• The Korean Journal of Physiology and Pharmacology
• /
• 제7권2호
• /
• pp.91-96
• /
• 2003

In Korean folk medicine, several herbs, Glycyrrhizae Radix, Persicae Semen, Salviae Radix, Angelicae Gigantis Radix, Zanthoxyli Fructus, Ginseng Radix Alba, Cnidii Rhizoma, and Carthami Flos, are known to enhance blood circulation and have wound healing or anti-inflammatory effects. These pharmacological actions prompted us to investigate whether these herbs might stimulate hair growth. Thus, using a mixture of their extracts called SPELA 707, we investigated their effects and found that SPELA 707 possessed significant hair cycle converting activity from the telogen phase to the anagen phase in C3H mice. Furthermore, we found that SPELA 707 enhanced the hair density in subjects with hair loss and also promoted the conversion of hair into the anagen phase in subjects with androgenetic alopecia. In addition, hair growth promotion effect of SPELA 707 occurred through inhibition of steroid $5{\alpha}$-reductase activity, which is known to block hair growth. Taken together, these results suggest that SPELA 707 has a potential to be used for the treatment of hair loss.

• Genomics & Informatics
• /
• 제9권3호
• /
• pp.93-101
• /
• 2011

The Hairless (HR ) gene regulates the expression of several target genes as a transcriptional corepressor of nuclear receptors. The hair follicle (HF), a small independent organ of the skin, resides in the epidermis and undergoes regenerative cycling for normal hair formation. HF development requires many genes and signaling pathways to function properly in time and space, one of them being the HR gene. Various mutations of the HR gene have been reported to cause the hair loss pheno-type in rodents and humans. In recent studies, it has been suggested that the HR gene is a critical player in the regulation of the hair cycle and, thus, HF development. Furthermore, the HR gene is associated with the Wnt signaling pathway, which regulates proliferation and differentiation of cells and plays an essential role in hair and skin development. In this review, we summarize the mutations responsible for human hair disorders and discuss the roles of the HR gene in HF development.

• Journal of Plant Biotechnology
• /
• 제49권4호
• /
• pp.316-324
• /
• 2022

Hair loss causes psychological stress due to its effect on appearance. Therefore, the global market for hair loss treatment products is rapidly growing. The present study demonstrated that ginseng berry-derived and sequence-modified peptides promoted the proliferation rate of dermal papilla (DP) cells and keratinocytes, in addition to having antioxidant properties. Moreover, the potential role of these ginseng berry peptides as TGF-β2 antagonists was confirmed through in silico computer docking. In addition to promoting the growth of ,the ginseng berry-derived peptides also promoted the proliferation of keratinocytes experimental Particularly, an unmodified ginseng berry-derived peptide (GB-1) and two peptides with sequence modifications (GB-2 and GB-3) decreased ROS generation and exhibited a protective effect on damaged HaCaT keratinocytes. Computer-aided peptide discovery was conducted to identify the potential interactions of important proteins with transforming growth factor-beta 2 (TGF-β2), a key protein that plays a crucial role in the human hair growth cycle. Our results demonstrated that MAGH, an amino acid sequence present in herbal supplements and plant-based natural compounds, can inhibit TGF-β2.

• 융합정보논문지
• /
• 제12권5호
• /
• pp.298-304
• /
• 2022

본 연구에서는 낮은 연령층과 여성에게도 확대되고 있는 탈모와 문제성 두피에 대한 기초 연구자료를 제공하고자, 문제성 두피를 가진 20대 여성을 대상으로 L-Menthol, Salicylic acid, Dexpanthenol이 함유되어 있는 B사의 헤어 앰플을 매일 사용하였을 때, 4주 후 두피 및 모발에 미치는 영향을 알아보고자 하였다. 본 연구 결과, L-Menthol, Salicylic acid, Dexpanthenol이 함유되어 있는 B사의 앰플을 사용하였을 때 연구 대상자들의 두피 상태가 실험 전에 비하여 염증 완화, 두피 열 및 홍반 감소, 가려움증과 모발 빠짐 감소, 청결해진 모공 상태, 모발 굵기 증가 등 개선 효과를 보였으며, 연구 대상자들의 두피 자가진단을 통해 실험 전과 후의 두피 만족도, 두피 생기와 탄력, 열 발생도, 세정 후 두피 당김, 가려움증에 대한 개선 효과가 나타났음이 확인되었다. 이와같은 연구 결과를 통하여 L-Menthol, Salicylic acid, Dexpanthenol이 함유된 제품이 문제성 두피 및 모발 개선에 도움이 될 것으로 사료되어 진다.

