• Molecules and Cells
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• 제20권2호
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• pp.263-270
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• 2005

Transactivation of EGF-receptor (EGFR) by G-protein coupled receptors (GPCRs) is emerging as an important pathway in cell proliferation, which plays a crucial role in the development of atherosclerotic lesion. Angiotensin II (Ang II) has been identified to have a major role in the formation of atherosclerotic lesions, although the underlying mechanisms remain largely unclear. We hypothesize that Ang II promotes the proliferation and migration of smooth muscle cells through the release of heparin-binding epidermal growth factor like growth factor (HB-EGF), transactivation of EGFR and activation of Akt and Erk 1/2, with matrix metalloproteases (MMPs) playing a dispensable role. Primary rat aortic smooth muscle cells were used in this study. Smooth muscle cells rendered quiescent by serum deprivation for 12 h were treated with Ang II (100 nM) in the presence of either GM6001 ($20{\mu}M$), a specific inhibitor of MMPs or AG1478 ($10{\mu}M$), an inhibitor of EGFR. The levels of phosphorylation of EGFR, Akt and Erk 1/2 were assessed in the cell lysates. Inhibition of MMPs by GM6001 significantly attenuated Ang II-stimulated phosphorylation of EGFR, suggesting that MMPs may be involved in the transactivation of EGFR by Ang II receptor. Furthermore Ang II-stimulated proliferation and migration of smooth muscle cells were significantly blunted by inhibiting MMPs and EGFR and applying HB-EGF neutralization antibody, indicating that MMPs, HB-EGF and EGFR activation is necessary for Ang-II stimulated migration and proliferation of smooth muscle cells. Our results suggest that inhibition of MMPs may represent one of the strategies to counter the mitogenic and motogenic effects of Ang II on smooth muscle cells and thereby prevent the formation and development of atherosclerotic lesions.

• 한국표면공학회지
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• 제43권1호
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• pp.25-30
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• 2010

Titanium and titanium alloys are widely used for orthopedic and dental implants for their superior mechanical properties, low modulus, excellent corrosion resistance and good biocompatibility. In this study, corrosion behaviors of nanotube formed on the bone plate of Ti-6Al-4V alloy for dental use have been investigated. $TiO_2$ nanotubes were formed on the dental bone plates by anodization in $H_3PO_4$ containing 0.6 wt % NaF solution at $25^{\circ}C$. Electrochemical experiments were performed using a conventional three-electrode configuration with a platinum counter electrode and a saturated calomel reference electrode. Anodization was carried out using a scanning potentiostat (EG&G Co, Model 263A USA), and all experiments were conducted at room temperature. The surface morphology was observed using field emission scanning electron microscopy (FE-SEM) and energy dispersive x-ray spectroscopy(EDS). The corrosion behavior of the dental bone plates was examined using potentiodynamic test(potential range of -1500~2000 mV) in a 0.9% NaCl solution by potentiostat (EG&G Co, PARSTAT 2273. USA). The inner diameter of nanotube was about 150~180 nm with wall thickness of about 20 nm. The interspace of nanotube to nanotube was 50 nm. The passive region of the nanotube formed bone plates showed the broad range compared to non-nanotube formed bone plates. The corrosion surface of sample was covered with corrosion products.

• 대한전자공학회논문지SP
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• 제40권2호
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• pp.20-28
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• 2003

최근 들어 ASIC(Application Specific IC)이나 소형 시스템에서 사용할 수 있는 더 빠르고 정확한 움직임 벡터 예측방법이 요구되고 있다. 전역탐색(Full Search: FS) 방법은 탐색영역의 모든 화소들을 탐색하여 움직임 벡터를 예측하는 방법으로 화질과 PSNR은 좋지만 반면에 많은 계산량이 요구된다. 기존의 고속 알고리즘들은 탐색 회수를 제한함으로써 계산량을 줄였기 때문에 움직임 벡터 예측의 정확도가 낮고, 움직임 보상시 SAD(Sum of Absolute Difference) 값이 높아지는 것을 감수해야한다. 본 논문에서는 영상에서의 현재 블록과 주변 블록과의 공간적인 상관도를 고려하여 예측된 움직임 벡터 (Predicted Motion Vector: PMV)를 이용하는 고속 움직임 탐색 방법을 제안한다. PMV 방법은 주변 블록의 움직임 벡터를 이용한 기존 방법들 보다 명확하고 간결하게 탐색을 수행할 수 있다. PMV 방법이 대표적인 기존 방법인 Nearest-Neighbors Search(NNS) 방법보다 속도 및 정확도 면에서 성능이 양호함을 대표적인 실험 시퀀스를 통하여 보였다.

