• 제목/요약/키워드: Hair Loss

검색결과 294건 처리시간 0.024초

A novel tetrapeptide for the treatment of hair loss identified in ginseng berry: in silico characterization and molecular docking with TGF-β2

  • Sung-Gyu Lee;Sang Moon Kang;Hyun Kang
    • Journal of Plant Biotechnology
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    • 제49권4호
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    • pp.316-324
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    • 2022
  • Hair loss causes psychological stress due to its effect on appearance. Therefore, the global market for hair loss treatment products is rapidly growing. The present study demonstrated that ginseng berry-derived and sequence-modified peptides promoted the proliferation rate of dermal papilla (DP) cells and keratinocytes, in addition to having antioxidant properties. Moreover, the potential role of these ginseng berry peptides as TGF-β2 antagonists was confirmed through in silico computer docking. In addition to promoting the growth of ,the ginseng berry-derived peptides also promoted the proliferation of keratinocytes experimental Particularly, an unmodified ginseng berry-derived peptide (GB-1) and two peptides with sequence modifications (GB-2 and GB-3) decreased ROS generation and exhibited a protective effect on damaged HaCaT keratinocytes. Computer-aided peptide discovery was conducted to identify the potential interactions of important proteins with transforming growth factor-beta 2 (TGF-β2), a key protein that plays a crucial role in the human hair growth cycle. Our results demonstrated that MAGH, an amino acid sequence present in herbal supplements and plant-based natural compounds, can inhibit TGF-β2.

L-Menthol, Salicylic acid, Dexpanthenol을 함유한 헤어 앰플이 두피 및 모발에 미치는 영향 (Effects of hair ampoules containing L-Menthol, Salicylic acid, and Dexpanthenol on scalp and hair)

  • 유선희;김나연
    • 융합정보논문지
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    • 제12권5호
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    • pp.298-304
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    • 2022
  • 본 연구에서는 낮은 연령층과 여성에게도 확대되고 있는 탈모와 문제성 두피에 대한 기초 연구자료를 제공하고자, 문제성 두피를 가진 20대 여성을 대상으로 L-Menthol, Salicylic acid, Dexpanthenol이 함유되어 있는 B사의 헤어 앰플을 매일 사용하였을 때, 4주 후 두피 및 모발에 미치는 영향을 알아보고자 하였다. 본 연구 결과, L-Menthol, Salicylic acid, Dexpanthenol이 함유되어 있는 B사의 앰플을 사용하였을 때 연구 대상자들의 두피 상태가 실험 전에 비하여 염증 완화, 두피 열 및 홍반 감소, 가려움증과 모발 빠짐 감소, 청결해진 모공 상태, 모발 굵기 증가 등 개선 효과를 보였으며, 연구 대상자들의 두피 자가진단을 통해 실험 전과 후의 두피 만족도, 두피 생기와 탄력, 열 발생도, 세정 후 두피 당김, 가려움증에 대한 개선 효과가 나타났음이 확인되었다. 이와같은 연구 결과를 통하여 L-Menthol, Salicylic acid, Dexpanthenol이 함유된 제품이 문제성 두피 및 모발 개선에 도움이 될 것으로 사료되어 진다.

Analysis of Trend of Studies on Microneedle Treatment System (MTS)

  • Chun, Hea-Sun;Song, Ho-Seub
    • 대한약침학회지
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    • 제24권4호
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    • pp.182-190
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    • 2021
  • Objectives: The purpose of this study was to analyze the microneedle therapy system (MTS) and its research methods for the past 10 years in Korea. Methods: Data on microneedle therapy system were collected using NDSL, KISS, RISS, and OASIS electronic databases from January 2010 to August 2021. "microneedle," "derma stamp," "microneedle therapy system" were used as the keywords. The present study, however, excluded data that were 1) unrelated to the microneedle therapy system, 2) from review/meta/protocol studies, and 3) from overseas studies. Data selected through the primary screening process, animal studies, case reports, and clinical data were included in the analysis. However, information data not related to the microneedle therapy system were excluded from the study. Results: Among the MTS-related papers published from January 2010 to August 2021, 7 animal research, 2 clinical trials, and 10 case studies were published. Based on the research topics, there were 8 papers on skin improvement and skin diseases, 7 papers on hair growth and hair loss, 3 papers on stability, and 1 paper on peripheral facial paralysis. Conclusion: Most of the studies related to MTS focused on skin, hair, and stability. The effect of MTS on hair growth and skin improvement has been confirmed, and it has been proven to have significant effects on the treatment of acne, acne scars, and hair loss in clinical practice. No serious side effects were observed during the MTS treatment, and the safety assessment confirmed that it was safe for use.

