• 대한한방소아과학회지
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• 제20권1호
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• pp.219-240
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• 2006

Objective : This experimental study was designed to determine the anti-obestic effects of Bangpoongtongsungcankamibang(BTSK). Method : In vitro, BTSK extracts of various concentration (50,100, 200 $200{\mu}g/ml$)were added examination. The protein and mRNA expression of $C/EBP{\alpha}$ and $PPAR{\gamma}$ receptor was measured by western blot assay and RT-PCR. In vivo, BTSK extracts of various concentration (100, $200{\mu}g/ml$) were orally administered to induced hyperlipidemic rats by poloxamer-407 for consecutive four weeks and serum triglyceride, total cholesterol were measured. This method applied to induced hyperlipidemic rats by triton WR-1339, too. Obesity induced rats by the high fat-diet for six weeks were orally administered BTSK extracts of various concentration (100, $200{\mu}g/ml$) and serum triglyceride, total cholesterol, LDL-cholesterol, triglyceride, LDL-cholesterol, triglyceride, HDL-cholesterol, hydroxy radical, superoxide dismuatse activity were measured. Results : I. In vitro 1. The 3T3-L1 cells' differentiation was significantly decreased by BTSK. 2. expression of $C/EBP{\alpha}$ and $PPAR{\gamma}$ was was significantly decreased by BTSK. II. In vitro 1. BTSK significantly reduced serum triglyceride, total cholesterol, contents in poloxamer-407 treated rat. 2. BTSK significantly reduced serum triglyceride, contents in Triton WR-1339 treated rat. But Total cholesterol did not show a significant change. 3. BTSK significantly reduced body weight gain of rat and adipose tissue mass of rats and serum triglyceride, LDL-cholesterol, contents and significantly increased HDL-cholesterol, HTR(HDL-cholesterol/Total-cholesterol) in rats with obesity induced by the high fat-diet. 4. BTSK reduced blood lipid peroxide, hydroxy radical and increased superoxied dismuatse(SOD) activity.

• BMB Reports
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• 제38권2호
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• pp.238-242
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• 2005

5-HT2A is one of major serotonin receptor that is involved in the action of serotonin-targeting drugs. Previous clinical studies have shown an unexpected association between lower cholesterol level and psychiatric diseases, in which T102C polymorphism of HTR2A, gene of 5-HT2A serotonin receptor, might be involved. Therefore, we hypothesized a potential association between lower cholesterol level and T102C polymorphism. The effect of the T102C polymorphism on the serum lipid profiles of 646 subjects without specific psychiatric disease was investigated. Genotype was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. There were significantly lower levels of total cholesterol ($193.6{\pm}35.0$ versus $202.1{\pm}45.5\;mg/dl$, p = 0.016) and HDL-cholesterol ($42.7{\pm}11.6$ versus $46.3{\pm}12.7\;mg/dl$, p = 0.004) in CC genotype than non-CC genotypes. Moreover, multivariate analysis showed that the CC genotype is a strong predictor of a lower HDL-cholesterol level (p < 0.001). In conclusion, this study shows that the CC genotype of the HTR2A gene is related to lower HDL-cholesterol level in Koreans. This is the first demonstration showing the potential genetic relationship between the serotonin receptor gene polymorphism and the HDL-cholesterol level.

• Journal of Nutrition and Health
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• 제15권1호
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• pp.47-53
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• 1982

The study was designed to observe the effects of dietary intake of three different levels of polyunsaturated to saturated fatty acid (P/S) ratio on plasma HDL - cholesterol and triglyceride in plasma and tissues of adult rats. Rats were assigned into the three diet groups, composed of protein 24%, carbohydrate 46%, and fat 30% of total caloric intake. However, the P/S ratio of fat was adjusted by using beef tallow, corn oil and perilla oil to give 0.2, 1.1 and 6.0. All groups were fed ad libitum for 4 week. Plasma cholesterol level was decreased but net significantly with increasing P/S ratio of dietary fat, and showed significant negative correlation coefficient. Plasma TG level was also decreased with increasing PUFA level of dietary fat. However, the effect of P/S ratio (6.0) was not greater than that of P/S ratio (1.1) on plasma TG concentration. This implied that high level of PUFA was not required to change plasma TG level as much in the case of HDL-cholesterol. Plasma HDL-cholesterol was significantly increased only in the group of P/S ratio 6.0 which suggested that high level of dietary PUFA was required to increase HDL level. There was a decreasing trend in the levels of total cholesterol and TG per g liver with increasing P/S ratio of dietary fat. There was no effect in the levels of TG per g skeletal muscle by P/S ratio but the level of cholesterol per unit skeletal muscle was rather increased with increased P/S ratio.