• 대한간호학회지
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• 제31권4호
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• pp.669-680
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• 2001

Purpose: This study is used to investigate the correlation among a stroke patient family's health, burden and quality of life. Method: Data was collected from one hundred twenty family care-givers registered at K and H Hospital in Seoul. Questionnaire data was drawn up by personal interviews aided by the staff nurses. The analyses of collected data are based on the rate of 100 percentage to the average, t-test, ANOVA, DMR, Pearson Correlation. Result: (1) The influential factors on physical health proved to be age, sex, academic career, matrimonial status, present occupation, economic situation, the relationship with the patient, the patient-caring term, and the family-formation. The psychological health issues were age, final academic career, matrimonial status, the relation with patient and the family-formation. Burdens were shown to be age, matrimonial status, the relation with patient, and the patient-caring term. The quality of life was determined by age, final academic career, matrimonial status, and the relationship with the patient, the patient- caring term, and the family-formation. (2) The rate of the physical condition was 2.87, the psychological condition 2.43, the sense of burden 3.08, and the quality of life was 2.42. (3) The rate of correlation between the burden and the quality of life was (r= -.547), the psychological health and the burden was (r= -.531), the physical health and the burden was (r= -.263), physical health and quality of life was (r= .301), psychological health, and quality of life was (r= .413). Conclusion: It follows from this study that there is a very close correlation among the stroke patient family's health, the burden, and quality of life. Therefore it is necessary that we should find various nursing intervention ways in order to mitigate the burden of family when caring for the stroke patients.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제50권6호
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• pp.263-270
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• 2001

The mechanical and electrical properties of the hot-pressed and annealed ${\beta}-SiC-TiB_2$,/TEX> electroconductive ceramic composites were investigated as function as functions of the liquid forming additives of $Al_2O_3+Y_2O_3$. The result of phase analysis of composites by XRD revealed ${\alpha}$-SiC(6H), $TiB_2$,/TEX>, and YAG($Al_5Y_3O_{12}$) crystal phase. The relative density and the mechanical properties of composites were increased with increasing $Al_2O_3+Y_2O_3$ contents in pressureless annealing method because YAG of reaction between $Al_2O_3$ was increased. The flexural strength showed the highest value of 458.9 MPa for composites added with 4 wt% $Al_2O_3+Y_2O_3$ additives in pressed annealing method at room temperature. Owing to crack deflection, crack bridging, phase transition and YAG of fracture toughness mechanism, the fracture toughness showed 7.1 MPa ${\cdot}\;m^{1/2}$ for composites added with 12 wt% $Al_2O_3+Y_2O_3$ additives in pressureless annealing method at room temperature. The electrical resistivity and the resistance temperature coefficient showed the lowest value of $6.0{\times}10^{-4}\;{\Omega}\;{\cdot}\;cm(25\'^{\circ}C}$ and $3.0{\times}10^{-3}/^{\circ}C$ for composite added with 12 wt% $Al_2O_3+Y_2O_3$ additives in pressureless annealing method at room temperature, respectively. The electrical resistivity of the composites was all positive temperature coefficient resistance(PTCR) in the temperature ranges from 25 $^{\circ}C$ to 700 $^{\circ}C$.

• Journal of Microbiology and Biotechnology
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• 제22권2호
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• pp.256-263
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• 2012

A strain of bacterium producing antifungal antibiotic was isolated and identification of the strain was attempted. We could identify the bacterium as being a Bacillus sp., based on morphological observation, physiological characteristics, and 16S rDNA sequence analysis, thus leading us to designate the strain as Bacillus sp. AH-E-1. The strain showed potent antibiotic activity against phytopathogenic and human pathogenic fungi by inducing mycelial distortion and swelling and inhibiting spore germination. The antibiotic metabolite produced by the strain demonstrated excellent thermal and pH (2-11) stability, but was labile to autoclaving. From these results, we could find a broader antifungal activity of Bacillus genus. Isolation and characterization of the active agent produced by the strain are under progress.

