• 제목/요약/키워드: HAG-10

검색결과 493건 처리시간 0.025초

Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell

  • Park, Eun-Hwa;Kim, Young-Joo;Yamabe, Noriko;Park, Soon-Hye;Kim, Ho-Kyong;Jang, Hyuk-Jai;Kim, Ji Hoon;Cheon, Gab Jin;Ham, Jungyeob;Kang, Ki Sung
    • Journal of Ginseng Research
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    • 제38권1호
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    • pp.22-27
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    • 2014

  • Background: Research has been conducted with regard to the development of methods for improving the pharmaceutical effect of ginseng by conversion of ginsenosides, which are the major active components of ginseng, via high temperature or high-pressure processing. Methods: The present study sought to investigate the anticancer effect of heat-processed American ginseng (HAG) in human gastric cancer AGS cells with a focus on assessing the role of apoptosis as an important mechanistic element in its anticancer actions. Results and Conclusion: HAG significantly reduced the cancer cell proliferation, and the contents of ginsenosides Rb1 and Re were markedly decreased, whereas the peaks of less-polar ginsenosides [20(S,R)-Rg3, Rk1, and Rg5] were newly detected. Based on the activity-guided fractionation of HAG, ginsenoside 20(S)-Rg3 played a key role in inducing apoptosis in human gastric cancer AGS cells, and it was generated mainly from ginsenoside Rb1. Ginsenoside 20(S)-Rg3 induced apoptosis through activation of caspase-3, caspase-8, and caspase-9, as well as regulation of Bcl-2 and Bax expression. Taken together, these findings suggest that heat-processing serves as an increase in the antitumor activity of American ginseng in AGS cells, and ginsenoside 20(S)-Rg3, the active component produced by heat-processing, induces the activation of caspase-3, caspase-8, and caspase-9, which contributes to the apoptotic cell death.

  • https://doi.org/10.1016/j.jgr.2013.11.007 인용 PDF KSCI

Use of the Thermodynamic Solution Properties of Xenon in n-Alkanes for the Examination of Models for the Cavity Formation Process

  • Park, Jung-Hag;Brady, James E.;Carr, Peter W.
    • Bulletin of the Korean Chemical Society
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    • 제10권3호
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    • pp.309-314
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    • 1989

  • The interaction energies of Xenon in n-alkanes were estimated by using three models for the cavity formation process, Hildebrand's regular solution theory, Pierotti's scaled particle theory and Sinanoglu-Reiss-Moura-Ramos' solvophobic theory in an attempt to examine the validity of three models. It appears that Pierotti's implementation of scaled particle theory yields a reasonable estimate of cavity formation energy over a considerable range in solvent size provided that the solute is spherical enough as are the inert gases.

  • https://doi.org/10.5012/bkcs.1989.10.3.309 인용 PDF