• Journal of Microbiology
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• v.42 no.2
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• pp.156-159
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• 2004

In general, the salinity of the ocean is close to 3.5％ and marine vibrios possess the respiratory chain-linked Na$\^$+/ pump. The influence of sodium chloride and the proton conductor carbonylcyanide m-chlo-rophenylhydrazone (CCCP) on the production of extracellular proteases in a marine Vibrio strain was examined. At the concentration of 0.5 M, sodium chloride minimally inhibited the activity of extra-cellular proteases by approximately 16％, whereas at the same concentration, the producton of extra-cellular proteases was severely inhibited. On the other hand, the production of extracellular proteases was completely inhibited by the addition of 2 ${\mu}$M CCCP at pH 8.5, where the respiratory chain-linked Na$\^$+/ pump functions.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.350-352
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• 2018

In this paper, we propose a smart indoor garden aquaculture system using PIC. In the proposed smart indoor garden aquaculture system, the aquaphonics system circulates the nutrient solution of the aquarium, the filtrate tank, and the flowerpot. The automated control system that controls the state of the nutrient solution through the various sensors and controls the pump and valve is designed. As a result of the verification of the smart indoor garden aquaculture system proposed in this paper, it was confirmed that the environment suitable for the survival of fish and plants was maintained by monitoring water temperature, DO, pH measured in real time. The water level in aquarium and flower pot was controlled through automatic operation of the Electric vale and pump.

• Plant Journal
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• v.11 no.2
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• pp.32-38
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• 2015

This study was conducted on combined cycle power plant consisting of HRSG with integral deaerator type to avoid tube failures of low pressure evaporator tubes. Based on the observation of pH variation at the discharge of boiler feed water pump by continuous pH measurement for a period of time, it was identified that pH of feed water is getting reduced as ammonia is distributed into vapor and liquid depending on the distribution ratio of ammonia in the LP drum after the deaerator. To solve this problem, the counterplan was prepared by reexamination of ammonia injection point and quantity. In conclusion, it was accomplished that 9.2~9.6 is the optimized pH range for boiler feed water by arranging additional piping for ammonia to inject directly to LP drum.

• 한국신재생에너지학회:학술대회논문집
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• 2006.06a
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• pp.445-450
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• 2006

유출지하수나 지표수를 열원으로 하는 지열히트펌프의 기초자료로 활용하기 위하여 Pond Loop형 열교환기를 설계, 제작하여 유동이 없는 수조 내에서 수조의 온도가 변화함에 따라 일정한 열교환기 입구온도를 유지하면서 열전달량을 측정하였다. 그 결과 수조를 Heat Source로 사용하는 경우 $5,500{\sim}4,500kcal/h$의 열량이 전달되었고, 수조를 Heat Sink로 사용할 경우 $5,200{\sim}3,500 kcal/h$의 열량이 전달되었다. 또한 열교환기 관내 유속이 증가함에 따라 열전달량이 증가하는 경향성을 확인할 수 있었고, 이는 동시에 열교환기 입출구의 차압을 증가시킴을 알 수 있었다. 열교환기의 설계단계에서 사용하였던 열전달관계식으로 구한총괄열전달계수, U와 실험값을 통해 유추한U값을 비교한 결과 실험에 의해 유추된 U값이 $24{\sim}27%$ 설계치보다 크게 나타났다. 본 연구를 통하여 유출지하수 뿐만 아니라 하수 및 하천수를 이용한 지열히트펌프의 기초자료를 확보할 수 있었다.

• Journal of Pharmaceutical Investigation
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• v.34 no.4
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• pp.283-288
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• 2004

The pharmacokinetics of nifedipine was studied after oral coadministration of nifedipine (5 mg/kg) with quercetin (1.5, 7.5, 15 and 30 mg/kg, respectively) and 0.5 h or 3days pretreatment with quercetin (1.5 and 7.5mg/kg) in rabbits. Pretreatment of quercetin significantly (p<0.05, at 0.5 h; p<0.01, at 3 days) increased the plasma concentration of nifedipine, but not significant in coadministraiton. The area under the plasma concentration-time curve (AUC) and the peak concentration $(C_{max})$ of nifedipine pretreated with quercetin were increased significantly (p<0.05, at 0.5 h; p<0.01, at 3 days) compared to the control. By coadministration of quercetin, only 7.5 mg/kg of quercetin increased plasma AUC and $C_{max}$ of nifedipine significantly (p<0.05) compared to the control. Plasma AUC of intravenous nifedipine (1 mg/kg) is $4235\;{\pm}\;1192\;ng/ml{\cdot}hr$. Pretreatment of quercetin significantly (p<0.05, at 0.5 h; p<0.01, at 3 days) increased the absolute bioavailability (AB%) of nifedipine to 23.9-29.2% compared to the control (17.8%). Coadministration of quercetin showed no significant effect on the AB% of nifedipine except for 7.5 mg/kg. It is suggested that quercetin alters disposition of nifedipine by inhibition of P-glycoprotein efflux pump and its first-pass metabolism. The dosage of nifedipine should be adjusted when it is administered chronically with quercetin in a clinical situation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.10
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• pp.1279-1289
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• 2013

