• 대한지역사회영양학회지
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• 제3권4호
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• pp.622-629
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• 1998

This study was performed to investigate the effect of dietary intakes and nutritional status for fatty liver male patients with fatty livers. General characteristics, nutritional knowledge, and dietary intakes were obtained from fatty liver male patients aged 20-60yr living in Seoul and Kyunggi province by individual interview and blood samples. The Results were as follows : the mean age of the subjects was 39yrs. Old and over half the subjects were overweight. Although nutritional knowledge, recognition, and accuracy scores were good, these did not affect the subject's health. The average alcohol intake of subjects was 79.8g/day and the drinking duration was 5-40yrs(average : 17yrs). The subjects drank alcohol over 4tiles/week and preferred Soju. Most side dishes taken with alcohol drinking by the subjects were foods from animal sources. Half of the subjects also drank alcohol the next day for breakfast as a hangover-chaser. The reasons for drinking were due to social relationships and by habit. Vitamin D and folate were lower than the RDA for Koreans, and other nutrient amounts were higher than the RDA. The amounts of aspartate amino-transferase(AST), Alanine amino-transferase(ALT), ${\gamma}$-glutamyl transpeptidase(${\gamma}$-GTP), Triglyceride(TG) for the subjects were higher. In conclusion, fatty liver patients drank excessively and frequently. It seems that heavy alcohol drinking is more prone to overweight or obese people and contributes to fatty livers. Therefore, the subjects need to be taken effectively educated about alcohol-induced liver damage and the importance of a balanced diet for on healthy liver.

• 동의생리병리학회지
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• 제34권5호
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• pp.245-254
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• 2020

The purpose of this study was to investigate the effects of natural herb mixture containing Laminaria japonica Areschoung (LAM) on fine dust-induced bronchitis in mice. Laminaria japonica Areschoung is main content of LAM, which is including fucoidan. Fucoidan extracted from phaophyta is known to prevent bronchitis and to defend against bacteria and virus infection. In this study, we experienced the effect of LAM on bronchitis and investigated gene expressions (e.g ; IL-8, COX-2, MCP-1) and bio-markers (e.g ; IL-8, PGE2, MUC5AC) associated with bronchitis by using A549 cells. Also, we investigated whether LAM can suppress the bronchitis in fine dust-induced animal models. We injected fine dust (50 ㎕) twice as INT (Intra-Nasal-Trachea) method. Then LAM (200 mg/kg and 400 mg/kg) were oral administered for 14 days. We analyzed the number of immune cells, immunoglobulin E, bio-markers level associated with bronchitis. LAM significantly decreased bio-marker (IL-1β, IL-6, IL-8, TNF-α, Histamine, PGE2), immune cells (white blood cell, neutrophil, lymphocyte, monocyte), and immunoglobulin E, that are increased by fine dust. Taken together, this study suggest that LAM can be used as effective herbal extract for bronchitis.

• Nutrition Research and Practice
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• 제17권6호
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• pp.1113-1127
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• 2023

BACKGROUND/OBJECTIVES: Excessive alcohol consumption has harmful health effects, including alcohol hangovers and alcohol-related liver disease. Therefore, methods to accelerate the alcohol metabolism are needed. Laurus nobilis is a spice, flavoring agent, and traditional herbal medicine against various diseases. This study examined whether the standardized aqueous extract of L. nobilis leaves (LN) accelerates the alcohol metabolism and protects against liver damage in single-ethanol binge Sprague-Dawley (SD) rats. MATERIALS/METHODS: LN was administered orally to SD rats 1 h before ethanol administration (3 g/kg body weight [BW]) at 100 and 300 mg/kg BW. Blood samples were collected 0.5, 1, 2, and 4 h after ethanol administration. The livers were excised 1 h after ethanol administration to determine the hepatic enzyme activity. The alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in the liver tissue were measured. RESULTS: LN decreased the serum ethanol and acetaldehyde levels in ethanol-administered rats. LN increased the hepatic ADH and ALDH activities but decreased the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities in the ethanol-administered rats. In addition, LN inhibited lipid peroxidation and increased the activities of SOD and GPx. CONCLUSIONS: LN modulates the mediators of various etiological effects of excessive alcohol consumption and enhances the alcohol metabolism and antioxidant activity, making it a potential candidate for hangover treatments.