• 동의생리병리학회지
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• 제24권2호
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• pp.319-327
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• 2010

This study was designed to investigate the hyperlipidemia-healing effect of liquid extract from Mageum-tang(麻芩湯), it was performed on the hyperlipidemia of rats induced by high cholesterol diet and Triton WR-1339. We prepared two types of hyperlipidemia model in rats induced by high cholesterol diet and Triton WR-1339. The amount of total cholesterol, HDL-cholesterol, LDL -cholesterol, triglyceride, phospholipid, free fatty acid, the activity of superoxide dismutase(SOD), and glutathione were measured. The liquid extract from Mageum-tang showed significant decreasing effects on total cholesterol, LDL- cholesterol, triglyceride, phospholipid, free fatty acid in the both model. And it showed significant increasing effects on HDL-cholesterol, the activity of SOD in both model and amount of glutathione in Triton WR-1339 model. These results suggest that liquid extract from Mageum-tang has healing efficacy on hyperlipidemia induced by high cholesterol diet and Triton WR-1339.

• Journal of Preventive Medicine and Public Health
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• 제29권2호
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• pp.173-186
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• 1996

본 연구는 40세 이상 중년의 남자 근로자 253명을 대상으로 신체 적합도 및 여가중 신체 활동과 혈중 지질 중 심혈관질환 발생에 특히 중요한 혈중 총콜레스테롤 값, HDL 콜레스테롤 값 및 총콜레스테롤/HDL 콜레스테롤 비와의 관련성을 알아 보기 위하여 시도된 단면조사연구이다. 단순분석에서 혈중 총콜레스테롤 값과 유의한 상관 관계가 있는 변수는 신체 적합도(r=-0.27), 비만지수(r=0.27)였다. 여가중 신체 활동은 총콜레스테롤 값이 170mg/dl 이상군에서만 총콜레스테롤 값과 유의한 상관관계(r= -0.20)가 있었다. HDL 콜레스테롤 값과 유의한 상관관계가 있는 변수들은 신체 적합도(r=0.15), 비만지수(r=-0.22)및 1주간 음주량(r=0.14)이였다. 총콜레스테롤/HDL 콜레스테롤 비와 유의한 상관관계가 있는 변수들은 신체 적합도(r=0.23), 비만지수(r=0.32), 총흡연지수(r=0.13), 1주간 음주량(r=-0.13) 및 야채 선호도(r=0.13)이었다. 신체 적합도는 안정시 맥박수와 중등도의 상관관계(r=-0.66)가 있었고, 여가중 신체 활동(r=0.19)및 비만지수(r=-0.18)와도 유의한 상관관계가 있었다. 다중회귀분석(Multiple linear regression) 결과 혈중 총콜레스테롤 값과 유의한 관련성을 보이는 변수는 신체 적합도(beta=-0.23)와 비만지수(beta=0.18)이었다. HDL 콜레스테롤 값과 유의한 관련성을 보이는 변수는 비만지수(beta=-0.25)뿐이었다. 총콜레스테롤/HDL 콜레스테롤 비와 유의한 관련성을 보이는 변수는 비만지수(beta=0.30)와 신체 적합도(beta=-0.16) 및 야채선호도(beta=0.14)이었다. 결론적으로 중년 남성 근로자들에서 신체 적합도는 비만지수와 함께 혈중 총콜레스테롤 값, HDL 콜레스테롤 값, 총콜레스테롤/HDL 콜레스테롤 비의 중요한 관련 요인이었다. 여가중 신체 활동은 혈중 총콜레스테롤 값이 170mg/dl 이상인 군에서만 혈중 총콜레스테롤 값과 관계가 있었고, 신체 적합도와는 관련성이 유의하지만 크지 않았다. 따라서 신체 적합도가 여가중 신체 활동보다 혈중 지질 농도의 더 중요한 관련요인이며, 앞으로 신체 활동에 관련된 역학적 연구에서 신체 적합도가 독립적이고 중요한 요인으로 추가되어야 할 것이다.

