• 제목/요약/키워드: HUMAN INTERFERENCE

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태양광발전장치의 낙뢰보호 시스템 (Lightning Protection System of Solar Power Generation Device)

  • 윤용호
    • 한국인터넷방송통신학회논문지
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    • 제23권2호
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    • pp.157-162
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    • 2023
  • 태양광발전 설비의 고장 중 서지에 의한 고장이 전체 고장률의 20% 차지하고 있으며 발전 중 수십에서 수백[A]의 에너지 방출과 인버터, 접속반 등의 전기적 손상은 전기안전사고로 이어지고 있다. 특히 낙뢰의 경우 전기회로에 이상 전압이 유기되어 절연을 파괴할 뿐만 아니라 이때 흐르는 전류는 화재의 원인이 되고 부품의 열화를 촉진하는 요인으로 작용한다. 이러한 작용으로 도심 밖에서 주택, 아파트, 관공서 등의 도심 내부로 확산하고 있는 태양광 발전장치의 전기 안전 문제가 대두되고 있다. 낙뢰는 필드 기반 및 전도성 전기 간섭을 유발하기에 이 효과는 케이블 길이 또는 도체 루프 증가와 관련하여 증가한다. 또한 서지는 태양광 모듈, 인버터 및 모니터링장치뿐만 아니라 건물 설비의 장치도 손상하기에 최종적으로는 태양광발전시스템의 화재로 인한 운영 중단과 이에 따른 재정손실을 유발하게 시킬 수 있다. 따라서 본 논문에서는 태양광발전시스템의 낙뢰발생으로 인한 화재 및 전기안전사고 증가로 인하여 재산피해 및 인명피해를 줄일 수 있는 목적으로 태양광발전장치의 낙뢰보호 시스템을 연구하고자 한다.

화분분석을 이용한 아산시 온양천 유역의 후빙기 후기 환경변화 (A Pollen Analysis on the Environmental Changes during the Later Half of the Postglacial Age around the Basin of Onyang River, Asan)

  • 박지훈
    • 한국지형학회지
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    • 제17권1호
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    • pp.39-48
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    • 2010
  • 충남 온양천 유역의 후빙기 환경변화를 밝히기 위한 사례연구로서 온양천의 지류인 금곡천의 상류부(이하 조사지역)에 분포하는 선상지 퇴적층을 대상으로 화분분석을 실시하였다. 시료채취지점은 해발고도 약 67.5m로 현재 냉온대 중부 식생대에 속한다. 분석결과는 다음과 같다. 조사지역 일대는 약 3,000yrB.P. 이후 크게 SC-I기(期)(Pinus가 우점하는 침엽수림시대) → SC-II기(期)(Quercus·Castanea가 우점하는 낙엽활엽수림시대) → ③ SC-III기(期)(Pinus-Quercus-Ulmus/Zelkova가 우점하는 침활혼효림시대)로 변천했다. 각 시대의 연대는 SC-I기(期)와 SC-II기(期)가 약 3,000~2,000yrB.P., SC-III기(期)가 약 2,000yrB.P.~현재로 수렴된다. 전국적 후빙기 화분대와 대비하면, SC-I기(期)와 SC-II기(期)는 RIIIa 그리고 SC-III기(期)는 RIIIb에 대비된다. 그리고 약 2,000yrB.P. 이후 조사지역 일대는 삼림파괴에 따른 소나무림의 분포역이 확대되었으며, 또한 메밀화분의 출현율이 높은 점 등을 고려할 때, SC-III기(期)는 인간간섭의 시대로서 이 시대에 들어서면서부터 삼림파괴가 본격화되었고, 당시 거주민들은 농경생활을 했었을 것으로 추정된다.

아산(牙山) 탕정평야(湯井平野)의 화분분석(花粉分析) (Pollen Analysis on Tangjeong Plains, Asan-Si, Korea)

  • 박지훈;장동호
    • 한국지형학회지
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    • 제17권2호
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    • pp.53-61
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    • 2010
  • 충남 아산 탕정평야의 충적층을 대상으로 화분분석과 연대측정을 실시하였다. 시료채취지점은 해발고도 약 12m로 현재 냉온대 중부 삼림대에 속한다. 분석결과는 다음과 같다. 조사지역 일대는 약 2,810yrB.P. 이후 크게 TJ-I기(期)(Pinus가 우점하는 침엽수림시대) → TJ-II기(期)(Pinus·Quercus가 우점하는 침·활혼효림시대) → TJ-III기(期)(Pinus가 우점하는 침엽수림시대)로 변천했다. TJ-II기(期)는 다시 TJ-IIa기(期)와 TJ-IIb기(期)로 세분된다. 각 시대의 연대를 보면, TJ-I기(期)는 약 2,810-1,500yrB.P., TJ-IIa기(期)는 약 1,500-1,370yrB.P., TJ-IIb기(期)는 약 1,370-770yrB.P. 그리고 TJ-III기(期)는 약 770yrB.P. 이후이다. 각 시대를 전국적 후빙기 화분대와 대비하면, TJ-I기(期)와 TJ-II기(期)는 후빙기 후기(RIII) 중에서 RIIIa 그리고 TJ-III기(期)는 RIII 중에서 RIIIb(인간간섭의 시대)에 대비된다. 그리고 탕정평야 일대의 구릉지에서 삼림파괴가 본격화 되어 2차림으로서 소나무림의 분포역이 확대되었던 시기는 약 770yrB.P. 이후라는 것이 밝혀졌다.

배터리 소모 공격에 대응하는 저전력 웨이크업 리시버의 적응형 파워 세이빙 메커니즘 (Adaptive Power Saving Mechanism of Low Power Wake-up Receivers against Battery Draining Attack)

  • 김소연;윤성원;이일구
    • 정보보호학회논문지
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    • 제34권3호
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    • pp.393-401
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    • 2024
  • 최근 사물인터넷(Internet of Things, IoT)이 인간의 안전, 생명, 자산과 직결되는 산업과 일상생활에 널리 활용되고 있다. 그러나 저가, 경량, 저전력 요건을 충족해야 하는 IoT 장치는 배터리 소모 공격과 간섭 때문에 배터리 라이프타임이 심각하게 단축되는 문제가 있다. 이러한 문제를 해결하기 위해 웨이크업 리시버(Wake-up Receiver, WuR)를 위한 802.11ba 표준이 등장했고, 이 기능은 와이파이 기반 IoT의 에너지 소비를 최소화하는데 중요한 역할을 하고 있다. 그러나 WuR 프로토콜은 지연시간과 오버헤드를 단축하기 위해서 보안 메커니즘을 고려하지 않았다. 따라서 본 연구에서는 배터리 소모 공격에 대응하기 위해서 저전력 웨이크업 리시버를 위한 적응형 파워 세이빙 메커니즘(Adaptive Power Saving Mechanism, APSM)을 제안한다. APSM은 공격이 잦은 환경에서 파워 세이빙 시간을 기하급수적으로 증가시킴으로써 비정상적으로 발생하는 파워 소모량을 최소화할 수 있다. 실험 결과에 따르면, APSM은 전체 트래픽 중 공격 비중이 10% 이상일 때 종래의 파워 세이빙 메커니즘(Legacy Power Saving Mechanism, LPSM)보다 13.77% 이상의 에너지 소비 효율을 개선할 수 있었다.

부유식 해상풍력발전기 하부구조물의 종경사각에 따른 주파수 영역 운동응답 분석 (A Frequency Domain Motion Response Analysis of Substructure of Floating Offshore Wind Turbine with Varying Trim)

  • 남인혁;최영명;한익승;임채옥;김진욱;신성철
    • 한국항해항만학회지
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    • 제48권3호
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    • pp.155-163
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    • 2024
  • 최근 탄소 저감에 대한 요구가 증가함에 따라 전 세계적으로 화석연료의 사용을 줄이고, 신재생 에너지에 대한 연구가 활발히 진행되고 있다. 신재생 에너지를 활용한 발전 방식 중, 부유식 해상풍력발전기는 설치제약이 적으며, 대규모 단지 구성이 수월한 장점이 있다. 부유식 해상풍력발전기의 파랑 중 운동응답 해석은 초기 설계 단계에서 필수적으로 수행되어야 한다. 본 연구는 부유식 해상풍력발전기 중반잠수식 해상풍력발전기에 대하여 종경사각에 따른 주파수 영역에서의 운동 해석을 수행하고, 종경사각에 따른 운동 특성에 미치는 영향을 평가하고자 하였다. 운동응답 분석은 6자유도 운동 중 Heave, Roll, Pitch에 대하여 수행하였다. 고유 주기 분석을 수행하여, 종경사각의 변화가 Heave, Pitch 운동은 유의미한 변화를 나타내진 않았지만, Roll 운동은 규칙적으로 변화함을 확인하였다.

APPLICATION OF FUZZY SET THEORY IN SAFEGUARDS

  • Fattah, A.;Nishiwaki, Y.
    • 한국지능시스템학회:학술대회논문집
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    • 한국퍼지및지능시스템학회 1993년도 Fifth International Fuzzy Systems Association World Congress 93
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    • pp.1051-1054
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    • 1993
  • The International Atomic Energy Agency's Statute in Article III.A.5 allows it“to establish and administer safeguards designed to ensure that special fissionable and other materials, services, equipment, facilities and information made available by the Agency or at its request or under its supervision or control are not used in such a way as to further any military purpose; and to apply safeguards, at the request of the parties, to any bilateral or multilateral arrangement, or at the request of a State, to any of that State's activities in the field of atomic energy”. Safeguards are essentially a technical means of verifying the fulfilment of political obligations undertaken by States and given a legal force in international agreements relating to the peaceful uses of nuclear energy. The main political objectives are: to assure the international community that States are complying with their non-proliferation and other peaceful undertakings; and to deter (a) the diversion of afeguarded nuclear materials to the production of nuclear explosives or for military purposes and (b) the misuse of safeguarded facilities with the aim of producing unsafeguarded nuclear material. It is clear that no international safeguards system can physically prevent diversion. The IAEA safeguards system is basically a verification measure designed to provide assurance in those cases in which diversion has not occurred. Verification is accomplished by two basic means: material accountancy and containment and surveillance measures. Nuclear material accountancy is the fundamental IAEA safeguards mechanism, while containment and surveillance serve as important complementary measures. Material accountancy refers to a collection of measurements and other determinations which enable the State and the Agency to maintain a current picture of the location and movement of nuclear material into and out of material balance areas, i. e. areas where all material entering or leaving is measurab e. A containment measure is one that is designed by taking advantage of structural characteristics, such as containers, tanks or pipes, etc. To establish the physical integrity of an area or item by preventing the undetected movement of nuclear material or equipment. Such measures involve the application of tamper-indicating or surveillance devices. Surveillance refers to both human and instrumental observation aimed at indicating the movement of nuclear material. The verification process consists of three over-lapping elements: (a) Provision by the State of information such as - design information describing nuclear installations; - accounting reports listing nuclear material inventories, receipts and shipments; - documents amplifying and clarifying reports, as applicable; - notification of international transfers of nuclear material. (b) Collection by the IAEA of information through inspection activities such as - verification of design information - examination of records and repo ts - measurement of nuclear material - examination of containment and surveillance measures - follow-up activities in case of unusual findings. (c) Evaluation of the information provided by the State and of that collected by inspectors to determine the completeness, accuracy