• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.75-79
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• 2012

Purpose: the study aimed to compare the quality of life (QOL) and radiotherapy complications among Chinese nasopharyngeal carcinoma (NPC) patients at different 3-dimensional conformal radiotherapy (3DCRT) stages adjusting for other variables. Methods: 511 NPC patients at different 3DCRT stages were enrolled. They were interviewed regarding SF-36, complications and socio-demographic variables and cancer- or treatment-related variables. Analysis of covariance (ANCOVA) based on SF-36, complications scores as dependent variables, 3DCRT stages as independent variables, and other variables as covariate were established. Results: The influencing factors of PCS included 3DCRT stages and age group. The influencing factors of MCS included 3DCRT stages and income. Most QOL scores of NPC patients were significantly associated with 3DCRT stage, after accounting for other variables. QOL scores of the patients receiving 3DCRT were the lowest, QOL scores of people after 3DCRT gradually increased. PCS scores of people greater than 5 years after 3DCRT was improved to or even better than the level before 3DCRT. The complications with significantly different scores of patients at different 3DCRT status included xerostomia, throat ache, hypogeusia, caries, hearing loss, snuffles. Conclusions: Clinicians should pay more attention to older NPC patients and patients with lower income. When patients receive 3DCRT, measures should be taken to reduce radiation injury to improve the patients' QOL.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.473-477
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• 2012

Introduction: The esophagus squamous cell carcinoma (ESCC) is one of the most deadly malignances, and a current challenge is the development of effective therapeutic agents. Our present work addressed the effect of HIF-$1{\alpha}$ siRNA alone or in combination with cisplatin on the growth of ESCC in nude mice. Materials and Methods: Xenografts were established by inoculating ESCC TE-1 cells in nude mice, and transplanted tumors were treated with HIF-$1{\alpha}$ siRNA, cisplatin alone or together. Growth was assessed by measuring tumor volume. HIF-$1{\alpha}$ mRNA and protein expression were detected using RT-PCR and immunohistochemistry, respectively. Apoptosis of ESCC TE-1 cells was analyzed by flow cytometry. Results: In our nude mice model, HIF-$1{\alpha}$ siRNA effectively inhibited the growth of transplanted ESCC, downregulating HIF-$1{\alpha}$ mRNA and protein expression, and inducing ESCC TE-1 cell apoptosis. Notably when combinated with cisplatin, HIF-$1{\alpha}$ siRNA showed synergistic interaction in suppressing tumor growth. Furthermore, the proportion of apoptotic cells in HIF-$1{\alpha}$ siRNA plus cisplatin group was significantly higher than that in cisplatin or HIF-$1{\alpha}$ siRNA-treated groups (P<0.05). Conclusions: Down-regulated HIF-$1{\alpha}$ expression induced by siRNA could effectively suppress the growth of transplanted ESCC $in$ $vivo$. HIF-$1{\alpha}$ siRNA could enhance the cytotoxicity of cisplatin, which suggests that a combination of these two agents may have potential for therapy of advanced ESCC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4513-4518
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• 2014

The prevalence of BRCA1 gene mutations in breast cancer differs between diverse ethnic groups. Relatively little information is known about patterns of BRCA1 mutations in early-onset breast cancer in women of Uighur or Han descent, the major ethnic populations of the Xinjiang region in China. The aim of this study was to identify BRCA1 mutations in Uighur and Han patients with early-onset (age <35 years), and sporadic breast cancer for genetic predisposition to breast cancer. For detection of BRCA1 mutations, we used a polymerase chain reaction single-stranded conformation polymorphism approach, followed by direct DNA sequencing in 22 Uighur and 13 Han women with early-onset sporadic breast cancer, and 32 women with benign breast diseases. The prevalence of BRCA1 mutations in this population was 22.9% (8/35) among early-onset sporadic breast cancer cases. Of these, 31.8% (7/22) of Uighur patients and 7.69% (1/13) of Han patients were found to have BRCA1 mutations. In 7 Uighur patients with BRCA1 mutations, there were 11 unique sequence alterations in the BRCA1 gene, including 4 clearly disease-associated mutations on exon 11 and 3 variants of uncertain clinical significance on exon 11, meanwhile 4 neutral variants on intron 20 or 2. None of the 11 BRCA1 mutations identified have been previously reported in the Breast Cancer Information Core database. These findings reflect the prevalence of BRCA1 mutations in Uighur women with early-onset and sporadic breast cancer, which will allow for provision of appropriate genetic counseling and treatment for Uighur patients in the Xinjiang region.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.165-165
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• 2017

