• Journal of Korean Neurosurgical Society
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• v.50 no.5
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• pp.426-433
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• 2011

Objective : The Histoculture Drug Response Assay (HDRA), which measures chemosensitivity using minced tumor tissue on drug-soaked gelfoam, has been expected to overcome the limitations of in vitro chemosensitivity test in part. We analyzed interim results of HDRA in malignant gliomas to see if the test can deserve further clinical trials. Methods : Thirty-three patients with malignant gliomas were operated and their tumor samples were examined for the chemosensitivity to 10 chosen drugs by HDRA. The most sensitive chemotherapy regimen among those pre-established was chosen based on the number of sensitive drugs or total inhibition rate (IR) of the regimen. The response was evaluated by 3 month magnetic resonance image. Results : Among 13 patients who underwent total resection of the tumor, 12 showed no evidence of disease and one patient revealed progression. The response rate in 20 patients with residual tumors was 55% (3 complete and 8 partial responses). HDRA sensitivity at the cut-off value of more than one sensitive drug in the applied regimen showed a sensitivity of 100%, specificity of 60% and predictability of 70%. Another cut-off value of >80% of total IR revealed a sensitivity of 100%, specificity of 69%, and predictability of 80%. For 12 newly diagnosed glioblastoma patients, median progression-free survival of the HDRA sensitive group was 21 months, while that of the non-sensitive group was 6 months ($p$=0.07). Conclusion : HDRA for malignant glioma was inferred as a feasible method to predict the chemotherapy response. We are encouraged to launch phase 2 clinical trial with chemosensitivity on HDRA.

• Korean Journal of Organic Agriculture
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• v.10 no.3
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• pp.1-24
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• 2002

This study aims to provide quite recent information on the organic agriculture in developed countries such as German, UK, Switzerland and USA and on the current activities of international research institutions of organic agriculture. The establishment and activity of ENOF in EU and ARNOA in Asia, IIRNOA in IFOAM was introduced shortly. I stitute of Organic Agriculture in FAL/Germany and FiBL in Switzerland. OMRI in USA, HDRA in UK and Schweisfurth Foundation in Germany were described. Also the educations in European universities for organic agriculture and the research activities and technical education system for organic farming were described. All of these informations could be useful for the further development of the strategy for Korean organic agriculture in education and research.