and validity of the information provided by the State and to resolve any anomalies and discrepancies. To design an effective verification system, one must identify possible ways and means by which nuclear material could be diverted from peaceful uses, including means to conceal such diversions. These theoretical ways and means, which have become known as diversion strategies, are used as one of the basic inputs for the development of safeguards procedures, equipment and instrumentation. For analysis of implementation strategy purposes, it is assumed that non-compliance cannot be excluded a priori and that consequently there is a low but non-zero probability that a diversion could be attempted in all safeguards ituations. An important element of diversion strategies is the identification of various possible diversion paths; the amount, type and location of nuclear material involved, the physical route and conversion of the material that may take place, rate of removal and concealment methods, as appropriate. With regard to the physical route and conversion of nuclear material the following main categories may be considered: - unreported removal of nuclear material from an installation or during transit - unreported introduction of nuclear material into an installation - unreported transfer of nuclear material from one material balance area to another - unreported production of nuclear material, e. g. enrichment of uranium or production of plutonium - undeclared uses of the material within the installation. With respect to the amount of nuclear material that might be diverted in a given time (the diversion rate), the continuum between the following two limiting cases is cons dered: - one significant quantity or more in a short time, often known as abrupt diversion; and - one significant quantity or more per year, for example, by accumulation of smaller amounts each time to add up to a significant quantity over a period of one year, often called protracted diversion. Concealment methods may include: - restriction of access of inspectors - falsification of records, reports and other material balance areas - replacement of nuclear material, e. g. use of dummy objects - falsification of measurements or of their evaluation - interference with IAEA installed equipment.As a result of diversion and its concealment or other actions, anomalies will occur. All reasonable diversion routes, scenarios/strategies and concealment methods have to be taken into account in designing safeguards implementation strategies so as to provide sufficient opportunities for the IAEA to observe such anomalies. The safeguards approach for each facility will make a different use of these procedures, equipment and instrumentation according to the various diversion strategies which could be applicable to that facility and according to the detection and inspection goals which are applied. Postulated pathways sets of scenarios comprise those elements of diversion strategies which might be carried out at a facility or across a State's fuel cycle with declared or undeclared activities. All such factors, however, contain a degree of fuzziness that need a human judgment to make the ultimate conclusion that all material is being used for peaceful purposes. Safeguards has been traditionally based on verification of declared material and facilities using material accountancy as a fundamental measure. The strength of material accountancy is based on the fact that it allows to detect any diversion independent of the diversion route taken. Material accountancy detects a diversion after it actually happened and thus is powerless to physically prevent it and can only deter by the risk of early detection any contemplation by State authorities to carry out a diversion. Recently the IAEA has been faced with new challenges. To deal with these, various measures are being reconsidered to strengthen the safeguards system such as enhanced assessment of the completeness of the State's initial declaration of nuclear material and installations under its jurisdiction enhanced monitoring and analysis of open information and analysis of open information that may indicate inconsistencies with the State's safeguards obligations. Precise information vital for such enhanced assessments and analyses is normally not available or, if available, difficult and expensive collection of information would be necessary. Above all, realistic appraisal of truth needs sound human judgment.

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지리산 국립공원의 식물상 연구 (The Floristic Study of Chirisan National Park in Korea)

  • 장창기;김윤영;지성진;고은미;양종철;장창석;엄정애;윤창영;장진성;이철호;김규식;오병운
    • 식물분류학회지
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    • 제37권2호
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    • pp.155-196
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    • 2007
  • 본 연구는 지리산 국립공원 지역에 대한 종합적인 식물상 연구로서 기존에 보고된 문헌들에 대한 고찰과 1년간의 실제적인 조사에 의해서 얻어진 표본자료를 근거로 하여 식물목록을 작성하였다. 실제 조사에서 밝혀진 지리산 국립공원지역의 관속식물 수는 실제 조사에서 확인된 분류군은 37목, 109과, 382속의 708분류군의 590종, 3아종, 95변종 및 20품종으로 이루어져 있었고, 22개의 문헌에만 나타나고 조사에서 확인되지 않은, 1,117분류군은 41목 130과 500속에 해당하는 901종 9아종 140변종 67품종 등으로 구성되어 있었다. 결론적으로 문헌 조사와 실제 야외 조사에서 밝혀진 지리산 소산식물의 총수는 1,825(708+1,117) 분류군으로 밝혀졌다. 이를 목록으로 제시하였다. 이 중에서 기존의 조사에서는 발견되지 않았으나 본 조사에서 최초로 밝혀진 분류군은 43분류군이었다. 실제 조사에서 확인된 식물들 중에서 한국특산 식물 31분류군, 산림청 지정 희귀 및 멸종위기식물 21분류군, 환경부 지정 식물구계학적 특정 식물종 중에서 3등급 이상에 해당하는 40분류군 등이 생육하고 있었으며, 27분류군의 한국 귀화식물이 밝혀졌다. 확인되지 않고 문헌조사에만 나타난 분류군 중에서 한국특산식물 45분류군, 산림청 지정 희귀 및 멸종위기식물 45분류군, 환경부 지정 식물구계학적 특정식물종 중에서 3등급 이상에 해당하는 121분류군 등이 생육하고 있으며 31분류군의 한국 귀화식물이 밝혀졌다. 이로 미루어 볼 때 지리산의 식생은 여러 가지 요인에 의해 서서히 변화되어 가고 있으며, 많은 중요한 식물 자원들이 사라져 가는 추세라고 판단되므로 이에 대한 대책 수립이 요구되어 진다.

BCR/ABL mRNA Targeting Small Interfering RNA Effects on Proliferation and Apoptosis in Chronic Myeloid Leukemia

  • Zhu, Xi-Shan;Lin, Zi-Ying;Du, Jing;Cao, Guang-Xin;Liu, Gang
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권12호
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    • pp.4773-4780
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    • 2014
  • Background: To investigate the effects of small interference RNA (siRNA) targeting BCR/ABL mRNA on proliferation and apoptosis in the K562 human chronic myeloid leukemia (CML) cell line and to provide a theoretical rationale and experimental evidence for its potential clinical application for anti-CML treatment. Materials and Methods: The gene sequence for BCR/ABL mRNA was found from the GeneBank. The target gene site on the BCR/ABL mRNA were selected according to Max-Planck-Institute (MPI) and rational siRNA design rules, the secondary structure of the candidate targeted mRNA was predicted, the relevant thermodynamic parameters were analyzed, and the targeted gene sequences were compared with BLAST to eliminate any sequences with significant homology. Inhibition of proliferation was evaluated by MTT assay and colony-formation inhibiting test. Apoptosis was determined by flow cytometry (FCM) and the morphology of apoptotic cells was identified by Giemsa-Wright staining. Western blotting was used to analyze the expression of BCR/ABL fusion protein in K562 cells after siRNA treatment. Results: The mRNA local secondary structure calculated by RNA structure software, and the optimal design of specific siRNA were contributed by bioinformatics rules. Five sequences of BCR/ABL siRNAs were designed and synthesized in vitro. Three sequences, siRNA1384, siRNA1276 and siRNA1786, which showed the most effective inhibition of K562 cell growth, were identified among the five candidate siRNAs, with a cell proliferative inhibitory rate nearly 50% after exposure to 12.5nmol/L~50nmol/L siRNA1384 for 24,48 and 72 hours. The 50% inhibitory concentrations ($IC_{50}$) of siRNA1384, siRNA1276 and siRNA1786 for 24hours were 46.6 nmol/L, 59.3 nmol/L and 62.6 nmol/L, respectively, and 65.668 nmol/L, 76.6 nmol/L, 74.4 nmol/L for 72 hours. The colony-formation inhibiting test also indicated that, compared with control, cell growth of siRNA treated group was inhibited. FCM results showed that the rate of cell apoptosis increased 24 hours after transfecting siRNA. The results of annexinV/PI staining indicated that the rate of apoptosis imcreased (1.53%, 15.3%, 64.5%, 57.5% and 21.5%) following treamtne with siRNAs (siRNA34, siRNA372, siRNA1384, siRNA1276 and siRNA1786). Morphological analysis showed td typical morphologic changes of apoptosis such as shrunken, fragmentation nucleus as well as "apoptotic bodies" after K562 cell exposure to siRNA. Western blot analysis showed that BCR/ABL protein was reduced sharply after a single dose of 50nmol/L siRNA transfection. Conclusions: Proliferation of K562 cells was remarkbly inhibited by siRNAs (siRNA1384, siRNA1276 and siRNA1786) in a concentration-dependent manner in vitro, with effective induction of apoptosis at a concentration of 50 nmol/L. One anti-leukemia mechanism in K562 cells appeared that BCR/ABL targeted protein was highly down-regulated. The siRNAs (siRNA1384, siRNA1276 and siRNA1786) may prove valuable in the treatment of CML.

