• Title/Summary/Keyword: Halicylindramide A

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Synthesis of Halicylindramide A Mimetics Containing Lactone Isosteres

  • Yeo, Sang-Hyuk;Seo, Hyun-Ju;Lim, Dong-Yeol
    • Bulletin of the Korean Chemical Society
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    • v.32 no.spc8
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    • pp.2916-2920
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    • 2011
  • Synthesis of halicylindramide A mimetics via solid-phase peptide synthesis is described. The N-Me-Gly-Thr residues in halicyclindramide A has been replaced by N-Me-Gly-Dpr, Lys, or N-Me-Gly-allo-Thr. Solution structures of the mimetics were compared by CD spectroscopy in an aqueous buffer and in TFE.