• 대한약침학회지
• /
• 제24권4호
• /
• pp.182-190
• /
• 2021

Objectives: The purpose of this study was to analyze the microneedle therapy system (MTS) and its research methods for the past 10 years in Korea. Methods: Data on microneedle therapy system were collected using NDSL, KISS, RISS, and OASIS electronic databases from January 2010 to August 2021. "microneedle," "derma stamp," "microneedle therapy system" were used as the keywords. The present study, however, excluded data that were 1) unrelated to the microneedle therapy system, 2) from review/meta/protocol studies, and 3) from overseas studies. Data selected through the primary screening process, animal studies, case reports, and clinical data were included in the analysis. However, information data not related to the microneedle therapy system were excluded from the study. Results: Among the MTS-related papers published from January 2010 to August 2021, 7 animal research, 2 clinical trials, and 10 case studies were published. Based on the research topics, there were 8 papers on skin improvement and skin diseases, 7 papers on hair growth and hair loss, 3 papers on stability, and 1 paper on peripheral facial paralysis. Conclusion: Most of the studies related to MTS focused on skin, hair, and stability. The effect of MTS on hair growth and skin improvement has been confirmed, and it has been proven to have significant effects on the treatment of acne, acne scars, and hair loss in clinical practice. No serious side effects were observed during the MTS treatment, and the safety assessment confirmed that it was safe for use.

• 한국지역사회생활과학회지
• /
• 제21권1호
• /
• pp.117-124
• /
• 2010

Recently, research on variables associated with hair styles are increasing with the spreading of total coordinated intention in the fields of clothing and cosmetology. In the present study, we focused on examining the skin temperature on the scalp(the vertex, temporal, and occiput), humidity on the occiput, skin temperatures (the forehead, back of ear, back of neck, upper back, abdomen, forearm, hand, thigh, calf, and foot), rectal temperature, total body mass loss by hair styles in a thermal neutral environment. Four young females participated as subjects. For a certain period, each subject had the five different hair styles in a random order: (1)Straight short hair(SS), (2)Perm waved short hair(PS), (3) Straight long hair(SL), (4)Perm waved long hair(PL), (5)Ponytail style(PT). Subjects wore briefs, bra, shirts with long sleeves, long legged training pants, and socks. The environmental variables of a climatic chamber were kept constant at $21{\pm}0.5^{\circ}C$ of air temperature and 55${\pm}$5%RH of air humidity. The results indicated the following: The skin temperature and humidity on the scalp did not show any significant differences among five different hair styles, but straight long hair style(SL)was the highest on the vertex, temporal, and occiput. The temporal skin temperature($29.8\sim30.8^{\circ}C$) was the highest, while the vertex skin temperature($28.7\sim30.1^{\circ}C$) was the lowest. Humidity on the occiput was the highest in the perm waved long hair style(PL). The back of ear skin temperature was significantly lower in the ponytail style(PT) than in the other four hair styles(p<.001). In the straight long hair style(SL), the skin temperature on the back of the neck and on the upper back were significantly higher than those of the other four hair styles(p<.01). Mean skin temperature and rectal temperature had no significant differences among hair styles. Total body mass was the highest in the perm waved long hair style(PL)(p<.05). We acquired fundamental data to enable the improvement of the current hair clinic system, wigs, functional hats, and helmets.

• 대한한방내과학회지
• /
• 제38권2호
• /
• pp.235-239
• /
• 2017

This case study describes the effect of Bojungikki-tang on chemotherapy-induced alopecia. Alopecia is a well-documented cause of distress to patients undergoing cancer treatment, but no approved pharmacological treatment exists for chemotherapy-induced hair loss. A 70-year-old female diagnosed with a cholangiocarcinoma and liver metastasis received chemotherapy, including gemcitabine and cisplatin, every three weeks. As a result of the continuous chemotherapy, she suffered various toxicity-related side effects, including bone marrow suppression, general weakness, nausea, peripheral numbness, and hair loss. Bojungikki-tang was initially administered to improve the patient's general weakness and fatigue. After three months of treatment, the patient's hair loss and general condition improved, and the color of the new hair was dark, despite the chemotherapy. The treatment did not improve other symptoms, such as bone marrow suppression and peripheral numbness. This case suggests that Bojungikki-tang could have a beneficial effect on chemotherapy-induced alopecia.

