• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2505-2510
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• 2014

Background: The standard radiotherapy (RT) fractionation practiced in India and worldwide is 50Gy in 25 fractions over 5 weeks to the chest wall or whole breast followed by tumour bed boost in case of breast conservation (BCS). A body of validated data exists regarding hypofractionation in breast cancer. We here report initial results for 135 patients treated at our center with the START-B type of fractionation. Materials and Methods: From May 2011 till July 2012, women with all stages of breast cancer (excluding metastatic), who had undergone BCS or mastectomy were planned for 40Gy in 15 fractions over 3weeks to chest wall/whole breast and supraclavicular fossa (where indicated) followed by tumour bed boost in BCS patients. Planning was done using Casebow's technique. The primary end point was to assess the acute toxicity and the cosmetic outcomes. Using cosmetic scales; patients were assessed during radiotherapy and at subsequent follow up visits with the radiation oncologist. Results: Of the 135 patients, 62 had undergone BCS and 73 mastectomy. Median age of the population was 52 years. Some 80% were T1&T2 tumours in BCS whereas most patients in mastectomy group were T3&T4 tumours (60%). 45% were node negative in BCS group whilst it was 23% in the mastectomy group. Average NPI scores were 3.9 and 4.9, respectively. Most frequently reported histopathology report was infiltrating ductal carcinoma (87%), grade III being most common (58%), and 69% were ER positive tumours, and 30% were Her 2 Neu positive. Triple negative tumours accounted for 13% and their mean age was young (43 yrs.) The maximum acute skin toxicity at the end of treatment was Grade 1 in 94% of the mastectomy grouppatients and 71% in BCS patients. Grade 2 toxicity was 6% in mast group and 23% in BCS group. Grade 3 was 6% in BCS group, no grade 3 toxicity in mastectomy patients and there was no grade 4 skin toxicity in any case. Post RT at 1 month; 39% of BCS patients had persisting Grade I skin reaction which was only 2% in mastectomy patients. At 3 months post RT, 18% patients had persisting hyperpigmentation. At 6 months 8% patients had persisting erythema in the BCS group only. Some 3% BCS and 8% mastectomy patients had lymph edema till the date of evaluation. Cosmetic outcome in BCS patients remained good to excellent 6 months post surgery and radiotherapy. 1 patient of BCS and 3 patients of mast had developed metastatic disease at the time of evaluation. Conclusions: Hypofractionated RT is well tolerated in Indian population with reduced acute skin toxicity and good cosmetic outcome. Regimens such as these should be encouraged in other centers to increase machine output time. The study is on-going to assess long term results.

• 유통과학연구
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• 제9권2호
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• pp.131-140
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• 2011

본 연구는 자금의 고령화 사회에서 실버소비자의 웰빙을 향상시키기 위한 근본적인 마케팅노력이 필요하다는 관점에서, 실버마케팅과 소비자웰빙의 연관성에 이론적 근거를 두고 있으며, 그 구체적인 연구목적은 첫째, 실버소비자의 건강기능 제품 만족을 결정하는 소비 전(全) 단계의 여러 가지 만족 요인이 실제로 소비자 웰빙에 영향을 미치는가를 일차적으로 실증 분석하고, 둘째, 제품 만족요인에 의해 소비자 웰빙을 가져오는 그 과정에서 실버소비자의 건강기능제품의 제품지식이 어떻게 영향을 미치는가를 이차적으로 실증 분석하는 데 둔다. 따라서, 실버소비자의 건강기능제품에 대한 제품만족은 건강관련 소비자 웰빙에 긍정적인 영향을 미칠 것이다. 연구가설 1과 실버소비자의 건강기능제품에 대한 제품지식에 따라 제품만족이 건강관련 소비자 웰빙에 미치는 영향은 긍정적으로 강화될 것이라는 연구가설 2를, 설문조사를 통한 자료수집과 통계적 실증분석에 의해 검증하였다. 검증결과, 연구가설 1은 채택되었으며, 연구가설 2는 부분적으로 채택되었다. 본 연구의 건강기능제품의 효율적 웰빙마케팅을 위한 실무적 시사점은 다음과 같다. 첫째, 건강제품의 실버소비자 웰빙수준을 높이기 위해서는 소비 사이클 전반에 걸친 다각적인 노력이 필요하며, 구입-준비-소비-유지-처분 전(全)단계에서 소비자의 장기적인 만족을 위한 건강기능제품을 개발해야 한다. 또한 소비자 웰빙은 다양한 욕구의 총합으로 구성되므로, 긍정적 정서적 경험의 증대와 부정적 정서적 경험의 저감의 목표를 동시에 충족시키기 위한 노력이 필요할 것이다. 둘째, 건강기능제품에 관한 실버소비자의 지식을 높이기 위한 마케팅 노력이 동시에 이루어져야 할 것이다 즉, 실버소비자의 제품지식을 높이기 위해서는 건강기능제품에 대한 친숙성과 전문성을 제고하고 다양한 경로를 통해 그들의 제품지식을 높이는 것이 필요하다. 단, 본 연구의 분석결과는 건강기능제품에 관한 소비자의 높은 지식은 건강기능제품의 준비만족과 유지만족에의 관점에서만 소비자웰빙에 긍정적인 효과의 강화를 보인다는 점에서 제한적이라고 할 수 있지만, 이러한 분석 결과는 제품지식이 준비단계의 욕구와 밀접한 관계를 가지며 유지단계의 정보 이용에 더욱 관련성이 있을 것이라는 선험적 인식을 보여 주고 있다. 결론적으로 실버소비자를 대상으로 제품만족, 제품지식 및 소비자웰빙에 대한 실증 연구가 부족한 실정에서 본 연구의 시도는 시의성이 있을 것으로 판단된다. 특히 실버소비자의 건강기능제품의 소비와 관련하여 제품만족의 전 단계가 소비자웰빙에 어떻게 영향을 미치는지에 대한 인과관계를 규명하였고, 그 과정에서 제품지식 수준의 조절변수 효과가 부분적으로 존재할 가능성이 있음을 관찰하였다는 점이 웰빙마케팅 연구에 기여하는 바라고 할 수 있을 것이다.

