• 한국산업보건학회지
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• 제20권1호
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• pp.70-78
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• 2010

The purpose of this study is to investigate the appropriate metabolite as biomarker for the biomonitoring of 1,3-butadiene(BD) inhalation exposure. We measured the hemoglobin adducts which were extracted from the blood of the ICR mice inhalation exposure with 100ppm and 500ppm 1,3-butadiene for 2 weeks(5 hr/day ${\times}$ 5 days/week). Hemoglobin adducts were the (N-2-hydroxy-3 -butenyl) valine (HB Val) and (N-2,3,4-trihydroxy-butyl)valine (THB Val). Body weights of the exposure groups were significantly lower from 11 exposure post-day in 100ppm BD inhalation mice and from 7 exposure post-day in 500ppm BD inhalation mice than in control. The levels of HB Val are 0.8~1.7pmol/mg globin for 100ppm BD inhalation exposure, and 2.1~4.4 pmol/mg globin for 500ppm BD inhalation exposure. The levels of THB Val are 15.0~22.0 pmol/mg globin in 100ppm BD inhalation exposure, and 34.8~45.7 pmol/mg globin for 500ppm BD inhalation exposure. So the levels of THB Val and HB Val are proportional relationship with BD exposure level. THB Val is 12.9~18.8 times higher level that HB Val in 100ppm BD exposure group and 10.4~16.6 times higher level than HB Val in 500ppm BD exposure group. We concluded that THB Val is an appropriate metabolite as biomarker for the biomonitoring for BD inhalation exposure.

• KSBB Journal
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• 제18권5호
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• pp.404-407
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• 2003

R. eutropha의 PHA 생합성 유전자를 포함하는 플라스미드 pSYL107을 가진 재조합 대장균 GCSC6576과 A. latus PHA 생합성 유전자를 포함하는 플라스미드 pJC4를 가진 fadR atoC 돌연변이주 재조합 대장균 LS5218의 유청으로부터 P(3HB-co-3HV) 합성을 비교하였다. 재조합 대장균 GCSC6576(pSYL107)의 플라스크 배양에서 acetic acid induction과 oleic acid의 첨가는 3HV 함량을 증가시켰다. 재조합 대장균 LS5218의 pH-stat 유가식 배양결과, 39시간에 균체농도 31.8 g/L, P(3HB-co-3HV) 농도 10.6 g/L, P(3HB-co-3HV) 함량 33.4%, 3HV 함량 6.26 mol%를 얻을 수 있었다.

• Journal of Preventive Medicine and Public Health
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• 제43권5호
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• pp.451-454
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• 2010

Objectives: The American Diabetes Association (ADA) has recently recommended the HbA1c assay as one of four options for making the diagnosis of diabetes mellitus, with a cut-point of $\geq$ 6.5%. We compared the HbA1c assay and the fasting plasma glucose level for making the diagnosis of diabetes among Korean adults. Methods: We analyzed 8710 adults (age 45-74 years), who were not diagnosed as having diabetes mellitus, from the Namwon study population. A fasting plasma glucose level of $\geq$126 mg/dL and an A1c of $\geq$ 6.5% were used for the diagnosis of diabetes. The kappa index of agreement was calculated to measure the agreement between the diagnosis based on the fasting plasma glucose level and the HbA1c. Results: The kappa index of agreement between the fasting plasma glucose level and HbA1c was 0.50. Conclusions: The agreement between the fasting plasma glucose and HbA1c for the diagnosis of diabetes was moderate for Korean adults.

• 한국의류학회지
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• 제29권8호
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• pp.1136-1145
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• 2005

The objective of this study was to determine factors affecting sun protective behavior and intention to buy UV protective clothing among outdoor sport persons in Korea. A self-administered questionnaire was distributed to mountain climbers, bikers and in-line skaters with a convenience sampling method. Two theoretical frameworks, health belief(HB) model and diffusion theory(DT) were used for the study. Based on HB model, sun protection behaviors(SPBs) were associated with cancer perception, perceived benefits, behavioral barriers and cues to actions based on the HB model. Based on DT model, intention to buy (ITB) was determined by an individual's perceived attributes of UV protective shirt. Appearance concern variables were added to the extended HB model. The extended DT model was proposed by adding the variables in the HB model and variables of appearance concern. Multiple regression analysis was applied. Results were as follows. First, perceived benefits, behavioral barriers, cues to action, and all three appearance concern variables as well as gender and age were significant determinants of SPB for Korean outdoor consumers. Second, relative advantage, compatibility, friability, behavioral barriers and cues to action with some appearance concern variables were significant in affecting intention to buy UV protective clothes. Extended HB model and extended DT model were useful to understand SPBs of Korean outdoor consumers.

