• Journal of Gastric Cancer
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• v.3 no.1
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• pp.19-25
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• 2003

Purpose: Dysregulation of apoptosis may attribute to development of cancer by abnormally prolonging cell viability with accumulation of transforming mutations. Survivin and HIAP (Human Inhibitors of Apoptosis)-1 were recently described as apoptosis inhibitors. Their pathogenic roles in gastric cancer are largely unknown. In the present study, we examined the expression of survivin and HIAP-1 in gastric cancer tissues and cell lines in order to elucidate the roles of survivin and HIAP-1 in the process of gastric carcinogenesis. Materials and Methods: Eight gastric cancer cell lines and five gastric cancer tissues were studied. The expression of survivin and HIAP-1 were evaluated by reverse transcription -polymerase chain reaction (RT-PCR), immunohistochemistry, and Western blot. Results: Western blot and RT-PCR analysis revealed survivin and HIAP-1 expression in all gastric cancer cell lines. Increased expression of survivin and HIAP-1 were found in all cases of gastric cancer tissues compared to normal tissues by Western blot analysis. In immunohistochemical analysis tumor cells were stained with anti-survivin and anti-HIAP-1 antibodies. Cell cycle dependence of survivin expression was preserved in gastric cancer cell lines. Conclusion: The results indicate that increased expression of survivin and HIAP-1 genes may play an important role in gastric cancer.

• 한국정보디스플레이학회:학술대회논문집
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• 2008.10a
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• pp.1645-1648
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• 2008

We successfully fabricated lowest-cost superior perform ance MVA LCDs with highest-yield, high transmission, high contrast-ratio, and wide viewing angle. Using the amplified intrinsic fringe field (AIFF) controlled MVA invented by Ong, we eliminated all protrusions and ITO slit geometries. We further achieved: (1) faster gray-gray response times without the over-drive technology, (2) faster tough mura, and (3) lower flicker and cross-talk in the row inversion driving schemes.