• 한국전문물리치료학회지
• /
• 제12권3호
• /
• pp.74-83
• /
• 2005

The purpose of this study was to produce the regression equation from non-exercise $VO_{2max}$ of healthy young adults and to develop a maximal oxygen consumption ($VO_{2max}$) regression model. This model was based on heart rate non-exercise predictor variables (rest heart rate, maximal heart rate/rest heart rate), as an extra addition to the general regression which can reflect an individual's inherent or acquired cardiorespiratory fitness. The subjects were 101 healthy young adults aged 19 to 35 years. Exercise testing was measured by using a Balke protocol for treadmill and indirect calorimetry. The prediction equation was analyzed by using stepwise multiple regression procedures. The mean of $VO_{2max}$ was $39.02{\pm}6.72\;m{\ell}/kg/min$ (mean${\pm}$SD). The greatest variable correlated to $VO_{2max}$ was %fat. The predictor variable used in the non-exercise $VO_{2max}$ included %fat, gender, habitual physical activity and $HR_{max}/HR_{rest}$. The non-exercise $VO_{2max}$ estimation was as follows: $VO_{2max}$($m{\ell}/kg/min$)=55.58-.41(%fat)+.59(physical activity rating)-2.69($HR_{max}/HR_{rest}$)-5.36 (male=0, female=1); (R=.85, SEE=3.64, R2=.72: including heart rate variable); $VO_{2max}$($m{\ell}/kg/min$)=48.47-.41(%fat)+.45(physical activity rating)-5.12 (male=0, female=1); (R=.84, SEE=3.74, R2=.70: with the exception of heart rate variable). As an added heart rate variable, there was only a 2% coefficient of determination improved. Therefore, these results demonstrated that heart rate variable correlation with a non-exercise regression model was very low. In conclusion, for healthy young korean adults, those variables that can affect non-exercise $VO_{2max}$ estimation turned out to be only % fat, gender, and physical activity. We suggest that further research of predictor variables for non-exercise $VO_{2max}$ is necessary for different patient groups who cannot perform maximal exercise or submaximal exercise.

• 동의생리병리학회지
• /
• 제18권2호
• /
• pp.528-533
• /
• 2004

The immune system acts to protect the host from infectious agents that exist in the environment and from other noxious insults. The immune system has two functional divisions: the innate and the acquired. Both components involve various factors such as cytokines. A number of methodologies exist to assess aspects of immune function. There are large inter-individual variations in many immune functions even among the healthy. Genetics, age, gender, smoking habits, habitual levels of exercise, alcohol consumption, diet, stage in the female menstrual cycle, stress, history of infections and vaccinations, and early life experiences are likely to be important contributors to the observed variation. While it is clear that individuals with immune responses significantly below 'normal' are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection. Oriental medicine is an important factor contributing to immune competence. The author investigated the immune enhancement effects of Bojungikkitanggami-bang (BITB). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. In the present study, the author investigated the effects of BITB on FST and blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactate dehydrogenase (LDH); creatinine; and total protein (TP). The author found that BITB (1 g/kg) significantly reduced the immobility time in the FST compared to the control. In addition, the contents of Glc, LDH, BUN, TP in the blood serum were increased in BITB (1g/kg)-fed group. Also, the author investigated the effects of BITB on the production of cytokines in human T-cell line, MOLT-4 cells. BITB (1 mg/ml) significantly increased the interferon (IFN)-vproduction compared with media control (about 2.2-fold for IFN-γ) at 24 h. However, BITB has not affect the production of IL-2 and IL-4. In addition, BITB increased the protein expression level of IFN-γ in MOLT-4 cells. Thus, BITB may have therapeutic value in generating or enhancing immune function in a clinical setting.