• 대한가정학회지
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• 제30권2호
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• pp.73-80
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• 1992

This study was attempted to investigate the prevalence of anemia and to obtain nutritional education data for high school girls by analyzing the factors influencing on anemia. Total fo 113 subjects(21 female high school students in Seoul and 92 female students in Inchon) were participated in this study from July 1 to July 15, 1990. Hb and Hct values were measured to evaluate the iron status. Duncan's multiple range test were performed for the comparison between the mean values of the various group. Correlations among various factors were analyzed by Pearson's correlation coefficient. The results of this study are summarized as follows. 1. The maen Hb and Hct values were 13.2g/dl and 41.3%. The rate of anemia of the subjects was 5.3% by the criteria of Hb concentration and 2.7% by the Hct value according to World Health Organization. 2. Subjects who had an early menarche had significantly higher weight and triceps than the ones ofr the girls with a late menarche. 3. There were positive relationships among Hb and Hct values, ages of memarche and cycle of menstruation. Hb, Hct values were significantly higher in the subjects who had frequent bed time snack, high intakes of meats and fishes group and vitamin A, and low calcium intake. In conculsion, the prevalence of anemia of the subjects was much lower than the previous years. There were positive relationships among Hb and Hct values, age of menarche, night snack, and intakes of meats and fishes and fruits. Therefore, it could be concluded that nutrition education should be emphasized for the high school girls to improve the quality of diet and prevent anemia.

• Nuclear Engineering and Technology
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• 제46권6호
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• pp.869-874
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• 2014

It was discovered in a Korean PWR that an extensive number of very short and shallow cracks in the SG tubes were undetectable by eddy current in-service-inspection because of the masking effect of sludge deposits. Axial stress corrosion cracks at the outside diameter of the steam generator tubes near the line contacts with the tube support plates are the major concern among the six identical Korean nuclear power plants having CE-type steam generators with Alloy 600 high temperature mill annealed tubes, HU3&4 and HB3~6. The tubes in HB3&4 have a less susceptible microstructure so that the onset of ODSCC was substantially delayed compared to HU3&4 whose tubes are most susceptible to ODSCC among the six units. The numbers of cracks detected by the eddy current inspection jumped drastically after the steam generators of HB4 were chemically cleaned. The purpose of the chemical cleaning was to mitigate stress corrosion cracking by removing the heavy sludge deposit, since a corrosive environment is formed in the occluded region under the sludge deposit. SGCC also enhances the detection capability of the eddy current inspection at the same time. Measurement of the size of each crack using the motorized rotating pancake coil probe indicated that the cracks in HB4 were shorter and substantially shallower than the cracks in HU3&4. It is believed that the cracks were shorter and shallower because the microstructure of the tubes in HB4 is less susceptible to ODSCC. It was readily understood from the size distribution of the cracks and the quantitative information available on the probability of detection that most cracks in HB4 had been undetected until the steam generators were chemically cleaned.

• 한국균학회지
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• 제42권3호
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• pp.231-234
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• 2014

Six unrecorded yeasts, Cryptococcus festucosus 41-3, Cryptococcus heveanensis 56-4, Debaryomyces nepalensis 95-4, Issatchenkia occidentalis 142-1, Dioszegia zsoltii 39-1, and Kwoniella europala 47-2 were screened from 108 yeasts isolated from flowers and fruits in orchards of Yesan-gun, Chungcheongnam-do, Korea. The morphological and cultural characteristics of these unrecorded yeasts were investigated. They had various shapes, including ellipsoidal, globose, and oval, and also had budding mode in vegetable reproduction, except I. occidentalis 142-1 (fission mode). K. europaea 47-2 only formed pseudomycelium. D. zsoliti 39-1 did not grow in yeast extract-malt extract medium, potato dextrose medium, and vitamin-free medium. C. festucosus 41-3 grew well in 5% NaCl-containing yeast extract-peptone-dextrose medium and had a growth pH range of 7.0~10.0. Three unrecorded yeasts Ogataea polymorpha HB45-1, Rhodotonula hinnulla HB62-2, and Cryptococcus rajasthanensis HB80-4 were screened from 51 yeasts isolated from flowers in Hanbat arboretum in Daejeon city, Korea. They were globose in shape and did not form pseudomycelium. In addition, O. polymorpha HB45-1 and C. rajasthanensis HB80-4 had budding mode in vegetable reproduction. All of them grew well in vitamin-free medium and C. rajasthanesis HB80-4 also grew in 50% glucose and 5% NaCl-containing YPD medium.