쾌적 환경에서 헤어스타일 유형이 인체 생리 반응에 미치는 영향 (Effects of Hair Style on Human Physiological Response in a Thermal Neutral Environment)

  • 김명주
    • 한국지역사회생활과학회지
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    • 제21권1호
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    • pp.117-124
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    • 2010
  • Recently, research on variables associated with hair styles are increasing with the spreading of total coordinated intention in the fields of clothing and cosmetology. In the present study, we focused on examining the skin temperature on the scalp(the vertex, temporal, and occiput), humidity on the occiput, skin temperatures (the forehead, back of ear, back of neck, upper back, abdomen, forearm, hand, thigh, calf, and foot), rectal temperature, total body mass loss by hair styles in a thermal neutral environment. Four young females participated as subjects. For a certain period, each subject had the five different hair styles in a random order: (1)Straight short hair(SS), (2)Perm waved short hair(PS), (3) Straight long hair(SL), (4)Perm waved long hair(PL), (5)Ponytail style(PT). Subjects wore briefs, bra, shirts with long sleeves, long legged training pants, and socks. The environmental variables of a climatic chamber were kept constant at $21{\pm}0.5^{\circ}C$ of air temperature and 55${\pm}$5%RH of air humidity. The results indicated the following: The skin temperature and humidity on the scalp did not show any significant differences among five different hair styles, but straight long hair style(SL)was the highest on the vertex, temporal, and occiput. The temporal skin temperature($29.8\sim30.8^{\circ}C$) was the highest, while the vertex skin temperature($28.7\sim30.1^{\circ}C$) was the lowest. Humidity on the occiput was the highest in the perm waved long hair style(PL). The back of ear skin temperature was significantly lower in the ponytail style(PT) than in the other four hair styles(p<.001). In the straight long hair style(SL), the skin temperature on the back of the neck and on the upper back were significantly higher than those of the other four hair styles(p<.01). Mean skin temperature and rectal temperature had no significant differences among hair styles. Total body mass was the highest in the perm waved long hair style(PL)(p<.05). We acquired fundamental data to enable the improvement of the current hair clinic system, wigs, functional hats, and helmets.

보중익기탕 투여 후 화학항암제로 인한 전신쇠약감 및 탈모호전 증례보고 (A Case Report of Chemotherapy-induced Alopecia Treated with Bojungikki-tang)

  • 이상헌
    • 대한한방내과학회지
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    • 제38권2호
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    • pp.235-239
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    • 2017
  • This case study describes the effect of Bojungikki-tang on chemotherapy-induced alopecia. Alopecia is a well-documented cause of distress to patients undergoing cancer treatment, but no approved pharmacological treatment exists for chemotherapy-induced hair loss. A 70-year-old female diagnosed with a cholangiocarcinoma and liver metastasis received chemotherapy, including gemcitabine and cisplatin, every three weeks. As a result of the continuous chemotherapy, she suffered various toxicity-related side effects, including bone marrow suppression, general weakness, nausea, peripheral numbness, and hair loss. Bojungikki-tang was initially administered to improve the patient's general weakness and fatigue. After three months of treatment, the patient's hair loss and general condition improved, and the color of the new hair was dark, despite the chemotherapy. The treatment did not improve other symptoms, such as bone marrow suppression and peripheral numbness. This case suggests that Bojungikki-tang could have a beneficial effect on chemotherapy-induced alopecia.

인체 유래 유산균 배합 융합 화장품의 탈모증 완화에 관한 유효성 연구 (Study on the efficiency of relieving hair loss of human body-derived lactobacillus combined cosmetics.)