• 유통과학연구
• /
• 제12권12호
• /
• pp.93-100
• /
• 2014

Purpose - This study investigated the effect of the negative affect on compulsive buying and the interaction effect of the negative affect depending on the level of mindfulness. Compulsive buying is defined as chronic, repetitive purchasing that becomes an overlearned and automatic way to cope with negative feelings, and compulsive buyers may be particularly susceptible to cognitive narrowing when shopping. Mindfulness may be defined as a coordinative regulatory process to increase the level of attention by recognizing the present experiences non-judgmentally. Hence, mindfulness can be related with negative psychological results such as general mental distress, especially compulsive buying. The purpose of the current study is to examine the relationship between compulsive buying and mindfulness. In another words, this study investigated the effect of the internal regulatory mechanism (that is, mindfulness) on the mental disorder resulting from negative affect in the area of consumption (that is, compulsive buying). Research design, data, and methodology - One hundred and twenty-five college students were recruited for this study. The subjects were classified into two groups according to the degree of the negative affect (High Negative Affect Group vs. Low Negative Affect Group) by the mean value of negative affect (=2.47). The subjects were classified into two other groups according to the degree of mindfulness (High Mindfulness Group vs. Low Mindfulness Group) by the mean value of mindfulness (= 3.47). To analyze the effect of negative affect on compulsive buying, the degree of compulsive buying of the High and Low Negative Affect Groups were compared. To examine the moderating effect of mindfulness by using factorial design, the interaction effect of the negative affect (High vs. Low) and the mindfulness (High vs. Low) were analyzed. Results - The degree of the compulsive buying was higher when the degree of the negative affect was higher than lower (3.06High Negative Affect Group vs. 2.87Low Negative Affect Group, p=.014). The difference in the degree of the compulsive buying was larger when the degree of the mindfulness was lower than higher. In other words, the interaction effect of the negative affect and the mindfulness on the compulsive buying could be found (F(1,124)=10.098, p<.01). Conclusions - The results of the current study showed that the compulsive buying is influenced by the negative affect and that the effect of the negative affect on the compulsive buying varies depending on the level of the mindfulness. These results can be interpreted to imply that consumers who are in a state of high mindfulness pay attention to every minute of experience and activate the coordinatory function and that, eventually, habitual and reflective responses such as compulsive buying are restricted. It is concluded that consumers' mindfulness can facilitate the self-regulatory responses and alleviate the influence of negative affect on compulsive buying. Based on these results, the theoretical and practical implications of this research were discussed and the limitations and future research areas were suggested.

• 대한영양사협회학술지
• /
• 제9권4호
• /
• pp.316-325
• /
• 2003

This study was carried out to compare the characteristics of the over weight elementary school students with those of desirable-weight children. Anthropometric parameters such as height, weight, BMI, body fat percentile, triceps skin fold thickness were measured. Dietary assessment and blood analysis were performed. The average ages of over weight children and desirable-weight children were 10.9$\pm$2.5 and 10.2$\pm$2.8 years, respectively. The means body fat percentile of over weight children and desirable-weight children were 27.5$\pm$3.7% and 20.2$\pm$3.8%. respectively. Plasma levels of TG, total cholesterol, LDL cholesterol, and HDL cholesterol of over weight children and desirable-weight children were 179.3$\pm$30.0, 104.9$\pm$26.6, 52.3$\pm$6.7 and 178.3$\pm$84.1 mg/dl, and those of desirable-weight children were 86.1$\pm$43.5, 183.7$\pm$16.5, 101.0$\pm$2.1 and 67.7$\pm$20.0 mg/dl, respectively. Plasma TG levels of over weight children were significantly higher than those of desirable weight children. On the other hand, plasma HDL-cholesterol levels of over weight children were significantly lower than those of desirable-weight children. Plasma levels of GOT and GPT were in normal range in both group however, GPT level of over weight children was higher than that of desirable weight children. Plasma levels of albumin, globulin, and BUN were all in normal range and no differences were found in both groups. Hematologic data did not show any difference between two groups except WBC, RBC and Hgb levels which were significantly higher in over weight group than those of desirable-weight children. Daily nutrients intake of over weight children and desirable-weight children were very similar and they were around the Korean RDA levels for each nutrients. However the intake of calcium of both groups were little over 50% of RDA. The consumption of dietary fiber was very low and the cholesterol intake was very high showing that the habitual meals of Korean school children were not well balanced.

• 대한교통학회지
• /
• 제30권6호
• /
• pp.27-36
• /
• 2012

국내 2010년도 음주운전 교통사고는 28,641건으로 전체 사고건수 226,878건의 12.62%를 차지하고 있지만, 사망자수는 781명, 부상자수는 51,364명으로 전체 교통사고 사망자수인 5,505명의 14.19%, 부상자수인 352,458명의 14.57%로 여전히 높은 비율을 차지하고 있다. 음주운전으로 인한 교통사고를 예방하기 위해서 경찰 단속이나 법적규제를 강화하는 등 다양한 노력을 기하고 있지만 음주운전에 대한 사회문화적 관용과 상습음주운전자 관리 부재등으로 인하여 음주 관련 교통사고가 쉽게 줄어들지 않고 있는 것이 현실이다. 본 연구에서는 음주운전의 특성 및 음주에 따른 운전행동 변화를 실증적으로 알아보기 위하여 정신운동검사와 차량시뮬레이터를 활용하여 국내운전자 26명을 대상으로 음주 전 후 정신운동 및 운전 수행 결과를 비교분석 하였다. 정신운동검사 결과의 경우, 음주 후에는 음주 전에 비하여 정답수가 감소하고 오답수는 증가하였으며 생략반응 또한 증가되는 경향을 나타냈다. 그리고 차량시뮬레이터 실험결과에서는 음주 전에 비하여 음주 후의 주행속도가 상대적으로 빨라졌으며 가속페달 답력 편차 및 차량편측위치 편차가 커지는 등 위험운전 행태를 보였다. 이러한 결과는 알코올이 운전자의 시각인지능력 및 주행안전성을 저하시킨다는 것을 보여준다. 마지막으로 본 연구의 제한점 및 향후 연구방향을 제시하였다.