• 한국축산식품학회:학술대회논문집
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• 한국축산식품학회 2004년도 제34차 추계 국제 학술대회
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• pp.367-370
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• 2004

본 연구는 콜레스테롤을 제거한 우유에 미세캡슐 키토올리고당을 첨가한 랫트 사료의 섭취량에 따른 체중 증가량, 총 콜레스테롤의 함량과 중성지질, HDL-cholesterol의 함량 변화를 연구하였다. 이 미세캡슐 키토올리고당을 SD 랫트에 매일 섭취시킨 결과HDL-cholesterol의 증가가 높게 나타났다. 본 실험에서, 혈중콜레스테롤 저하 기능이 있는HDL-cholesterol 수치가 증가하는 결과를 나타내므로 혈중 콜레스테롤 저하 기능성 우유로서의 기능이 있다고 사료된다.

• 한국가금학회지
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• 제29권2호
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• pp.95-100
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• 2002

타우린이 산란계의 지방대사에 미치는 영향을 구명하기 위하여 두 번의 시험을 수행하였다. 시험 1에 있어서 19주령 산란계를 사료에 타우린을 첨가하지 않은 대조구, 0.4%,0.8%그리고 1.2%를 첨가한 4가지 시험구에 균일하게 분포시켜 10주 동안 사양하였다. 1.2%타우린 첨가시 산란계의 복강지방 량은 대조구에 비하여 29.2% 낮았다. 혈청 중 중성지방과 HDL-콜레스테롤의 농도는 처리구간 타이가 없었으나 총 콜레스테롤의 농도는 1.2% 타우린 첨가구가 대조구에 비하여 22.4%높았다. 간의 중성지방과 총 콜레스테롤의 농도는 0.8%그리고 1.2%타우린 첨가구가 대조구에 비하여 각각 26.1%와 26.4% 그리고 28.2%와 26.4% 낮았고, HDL-콜레스테롤의 농도도 1.2% 첨가구가 대조구에 비하여 33.9%낮았다. 시험 2에서는 81주령 산란계를 사료에 타우린을 첨가하지 않은 대조구, 1%그리고2%첨가한3가지 시험구에 균일하게 분포시켜 6주 동안 사양시험을 실시하였다. 1% 타우린 첨가구는 대조구에 비하여 복강지방량이 25%감소하였으나, 혈청 중 중성지방, 총콜레스테롤 및 HDL-콜레스테롤의 농도는 대조구와 차이가 없었다. 그러나 2% 타우린 첨가구는 대조구에 비하여 혈청 중 중성지방과 콜레스테롤의 농도가 각각 44%와 19.8% 낮았으며, HDL-콜레스테롤 농도는 대조구에 비하여 75% 높았다. 그리고 간의 중성지방과 총 콜레스테롤의 농도의 경우, 1%첨가구가 대조구에 비하여 각각 36.8%와 23%낮았으나, 2%첨가구는 대조구에 비하여 각각 78.4%와 70% 높았다. 또한 간의 HDL-cholesterol 농도의 경우, 1% 첨가구는 대조구와 차이가 없었으나 2% 첨가구는 62.8% 높았다. 본 연구의 결과는 산란계에 타우린의 급여는 복강지방의 축적을 억제하며, 이는 중성지방과 콜레스테롤 대사의 변화를 수반한다는 것을 보여준다.는 역할을 한다. 소풍의 적절한 활용은 시각적 요소 및 비언어적 전달요소에 의한 정보전달을 중심으로 주목률을 높일 뿐만 아니라 그에 뒤따르는 소구과정의 단계를 증폭시키고 가속화시킨다. 또한 소품의 사용은 광고물의 분위기나 가치, 신념 등도 전달할 수 있다. 따라서 좀더 많은 새로운 모험과 실험이 많아질수록 광고의 미래전망이 밝아질 것으로 예측된다.t and t-test were utilized for the statistical analysis of each parameter. The results showed that the differences in AU $C_{0-}$30hr/, $C_{max}$ and $T_{max}$ between two were ~5.66, 1.74 and 0.00%, respectively. Minimum detectable differences ($\Delta$) at $\alpha$=0.05 were less than$\pm$ 20% except $T_{max}$ (8.44, 18.36, and 33.86%, respectively). The 90% confidence intervals of all parameters were within $\pm$20% (-10.60~ -0.72, -9.00~12.49 and -19.81~19.81%, respectively). Therefore, it is concluded that the two formulations are bioequivalent for both the extent and the rate of absorption after single dose administration.ation.ion.ion.ation.

