• Biomedical Science Letters
• /
• v.1 no.1
• /
• pp.27-35
• /
• 1995

Several studies showed that the immunological factors such as CD4+ cell number, CD4%, CD8+ cell number and CD4/CD8 ratio and the serological factors such as, ${\beta}^2$-microglobulin(${\beta}^2$-MG), neopterin, soluble CD4, and soluble CD8 are related to the risk of development of AIDS. Especially, the CD4+ cell counts have been used to monitor progresson of HIV disease, to stratify, and to follow patients in clinical trials. Recently, the Centers for Disease Control and Prevention(CDCP) in USA has made the CD4+ cell count as a part of the classification of HIV disease. It is composed of 3 categories such as 1, 2, and 3 which asr $\geq$ 500/$mm^3$, 200/$mm^{3} $\geq$ and < 500/$mm^3$, and < 200/$mm^3$, respectively. In this study, to estimate the differences of immunological factors between HIV-infected and normal human groups in Korea, CD4+ T and CD8+ T cells, and the CD4/CD8 ratio were measured in 185 HIV-infected subjects and 140 healthy adult subjects. The lymphocyte subsets such as CD4+ T and CD8+ T were analysed by flow cytometer(FACStar) with two-color immunofluorescent stain using monoclonal antibodies such as anti-CD4 and anti-CD8 antibodies. The absolute numbers and percentages of CD4+ T and CD8+ T and the CD4/CD8 ratio of HIV infected persons were $462\pm{277}/mm^3$, $18.2\pm7.7%$, $1,170\pm{534}/mm^3$, $47.0\pm10.6%$ and $0,43\pm0.26 whereas those of uninfected persons were $886\pm{299}mm^3$, $32.9\pm{7.0%}, 730{\pm}259/mm^3$, $26.8\pm6.4%$ and $1.31\pm0.46$(P<0.01). In addition, estimating the reference values of peripheral blood lymphocyte subsets of Korean, the absolute numbers and percentages of CD4+ T and CD8+ T and the CD4/CD8 ratio of 140 healthy adults persons were measured and compared with those of foreigners. The reference ranges of CD4+ T cells, CD8+ T cells, CD4％, CD8%, and the CD4/CD8 ratio and 1.31$\pm$0.46, respectively. The significant differences were not observed when compared with those of foreigners. However a little difference was observed in the percentages of CD4+ T and the absolute numbers of CD8+ T between the normal values of Korean and those of foreigners were $43.6\pm8.9%$, $560\pm{230}/mm^3$. This result can also be useful as a basic data for the treatment and surveillance of HIV-infected patients in Korea.

• RED RIBBON
• /
• s.61
• /
• pp.10-11
• /
• 2004

전세계적으로 2003년 말 HIV감염자는 3,780만 명에 달하며 그중 여성이 차지하는 비율은$45\%$로 1,700만 정도 되며 15세 미만의 감염자가 210만 명을 차지한다. 우리나라의 경우 2004년 6월까지 총 2,842명의 감염자가 있으며 그중 여성 감염자는 288명으로 $10\%$를 차지,$70\%$이상이 20세에서 39세 사이의 가임기 연령이다. 이성간의 성접촉이 주된 감염경로인 아프리카와 아시아 일부 국가를 보면 남녀의 성비가 1:1에 가까운 데 비하여 우리나라 감염자의 성별 분포는 그렇지 않은 게 특징이다. 하지만 감염경로를 고려해 본다면 우리나라에서도 여성 감염자가 앞으로 더욱 증가할 수 있으며, 이는 향후 수직감염에 의한 신생아 감염도 늘 수 있어 무엇보다도 이에 따른 올바른 교육과 적절한 치료가 중요하다고 할 수 있겠다.

• RED RIBBON
• /
• s.63
• /
• pp.20-22
• /
• 2005

항문외과에서 에이즈 감염을 의심해야 할 경우는 항문 성교에 의한 물리적인 병변 및 성병의 형태로 나타나는 경우와 에이즈에 의해 면역이 저하됨에 따라 나타나는 여러 가지 기회 질환의 형태로 나타날 수 있다. HIV 감염자 및 AIDS환자의 항문, 직장 병변은 면역 저하와 관련된 여러 종류의 드문 감염질환과 종양의 형태로 나타날 수 있고 2가지 이상의 질병이 복합적으로 나타나는 경우가 흔하다. 많은 감염이 항문 성교를 받는 동성연애 남성에서 나타나지만 항문 성교의 과거력이 없는 이성 연애 남성 및 여성에게서도 생길 수 있다. 최근에는 이성간의 항문 성교가 HIV 감염의 중요한 원인 중 한가지로 강조되고 있다.