In recent times, turbomolecular pumps (TMPs) have been used frequently to generate and maintain high and clean vacuum. Because of the high-speed rotation of the rotor, its structural safety should be treated as the first design concern. This paper presents the structural analysis and optimization of rotor blades of a TMP. To increase the numerical efficiency in the finite element modeling and analysis, the P-method provided in Pro/ENGINEER was used for simulation. The structural responses for several types of rotor blades were investigated, and the effects of the blade angle, blade length, and round size are thoroughly studied for each type of TMP blade. In addition, structural optimization to reduce and even the maximum stress at each stage of the TMP by changing the size of rounds between the blade and the hub was performed very successfully by using the P-method.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.18 no.2
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• pp.102-107
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• 2007

Laryngopharyngeal reflux disease (LPRD) is the result of retrograde flow of gastric contents to the laryngopharynx. Laryngoscopic findings and special questionnaires are first step of diagnosis of LPRD. Empiric trials of Proton pump inhibitor' test (PPI test) is recommended as treatment and diagnosis. However confirmation of reflux is then recommended primarily in patients with persistent symptoms despite acid-suppressive therapy. The 24 hour ambulatory double pH monitoring has been a gold standard method in diagnosis of LPRD even though it has some limitation. The combined multichannel intraluminal impedance and pH monitoring is a new-rising test tool. It can detect acid/non-acid, liquid/gaseous reflux and clearance of refluxate. The water siphon test is also used for diagnosis of LPRD.

• Biomedical Science Letters
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• v.13 no.3
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• pp.197-206
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• 2007

P2X receptors are membrane-bound ion channels that conduct $Na^+,\;K^+$, and $Ca^{2+}$ in response to ATP and its analogs. There are seven subunits identified so far ($P2X_1-P2X_7$). $P2X_2$ receptors are known to be expressed in a wide range of organs including brains and adrenal grands. PC12 cells are originated from adrenal grand and differentiated by nerve growth factor or pituitary adenylate cyclase activating poly peptide (PACAP). Previous studies indicate that $P2X_2$ receptor activation in PC12 cells couples to $Ca^{2+}-dependent$ release of catecholamine and ATP. It is known that acidic pH potentiates ATP currents at $P2X_2$ receptors. This leads to a hypothesis that $P2X_2$ receptors may play an important role in PC12 cell differentiation, one of the characteristics of which is neurite outgrowth, induced by the hormones under lower pH. In the present study, we isolated several clones which potentiate neurite outgrowth by PACAP in acidic pH (6.8), but not in alkaline pH (7.6). RT-PCR and electrophysiology data indicate that these clones express only functional $P2X_2$ receptors in the absence or presence of PACAP for 3 days. Potentiation of neurite outgrowth resulted from PACAP (100 nM) in acidic pH is inhibited by the two P2X receptor antagonists, suramin and PPADS ($100\;{\mu}M)$ each), and exogenous exprerssion of ATP-binding mutant $P2X_2$ receptor subunit ($P2X_2[K69A]$). However, acid sensing ion channels (ASICs) are not involved in PACAP-induced neurite outgrowth potentiation in lower pH since treatments of an inhibitor of ASICs, amyloride ($10\;{\mu}M$), did not give any effects to neurite extension. The vesicular proton pump ($H^+-ATPase$) inhibitor, bafilomycin (100 nM), reduced neurite extension indicating that ATP release resulted from $P2X_2$ receptor activation in PC12 cells is needed for neurite outgrowth. These were confirmed by activation of mitogen activated protein kinases, such as ERKs and p38. These results suggest roles of ATP and $P2X_2$ receptors in hormone-induced cell differentiation or neuronal synaptogenesis in local acidic environments.

• Proceedings of the SAREK Conference
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• 2003.07a
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• pp.94-94
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• 2003

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.27 no.2
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• pp.78-83
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• 2016

Laryngopharyngeal reflux (LPR) disease is an extraoesophageal variant of gastro-esophageal reflux disease that can affect the larynx and pharynx. LPR is associated with symptoms of laryngeal irritation such as throat clearing, coughing, and hoarseness. The main diagnostic methods currently used are laryngoscopy and pH monitoring. The most common laryngoscopic signs are redness and swelling of the throat. However, these findings are not specific of LPR and may be related to other causes or can even be found in healthy individuals. Furthermore, the role of pH monitoring in the diagnosis of LPR is controversial. A therapeutic trial with proton pump inhibitors (PPIs) has been suggested to be cost-effective and useful for the diagnosis of LPR. However, the recommendations of PPI therapy for patients with a suspicion of LPR are based on the results of uncontrolled studies, and high placebo response rates suggest a much more complex and multifactorial pathophysiology of LPR than simple acid reflux. Laryngoscopy and pH monitoring have failed as reliable tests for the diagnosis of LPR. Empirical therapy with PPIs is widely accepted as a diagnostic test and for the treatment of LPR. However, further research is needed to develop a definitive diagnostic test for LPR.