모돈은 사육 특성상 제한된 파일롯 공간 안에 장시간 머물기 때문에 과중한 몸무게에 의한 지제 이상, 섭식 등의 불량, 수면상태의 불량 등을 지속적으로 관찰해야 하는 대상이다. 측면에 다수의 초음파 센서를 설치하여 기립의 상태 및 운동 시 몸체 궤적의 특성을 분석하여 종합적으로 모돈의 행동 특성을 정량화 하고자 하였다. 이 과정에서 계측 신호의 값을 대수적으로 비교하는 방식에 한계가 있음을 발견하였고, 이를 해결하고자 10 Hz/Ch 내외의 시계열 상대거리 궤적 신호를 주파수 도메인으로 변경하여 분석을 수행하였다. 일정 주파수에 집중되어 있는 주파수 값의 크기 변화(파워 스펙트럼 밀도)를 기준으로 모돈의 움직임의 정상 상태 유무 판별이 가능하였다. 단, 이러한 분석은 계측 데이터를 일괄 처리 방식으로 분석하는 방법으로 도출이 되었으므로, 계측과 정량 분석을 동시에 수행하기 위한 개선이 필요하였다. 계측 시스템에서 사용한 마이크로 프로세서는 Nucleo-446(STMelectronics, CA, USA)로 180 Mhz의 클럭 속도로 작동하나, 총 100 Hz 내외의 16비트 계측 신호에 대해 추가적으로 FFT 등의 주파수 변환 신호 처리를 수행하기에는 연산 능력이 부족하였다. 한편, 주파수 분석의 주기를 1분 단위로 할 경우 처리해야할 정보의 크기는 $100{\times}60{\times}5{\times}2Byte$ 이므로 1분 내에 해당 연산을 종료할 수 있는 추가의 연산 장치가 필요하였다. 계측과 주파수 도메인 변환 연산을 동시에 수행하기 위하여 1 Ghz의 연산능력을 가진 ARM A9 계열의 초소형 멀티코어 AP인 NanoPi Neo Air(Friendlyarm, Guangzhou, China)을 선정하였다. 4개의 코어를 각각 계측, Median 필터링, Smoothing 연산, FFT 분석에 사용하여 1분 단위, 2분 단위, 5분 단위의 주파수 분석을 동시에 수행하였다. 병렬 연산 라이브러리는 오픈 소스인 MPICH(www.mpich.org)를 이용하였다. 상대적으로 여유있는 자원을 보유하고 코어를 실시간으로 결정하여 다수의 모돈 개체 동시 모니터링을 위한 네트워크 연결 역할을 동시에 수행하도록 하였다. 1주일 내외의 요인 실험 수행 결과, 약 70 Mbyte의 데이터가 축적이 되었으며, 1분 단위, 2분 단위, 5분 단위의 주파수 도메인 변환 후 결과를 동시에 취득할 수 있었다. 일부 주파수 도메인 상의 파워 밀도 값이 모돈의 행동 특성에 분석에 유효한 정보를 제공함을 발견하였다. 모돈사 내 현장 보급이 가능한 초소형 AP와 멀티 코어 기반 병렬 처리 기법을 이용한 현장 진단 시스템 개발 연구를 지속적으로 수행할 것이다.

• Journal of Distribution Science
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• v.14 no.1
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• pp.67-74
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• 2016

Purpose - In this paper, the degree of similarity and dissimilarity between pairs of 50 major cities in China can be shown on the basis of three evaluation variables(internet businessman index, internet shopping index and e-commerce development index). Dissimilarity distance matrix is used to analyze both similarity and dissimilarity between each fifty city in China by calculating dissimilarity as distance. Higher value signifies higher degree of dissimilarity between two cities. Cluster analysis is exploited to classify 50 cities into a number of different groups such that similar cities are placed in the same group. In addition, multidimensional scaling(MDS) technique can obtain visual representation for exploring the pattern of proximities among 50 major cities in China based on three development performance attributes. Research design, data, and methodology - This research is performed by the 2013 report provided with AliResearch in China(1/1/2013~11/30/2013) and utilized multivariate methods such as dissimilarity distance matrix, cluster analysis and MDS by using CLUSTER, KMEANS, PROXIMITIES and ALSCAL procedures in SPSS 21.0. Results - This research applies two types of cluster analysis and MDS on three development performances based on the 2013 report of Aliresearch. As a result, it is confirmed that grouping is possible by categorizing the types into four clusters which share similar characteristics. MDS is exploited to carry out positioning of both grouped locations of cluster and 50 major cities belonging to each cluster. Since all the values corresponding to Shenzhen, Guangzhou and Hangzhou(which belong to cluster 1 among 50 major cities) are very large, these cities are superior to other cities in all three evaluation attributes. Twelve cities(Beijing, ShangHai, Jinghua, ZhuHai, XiaMen, SuZhou, NanJing, DongWan, ZhangShan, JiaXing, NingBo and FoShan), which belong to cluster 3, are inferior to those of cluster 1 in terms of all three attributes, but they can be expected to be the next e-commerce revolution. The rest of major cities, in particular, which belong to cluster 4 are relatively inferior in all three attributes, so that this automatically evokes creative innovation, which leads to e-commerce development as a whole in China. In terms of internet businessman index, on the other hand, Tainan, Taizhong, and Gaoxiong(which belong to cluster 2) are situated superior to others. However, these three cities are inferior to others in an internet shopping index sense. The rest of major cities, in particular, which belong to cluster 4 are relatively inferior in all three evaluation attributes, so that this automatically evokes innovation and entrepreneurship, which leads to e-commerce development as a whole in China. Conclusions - This study suggests the implications to help e-governmental officers and companies make strategies in both Korea and China. This is expected to give some useful information in understanding the recent situation of e-commerce in China, by looking over development performances of 50 major cities. Therefore, we should develop marketing, branding and communication relevant to online Chinese consumers. One of these efforts will be incentives like loyalty points and coupons that can encourage consumers and building in-house logistics networks.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.3
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• pp.1-13
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• 2015

