skeletal correction. Therefore comprehensive hard and soft tissue reconstruction is needed for treating the hemifacial atrophy. In this case report, we experienced a successful result after combined orthognathic and microvascular adipofascial flap reconstruction for hemifacial atrophy patient.

• 대한두경부종양학회지
• /
• 제39권1호
• /
• pp.11-14
• /
• 2023

The primary treatment of oral cavity cancer is still surgery. By discussing the surgical treatment of oral cavity cancer, the basic concept of head and neck surgery could be thoroughly reviewed. The oral cavity is defined as the hard palate and the anterior 2/3 of the tongue. With appropriate reconstruction, most defects can be repaired without a significant change in quality of life, unlike in the oropharynx or hypopharynx, where aspiration problems frequently occur. The selection of a surgical approach that can provide an appropriate field of view to obtain a resection margin of 5 mm or more has become the core of head and neck surgery. The role of prophylactic neck dissection is also well established in oral cavity cancer patients. Mandibulotomy for access to the oral cavity or mandibulectomy due to cancer invasion requires bony surgical techniques, and reconstruction also requires bone tissue reconstruction techniques as well as soft tissue. Therefore, oral cancer surgery is the most important primary area where all techniques of head and neck surgery are mobilized.

• 한국작물학회지
• /
• 제54권3호
• /
• pp.320-326
• /
• 2009

우리나라 재래 수집종인 제비콩, 갓끈동부와 쥐눈이콩은 종피가 매우 두껍고 딱딱하여 물 흡수가 어려워 발아율이 각각 26%, 17%와 5%에 불가하다. 이들 종자는 저장성에서 그 가치가 높이 평가되지만, 포장에 파종할 때 발아율이 낮아 문제가 되고 있다. 본 연구에서는 이들 종자의 발아율을 향상시키기 위하여 몇 가지 종피약화 처리를 실시하여 가장 효과적인 방법을 도출하였다. 종피약화 처리방법 중 가장 정상묘율이 높은 것은 제비콩은 tap water ($20^{\circ}C$)에서 24시간 침지 했을 때 85%이였으며, 갓끈동부는 hot water에서 8시간 침지했을 때 45%이였다. 그러나 소립이고 경도가 높은 쥐눈이콩은 진한 sulfuric acid에 10분간 침지 했을 때 72%의 정상묘율을 보였다.

• Archives of Plastic Surgery
• /
• 제35권5호
• /
• pp.603-606
• /
• 2008

Purpose: Sclerosing lipogranuloma is an unusal benign condition of the genitalia following injections into the genitalia with exogenous paraffin or mineral oil. A few cases have been reported in which sclerosing lipogranuloma of the lid was caused by paraffin-containing ointment plugs after the endonasal sinus surgery. A 52-year-old man presented with a painless hard mass of the right lower lid after the MRI scan at the Ophthalmology department. Nine months before, he had undergone right maxilla sinus surgery through the oral incision. And he was also gotten nasal packing with Vaseline gauze after the surgery. Methods: The round shaped two masses in the Right lower lid were approximately $1.0{\times}1.0cm$ in size. There were no size or color change, bleeding and ulceration. The MRI scan showed a suspicious part of an abscess of benign tumor. Also, He was planned cyst remove through the endonasal surgery due to the mucoid cyst in the right maxillary sinus in the ENT dept. Under the general anesthesia, the patient underwent surgical excision through a subcilliary incision with endonasal sinus surgery. The masses were in deep subcutaneous orbital fat with no connection with right maxillary sinus. Results: The masses were excised $2.1{\times}0.7cm$ in size including surrounding necrotic fatty tissue. Histopathological diagnosis was 'sclerosing lipogranuloma' due to paraffin or similar substance with fat necrosis and cystic change. This tissue was positive in PAS, S-100, CD68 reaction. Conclusion: It is extremely rare to find a granulomatous orbital lesion arising to a endonasal surgery. In conclusion, if sclerosing lipogranuloma is suspected excisional biopsy should be undertaken. Surgery should be reserved for recurrent or refractory cases when steroids have failed as first-line treatment at the 6-month follow-up examination, There was no complication or recurrence.

• 대한치과교정학회지
• /
• 제25권4호
• /
• pp.375-401
• /
• 1995

성장기 골격성 제III급 부정교합의 원인은 상악 열성장, 하악 과성장과 두 양상의 조합형태로 나뉠 수 있다. 이중 상악 열성장을 동반한 성장기 골격성 제III급 부정교합의 경우, 상악골 전방견인 장치의 사용이 추천되고 있는데, 이러한 장치의 치료효과는 상악골의 전하방 이동과 하악골의 후하방 회전으로 알려져 있다. 국내외 선학들에 의해 상악골 전방견인 장치의 치료효과에 대한 많은 동물실험과 임상실험 결과가 발표되었으나, 연조직 측모 변화에 대한 연구는 미비한 상태이고, 또한 치료를 받은 환자간의 치료효과에 대한 비교도 부족한 상태이다. 이에 저자는 상악골 열성장으로 인한 성장기 골격성 제III급 부정교합으로 진단받고, 상악골 전방견인 장치로 치료 받은 93명의 환자를 성별, 치료개시 나이별, 구개봉합 opening여부(구강내 장치), 안모성장 형태에 따라 분류하여, 각 유형에 따라 어떠한 경조직과 연조직 측모의 변화가 관찰되는지 여부와, Angle씨 제 I 급 부정교합의 정상군 20명과 상악골 전방견인 장치로 치료받은 환자 사이에 경조직과 연조직에 있어서 성장량과 치료량에 어떠한 관계가 있는지 비교하여 다음의 결론을 얻었다. 1. 상악골 전방견인 장치 사용시 골격적 계측항목과 치아와 연조직 계측항목에서 성장량보다 많은 치료에 의한 변화량을 관찰할 수 있었다. 2. 남녀별 치료개시 나이에 따른 상악골 전방이동량과 하악골의 후하방 회전량에는 유의차가 없었다. 3. R.P.E.에서 La-Li보다 유의성 있는 상악골(A point)의 전방이동을 보였으며, 상악 전치의 순측 돌출이 La-Li를 사용하였을때 보다 감소되었다. 4. 안모성장 형태에 따라서는 상악골 전방이동량에는 유의차가 없었으나, 하악골의 후하방 회전을 나타내는 계측치에서 counterclockwise군이 clockwise군보다 많은 변화를 나타냈다. 5. 상순과 하순의 후경변화는 하부 골조직과 상하악 치아의 위치변화와 높은 상관관계를 보였으며, 상순의 고경과 nasolabial angle이 증가하고, mentolabial angle이 감소되었다.

• International Journal of Advanced Culture Technology
• /
• 제6권4호
• /
• pp.275-283
• /
• 2018

Cancer show distinct pattern of gene expression when it is compared to normal. This difference results malignant characteristic of cancer. Many cancer drugs are targeting this difference so that it can selectively kill cancer cells. One of the recent demand for personalized treating cancer is retrieving normal tissue from a patient so that the gene expression difference between cancer and normal be assessed. However, in most clinical situation it is hard to retrieve normal tissue from a patient. This is because biopsy of normal tissues may cause damage to the organ function or a risk of infection or side effect what a patient to take. Thus, there is a challenge to estimate normal cell's gene expression where cancers are originated from without taking additional biopsy. In this paper, we propose in-silico based prediction of normal cell's gene expression from gene expression data of a tumor sample. We call this challenge as reverting the cancer into normal. We divided this challenge into two parts. The first part is making a generator that is able to fool a pretrained discriminator. Pretrained discriminator is from the training of public data (9,601 cancers, 7,240 normals) which shows 0.997 of accuracy to discriminate if a given gene expression pattern is cancer or normal. Deceiving this pretrained discriminator means our method is capable of generating very normal-like gene expression data. The second part of the challenge is to address whether generated normal is similar to true reverse form of the input cancer data. We used, cycle-consistent adversarial networks to approach our challenges, since this network is capable of translating one domain to the other while maintaining original domain's feature and at the same time adding the new domain's feature. We evaluated that, if we put cancer data into a cycle-consistent adversarial network, it could retain most of the information from the input (cancer) and at the same time change the data into normal. We also evaluated if this generated gene expression of normal tissue would be the biological reverse form of the gene expression of cancer used as an input.

• 대한치과교정학회지
• /
• 제29권5호
• /
• pp.627-635
• /
• 1999

하안면의 장경이 길고 웃을 때 치은이 과다 노출되거나 전치부 개방교합을 나타내는 상악골의 수직적 과성장 환자의 치료법으로 상악골의 수술적 상방이동이 고려되어질 수 있다. 이 방법에 의하여 기능적으로 만족스러운 결과를 가져오더라도 심미적 개선이 중요한 부분인 만큼 장기간에 걸친 연조직 변화를 관찰하여 임상적으로 중요하다고 생각되어지는 상악골 상방이동에 대한 상, 하순의 수직적 변화 특히 안정위시의 상악전치와 상순간의 관계의 변화와 상하순간의 이개 거리의 장기간에 걸친 변화를 관찰하는 것이 수술계획 시 치료결과에 대한 심미적 만족도를 높여 줄 수 있다. 따라서 이번연구를 통하여 상악골의 수직적 상방이동 후의 장기간에 걸친 연조직 변화를 관찰하여 상악골의 수술적 상방이동에 의한 치료계획 시 도움을 주고자 하였다. 이를 위해 술 후 최소한 5년이 경과되고 2mm 이상의 수술적 상방이동이 이루어진 49명의 환자의 술 전, 술 후 1년, 술 후 5년의 측모 두부방사선 규격사진을 이용하여 다음과 같은 결론을 얻었다. 1) 코의 하부와 상순의 연조직 계측점의 술 전과 술 후5년의 비교 시 superior labial sulcus의 상방이동과 pronasale의 전방이동만이 유의성있는 변화를 보였다. 2) 술 후 1년까지 하순의 전상방으로의 이동이 그 후 후하방으로 변화되는 경향을 보였으나 술 전과 술 후 5년의 비교시 전상방으로의 전위가 유지되었고 이부성형술을 한 군에서 변화가 더욱 뚜렷하였다. 3)상순의 길이와 홍순(upper vermilion)의 수직적 변화는 술 후 1년까지 감소되었다가 그 후 증가되어 술 전과 비교시 유의성있는 변화가 없었으나 하순의 길이의 증가와 홍순(lower vermilion)의 수직적 감소는 술 후 1년과 5년에서 계속 지속되었다. 4) 안정위시 상악전치의 노출이 지속적으로 유의성있는 감소를 나타냈고, 상하순간의 거리도 지속적 감소를 보였는데 이는 수술에 의한 상악골 상방 이동양보다 큰 감소였다. 5) 술 후 1년 이후에 나타나는 연조직의 하방 이동이 악골의 하방 이동 보다 크게 나타나는 경향을 보였다.