• Sleep Medicine and Psychophysiology
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• v.18 no.1
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• pp.40-44
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• 2011

Narcolepsy is a sleep disorder, which is characterized by excessive daytime sleepiness (EDS) that is typically associated with cataplexy, sleep fragmentation and other REM sleep-related phenomenon such as sleep paralysis and hypnagogic hallucination. Narcoleptic symptoms can be developed from various medical or neurological disorders. A 17-year-old male patient admitted for the evaluation of EDS which started three-month ago. He slept more than 18 hours a day with cataplexy and hypnagogic hallucination. He was obese with body mass index (BMI) of 30.4 kg/$m^2$. After admission he was newly diagnosed to the thyrotoxicosis. T3 391.2 ng/dL (60-181), free T4 4.38 ng/dL (0.89-1.76), TSH <0.01 ${\mu}IU$/mL (0.35-5.5) were measured. His pulse rate ranged 70-90 beats per minute and blood pressure ranged 150/100-120/70 mmHg. Polysomnography revealed many fragmentations in sleep with many positional changes (81 times/h). Sleep onset latency was 33.5 min, sleep efficiency was 47.9%, and REM latency from sleep onset was delayed to 153.6 min. REM sleep percent was increased to 27.1%. Periodic limb movement index was 13.4/h. In the multiple sleep latency test (MSLT), average sleep latency was 0.4 min and there were noted 3 SOREMPs (Sleep Onset REM sleep period) on 5 trials. We couldn't discriminate the obvious sleep-wake pattern in the actigraph and his HLA DQB1 $^*0602$ type was negative. His thyroid function improved following treatment with methimazole and propranolol. Vital sign maintained within normal range. Cataplexy was controlled with venlafaxine 75 mg. Subjective night sleep continuity and PLMS were improved with clonazepam 0.5 mg, but the EDS were partially improved with modafinil 200-400 mg. Thyrotoxicosis might give confounding role when we were evaluating the EDS, though sleep fragmentation was one of the major symptoms of narcolepsy, but enormous amount of it made us think of the influence of thyroid hormone. The loss of sleep-wake cycle, limited improvement of EDS to the stimulant treatmen, and the cataplexy not supported by HLA DQB1 $^*0602$ should be answered further. We still should rule out idiopathic hypersomnia and measuring CSF hypocretin level would be helpful.

• Clinical and Experimental Pediatrics
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• v.48 no.2
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• pp.178-185
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• 2005

Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo-HSCT). Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ${\pm}13$-cis-retinoic acid(CRA) before transplant, and CRA was used, posttransplant, in six patients. Results : Only three patients were in complete remission(CR) at the time of transplantation. Initial chimeric status revealed complete donor chimerism(CC) in five patients, mixed chimerism(MC) in five and autologous recovery(AR) in one. One patient with MC having persistent splenomegaly eventually turned to CC and CR after rapid tapering of cyclosporine, combined with daily use of CRA. An AR case relapsed shortly after transplant but was rescued with second, unrelated cord blood transplantation. Ultimately, six patients are alive, event-free, with a median follow-up of 15.5 months posttransplant. All three deaths occurred in patients who failed to achieve CC, leading to disease progression. Conclusion : We suggest that graft-versus-leukemia effect play an important role and CRA a possible role in posttransplant leukemic involution in JMML. In patients whose leukemic burden is still high with MC after transplant, early tapering of immunosuppressants and introduction of CRA might provide a chance of a cure for some patients.

• Advances in Traditional Medicine
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• v.5 no.4
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• pp.251-261
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• 2005

Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. RA is characterized by chronic inflammation of the synovial membrane in the joint, which leads to the progressive destruction of articular cartilage, ligament and bone. Several cytokines such as tumor necrosis $factor-{\alpha}\;TNF-{\alpha}\;and\;interleukin-1{\beta}\;(IL-1{\beta})$ and interleukin-6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. Genome wide screening of subjects suffering from autoimmune diseases especially arthritis revealed linkage to inflammatory molecules like $TNF-{\alpha},\;IL-1{\beta}$ and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappaB $(NF-{\kappa}B)$ and human leucocyte antigen/major histocompatibility complex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in the light of genome wide screening results has been discussed to reinforce the therapeutic potential and the pharmacological basis of the herbal drugs.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2000.06a
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• pp.258-262
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• 2000

This paper reports on the development of the analysis program of the valve train system, IV-TAP. It is essential to verify the stability of the design and to improve the performance of the system. In order to do that effi챠ently, it is required that integrated and interactive simulation analysis program. IV-TAP is developed in the base of the object-oriented, capsulation, modulization, OLE(objected linking and embedding) and variational design theory. So it contain the expandability and flexibility of the structure. In additon to that, it is programed to make the convenient user interface by using the visualization programming. It can support the modification of the valve element as well as the development of the valve system in the beginning. It is expected to reduce the money and effort for design the valve train system.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.4
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• pp.139-148
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• 2006

Valve train is one of the important noise sources in idling engines. Valve train noise comes mostly from two different impacts. One is the impact between cam and tappet at the beginning of the valve open period, which is an important source of impulsive noise of valve trains. The other is the impact between valve and valve seat at the closing of the valve open period. In case of mechanical lash adjusters, it is very difficult to control the initial impact. In this paper, we designed various types of cam profiles, especially in the opening ramp design, and investigated the effect of cam profiles on the magnitude of the initial impact. The effects that some cam design parameters have on the impulsive noise are also observed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.9
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• pp.3271-3276
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• 2010

Preparing to reclaim the wartime operational control of South Korea's armed forces, Korea Military have to embattle the right capability in relation to conduct of the war. Although Korea Military are operating Joint Exercise Simulation Training System, they are having a lot of difficulties because of interoperability according to a joint exercise with USA military and pursue an independent korea military models. Therefore this study analyzes technical problems and proposes some measures to establish Exercise Simulation System out of regard for South Korea's self defense.

