• Journal of Integrative Natural Science
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• v.9 no.1
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• pp.41-61
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• 2016

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Phosphoinositide 3-kinases (PI3Ks) play important role in Non-Small Cell Lung Cancer. PI3Ks constitute a lipid kinase family which modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth. Herein, we describe the ligand based pharmacophore combined with molecular docking studies methods to identify new potent PI3K inhibitors. Several pharmacophore models were generated and validated by Guner-Henry scoring Method. The best models were utilized as 3D pharmacophore query to screen against ZINC database (Chemical and Natural) and the retrieved hits were further validated by fitness score, Lipinski's rule of five. Finally four compounds were found to have good potential and they may act as novel lead compounds for PI3K inhibitor designing.

• Proceedings of the Korean Society of Computer Information Conference
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• 2011.06a
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• pp.51-54
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• 2011

Telematics services include automatic location tracking for emergency rescue, which is available for use in case of a car accident due to falling off roadways. This paper presents a simulation study on how far a car will fall before it hits the ground, if dropped off the roadway due to an accident or a natural disaster. The greatest distance the falling car can travel is presented in this paper, on the assumption that air resistance as well as the direction and size of the acceleration due to gravity is negligible.

• Smart Structures and Systems
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• v.23 no.2
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• pp.173-184
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• 2019

The main objective of this study is to evaluate the true fracture energy and monitor the damage progression in steel fibre reinforced concrete (SFRC) specimens using acoustic emission (AE) features. Four point bending test is carried out using pre-notched plain and fibre reinforced (0.5% and 1% volume fraction) - concrete under monotonic loading. AE sensors are affixed at different locations of the specimens and AE parameters such as rise time, AE energy, hits, counts, amplitude and duration etc. are obtained. Using the captured and processed AE event data, fracture process zone is identified and the true fracture energy is evaluated. The AE data is also employed for tracing the damage progression in plain and fibre reinforced concrete, using both parametric- and signal- based techniques. Hilbert - Huang transform (HHT) is used in signal based processing for evaluating instantaneous frequency of the acoustic events. It is found that the appropriately processed and carefully analyzed acoustic data is capable of providing vital information on progression of damage on different types of concrete.

• IEMEK Journal of Embedded Systems and Applications
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• v.16 no.1
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• pp.29-34
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• 2021

We developed a pet care robot that can be controlled outdoors. Through the smartphone application, the pet owners can watch the situation in the house and manipulate the robot to make their pet happy. The video data in the house is transmitted to the application through the webcam installed at the house. The robot can not only perform user's command but also do six basic macro action. The obstacle avoidance function using the current sensor can be activated if the user want to use. When the robot hits to something, it moves back and rotates by arbitrary angle, and then moves forward.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.05a
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• pp.587-590
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• 2020

스마트폰, GPS 장비, 위치 기반 소셜네트워크의 발달로 방대한 이동 경로 데이터 수집이 가능하게 됐다. 이를 통해 다양한 분야에서 GPS 데이터를 가지고 사람의 이동성을 분석하고 POI를 예측하는 기회가 많아졌다. 실생활에서 사람의 이동성은 다양한 상황에 영향을 받지만, 실제 GPS 데이터는 위치, 시간 정보의 수준이다. 따라서 다양한 상황을 내재하는 정보가 사람의 이동성 분석과 POI 예측에 필요하다. 본 논문에서는 POI의 순위, 사용자의 POI 활동, 카테고리 선호도 같은 맥락적 특징을 이용하여 이에 관련된 상황에 맞는 POI 시퀀스를 예측하는 Contextual LSTM 기반 딥러닝 기법을 제안한다. Contextual LSTM은 사람의 이동성에 영향을 주는 시퀀스의 맥락적 특징을 모델에 통합하기 위해 LSTM을 확장한다. 제안된 기법은 HITS 알고리즘과 여러 제약조건 기반으로 추출한 맥락적 특징별로 딥 러닝 모델에 통합하여 각각 POI 시퀀스를 검출했으며, 다양한 맥락적 특징에 대해서 공공 데이터와 수집한 데이터로 평가하였다.

• Asia Marketing Journal
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• v.11 no.2
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• pp.53-72
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• 2009

In the summer of 2008, the movie Dachimawa Lee: Villain, Get on the Express to Hell is waiting for its first release. This movie is based on a short film which was tremendously popular when it was first introduced on the internet in 2000, and the director Ryu Seung Wahn is expecting a mega hit of the movie this summer. Showbox is one of the leading movie distributors in Korea. After a series of blockbuster hits such as Welcome to Dongmakgol, The Host, and The Chaser, Showbox is now in stagnation. Along with sluggish economy in Korea, most of recent movies distributed by them didn't even reach the breakeven. However, expectation on the upcoming movie, Dachimawa Lee, is higher than ever. Marketing department of Showbox has to decide what kind of media channel to choose and which marketing strategy to apply. It needs to make a decision about whether to target the so-called mania group or the general public of much bigger size. In this case study, the distinctiveness of the movie marketing and its process will be discussed. Moreover, the marketing strategies for Dachimawa Lee's success will be examined in the Showbox's point of view.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.193-197
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• 2016