• 한국식품저장유통학회지
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• 제30권4호
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• pp.617-629
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• 2023

Reactive oxygen species are the byproducts of metabolic processes in the body, However, excessive amount may cause side effects such as cancer. Therefore, to reduce the production of these species, but their long-term administration at high doses may induce side effects. Hence, natural materials with antioxidant activities are attracting attention. Two of these natural materials are soybean sprouts and Hovenia dulcis Thunb. fruits, but few studies have evaluated the effects of their combination. Thus, we prepared a soybean sprout extract containing 1.5% H. dulcis Thunb. fruit concentrate (BHM) to develop a functional food material derived from natural products and then confirmed its physicochemical properties and physiological activity. Among the organic acids detected in BHM, malic acid exhibited the highest content of 1,451.03 ppm, and the main free sugars were glucose (645.48 ppm) and fructose (738.11 ppm). Taurine was the most abundant free amino acid at a concentration of 11.95 ppm, followed by those of arginine (10.97 ppm) and glutamic acid (10.16 ppm). Analyses of the mineral components revealed large amounts of Zn and Fe in BHM, and the respective total polyphenol and flavonoid contents in BHM were 957.16 and 601.93 ppm. The DPPH radical and H₂O₂ scavenging activities and reducing power indicated excellent antioxidant efficacy compared to the positive controls. Furthermore, blood alcohol and acetaldehyde concentrations were measured to confirm the hangover-relieving effects of BHM, with both significantly decreased (p<0.05). BHM displays potential for development as a functional food, and the results of this study may be used as basic data in further research.

• 한국조리학회지
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• 제20권2호
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• pp.214-231
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• 2014

본 연구는 중국인 유학생의 전반적인 음주 특성, 막걸리의 음용 실태 및 인식을 알아보고자 하였다. 중국인 유학생 550명을 대상으로 2012년 5월 2일부터 6월 30일까지 설문조사를 실시하였으며, 461부를 최종 분석에 사용하였다. 한국거주기간이 길수록 한 달 용돈이 많을수록 1회 음주량과 음주 빈도가 높았으며, 맥주를 가장 선호하였고 막걸리를 두 번째로 선호하였다. 술을 마시는 학생의 97.5%가 막걸리를 마셔본 경험이 있으며, 막걸리 음주 빈도와 1회 음주량은 한국거주기간이 길수록 증가하였으며, 주로 음식점과 전문 주점에서 마시는 것으로 나타났다. 막걸리의 맛과 마시는 분위기를 선호하며, 막걸리의 맛과 두통을 비선호하였다. 막걸리 종류에 대한 인지도는 낮았으며, 막걸리 가격과 건강 증진 효과에 대해서 각각 92.4%와 85.8%가 긍정적인 답변을 하였다. 이상의 결과는 중국인의 기호에 적합하며 두통과 같은 숙취를 개선한 고품질 막걸리를 개발하고, 건강 지향적인 웰빙주임을 적극적으로 홍보하는 마케팅 전략이 필요함을 시사한다.

• 동의생리병리학회지
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• 제21권5호
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• pp.1081-1086
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• 2007