• 방송공학회논문지
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• 제9권4호
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• pp.434-445
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• 2004

대부분의 비디오 부호화기에서 움직임 예측은 부호화된 영상의 화질을 결정하는 중요한 기술이다. 그러나 일반적으로 많이 사용되는 전역 탐색 방법은 많은 연산량이 필요하다는 단점이 있다. 이를 개선하기 위한 기존의 고속 움직임 예측 방법들은 연산량을 줄이기 위한 복잡한 프로그램 구조를 가지고 있어서 DSP와 같은 전용 프로세서에 구현하기가 부적합하다. 본 논문에서는 미디어 프로세서에 적합한 효율적인 움직임 탐색 방법을 제안한다. 주위 블록 간의 공간적 상관도를 이용해 예측 움직임 벡터를 구할 수 있으며, 또한 탐색 영역을 축소시킴으로써 전체 연산량을 줄일 수 있다. 제안된 방법의 효율을 확인하기 위하여 MPEG-4 SP@L3(Simple Profile at Level 3) 부호화기를 TM1300에서 구현하였다. 제안한 방법은 TM1300 프로세서 상에서 전역 탐색 방법에 근접한 화질을 유지하며 기존 고속 움직임 예측 방법보다 향상된 성능을 보였다.

• 방송공학회논문지
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• 제10권3호
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• pp.392-400
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• 2005

모바일 환경에서의 효과적인 동영상 압축을 위한 고집적 MPEG-4@SP 동영상 압축기인 VideoCore의 구조를 제안한다. 동영상 압축을 수행할 때 움직임 추정, 움직임 보상, 양자화, 이산여현부호화, 가변장부호화와 같은 기능은 외부 메모리 처리가 빈번하기 때문에 높은 메모리 대역폭을 필요로 한다. 본 논문에서 제안한 움직임 추정기는 소용량의 로컬 메모리를 효과적으로 운용함으로써 대용량 외부 메모리와의 메모리 대역폭을 최소화하는 동영상 압축을 가능하게 한다. 또한 제안한 동영상 압축기 구조는 가장 계산량이 많은 움직임 추정부와 이를 제외한 나머지 기능들을 동시에 구동시키는 파이프라인 구조를 채택함으로써 낮은 동작 주파수에서 실시간 고화질 동영상 압축을 실현한다.

• 인터넷정보학회논문지
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• 제10권6호
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• pp.27-36
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• 2009

기존의 음성통신 위주의 공중전화망 (PSTN) 시스템은 TCP/IP 프로토콜을 사용하는 데이터통신 위주의 IP 망으로 진화하고 있으며, IP 망을 이용하여, 멀티미디어 서비스를 제공할 수 있는 VoIP (voice over IP) 서비스를 제공한다. 본 논문은 원격지의 사용자에게 해당 가정의 로봇이 제공하는 VoIP 서비스를 사용하여, 홈오토메이션 기능을 제공하기 위한 시스템을 제안한다. 본 논문에서 구현한 시스템은, VoIP서비스를 위한 대표적인 시그널링 표준인 HTTP (hyper-text transfer protocol) 기반의 SIP (session initiation protocol) 를 이용하여, 시그널링 프로토콜을 구성하였으며, 원격사용자와 로봇 내 장착된 카메라를 통해 가정의 환경을 모니터링하기 위한 RTP (real-time transport protocol)과 홈오토메이션 신호전달을 위한 DTMF (dual tone multi-frequency) 신호 전송프로토콜을 제공한다. 본 논문에서 제안한 시스템을 실제 구현하여 로봇의 통신모듈로 구성하였으며, KT 망을 통한 영상통화 및 제어신호 전달품질측정결과, 대부분의 트래픽환경에도 원활한 로봇제어 및 평균 MOS 9.15 이상의 우수한 영상품질을 보임을 확인하였다.

• Journal of Ginseng Research
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• 제45권2호
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• pp.254-263
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• 2021

Background: A chronic social defeat stress (CSDS) model has been proposed as relevant to stress-induced behavioral change in humans. In this study, we examined the effect of Korean Red Ginseng (KRG) on CSDS-induced mood disorders and protein expression in an animal model. Methods: To evaluate the effect of KRG on social defeat stress, test mice were exposed in the resident aggressor's home cage compartment for 14 days beginning 1 h after KRG treatment (10, 20, and 40 mg/kg, per oral (p.o.)). After the exposure, behavioral tests to measure anxiety, social interaction, and depression-like behavior were performed. To investigate the underlying mechanism, N-methyl-D-aspartate receptor expression levels in CSDS-induced mice were evaluated using Western blot analysis. Results: CSDS induced anxiety-like behaviors by decreasing central activity in the open-field test and open-arm approach in the elevated plus maze test and led to social avoidance behavior in the social interaction test. CSDS mice showed upregulated NR1, NR2A, and NR2B expression in the hippocampus. KRG 20 and 40 mg/kg ameliorated anxiety-like activities and KRG 20 mg/kg alleviated social avoidance by decreasing time in the corner zone. KRG treatment recovered CSDS-induced NR1, NR2A, and NR2B protein levels in the hippocampus. Conclusion: These results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus.