• 감성과학
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• 제14권2호
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• pp.269-278
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• 2011

본 연구에서는 집중력 시에 통상적인 방법으로 사용되는 EEG 선호의 theta/alpha 값과 심박변이도(HRV) 변수들의 상관관계를 분석하기 위함이다. 각 주파수 대역에 따른 EEG 선호의 파행과 자율신경계 변화를 연구한 논문들을 바탕으로, 본 연구에서는 집중상태에 따른 theta파의 변화와 alpha파의 신호를 분석하여 theta/alpha 값으로 중추신경계 변화를 평가하였다. 또한 자율신경계에서 생리학적 변화는 HRV 변수들(beat interval, SDNN, RMSSD, NN50, LF, HF, LF/HF)로 평가/해석하였다. 실험방법은 신경 인지 검사 프로그램인 CNT 4.0을 이용하여 21 명의 건강한 피험자들의 청각 집중력 테스트를 수행하였고, EEG 신호와 PPG 신호를 분석하였다. EEG로부터 추출한 theta/alpha값과 PPG로부터 추출한 HRV변수들은 중다회귀분석을 이용하여 각각의 조합에 따른 두 지표간의 상관관계를 평가하였다. theta/alpha와 심혈관계의 변수들의 상호연관성은 {SDNN(2), HF(6)} 변수가 포함된 3차원 이상의 조합에서 상대적으로 유효하게 나타났다. 결과적으로 고차원 HRV 변수 조합이 저차원 조합보다 theta/alpha 와 상대적으로 높은 상관관계($R^2=0.253$; 7차원)를 나타내었고, 통계적 유의성(p<0.05)을 만족하였다.

• 대한물리의학회지
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• 제14권4호
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• pp.133-142
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• 2019

PURPOSE: This study examined the effectiveness of an active lifestyle on the HRV and fitness of the older female adults. METHODS: Eighty female older adults (72.68±3.78 years) were sampled from a senior wellness institute. Accelerometers were distributed to each participant to have the device attached to them for one week, and the physical activity data (Energy expenditure in Kcal) of each participant were analyzed. Participants were divided into 3 groups (<1,000 Kcal vs 1,000 to 1,500 Kcal vs ≥1,500 Kcal) based on the amount of weekly physical activity. Before and after data analysis, the HRV was measured at resting state and the Senior Fitness Test was performed. RESULTS: One way ANOVA showed a significant difference in the HRV between the three groups. Group A (≥ 1,500 Kcal) was superior in HF and HF/HF + LF whereas Group C (<1,000 Kcal) showed high level of LF, LF/HF, and LF/HF+LF. The same statistics revealed significant differences in fitness. Most of the fitness variables were superior in Group A and B compared to Group C. Significant correlations were observed between physical activity and both HRV and in fitness. CONCLUSION: Theses results suggest that an active lifestyle may be an effective intervention for the prevention of both cardiometabolic disorder and improvement of the fitness level in older female adults.

• 대한한방내과학회지
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• 제29권3호
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• pp.778-786
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• 2008

Objectives : This study was to investigate the short time effect of caffeine on heart rate variability(HRV) and the effect of Neiguan(PC6) acupuncture stimulation on HRV. Methods : 27 healthy adult volunteers were randomly allocated to two groups: Neiguan group (N=13) or placebo group (N=14). The study was carried out under a randomized double-blinded placebo-controlled trial method. Each group orally received the same tablets with 200 mg caffeine. After 1 hour, acupuncture was applied to the Neiguan(PC6) points for the Neiguan group, and for the placebo group was applied to a non-acupuncture point. Both groups were estimated with HRV 3 times, before and after caffeine ingestion, 20 minutes after acupuncture stimulation. Results : After taking caffeine, pulse rate, mean-HRV, and pNN50(the proportion derived by dividing NN50 by the total number of NN intervals) decreased, SDNN(standard deviation of all normal-to-normal (NN) intervals), RMSSD (the root square of successive differences), TP log, HF(high frequency), and HRV index was increased. There were significant changes to the autonomic nervous system after taking caffeine. There were no significant differences between the two groups after acupuncture at Neiguan. Conclusion : Caffeine could induce general activation of the autonomic nervous system. Neiguan acupuncture stimulation may not have significant influence on the autonomic nervous system.

• 대한한방부인과학회지
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• 제28권3호
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• pp.30-39
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• 2015

Objectives This study aims to analyze Heart Rate Variability (HRV) in women after missed abortion compared with healthy women Methods We studied 35 women who visited Kang-Nam Kyung-Hee Korean Hospital after missed abortion from 01 January 2012 to 28 February 2015 (missed abortion group) and 35 normal women visiting medical examination center from 1 January 2014 to 31 December 2014 (Normal Group). We measured HRV of each women and investigated the difference of HRV between two groups. Results The standard deviation of NN intervals (SDNN) in Missed abortion group is lower than normal group. The square root of the mean square difference of successive NNs (RMSSD) in Missed abortion group is lower than normal group. However there was no significant difference. Total Power (TP) and Low frequency power (LF) is significantly lower in Missed abortion group compared with normal group. High frequency power (HF), Very low frequency power (VLF) and LF/HF ratio in missed abortion group is lower than normal group. but There was no significant difference. Conclusions Missed abortion group is lower in function of overall autonomic nervous system, especially sympathetic nerve.

• 한국학교보건학회지
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• 제30권3호
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• pp.266-273
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• 2017

Purpose: This study was performed to compare the mental health of school age children residing in urban and rural areas and to analyze the correlations between the subjective mental health indicators such as depression and attention deficit-hyperactivity behavior and heart rate variability (HRV) indicators. Methods: For this study, a convenience sample of one hundred and three children was recruited. Depression and attention deficit-hyperactivity behavior were measured using self-reported questionnaires and HRV indicators were measured using an electronic instrument. Results: Among the HRV parameters of the rural children, their normalized LF and the LF / HF were significantly lower than those of the urban children. The RMSSD and the normalized HF were statistically significantly higher. The level of depression showed a significant positive correlation with the normalized LF and LF/HF, but showed a negative correlation with the normalized HF. Also, the level of attention deficit-hyperactivity behavior was significantly correlated with the normalized LF, LF/HF, and the normalized HF. Conclusion: Based on the findings, we expect that HRV indicators can be applied to predict the level of depression and attention deficit-hyperactivity behavior in elementary school children.

• 한국어병학회지
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• 제11권2호
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• pp.129-136
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• 1998

1997년 3월 전라남도 및 경상남도의 해산어 육상 및 가두리 양식장에서 양성 중이던 넙치가 HRV(hirame rhabdovirus, Rhabdovirus olivaceus) 감염증과 유사한 증상을 나타내어 그 원인을 조사한 결과 새로운 rhabdovirus가 분리 되었다. 분리 바이러스(DF-9708)는 RTG-2 및 EPC 세포주에서 $15^{\circ}C$로 배양하였을 때 랩도바이러스 특유의 세포변성효과(CPE)를 나타내었으나 CHSE-214에서는 증식되지 않았다. 투과전자현미경으로 감염 세포내의 바이러스 입자 형태를 관찰해본 결과 bullet-shape의 크기 $70nm{\times}100\sim150nm$으로 인벨롭을 가진 바이러스였다. 분리바이러스는 pH 3 및 diethyl ether의 처리 조건에서는 감염성을 상실하였고, 열($50^{\circ}C$ 5 min, $60^{\circ}C$ 1 min)에도 약한 성상을 나타내었다. DNA 저해제인 IUdR $10^{-4}$M 처리에 의해서는 바이러스 감염가에 영향을 받지 않았다. 분리 바이러스는 Anti-HRV(8401-H) rabbit serum에 의해서만 중화 되었고, 전염성 조혈기 괴사증 바이러스(IHNV), 연어과 레오바이러스(CSV), 바이러스성 선회병 바이러스(RVS) 및 전염성 췌장괴사증 바이러스(IPNV) 등의 국내에서 분리되어지는 바이러스 항체로는 중화되지 않았다. 초원심법으로 정제한 분리 바이러스를 전기영동 한 결과 polymerase(L), glycoprotein(G), nucleoprotein(N) 및 2개의 matrix proteins(M1 및 M2)으로 구성되어져 있었으며, 각 단백질의 분자량은 L, 160 kDa; G, 55 kDa; N, 45 kDa; M1, 26 kDa; M2, 22 kDa의 크기로 계산되었다. 새롭게 분리된 바이러스는 외부증상으로는 기존의 HRV 감염과 유사한 점을 나타내었으나 그 바이러스학적 특성에 있어 약간의 차이점이 있어 본 분리바이러스를 우선 Nubchi rhabdovirus(NRV)(HRV-like)로 부르기로 한다.

• 동의신경정신과학회지
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• 제13권1호
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• pp.19-37
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• 2002

Objectives : This study sought to define autonomic functional difference on heart rate variability between headache patients and normal subjects Methods : We determined, heart rate variability of 52 headache patients and 30 normal subjects by means of three time domain measures: Mean PR(mean pulse rate), SDNN(standard deviation of all normal R-R intervals), RMSSD(the square root of the mean of sum of the squares of differences between adjacent normal R-R intervals), and five frequency domain measures: TP(total power), VLF(very low frequency), LF(low frequency), HF(high frequency). Results : 1) RMSSD, TP, HF, HF Norm of HRV decreased with aging and LF Norm, LF/HF increased with aging in headache patients. 2) There was no significant differences between migraine and tention headache in any standard index of HRV, whereas, HRV of total headache patients were smaller than those of normal subjects. 3) In the gender comparison, SDNN, RMSSD, HF of tention headache patients were the smallest and then migraine patients, normal subjects in order with man, whereas, LF Norm, LF/HF of normal subjects were the smallest with man. RMSSD of migraine patients were the smallest and then tention headache patients, normal subjects in order with women. 4) In the term of history of headache patients, SDNN, RMSSD were getting lower as long term. 5) There was no significant differences of HRV in physical symptom of headache patients. Conclusions : All of these results show that standard index of HRV of headache patients were significantly different with normal subjects.