최근국제항공보안대책(最近國際航空保安対策)의 제간제(諸間題) -특히 법적측면(法的測面)을 중심(中心)으로- (Some New Problems of International Aviation Security- Considerations Forcused on its Legal Aspects)

  • 최완식
    • 항공우주정책ㆍ법학회지
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    • 제5권
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    • pp.53-75
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    • 1993
  • This article is concerned with the comment on "Some New Problems of International Aviation Security-Considerations Forcused on its Legal Aspects". Ever since 1970, in addition to the problem of failure to accept the Tokyo, Hague and Montreal Conventions, there has been also the problem of parties to them, failing to comply with their obligations under the respective treaties, in the form especially of nominal penalties or the lack of any effort to prosecute after blank refusals to extradite. There have also been cases of prolonged detention of aircraft, passengers and hostages. In this regard, all three conventions contain identical clauses which submit disputes between two or more contracting States concerning the interpretation or application of the respective conventions to arbitration or failing agreement on the organization of the arbitration, to the International Court of Justice. To the extent to which contracting States have not contracted out of this undertaking, as I fear they are expressly allowed to do, this promision can be used by contracting States to ensure compliance. But to date, this avenue does not appear to have been used. From this point of view, it may be worth mentioning that there appears to be an alarming trend towards the view that the defeat of terrorism is such an overriding imperative that all means of doing so become, in international law, automatically lawful. In addition, in as far as aviation security is concerned, as in fact it has long been suggested, what is required is the "application of the strictest security measures by all concerned."In this regard, mention should be made of Annex 17 to the Chicago Convention on Security-Safeguarding International Civil Aviation against Acts of Unlawful Intereference. ICAO has, moreover, compiled, for restricted distribution, a Security Manual for Safeguarding Civil Aviation Against Acts of Unlawful Interference, which is highly useful. In this regard, it may well be argued that, unless States members of ICAO notify the ICAO Council of their inability to comply with opecific standards in Annex 17 or any of the related Annexes in accordance with Article 38 of the 1944 Chicago Convention on International Civil Aviation, their failure to do so can involve State responsibility and, if damage were to insure, their liability. The same applies to breaches of any other treaty obligation. I hope to demonstrate that although modes of international violence may change, their underlying characteristics remain broadly similar, necessitating not simply the adoption of an adequate body of domestic legislation, firm in its content and fairly administered, but also an international network of communication, of cooperation and of coordination of policies. Afurther legal instrument is now being developed by the Legal Committee of ICAO with respect to unlawful acts at International airports. These instruments, however, are not very effective, because of the absence of universal acceptance and the deficiency I have already pointed out. Therefore, States, airports and international airlines have to concentrate on prevention. If the development of policies is important at the international level, it is equally important in the domestic setting. For example, the recent experiences of France have prompted many changes in the State's legislation and in its policies towards terrorism, with higher penalties for terrorist offences and incentives which encourage accused terrorists to pass informations to the authorities. And our government has to tighten furthermore security measures. Particularly, in the case an unarmed hijacker who boards having no instrument in his possession with which to promote the hoax, a plaintiff-passenger would be hard-pressed to show that the airline was negligent in screening the hijacker prior to boarding. In light of the airline's duty to exercise a high degree of care to provide for the safety of all the passengers on board, an acquiescence to a hijacker's demands on the part of the air carrier could constitute a breach of duty only when it is clearly shown that the carrier's employees knew or plainly should have known that the hijacker was unarmed. The general opinion is that the legal oystem could be sufficient, provided that the political will is there to use and apply it effectively. All agreed that the main responsibility for security has to be borne by the governments. A state that supports aviation terrorism is responsible for violation of International Aviation Law. Generally speaking, terrorism is a violation of international law. It violates the sovereign rights of states, and the human rights of the individuals. We have to contribute more to the creation of a general consensus amongst all states about the need to combat the threat of aviation terrorism. I think that aviation terrorism as becoming an ever more serious issue, has to be solved by internationally agreed and closely co - ordinated measures.

