• Title/Summary/Keyword: HL-60 Cells

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Cultivation Limit of Vitex rotundifolia, Tetragonia tetragonoides and Glehnia littoralis at Coastal Area and Physiological Vitality of RAW 264.7 cell and HL-60 cell (해안지대 순비기나무, 번행초, 갯방풍의 재배한계 및 RAW 264.7 세포와 HL-60세포의 생리활성)

  • Kim, Ji-Hoon;Park, Sun-Soon;Song, Chang-Khil
    • Korean Journal of Medicinal Crop Science
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    • v.16 no.1
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    • pp.44-50
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    • 2008

  • The cultivation boundary areas and biological activator efficacies of Vitex rotundifolia, Tetragonia tetragonoides and Glehnia littoralis were investigated. Investigation of coastal areas revealed the East and West cultivation boundary areas of Vitex rotundifolia and Gelhnia littoralis to be the Taean Peninsula, Taean-gun and Gangwon-do, Donghae-City. The East and West coastal cultivation boundary areas of Tetragonia tetrragonoides are Jeollanam-do and Kyeongsangbuk-do, Ulleung-gun. The natural habitat is less than 200 m from the coastal area. Most of the Vitex rotundifolia, Tetragonia tetragonoides and Glehnia littoralis grow naturally in a region of mixed sand, clay and loam, in direct sunlight. No dominant vegetation was located. To analyze anti-inflammatory efficacy, RAW 264.7 cells were used. Vitex rotundifolia, Tetragonia tetragonoides and Glehnia littoralis inhibited inflammation by 37%, 12% and 10% in $100{\mu}g/m{\ell}$, respectively. However, the anti-inflammatory efficacy of Glehnia littoralis was invalid. Analysis of anti-cancer activity was accomplished using HL-60 cells. Glehnia littoralis revealed 60% and 72% inhibition activity in $100{\mu}g/m{\ell},\;and\;200{\mu}g/m{\ell}$ respectively. No cytotoxicity inhibition activity was investigated in Vitex rotundifolia and Tetragonia tetragonoides.

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The Antiproliferative Effects of Compounds Isolated from Schisandra chinensis (오미자로부터 분리된 화합물의 암세포 증식 억제 효과)

  • Suh, Won-Se;Park, So Yeon;Min, Byung Sun;Kim, Sea Hyun;Song, Jeong Ho;Shim, Sang Hee
    • Korean Journal of Food Science and Technology
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    • v.46 no.6
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    • pp.665-670
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    • 2014

  • We isolated twelve lignans and three terpenoids were isolated from the n-hexane fraction of Schisandra chinensis extract. Using spectroscopic data and comparison with available literature, the following compounds were identified: (1) wuweizisu C, (2) gomisin N, (3) deoxyschisandrin, (4) gomisin A, (5) schisandrin, (6) chamigrenal, (7) schisanlactone D, (8) methylgomisin O, (9) angeloylgomisin O, (10) (-)-gomisin $L_2$, (11) schisandronic acid, (12) (-)-gomisin $L_1$, (13) (+)-gomisin $K_3$, (14) gomisin J, and (15) tigloylgomisin H. Notably, this was the first finding that compound (8) was isolated from this plant. Each compound was evaluated for its in vitro cytotoxic activities toward HL-60 (human leukemia), HeLa (human cervical carcinoma), and MCF-7 (breast cancer) cell lines. Compounds (7), (8), and (9) exhibited strong cytotoxic effects on HL-60 ($IC_{50}$ 7.37, 6.60, and $8.00{\mu}M$, respectively), whereas compound (6) exhibited weak cytotoxicity towards MCF-7 ($IC_{50}$ $30.50{\mu}M$). In addition, compound (8) showed the strongest activity towards HeLa cells ($IC_{50}$ $1.46{\mu}M$).

  • https://doi.org/10.9721/KJFST.2014.46.6.665 인용 PDF KSCI