This study was performed to investigate the medicinal effects of the herbal combination extracts-2 (HCE-2), consisting of Artemisia capillaris Thunb., Lonicera japonica Thunb., Prunella vulgaris var. lilacina, and Hovenia dulcis Thunb. on the alcohol-induced liver injury in rats. The rats were randomly divided into four groups: normal group (n =6), non-treated control group (n =6), saline-treated group (n =6) and the herbal combination extract (HCE-2)-treated group (n =6). The rats in the alcohol-loaded groups were orally administered with ethanol at a daily dose of 4 g/kg-body weight for 5 weeks. Thirty minutes before the ethanol injection, saline or herbal combination extracts was administered by using a gastrogavage. Blood and liver tissue samples were taken out from the hearts and livers of the rats, respectively, on 15th and 38th days. The activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured using an enzyme-linked immunosorbent assay (ELISA). We also investigated the protective effect of the herbal combination extracts by Hematoxylin-Eosin staining on histological sections of rat liver. In this study, the oral administration of the herbal combination extracts significantly reduced the serum levels of AST and ALT, which had been raised by alcohol-induced liver injury. Histological analysis and apparent observation of liver also showed the preventive effect of the herbal combination extracts in a chronic alcohol-induced rat model. Theses results revealed that the herbal combination extracts effectively prevented hepatic damage consequent to the chronic exposure to repetitive administration of ethanol and could be used as a primary resource of a health beverage or herbal medicine, alleviating the alcohol-induced hepatic injury and hangover symptoms.

• 한국식생활문화학회지
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• 제12권5호
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• pp.495-508
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• 1997

The purpose of this study is to investigate the dietary patterns and behaviors of self-boarding college students in Wonju. This survey was carried out through questionnaries and the subjects were 118 man and 145 woman students of five colleges in Wonju. The results of this study were summarized as follows: 1. The students who live in Kangwon Province, reaching 49.0% of the subjects, are the most prevalent. In the frequency of homecoming, 'twice a month' is the greatest. One-room system is the most prevalent in the self-boarding patterns. 2. 90.8% of the students have the electric rice cooking pot. Portable gas range, gas range, electric stove, in this order, are more general as cooking appliances. Specially, more than half of students, either male or female, have refrigerators. 3. 80.4% of students cook their own meal. 'once a day' in cooking frequency is the most prevalent. 4. The students, either male or female, prepare breakfast and dinner for themselves at home, and have lunch at the school cafeteria. They choose boiled rice mostly at any mealtime. 5.In the frequency of drinking, 'three times a week' in man students and 'two or three times a month' in woman students are the most prevalent. The drink shop and their own self-boarding room are most preferred as the place for drinking in the both case of male and female. 6. In the quantity of drinking of male students, 'more than three bottles of Soju', 'two bottles of Soju', and 'one bottle of Soju', in this order, are recorded more frequently and in the case of female students, comes 'one bottle of Soju' and 'one bottle of beer' in that order. 7. Male students drink to have a dim consciousness and female students to feel good. In this case there are differences. 8. After drinking in the previous night, more female students have a breakfast than male. While more female students have any kind of food, most of male students have a broth to relieve hangover or ramyun. 9. The causes for no breafast after drinking were 'rising late', 'stomachache', 'habits' in this cider. 10. After students self-examine their own health, they express their health state as 'usual', 'very healthy' 'not healthy' in this order. Most of male and female students point out the stomach as a painful part.

• 농약과학회지
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• 제12권3호
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• pp.256-261
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• 2008

최근 충북 영동지방을 중심으로 대발생되고 있는 갈색여치에 대하여 친환경적인 방법으로 유인트랩을 이용한 방제를 검토하였다. 농가에서 쉽게 구할 수 있는 PET 프라스틱 빈병을 이용하여 Fish 트랩을 제작하였다. 유인조성물로서 상수리나무잎 대비 과일의 과육 및 과일 주스, 막걸리와 어분을 영동지역 포장에 직접 처리하여 유인효과를 비교하였다. 1일 동안의 유인력을 검토한 결과, 본 연구에서 제작하여 적용한 Fish 트랩이 Funnel 트랩에 비해 높은 유인효과를 보였으며, 유인 조성물 효과는 복숭아주스(32.7마리) > 막걸리+어분(31.3마리) >막걸리(27.0마리) > 배주스(19.0마리) > 사과주스(17.2마리) > 어분(16.7마리) > 포도주스(14.4마리) > 상수리나무잎(2.3마리) 순서로 나타났다. 과일의 과육에 대한 유인효과에 비해 과일 주스의 효과가, 그리고 트랩을 지면에 설치 시 보다 지상 1m의 높이에 처리했을 때 유인효과가 높게 나타났으며, 막걸리+어분의 유인지속성은 방부제를 혼합 처리한 유인트랩에서 그 효과가 지속되었다.