  • 민경남
    • 한국융합학회논문지
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    • 제13권5호
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    • pp.35-43
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    • 2022
  • 인체 유래 Leuconostoc mesenteroides 배양액을 함유한 에센스로 탈모 증상 완화에 대한 유효성을 검증하고 기능성 화장품 소재로써의 가능성 여부를 규명고자 41명의 피험자를 시험군과 대조군으로 분류하여 2021. 4. 15 ~ 2021. 11. 4 까지 총 24주간 이중맹검, 대조시료, 단일기관, 무작위 배정 인체적용시험을 시행하였다. 포토트리코그램을 통한 모발 수(N/cm2)는 시험군에서 8주, 16주, 24주 후 모두 유의미한 차이가 (p<0.001) 있었고 연구자의 육안 평가는 시험 24주 후부터 수치 상 호전된 것으로 나타났다. 피험자 주관 평가는 8주, 16주, 24주 후 시험군과 대조군 간 모발 수 변화량이 유의미한(p<0.017) 차이를 보여 L. mesenteroides 배양액 1%를 함유한 에센스는 탈모 증상 완화에 유효한 것으로 확인되었다. 이러한 결과로 인체 유래 유산균 L. mesenteroides는 향후 탈모 예방을 위한 다양한 제형의 기능성 화장품 소재로 활용 가능할 것으로 기대된다.

탈색 시술 시 미스트 사용 여부에 따른 모발의 변화 (Hair Changes with the Use of Mist during Hair Bleaching)

  • 김은비;임순녀
    • 한국염색가공학회지
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    • 제30권4호
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    • pp.304-312
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    • 2018
  • This study reduced the number of hair bleachings and used a hair steamer machine to reduce hair damage during hair coloring. In addition, such treatment was given, focusing on the use of hair mist. When the $L^{\ast}a^{\ast}b^{\ast}$ values for bleached hair were measured using a spectrum colorimeter, the mist steamer-based hair revealed higher brightness. Hair damage was low when moisture contents were high after hair drying with the use of the mist steamer machine. The mist treatment-less hair showed more blurred cuticle boundaries than mist-treated hair. In other words, this confirms that cuticles are protected by the use of a mist steamer machine during hair bleaching. It appears that this could minimize hair loss and meet clients' aesthetic needs and satisfaction during color bleaching/coloring.

수분거동 패턴에 따른 차폐막 설정을 통한 모발단백질 소실방지 (Prevention of Protein Loss Using A Shield Coating According to Moisture Behavior in Human Hair)

  • 송상훈;임병택;손성길;강내규
    • 대한화장품학회지
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    • 제46권1호
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    • pp.57-65
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    • 2020
  • 세정 과정에서 물에 의한 단백질 소실을 차폐막을 통해서 방지 하고자 먼저 모발 내부의 물 거동 경로를 파악하였다. 이를 위해서 소수성을 가지는 건강한 모발과, 모발 내부는 정상이지만 표면의 최외곽 지질층에서 18-methyleicosanoic acid (18-MEA)만 소실시켜 친수성이 된 모발과, 다시 표면에 18-MEA를 결합시킨 회복모를 이용해서 모발 수분의 거동을 파악하였다. 모발에 열을 가할 때 일어나는 수분 증발에 따른 질량 변화를 관찰한 결과 표면이 소수성인 모발들은 39 s와 151 s의 두개의 시간 상수로 감소하였다. 이에 반해 표면이 친수성으로 변한 손상 모발에서는 83 s의 하나의 빠른 시간 상수로 감소함을 확인하였는데, 이는 모발 내부에 있는 비결합과 결합 수분들이 외곽으로 빠져나올때 모발 표면에 소수성 막이 없음으로써 바로 용출됨을 반증한다. 따라서 세정과정에서 모발 내부의 단백질 용출을 효율적으로 방지하기 위해서는 모발 표면을 소수성 코팅하여 물분자의 거동을 저지시킬 필요가 있을 것이라는 가정한 결과 친수성 polyethylene glycol (PEG)를 코팅한 경우 179 ㎍/mL의 단백질이 용출한데 반해서 소수성 polydimethylsiloxane (PDMS)를 코팅한 모발은 보다 적은 148 ㎍/mL를 용출하였으며, 표면을 소수성 및 친수성으로 코팅하여 모발 내부 단백질을 검량하여 비교하였다. 마침내 소수성 차폐막이 세정 과정에서 모발 단백질 소실을 방어하는 방법이 됨을 확인하였고, 이 소수성 지표를 lateral force microscopy (LFM) 값으로 환산하여 정리하였다. 마침내 이 연구 결과물은 세정 과정에서 발생하는 단백질 소실을 소수성 코팅막을 부여함으로써 막을 수 있는 모발 세정제품 개발에 기여할 수 있다.