• 대한구강악안면병리학회지
• /
• 제41권3호
• /
• pp.121-129
• /
• 2017

Coffee (Coffea spp.) is one of the most important agricultural commodities, being widely consumed in the world. Various beneficial health effects of coffee have been extensively investigated, but data on habitual coffee consumption and its bio-physiological effect have not been clearly explained as well as it is not proved the cause and effect between drinking coffee and its bio-physiological reactions. We made the dialyzed coffee extract (DCE), which is absorbable through gastrointestinal tract, in order to elucidate the cellular effect of whole small coffee molecules. RAW 264.7 cells, a murine macrophage lineage, were directly treated with DCE, i.e., DCE-2.5 (equivalent to 2.5 cups of coffee a day), DCE-5, and DCE-10, for 12 hours, and their protein extracts were examined by immunoprecipitation high performance liquid chromatography (IP-HPLC). RAW 264.7 cells differently expressed the inflammation-related proteins depending on the doses of DCE. RAW 264.7 cells treated with DCE showed marked increase of cathepsin C, cathepsin G, CD20, CD28, CD31, CD68, indicating the activation of innate immunity. Particularly, the macrophage biomarkers, cathepsin G, cathepsin C, CD31, and CD68 were markedly increased after DCE-5 and DCE-10 treatments, and the lymphocyte biomarkers, CD20 and CD28 were consistently increased and became marked after DCE-10 treatment. On the other hand, RAW 264.7 cells treated with DCE showed consistent increase of IL-10, an anti-inflammatory factor, but gradual decreases of different pro-inflammatory proteins including $TNF{\alpha}$, COX-2, lysozyme, MMP-2, and MMP-3. In particular, the cellular signaling of inflammation was gradually mitigated by the reduction of $TNF{\alpha}$, COX-2, IL-12, and M-CSF, and also the matrix inflammatory reaction was reduced by marked deceases of MMP-2, MMP-3, and lysozyme. These anti-inflammatory expressions were consistently found until DCE-10 treatment. Therefore, it is presumed that DCE may have dynamic effects of innate immunity activation and pro-inflammation suppression on RAW264.7 cells simultaneously. These effects were consistently found in the highest dose of coffee, DCE-10 (equivalent to 10 cups of coffee a day in man), that might imply the small coffee molecules were accumulated in RAW 264.7 cells after DCE-10 treatment and produce synergistic cytokine effects for innate immunity activation and anti-inflammatory reaction concurrently.

• 대한한방내과학회지
• /
• 제28권1호
• /
• pp.47-67
• /
• 2007

Objectives : This study was aimed to investigated the warning signs and its relationship with the other characteristics in acute stroke patients. Methods : 225 acute stroke patients were recruited at the Department of Cardiovascular and Neurologic Diseases (Stroke Center) of Kyung Hee University Oriental Hospital from October 2005 to September 2006. We evaluated their stroke type with brain MRI, their warning signs, and general characteristics such as age, sex, past history, risk factors, etc. Results : 225 subjects were included in the final analysis. In the subjects' general characteristics, the most common etiology of stroke was small vessel occlusion. In the assessment of the subjects' warning signs, the frequency of tension felt at the cervical area was highest followed by blepharospasm, sensory dysfunction (one side of numbness, tingling sensation, dead sensation), one side paralysis or weakness, etc. After analyzing etiology, cerebral hemorrhage had more facial spasm sign and hypertension than cerebral infarction. On the other hand, cerebral infarction had more diabetes and sensory dysfunction (one side of numbness, tingling sensation, dead sensation) than cerebral hemorrhage. Among stroke locations, subjects with their brain lesion in the cortex had more warning sings of motor dysfunction such as one side paralysis, or weakness. Multiple lesions showed a close relationship with smoking habit and were more common in males than in females. The under 65 years old group were more commonly associated with alcohol consumption, accidental mental stress and blepharospam than the over 65 years old group. In the group of under 65 years old, males more commonly had lesions in occipital lobe, alcohol consumption and smoking habit than females. Otherwise, females more commonly had vision dysfunction and blepharospasm than males. In the group of over 65 years old, males more commonly had cortex lesion than females. On the other hand, Females more commonly had accidental mental stress than males. Conclusions : We observed various warning signs and their distribution in acute stroke patients. The subjects' brainlesions and their etiology seemed to affect the features of the warning signs. Hypertension, diabetes and hyperlipidemia were also related to etiology of stroke and some habitual problems such as smoking and drinking seemed to reduce the age of stroke ictus. Although a concrete conclusion can hardly be drawn from this study, it reminds physicians of the importance of warning signs which appear among their patients.