• 대한한방내과학회지
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• 제27권2호
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• pp.488-499
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• 2006

Objectives : This study was executed in order to examine relationship between Sasang constitution and serum lipids in CVA patients. Method and Results : This study was done with 104 cases of stroke patients who admitted to department of the internal medicine Wonkwang university oriental hospital from September in 2004 to August in 2005. A study on the relationship among serum lipids : In T-cholesterol and triglyceride, T-cholesterol and HDL-cholesterol, LDL-cholesterol and HDL-cholesterol. T-cholesterol and LDL-cholesterol, they had positive correlation each other. Between triglyceride and HDL-cholesterol, they had negative correlation each other. Distribution of serum lipids which it follows in stroke type : T-cholesterol, HDL-cholesterol and LDL-cholesterol average of cerebral hemorrhage is higher than cerebral infarction. Distribution of serum lipids which it follows in Sasang constitution : T-cholesterol, triglyceride and LDL-cholesterol average of Taeyumin was higher than different types of Sasang constitution But it didn't have no statistically consideration Conclusions : The relationship between Sasang constitution and Serum lipids was not proven.

• 대한본초학회지
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• 제23권1호
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• pp.17-22
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• 2008

Ojectives : Cheonggukjang(natto) is known to have anti-hyperlipidemic action. This study was designed to investigate whether Herbal-cheonggukjang (HC, Herbal-natto) is more effective than cheonggukjang only, Methods : We investigated anti-hyperlipidemic effects of HC in hyperlipidemic rats induced by high-fat diet in terms of observation on levels of total cholesterol, HDL-cholesterol and triglyceride in serum. HC was made by cheonggukjang added Codonopsis Lanceolata, Houttuynia cordata and Lentinus edodes in indicated concetrations. Results : In this experiment, hyperlipidemic rats showed elevated levels of total cholesterol and triglyceride, and also showed lowered level of HDL-cholesterol. Oral administration of HC decreased levels of total cholesterol and triglyceride, Cheonggukjang(natto) did not affect levels of total cholesterol, HDL cholesterol and triglyceride. Conclusions : In these results, oral administration of HC decreased total cholesterol and triglyceride effectively. These results demonstrate that HC is useful to modulate cholesterol and triglyceride in serum.

• Journal of Nutrition and Health
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• 제29권6호
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• pp.642-650
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• 1996

ApoE 유전자의 다형성은 인체 혈중 콜레스테롤 농도의 정상분포를 설명하는 중요한 인자이다. 특히, E2 와 E4 allele들은 고지혈증환자의 혈중에 현저히 나타나며, 각 다른 인종간의 이틀의 상대빈도수가 관상 동맥 질환 유발 위험도와의 상관관계가 아주 높다. Apo E 유전자의 다형성이 혈중 지질 대사변화 에 미치는 영향에 관한 실험은 105명의 건강한 한국여성을 대상으로 시행되었다. Apo E alleles의 한국 인 상대빈도수는 E3가 0.848, E4가 0.087, 그리고 E2는 0.067이었다. 본 연구에서는 E2/2 표현형이 나 타나지 않았지만, 중국 및 일본인과 같이 E4와 E2 allele가 아주 낮았다 최고및 최저혈압, 맥박(p