• Pediatric Infection and Vaccine
• /
• v.26 no.1
• /
• pp.66-70
• /
• 2019

Trans-placental neonatal human immunodeficiency virus (HIV) infection is common in Africa; however, it is not yet reported in the Republic of Korea. With the increasing incidence of HIV infection, especially in the reproductive age group, the risk of the vertical transmission of HIV is also increasing. We report the first case of HIV infection acquired in-utero in a newborn in Korea. The baby is growing well with normal development.

• Tuberculosis and Respiratory Diseases
• /
• v.61 no.6
• /
• pp.554-561
• /
• 2006

Background: In AIDS patients, the respiratory tract is one of the most frequently involved site of by an opportunistic infection, and an even common, casual pulmonary infection manifests in a peculiar ways in AIDS patients. In Korea, because of the low prevalence of AIDS, there is insufficient data compared with other Southeast Asian counties. However, considering the sexual behavior of the younger generation, it is expected that it will not be long before AIDS becomes a major public health issue in Korea. This study examined the clinical manifestation of HIV positive people and AIDS patients. The pulmonary manifestion of HIV-positive was evaluated. This study focused on the differences in the clinical manifestation between AIDS patients with pulmonary disease and simple HIV positive people. The characteristics of common pulmonary infections in AIDS patients were also analyzed. Method: The medical records of 28 HIV positive patients who visited the hospital of ChungAng University Hospital from January, 2001 to February, 2006 were analyzed retrospectively. Result: Twenty-seven patients out of 28 HIV positive patients were male and the average age was 40.6(23-65). Patients in their thirties were most commonly affected. Elven patients had pulmonary diseases. Pulmonary tuberculosis (4 cases) and pneumocystis pneumonia (4 cases) were the most common respiratory infection. One patient showed a peculiar type of systemic cryptococcus. which was accompanied by lung and pleural dissemination. The CD4+lymphocyte count of patients with a pulmonary infection was significantly lower in patients with a pulmonary manifestation than those with only a HIV infection ($79.5/mm^3$ vs $400/mm^3$, respectively)(p<.05). Patients with pulmonary disease were in a more severe immunosuppressive state. There were 4 patients with pulmonary tuberculosis, 4 with pneumocystis pneumonia, 4 with secondary syphilis, 2 with primary syphilis, and 2 with HZV infection. The average CD4 lymphocyte counts was $56/mm^3$ in those with pulmonary tuberculosis, $42/mm^3$ in those with pneumocystis pneumonia, and $455/mm^3$ in those with secondary syphilis. Conclusion: This study examined the clinical manifestation of HIV positive patients, particularly AIDS patients with pulmonary disease, A more severe immunosuppressive status was observed in HIV-related pulmonary compared with those with HIV-related extrapulmonary disease, and the frequency of pulmonary tuberculosis in pulmonary disease was higher than expected. Respiratory infection in AIDS manifest in uncommon ways e.g. disseminated cryptococcosis involving the lung and pleura. Evidently, AIDS patients with a respiratory infection have a more severe form of immunosuppression than those with a simple HIV infection. As expected, patients with a pulmonary infection were in a more severe immunosuppressed state than those with a simple HIV infection. Opportunistic infections can show peculiar clinical presentations in AIDS patients.

• RED RIBBON
• /
• s.14
• /
• pp.16-18
• /
• 1997

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.17 no.6
• /
• pp.187-193
• /
• 2017

In order to investigate the relationship between HIV / AIDS and the malformed entertainment industry caused by the prostitution after the prostitution law, this paper visualizes the number of entertainment industry relative to the population density and the number of infected persons using the R program. Also, let's try to grasp the cause of whether any unexpected variable acts via correlation and whether the numerical value of HIV / AIDS-infected person is high in the vicinity of a secret store due to external factors. therefore, In order to create a healthy society, let us examine the goals and attitudes that we should aim for big data analysis through R, and discuss the areas that need further research in the future.

• RED RIBBON
• /
• s.28
• /
• pp.24-26
• /
• 1999

• RED RIBBON
• /
• s.63
• /
• pp.23-23
• /
• 2005

2004년 10월 29일 미국 Department of Health and Human Services (DHHS)에서 발행한 '성인 및 청소년 HIV-1감염자에서 항레트로바이러스제 사용 지침(Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents)'의 내용 중에서 기존의 내용(2004년 3월 발행된 지침)과 변화된 것들을 정리하였다.

• RED RIBBON
• /
• s.55
• /
• pp.34-35
• /
• 2003