• 감성과학
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• 제18권1호
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• pp.39-48
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• 2015

P300 숨긴정보검사는 전통적인 대응수단에 큰 영향을 받지 않는 것으로 알려져 있다. 본 연구에서는 전형적인 세 자극 프로토콜을 사용한 P300 숨긴정보검사가 새로운 대응수단에 영향을 받는지 검증하였다. 세 가지 유형의 대응수단을 사용하였다. 첫 번째는 순차적 대응수단으로, 무관련자극이 제시될 때마다 왼손 검지손가락에 힘주기, 오른쪽 발가락에 힘주기, 마음속으로 어머니 이름 부르기, 마음속으로 아버지 이름 부르기를 순서대로 하나씩 수행하는 것이었다. 나머지 두 개의 대응수단은 부분 매칭 대응수단으로 네 개의 무관련자극 중 특정한 2개의 무관련자극에만 반응을 하는 것이었다. 두 번째는 행동적 부분 매칭 대응수단으로, 특정한 한 무관련자극이 제시되면 왼손 검지손가락에 힘을 주고, 특정한 다른 무관련자극이 제시되면 오른쪽 발가락에 힘을 주는 것이었다. 세 번째는 정신적 부분 매칭 대응수단으로, 특정한 한 무관련자극이 제시되면 마음속으로 어머니 이름을 부르고, 특정한 다른 무관련자극이 제시되면 마음속으로 아버지 이름을 부르는 것이었다. 실험결과, 순차적 대응수단을 사용하는 것은 예상과는 달리 P300 숨긴정보검사의 정확판단율을 77%에서 92%로 증가시켰다. 부분 매칭 대응수단은 P300 숨긴정보검사의 정확판단율에 부정적인 영향을 미쳤다. 물리적 대응수단은 정확판단율을 77%에서 46%로 감소시켰으며, 정신적 대응수단은 정확판단율을 100%에서 69%로 감소시켰다. 대응수단의 사용을 억제하거나 탐지할 수 있는 기법의 개발 필요성을 논의하였다.

• 만화애니메이션 연구
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• 통권24호
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• pp.25-48
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• 2011