• 한국융합학회논문지
• /
• 제13권5호
• /
• pp.35-43
• /
• 2022

인체 유래 Leuconostoc mesenteroides 배양액을 함유한 에센스로 탈모 증상 완화에 대한 유효성을 검증하고 기능성 화장품 소재로써의 가능성 여부를 규명고자 41명의 피험자를 시험군과 대조군으로 분류하여 2021. 4. 15 ~ 2021. 11. 4 까지 총 24주간 이중맹검, 대조시료, 단일기관, 무작위 배정 인체적용시험을 시행하였다. 포토트리코그램을 통한 모발 수(N/cm²)는 시험군에서 8주, 16주, 24주 후 모두 유의미한 차이가 (p<0.001) 있었고 연구자의 육안 평가는 시험 24주 후부터 수치 상 호전된 것으로 나타났다. 피험자 주관 평가는 8주, 16주, 24주 후 시험군과 대조군 간 모발 수 변화량이 유의미한(p<0.017) 차이를 보여 L. mesenteroides 배양액 1%를 함유한 에센스는 탈모 증상 완화에 유효한 것으로 확인되었다. 이러한 결과로 인체 유래 유산균 L. mesenteroides는 향후 탈모 예방을 위한 다양한 제형의 기능성 화장품 소재로 활용 가능할 것으로 기대된다.

• 한국염색가공학회지
• /
• 제30권4호
• /
• pp.304-312
• /
• 2018

This study reduced the number of hair bleachings and used a hair steamer machine to reduce hair damage during hair coloring. In addition, such treatment was given, focusing on the use of hair mist. When the $L^{\ast}a^{\ast}b^{\ast}$ values for bleached hair were measured using a spectrum colorimeter, the mist steamer-based hair revealed higher brightness. Hair damage was low when moisture contents were high after hair drying with the use of the mist steamer machine. The mist treatment-less hair showed more blurred cuticle boundaries than mist-treated hair. In other words, this confirms that cuticles are protected by the use of a mist steamer machine during hair bleaching. It appears that this could minimize hair loss and meet clients' aesthetic needs and satisfaction during color bleaching/coloring.

• 대한화장품학회지
• /
• 제46권1호
• /
• pp.57-65
• /
• 2020

세정 과정에서 물에 의한 단백질 소실을 차폐막을 통해서 방지 하고자 먼저 모발 내부의 물 거동 경로를 파악하였다. 이를 위해서 소수성을 가지는 건강한 모발과, 모발 내부는 정상이지만 표면의 최외곽 지질층에서 18-methyleicosanoic acid (18-MEA)만 소실시켜 친수성이 된 모발과, 다시 표면에 18-MEA를 결합시킨 회복모를 이용해서 모발 수분의 거동을 파악하였다. 모발에 열을 가할 때 일어나는 수분 증발에 따른 질량 변화를 관찰한 결과 표면이 소수성인 모발들은 39 s와 151 s의 두개의 시간 상수로 감소하였다. 이에 반해 표면이 친수성으로 변한 손상 모발에서는 83 s의 하나의 빠른 시간 상수로 감소함을 확인하였는데, 이는 모발 내부에 있는 비결합과 결합 수분들이 외곽으로 빠져나올때 모발 표면에 소수성 막이 없음으로써 바로 용출됨을 반증한다. 따라서 세정과정에서 모발 내부의 단백질 용출을 효율적으로 방지하기 위해서는 모발 표면을 소수성 코팅하여 물분자의 거동을 저지시킬 필요가 있을 것이라는 가정한 결과 친수성 polyethylene glycol (PEG)를 코팅한 경우 179 ㎍/mL의 단백질이 용출한데 반해서 소수성 polydimethylsiloxane (PDMS)를 코팅한 모발은 보다 적은 148 ㎍/mL를 용출하였으며, 표면을 소수성 및 친수성으로 코팅하여 모발 내부 단백질을 검량하여 비교하였다. 마침내 소수성 차폐막이 세정 과정에서 모발 단백질 소실을 방어하는 방법이 됨을 확인하였고, 이 소수성 지표를 lateral force microscopy (LFM) 값으로 환산하여 정리하였다. 마침내 이 연구 결과물은 세정 과정에서 발생하는 단백질 소실을 소수성 코팅막을 부여함으로써 막을 수 있는 모발 세정제품 개발에 기여할 수 있다.