떫은감 추출물의 발모 및 탈모의 기능성 효과 (The Functional Effects for the Prevention and Treatment on Hair Loss from Astringent Persimmon Fruit Extracts)

  • 임형식
    • 문화기술의 융합
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    • 제4권3호
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    • pp.253-259
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    • 2018
  • 떫은감 자원은 전통적으로 다방면의 여러 조직학적 질병을 치료하고 모발 성장을 비롯한 다양한 생물학적 활성에 매우 높은 효과가 있음이 알려져 왔다. 본 연구는 대머리 패턴의 검은 쥐 모델에 유전적으로 입증된 떫은감 추출물에 대한 발모 및 탈모방지 효능을 알아보고자 하였다. 표준화된 제형을 사용하여 대조군, 떫은감 추출물(10 mg/mouse/day)과 양성대조군인 미녹시딜(2 %)을 매일 두번씩 모발이 성장할 때까지 매일 등 피부에 일정량씩 도포 투여하여 조사하였다. C57BL/ 6 Black 쥐에서 모발 성장 세대를 통해 모발 성장의 변화 패턴이 관찰되었다. 모발 존재 면적과 모발의 길이는 처리 대조군 마우스 보다 떫은감 처리 마우스 처리구에서 유의하게 증가 하였다 (P>0.001). 또한 조직학적 평가에서도 대조군과 비교하여 떫은감 추출물의 처리구에서 모낭세포의 숫자가 현저하게 증가하였다. 따라서 본 실험 결과를 통하여 떫은감 추출물을 피부 도포시 누드 마우스의 모발 성장을 촉진하고 모발의 존재 영역을 확장시키고 모발 길이를 증가시켜 장기 모발 성장기의 지표가 될 수 있음을 알 수 있었다.

Comparison of Saccharina japonica-Undaria pinnatifida Mixture and Minoxidil on Hair Growth Promoting Effect in Mice

  • Park, Ki Soo;Park, Dae Hwan
    • Archives of Plastic Surgery
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    • 제43권6호
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    • pp.498-505
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    • 2016
  • Background Algae have traditionally been used for promotion of hair growth. Use of hair regrowth drugs, such as minoxidil, is limited due to side effects. The aim of this study was to examine a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) on hair growth and to compare the promoting effect of hair growth by a 3% minoxidil and a L-U mixture. Methods To evaluate the hair growth-promoting activity, saline, 50% ethanol, 3% minoxidil, and the L-U mixture were applied 2 times a day for a total of 14 days on the dorsal skin of C57BL/6 mice after depilation. Analysis was determined by using a high-resolution hair analysis system, real-time polymerase chain reaction, and H&E staining. Results On day 14, the hair growth effect of the L-U mixture was the same as that of the 3% minoxidil treatment. The L-U mixture significantly (P<0.05) stimulated hair growth-promoting genes, as vascular endothelial growth factor (VEGF) and insulin-like growth factor -1. Increase of VEGF was observed in the L-U mixture group compared with minoxidil and the negative control. In contrast, the L-U mixture suppressed the expression of transforming growth factor-${\beta}1$, which is the hair loss-related gene. In histological examination in the L-U mixture and minoxidil groups, the induction of an anagen stage of hair follicles was faster than that of control groups. Conclusions This study provides evidence that the L-U mixture can promote hair growth in mice, similar to the effect from minoxidil, and suggests that there is potential application for hair loss treatments.