환상은 역사적인 측면과 공시적 측면을 살펴 볼 때, 크게 경이와 기괴의 두 가지 계열성을 가지며 다양한 의미체계를 가진다. 경이는 고전적인 형이상학체계와 마법담의 전통을 한 축으로 하는 조화롭고 풍부한 환상의 세계이고, 기괴는 근현대의 문제적 의식으로부터 출발하여 부조리와 부정적 진실을 발견하고자 하는 전복적인 환상 세계이다. 만화에서는 매체적 특징상 리얼리티보다 환상을 사용하기가 유리하다. 그러나 환상과 만화의 연관관계가 구체적으로 논의된 바는 드물다. 본 논문은 환상에 대해 기괴와 경이의 계열성으로 이해하는 데서부터 출발하여 기괴와 경이의 다양한 조합을 드러낸 만화작가 유시진의 작품들의 경향을 살펴봄으로써 각 계열의 환상이 만화의 개별 작품의 스타일과 주제의식에 어떻게 영향력을 주고받는지 알아보았다. 작가 유시진은 현대 작가답게 기괴 계열의 감성으로 작품을 시작하였으나 자의식과 관련된 주제를 발전시켜가면서 동시에 견고한 2차세계의 경이계열 환상세계를 구축하고자 노력했다. 그러나 "신명기"에서 환상세계가 작품의 주제를 압도하는 양상을 겪었다. 이후 작품인 "폐쇄자"와 "온"에서는 자의식을 붕괴하고, 새롭게 만들어가는 과정을 혼합된 환상양식을 통해 이루었고, 이러한 터닝 포인트 이후 유시진의 작품은 주제의식과 환상양식에 있어서 보다 일관되게 기괴 계열의 성향을 드러내고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1347-1350
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• 2016

Background: Breast cancer prognosis is influenced by several histopathology and clinical factors including expression of Ki67 which may have a predictive role in lymph node negative breast cancer patients. The aim of this study was to assess Ki67 expression in breast cancers without axillary lymph node involvement and to evaluate its prognostic value with regard to disease-free survival. Materials and Methods: Subjects were selected from non-metastatic invasive breast cancer patients who were referred to the oncology department of Ghaem hospital during 1 April 2001 to 1 April 2008. Ki67 levels were measured using immunohistochemistry (IHC) and compared with clinicopathological features. The relation of Ki67 expression with disease-free survival was also analysed. Results: A total of 106 women with a mean age of 49 were examined. Some 94.3% were classified as having invasive ductal carcinomas and the mean tumour diameter at the time of diagnosis was 2.8 cm. Some 50.9% of cases were ER positive and 47.2% were PR positive. P53 expression was positive in 48.1% of the cases. According to the IHC results, only 8.5% of the patients were Her2/neu positive. Ki67 was positive in 66 (62.3%) with a significant relation to lower age (p=0.0229) and P53 positivity (p=0.005). After an average of 40-months follow up, 13 (12.3%) demonstrated recurrence, most commonly systemic. Of 13 cases with relapse, 10 patients (77%) were Ki67 positive. Conclusions: In our population Ki67 appeared to be an independent prognostic factor for three-year survival. However, we stress that a survival study with a bigger sample size would help to support this conclusion.

• 한국학교보건학회지
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• 제15권1호
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• pp.63-72
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• 2002

The purpose of this study was to find out the relationship between self-esteem and mental health in Middle school students, and provided basic data to develop a nursing program for the prevention of mental disease and the promotion of mental health in adolescence. Subjects were 153 students in the third year of three middle schools located in K city. Instruments used in this study were the self-esteem questionnaire developed by Choi, B. K. & Jun, G. Y.(1993) and the simplified SCL-90 developed by Lee, H. K.(1986) for measuring mental health. Data were analyzed by Cronbach's alpha, descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient by using SPSS/PC+ program. It was found that the mean score of the self-esteem was 3.20. The score of self-esteem in family was high and the score of self-esteem in school was low. The mean score of mental health was 1.94. The scores of depression, obsessive-compulsive and interpersonal sensitivity were high, the scores of phobic anxiety and somatization were low. There were significant differences among religions (F=2.709, p= .032), and between personalities (t=-2.285, p= .024) with respect to self esteem. There were no significant differences between general characteristics variables and mental health. However there was significant negative correlation between the mean self-esteem score and the mean mental health score (r=-.431, p= .000). In conclusion, mental health is strongly related to self-esteem. If and adolescent who suffers from mental health is not received proper treatment, his or her mental health prohibits him from managing sound social life even after grown-up. Thus, nursing intervention in adolescence should be developed to enhance the self-esteem of adolescence and to help him raise sound mind.