• Journal of the Korea Institute of Military Science and Technology
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• v.10 no.1
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• pp.70-77
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• 2007

Simulation Based Acquisition(SBA) gains interest from the defense acquisition community. To accomplish SBA efficiently, M&S should be collaborately used in. This paper proposes PBA(PlugIn-Based Architecture) that is a common software development infrastructure and provides reuse mechanism with plugin components. PlugIns are reuse entity possible to plug-in-play statically and dynamically. This architecture supports stand alone simulation and HLA-compliant distributed simulation also.

• Proceedings of the Korea Society for Simulation Conference
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• 2002.05a
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• pp.103-108
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• 2002

본 연구는 이산 사건 시스템 형식론(DEVS: Discrete Event System Specification)을 이용한 가상전장 모델링 및 시뮬레이션 방법론을 제안한다. 기존 군체계에 관련된 모델링 기술은 물리적 모델링, 비쥬얼 모델링, 또는 개념적 모델링 등 개별 기능중심의 단편적 플랫폼 모델링에 그치고 있으며, 무기체계 분석 시뮬레이션도 개별 단위체 중심으로 평가되어져서, 다양하고 종합적인 그리고 상호운영성과 재사용성 등을 고려한 통합 모델링 및 시뮬레이션 환경을 제공하지 못하는 단점을 갖는다. 따라서 본 논문에서는 개별 전투병력에서부터 첨단 무기체계에 이르는 다양한 전장 요소들을 계층 구조적으로 통합함으로써 장에서 발생될 수 있는 개별 전투병력의 미시적 행동 특성뿐 아니라 분대/중대/대대/사단급 단위의 거시적 전략/전술에 대한 묘사까지도 가능한 가상전장 모델링 및 시뮬레이션 환경을 제안한다. 제안된 방법론은 분대 단위의 가상 전장 환경에 대한 사례연구를 통해 검증하였으며, 향후 연구로는 대단위 가상전장에 대한 묘사를 위한 HLA 분산 시뮬레이션 기술의 적용에 대한 연구가 필요할 것이다.

• Proceedings of the Korea Society for Simulation Conference
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• 2002.05a
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• pp.53-59
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• 2002

본 연구는 이산 사건 시스템 형식론(DEVS: Discrete Event System Specification)을 이용한 가상전장 모델링 및 시뮬레이션 방법론을 제안한다. 기존 군체계에 관련된 모델링 기술은 물리적 모델링, 비쥬얼 모델링, 또는 개념적 모델링 등 개별 기능중심의 단편적 플랫폼 모델링에 그치고 있으며, 무기체계 분석 시뮬레이션도 개별 단위체 중심으로 평가되어져서, 다양하고 종합적인 그리고 상호운영성과 재사용성 등을 고려한 통합 모델링 및 시뮬레이션 환경을 제공하지 못하는 단점을 갖는다. 따라서 본 논문에서는 개별 전투병력에서부터 첨단 무기체계에 이르는 다양한 전장 요소들을 계층 구조적으로 통합함으로써 전장에서 발생될 수 있는 개별 전투병력의 미시적 행동 특성뿐 아니라 분대/중대/대대/사단급 단위의 거시적 전략/전술에 대한 묘사까지도 가능한 가상전장 모델링 및 시뮬레이션 환경을 제안한다. 제안된 방법론은 분대 단위의 가상전장 환경에 대한 사례연구를 통해 검증하였으며, 향후 연구로는 대단위 가상전장에 대한 묘사를 위한 HLA 분산 시뮬레이션 기술의 적용에 대한 연구가 필요할 것이다.

• Proceedings of the IEEK Conference
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• 2002.07b
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• pp.1324-1326
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• 2002

This paper concerns the development of distributed interactive simulation of a road traffic system. The simulation involved models of multiple and distributed road vehicles running on different locations. The simulation system represented a traffic system as if the distributed simulation models were in the same environment. The development of the distributed road traffic simulation was based on High Level Architecture (HLA), a state-of-the-art IEEE standard for the distributed and real-time simulation. Other work concerned modeling and simulating the road vehicles and building the map database for the virtual distributed shared environment. The information used in the simulation system was only in X-axis and Y-axis as the insignificant data in the Z-axis was omitted to simplify the simulation. However, the traffic system has visualized a 3-D coordinate system. The road vehicle models were able to avoid collision. The next direction of a vehicle can be chosen from the provided choices of further paths.