• 한국식품조리과학회지
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• 제17권3호
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• pp.218-223
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• 2001

양파김치 제조에 사용된 양파, 로즈마리, 타임엑기스의 기능성은 다음과 같다. 대두유를 이용한 과산화물가의 변화는 배양 2일부터 증가하기 시작하였는데 로즈마리엑기스는 BHA, BHT와 비슷한 항산화효과를 나타냈으며, 양파엑기스는 BHA, BHT에 비하여 높았으나 대조구보다는 약간 낮아 항산화효과가 있음을 나타내었고 타임엑기스는 거의 항산화효과가 없는 것으로 나타났다. Thiocyanate방법에 의한 항산화력의 효과는 12일간 4$0^{\circ}C$에서 배양하면서 측정한 결과 BHT, BHA, 로즈마리엑기스, 양파엑기스 순으로 항산화 효과를 보여 주었으나 타임엑기스는 POV값의 변화에서와 마찬가지로 항산화효과가 없는 것으로 생각된다. 그람 양성균 7종, 그람 음성균 3종, 효모 2종, 곰팡이 2종 등 모두 14균주를 사용해 항균활성을 검색한 결과 양파엑기스는 거의 모든 그람 양성균에 항균활성을 보여주나 식중독과 관련된 대장균이나 살모넬라균에는 거의 활성을 나타내지 않았으며, 효모와 곤팡이에 대하여도 거의 활성을 나타내지 못하였다. 로즈마리엑기스도 모든 그람 양성균에 대하여 항균활성을 보여주었으며 특히 김치숙성과 관련된 Lac. plantrarum에 강한 활성을 나타내었고 E. coli와 Salmonella typhimurium에도 활성을 보여주었다. 타임엑기스는 그람 양성균에만 약한 항균활성을 보여주나 그 외의 균에 대하여는 거의 활성을 나타내주지 않았다. 혈중알콜농도 측정 결과 양파엑기스, 로즈마리엑기스 및 타임엑기스는 농도 의존적으로 혈중 alcohol을 감소시켜 숙취에 어느정도 효과가 있는 것으로 생각된다. 항고혈압 실험결과 대조군인 propranolol 투여군은 투여 후 3일째부터 유의성 있는 혈압강하 작용을 나타내었으며 양파엑기스는 투여후 3일째부터 6일째까지 지속적으로 유의성 있는 혈압강하 작용을 보여 주었으나 로즈마리엑기스는 아무런 영향이 없었으며 타임엑기스는 오히려 상승하는 경향이 있었다.

• 한국식품조리과학회지
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• 제30권5호
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• pp.613-619
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• 2014

홍합을 함유한 숙취 해소용 식품 개발의 근거를 확보하기 위하여 12종류의 열수 추출물을 제조하였다 - A(겨우살이); B(냉이); C(칡); D(콩나물); E(헛개나무); F(홍합); G(홍합과 겨우살이); H(홍합과 냉이); I(홍합과 칡); J(홍합과 콩나물); K(홍합과 헛개나무). C 추출물이 alcohol dehydrogenase(ADH)와 acetaldehyde dehydrogenase(ALDH)의 활성을 가장 크게 증가시켰으나, 홍합과 혼합한 경우에는 상승 효과를 보이지 않았다. 칡을 함유한 경우를 제외하고는 H 추출물이 높은 ADH($237.4{\pm}1.7%$)와 ALDH($136.5{\pm}2.1%$) 활성을 보였다. 또한, H 추출물은 가장 높은 DPPH 라디칼 소거능($93.9{\pm}0.1%$)과 안지오텐신 전환효소(ACE) 저해능($42.7{\pm}1.6%$)을 나타내었다. 홍합과 냉이를 혼합한 경우에는 alcohol dehydrogenase 활성과 ACE 저해능이 상승되는 시너지 효과를 확인하였다.