• 말소리와 음성과학
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• 제7권4호
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• pp.93-99
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• 2015

In case of PAS test, the air is sometimes leaked although the mask is tightly attached to the face, which is not reliable on the measured values. Therefore, this study aimed to assist the clinical practice suggesting the test method of PAS without air leakage. In the healthy subjects with 12 males and 12 females over 19 years old, three types of tests were performed on the voicing efficiency among the protocol of PAS Model 6600. They are; first, to attach the mask tightly to the face holding the handle of PAS with the subject's two hands (Method 1); second, to attach the mask tightly to the face holding the handle of PAS with the subject's one hand and pushing the body of PAS strongly with the other hand (Method 2); and third, to attach the mask tightly to the face pushing the upper part of the mask by the tester when the subject attached the mask to his or her face holding the handle of PAS with two hands (Method 3). Upon the study analyses, the mean negative pressure, the mean phonogram, subglottic air pressure, and voicing efficiency were shown to be statistically significantly different during PAS test in males depending on the methods. (p<.05) In case of females, only the target airflow rate showed significant difference depending on the methods during PAS test. (p<.001) In conclusion, Method 2 enhanced the noise level and strength while Method 1 was likely to leak the air more compared to the other two methods in males. In case of females, Method 1 showed significant leakage of the air flow. Not to allow the air flow leakage without affecting the outcome of PAS test, it will be the most useful for the tester to push the mask to the subject's face tightly (Method 3).

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제24권2호
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• pp.57-64
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• 2013

This study was conducted to evaluate the psychological changes and influences of child actors depending on their role. First, we met the film producer of Dogani and discussed about the filming condition. Second, we visited filming locations during the filming of Neighborhood, when shooting of parts involving the female child actor was taking place and evaluated the emotional states of the child actor before and after she played her role. Third, we interviewed various people of the movie industry, which included adult actors, directors, a professor of films and broadcasting who was a former child actor and a scriptwriter. In case of the film Dogani, the production crew provided enough care and protection and we concluded that child actors had no psychological sequelae. After interviewing the child actor and visiting filming locations, we confirmed that the child actor was not influenced by playing certain roles. In addition, after interviewing various people related to filming, we thought that child actors might not have psychological sequelae related to the character played. To the best of our knowledge, this is the first study about influences of the playing character for child actors. We concluded that playing certain roles would not have negative effects on child actors.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1277-1280
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• 2015

Aim: To report epidemiologic and anatomoclinical transitions of inflammatory breast cancer (IBC) in Tunisia. Materials and Methods: Data including clinico-pathological data for 208 cases of T4d or PEV 3 non-metastatic breast cancer diagnosed between 2005 and 2010 were collected from patient records. Chi2 and Z tests were used to compare variables with two Tunisian historical series and a series about Arab-American patients. Results: Thirty three percent of our patients had their first child before 23 years of age and 56% had their menarche before 12 years, 75% never receiving oral contraception. Obesity was observed in 42% of women and IBC occurred during pregnancy in 13% of cases. Tumor grade was II-III in 90% of cases, HR was negative in 52%, HER2 was over expressed in 31% and invasion of more than 3 axillary nodes occurred in 18% of patients. We observed a pCR rate of 19% after neoadjuvant treatment (anthracyline-taxane used in 79%, trastuzumab in 27% ). Compared to historical Tunisian series (since 1996), IBC epidemiology remained stable in terms of median age, menopausal status and obesity. However we observed a significant decrease in median clinical tumor size and number of positive axillary lymph nodes. Comparison to IBC in Arab-Americans showed a significant difference in terms of median age, menopausal status, positivity of hormonal receptors and educational level. Conclusions: Our assessment of epidemiologic transition showed a reduction of clinco-pathological stage of IBC, keeping the same characteristics as compared to Tunisian historical series over a period of 14 years. Features seem to be different in Arab-American patients, probably related to migration, "occidentalization" of life style and improvement in socio-economic level.

• 한국콘텐츠학회논문지
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• 제16권3호
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• pp.102-115
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• 2016

본 연구는 중학생 청소년의 학대피해경험이 자아탄력성에 미치는 영향과 사회적 지지의 조절효과를 살펴보았다. 이를 위하여 부산시내 중학생 1, 2, 3학년 568명을 대상으로 조사하여 분석하였다. 먼저 청소년의 피학대경험은 자아탄력성에 영향을 미치는 것으로 나타났다. 구체적으로 학년이 낮을수록 그리고 학대피해 경험이 없을수록 자아탄력성은 증가하였다. 두 번째, 청소년의 피학대경험이 자아탄력성에 미치는 영향에서 사회적 지지는 조절효과를 가는 것으로 나타났다. 이상의 결과를 중심으로 학대피해 청소년의 부정적 경험에도 불구하고 자신의 환경과 상황을 이겨낼 수 있는 힘이라고 할 수 있는 자아탄력성을 높이기 위하여 가정, 학교, 지역사회와 국가의 사회적 지지 방안을 제언하였다.