The performance of Precision Guided Missiles is estimated by using hit probability only, which is calculated by hits against total amounts of fires in current domestic live-fire tests. It has a limitation in judging the performance of all produced Precision Guided Missiles by using the calculated hit probability according to the result of live-fire test, because the overall characteristics of the produced Precision Guided Missiles are not considered. In other words, a method is needed to estimate the confidence level which is more reliable than simply calculated hit probability according to the result of live-fire test for guaranteeing the hit probability of Precision Guided Missiles by certain level, which is already being operated or produced. This paper introduces a method to estimate the confidence level of Precision Guided Missiles by minimum live-fire tests using Hypergeometric distribution and Bayes' rule suitable for the characteristics of Precision Guided Missiles, which are small production, high costs and unable to check whether the missile hits the target or not before the live-fire tests. Also, this paper suggests a reasonable confidence level for showing the performance of the Precision Guided Missiles using the results of live-fire tests and domestic and foreign literature, when the result of live-fire tests will be decided.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.273-286
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• 1997

Objective：This study was designed to evaluate effects of methylphenidate(MPH) on event-related potentials(ERP) and continuous performance test(CPT) in attention-deficit hyperactivity disorder (ADHD) and to see the correlation between changes in ERP and changes in performance. Method：ERP and CPT were used to examine the acute effects of MPH(0.5mg/kg) in eleven ADHD boys(89-103 months old). Results：1) After MPH administration, P3 latency to nontarget stimuli at Fz was significantly decreased (p<0.01) and P2 amplitudes to target stimuli at Pz and at Oz and P3 amplitude to target stimuli at Cz were significantly increased(p<0.05). 2) Commission error and omission error in the CPT-X and commission error in the CPT-AX were decreased(p<0.01), and hits and perceptual sensitivity(d') in the CPT-X and d′ in the CPT-AX were increased(p<0.01). 3) The change of P3 latency to nontarget stimuli at Fz and the change of d′ in the CPT-X were negatively correlated(p<0.05), and the change of P2 amplitude to target stimuli at Pz and d′ in the CPT-AX were positively correlated(p<0.05). Conclusion：MPH improves change orienting reaction, the delivery of task relevant information, accuracy and perceptual sensitivity in ADHD. And the increase of ability to discriminate targets from non-targets reflects reduced evaluation time in large memory component task and enhanced change orienting reaction in simple task.

• The Korean Journal of Malacology
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• v.28 no.4
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• pp.377-384
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• 2012

The importance of biological resources has been gradually increasing, and mollusks have been utilized as main fishery resources in terrestrial ecosystems. But little is known about genomic and transcriptional analysis in mollusks. This is the first report on the transcriptomic profile of Meretrix lusoria. In this study, we constructed cDNA library and determined 542 of distinct EST sequences composed of 284 singletons and 95 contigs. At first, we identified 180 of EST sequences that have significant hits on protein sequences of the exclusive Mollusks database through BLASTX program and 343 of EST sequences that have significant hits on NCBI NR database. We also found that 211 of putative sequences through local BLAST (blastx, E < e-10) search against KOG database were classified into 16 functional categories. Some kinds of immune response related genes encoding allograft inflammatory factor 1 (AIF-1), B-cell translocation gene 1 (BTG1), C-type lectin A, thioester-containing protein and 26S proteasome regulatory complex were identified. To determine phylogenetic relationship, we identified partial sequences of four genes (COX1, COX2, 12S rRNA and NADH dehydrogenase) that significantly matched with the mitochondrial genomes of 3 species-Ml (Meretrix lusoria), Mp (Meretrix petechialis) and Mm (Meretrix meretrix). As a result, we found that there was a little bit of a difference between sequences of Korean isolates and other known isolates. This study will be useful to develop breeding technology and might also be helpful to establish a classification system.

• Journal of Korea Entertainment Industry Association
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• v.14 no.4
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• pp.169-186
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• 2020

This study selected 127 powerful Korean film producers, directors, and actors whose stable audience drawing power has been proven over the past seven years from 2013 to 2019, and viewed their network through social network analysis(SNA) to explain their power structure. It also explained the changes compared to the results of previous studies conducted on box office hits from 1998 to 2012. The producers who showed the highest audience drawing power over the past seven years were KANG Hae-jung, JANG Won-seok, LEE Eugene, HAN Jae-duk. BONG Joon-ho, KIM Yong-hwa, and RYOO Seung-wan as directors and SONG Kang-ho, HA Jung-woo, and HWANG Jung-min as actors were confirmed to exhibit the most stable audience drawing power. Meanwhile, the network formed by the 127 leading producers, filmmakers, and actors was analyzed based on closeness/ degree/eigenvector/betwenness centrality, and the result discovered a strong network involving JANG Won-seok, HAN Jae-duk, CHO Jin-woong, Don LEE, and HWANG Jung-min. This study is meaningful in that it included producers, the position which has never been discussed in previous local studies to analyze the network influencing star casting, and selected accurate box office hits by checking whether the concerned films actually reached break-even point rather than simply relying on the number of audiences or total revenue they garnered. Nonetheless, it left a hole to be filled in that it did not include the role of the management companies in the network. Therefore, a relevant follow-up discussion would be needed.