• 대한한의진단학회지
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• 제15권3호
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• pp.245-260
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• 2011

Objectives: The aim of this experiment is to know the effect of Mountain Cultivated Ginseng Pharmacopuncture on Heart Rate Variability (HRV), Pulse wave velocity (PWV) in Middle Aged Women. Methods: We investigated on 40 women of breast cancer patients. First, we measured their Heart Rate Variability(HRV), Pulse wave velocity (PWV) and then Mountain Cultivated Ginseng Pharmacopuncture $20m{\ell}$ were injected on them. After 30 minutes, we measured Heart Rate Variability(HRV), Pulse wave velocity(PWV) again. As a result, method of non-equivalent control group non-synchronized design were used for evaluation. Results: In HRV, Mean HRV is significantly decreased from 69.15 to 63.34 after injection. Mean RR is significantly increased from 877.20 to 962.10 after injection. SDNN is significantly increased from 32.56 to 41.34 after injection. PNN50 is significantly decreased after injection. RNSSD, SDSD, TP, VLF is significantly increased after injection. Stress Resistance ability is significantly increased from 37.55 to 44.60 after injection. And In PWV, E-R, E-L, H-R, H-L is significantly decreased after injection. Conclusions: Effect of Mountain Cultivated Ginseng Pharmacopuncture on Heart Rate Variability (HRV) increased adaptability of autonomic nervous system and on Pulse wave velocity (PWV) decreased arterial stiffness.

• 대한한방부인과학회지
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• 제24권4호
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• pp.95-104
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• 2011

Objectives: The purpose of this study is to investigate the relationship between the degree of menopausal symptom and granulocyte/lymphocyte ratio, and heart rate varibility(HRV). Methods: From 11th April 2011 to 20th May 2011, a total 30 female subjects (age 41-60) was recruited. We evaluated the degree of menopausal symptoms by Kupperman' s index and measured subject's WBC differential count and HRV. The data were analyzed by Kruskal-Wallis test and Spearman correlation test using SPSS/PC ver 13.0 program. Results: 1. There was no statistically significant difference in granulocyte/lymphocyte ratio and HRV among 4 classified groups according to Kupperman's index.- Mild, Moderate, Severe and Urgent. 2. Granulocyte ratio and general symptom score(within Kupperman's index) significantly showed negative correlation coefficient(r=-0.499, p=0.005), and Lymphocyte ratio and general symptom score significantly showed positive correlation coefficient (r=0.374, p=0.042). 3. Granulocyte/lymphocyte ratio and HRV showed no significant correlation. Conclusions: There was no significant relation among the degree of menopausal symptoms and granulocyte/lymphocyte ratio, and HRV. But furthermore large scale study is required.

• Journal of Korean Biological Nursing Science
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• 제23권1호
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• pp.22-30
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• 2021

Purpose: This descriptive study aimed to investigate heart rate variability (HRV) according to sex and to elucidate the influence of negative emotion such as levels of stress, anxiety and depression on HRV among Korean college students based on a neurovisceral integration model. Methods: A descriptive study design was used. Eighty-six healthy college students participated in the study. Resting HRV and standing HRV on orthostatic stimulation were measured for 5 minutes during 4-6 p.m. in the afternoon. Levels of stress, anxiety and depression were assessed using the Global assessment of recent stress, State-Trait Anxiety Inventory and Beck Depression Index, respectively. Results: Out of the 86 students, 47 (54.7%) were men and 39 (45.3%) were women. Root mean square of the differences between adjacent RR intervals (RMSSD) and normalized high frequency (nHF) on standing HRV were significantly lower in men than in women (p= .005, p= .019, respectively). Male gender (β= 0.30, p= .013), higher level of stress (β= -0.36, p= .009) and lower level of depression (β = 0.30, p= .044) exerted a significant influence on decreased nHF in the multiple regression analysis. Conclusion: We suggest that men are more vulnerable to having reduced vagal activity on HRV than women. Since male gender, higher level of stress and lower level of depression level influenced decreased vagal activity, strategies are needed to improve stress and depression rather than anxiety especially for men, which contribute to promoting HRV to prevent cardiac health diseases.