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양전자 방출핵종 $^{68}$Ga을 이용한 NOTA와 DOTA의 표지 및 시험관내 특성 연구 (Radiolabeling of NOTA and DOTA with Positron Emitting $^{68}$Ga and Investigation of In Vitro Properties)

  • 정재민;김영주;이윤상;이동수;정준기;이명철
    • Nuclear Medicine and Molecular Imaging
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    • 제43권4호
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    • pp.330-336
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    • 2009
  • 목적: $^{68}$Ge/$^{68}$Ga-제너레이터에서 생산되는 PET용 방사성동위원소인 $^{68}$Ga을 NOTA와 DOTA에 표지하는 조건을 확립하고 이의 안정성 및 단백질 결합 특성을 연구하였고, 여러 가지의 금속이온 공존시 표지효율에 미치는 영향도 관찰하였다. 대상 및 방법: 여러 가지 농도의 NOTA 3HCl과 DOTA 4HCl에 $^{68}$Ge/$^{68}$Ga-제너레이터에서 0.1 M HCl로 용출한 $^{68}$GaCl$_3$ 6.66$\sim$272.8 MBq 1.0 mL와 합치고 초산나트륨 또는 탄산나트륨 완충액을 사용하여 다양한 pH 조건에서 반응하였다. 다양한 금속이온(CuCl$_2$, FeCl$_2$, InCl$_3$, FeCl$_3$), GaCl$_3$, MgCl$_2$, CaCl$_2$)과 0.373 mM NOTA를 $^{68}$Ga(6.77$\sim$8.58 MBq)으로 표지할 때 표지효율을 관찰하였다. $^{68}$Ga의 표지효율은 ITLC-SG고정상으로 하고 아세톤과 생리식염수를 이동상으로 하여 측정하였다. 최적의 pH 조건에서 $^{68}$Ga-NOTA와 $^{68}$Ga-DOTA를 표지한 후 4 시간 동안 안정성을 확인하고, 사람 혈청에서의 단백질 결합능을 평가하였으며, 지용성 정도를 측정하기 위하여 octhanol distribulion 실험을 실시하여 log P값을 구하였다. 결과: $^{68}$Ga-NOTA와 $^{68}$Ga-DOTA의 치적 표지 pH 조건은 각각 pH 6.5와 3.5였고, NOTA는 실온에서 표지가 잘 되었으나 DOTA는 가열이 필요하였다. MgCl$_2$와 CaCl$_2$의 존재는 $^{68}$Ga-NOTA의 표지 효율에 영향을 미치지 않았으나 CuCl$_2$, FeCl$_2$, InCl$_3$, FeCl$_3$, GaCl$_3$이 존재할 경우에는 표지효율이 감소하였다. $^{68}$Ga-NOTA와 $^{68}$Ga-DOTA는 실온에 그대로 두거나 사람혈청과 37$^{\circ}C$에 두었을 때 4 시간 이상 안정하였고, 사람 혈청 단백질 결합능은 2.04$\sim$3.32%로 낮았으며, log P 값은 -3.07로 수용성을 보였다. 결론: $^{68}$Ga의 표지에는 NOTA가 DOTA에 비하여 이상적인 양기능성 킬레이트제로 쓰일 수 있음을 알았다. 또한 $^{68}$Ga-NOTA는 금속이온 존재시 표지효율이 떨어질 수 있지만 안정하고 낮은 단백질 결합을 보였다.