• 폴리머
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• 제31권3호
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• pp.233-238
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• 2007

Poly(glycolic acid) (PGA)와 poly [(R) -3-hydrokybutyrate] (P3HB) 및 poly(butylenes succinate-co-L-lactate) (PBSL) 복합재료를 체내에서 서로 다른 가수분해속도를 보완하여 저가의 의료용 흡수성 복합재료로 응용하고자 연구하였다. 그 결과 PBSL/PGA와 P3HB/PGA 복합섬유는 인산염 완충용액 중에서 가수분해되는 것이 확인되었으며, PBSL/PGA 복합섬유는 PGA의 분해에 의해 발생된 glycolic acid에 의해 PBSL의 분해가 촉진되는 메카니즘이 확인되었다. PBSL/PGA 복합섬유는 lipase PS가 존재함에 의해 상당히 빠른 가수분해가 발생하는 것이 확인되었으며, 대기중에서는 거의 가수분해가 발생되지 않는 것을 알 수 있었다. P3HB/PGA 복합섬유 역시 대기중에서 적당한 인장강도를 유지하고 있는 것이 확인된 것으로 보아 본 연구를 통하여 이들 복합섬유는 의료용 흡수성 복합재료와 환경 적합재료로서 응용이 가능할 것으로 판단된다.

• 한국결정학회지
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• 제7권1호
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• pp.81-87
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• 1996

석영 boat를 반응용기로 쓰는 수평 Bridgman 법에서, GaAs 단결정에 유입되는 Si 농도를 Ga-As 계의 상평형에 근거한 열역학적 평형을 가정하여 성장방법 별로 계산하였고, Hall 측정에 의한 전자 농도 측정치와 비교하였다. 단일 온도대역 수평 Bridgman(1-T HB) 법의 경우 Si 농도의 계산치가 5.3 ×10 15(atoms/cm3)인데 비해 실험치는 9.8 ×10 15(/cm3) 이었고, 이중 온도대역 수평 Bridgman(2-T HB) 법에서는 계산치가 1.1 ×10 16(atoms/cm3), 측정치가 1.5 ×10 16(/cm3) 인 것으로 각각 나타났다. 한편 1-T나 2-T HB 법에 비하여 성장시간이 절반 정도인 VGF(vertical gradient freeze) 방법의 경우 이론치와 실험치가 비교적 일치 하였고 그 값은 (6∼8) ×10 15 (atoms/cm3)인 것으로 나타났다.

• The Korean Journal of Physiology
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• 제1권2호
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• pp.185-191
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• 1967

In order to evaluate the elimination of CO through the lung comparing with the decrease of CO content in the blood, authors had induced acute CO poisoning on 9 dogs. Arterial CO-Hb saturation, CO concentration, %, in expired gas and eliminated CO amount through the lung were measured at 1,5,10,30,60, and 120 minutes after acute CO poisoning in 6 dogs breathing room air and 3 dogs breathing room air and oxygen alternately. Results obtained are summarized as follows. In room air breathing group, arterial CO-Hb saturation averaged 50.8% , and 53.67 ml of CO was blew off through the lung during 120 minutes and in alternately air and oBygen breathing group, the arterial CO-Hb saturation averaged 65.6% and 95.6 ml of CO was blew off through the lung. The amount of CO eliminated in expired gas for 120 minute was much less than the amount of decreased CO in arterial blood which was calculated with the decreased CO-Hb content in the estimated circulating blood volume. Such difference between the amount of eliminated CO in expired gas and the decreased CO in blood might be attributed to the oxidation of CO to $CO_2$ in the tissues. Concentration of CO in expired gas was markedly increased and the rate of decrease in arterial CO-Hb saturation is enhanced by oxygen breathing. In early period of recovery from acute CO poisoning, neither the CO concentration in expired gas, nor, the rate of CO elimination (unlit 2 minutes after CO poisoning) showed close correlation with the blood CO-Hb saturation level. The reason seemed to be due to irregularly depressed or unevenly stimulated respiration which were induced by acute CO poisoning.