Strong ties such as family members, relatives and close friends have been widely acknowledged as a vital factor when a potential entrepreneur attempts to initiate entrepreneurial activity. Recent theoretical arguments focus that family social capital, a form of social capital, that is embedded in family relationships can contribute to venture creation as well as to the development of competitive advantage for established firms. Meantime, there have been arguments that the most dominant single entrepreneurial ethnic group in the world is the Chinese people, while the People's Republic of China is widely recognized as fast growing economic power that is driven by entrepreneurial ventures in a large scale. This study tests the effect of perceived relational supports typically being provided by family members, close relatives and friends on forming self-efficacy and entrepreneurial motivation of university students by using samples collected from 4 Korean Universities(Wonkwang, Baekseok, Soongsil and Dankook university) and Guangzhou University in China. The mediating of self-efficacy was also tested to gain better understanding of the role of the variable. The results of the study suggest that 1) both self-efficacy and entrepreneurial motivation are influenced positively by the perceived relational supports, 2) self-efficacy of university students affects their entrepreneurial motivation positively, 3) self-efficacy is appeared to be mediated partially for China in between perceived relational supports and entrepreneurial motivation, but the same variable is exhibited a full mediation in the same path of the research model for Korea, which was a distinction between the students of two countries in this study. Discussion and practical implication on the results are provided.

• The Journal of the Korea Contents Association
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• v.20 no.10
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• pp.216-232
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• 2020

This research aims to analyze the characteristics of modern public sculptures in Chinese historical and cultural cities, and explore how public sculptures can effectively intervene in historical and cultural elements to show their placeness. In addition, this research provides basic information for the place significance and application of public sculptures. First, the theoretical basis was provided by understanding the concept of historical and cultural city and the concept of Placeness. Second, the related literature and cases were summarized to analyze the expressive characteristics of public sculptures, and the eight factors most related to the place-related characteristics were selected through the evaluation of characteristics from 10 experts. Third, as a case analysis, this study selected 60 cases from 7 magazines with the highest publication volume among public sculptures in China's representative cities, Shanghai, Beijing, and Guangzhou, and finally 15 public sculptures were selected through expert selection. In general, Whether to explore historical and cultural elements or the city's modern humanistic atmosphere, the public sculptures of the three cities all reflect different places.It is the development trend of public sculpture to combine the artistic originality and interaction with the public brought by unique advanced technology, and use the unique historical and human elements of the city to create places that are different from other regions.

• Journal of Distribution Science
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• v.12 no.2
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• pp.7-16
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• 2014

Purpose - The purpose of this study is to target Chinese consumers of Korean agri-food through the analysis of agri-food brand identity images to set future directions for proposed agri-food exports to China. Since negotiations began for a free trade agreement (FTA) between Korea and China, some Koreans have worried about the Korean agriculture sector. The world trading system has undergone many changes in recent years. Since the start of FTA negotiations on agriculture, China and Korea have faced a heightened sense of crisis. China is trying to export agricultural products so actively that its agricultural exports could increase by more than 7% annually. China exported about one-tenth of its agricultural products to Korea in the period 2002-2010. Recently, the importance of brand identity has tended to increase, as the world becomes one unified market. In this situation, we should try to promote agri-food exports to China. It is very important to understand consumers' recognition of Korean food and the image of the Korean agri-food industry, to establish an export strategy. Research design, data, and methodology - This study targeted 2,800 adult men and women aged 25-59 years living in four major cities in China (Beijing, Shanghai, Guangzhou, and Qingdao) with a household income within the top 10% level in the China, using the one-to-one interview survey method. In addition, four groups by region (eight people per group) for a total of 32 groups were surveyed by using the focus group interview (FGI) research method, and impressions of imported agri-food were surveyed using 17 questions about fresh agri-food and 22 questions on processed agri-food. Factor analysis, brand positioning, biplot analysis, and so on, were carried out based on the results of these surveys. This research presents the brand identity of Korean food; according to the analyses, the brand identity is based on trust, safety, and attractiveness. Result - Factor analysis results showed that Chinese consumers expect four major qualities in imported fresh agri-food: freshness/safety, attractive appearance, premium branding, and excellent taste/quality. In the case of processed agri-food, it turned out that Chinese consumers are focused on safety/hygiene/freshness, health, and taste. In addition, in the fresh agri-food analysis by country, American foods had the upper hand; the image of American foods was also recognized as the most positive for processed agri-food. Meanwhile, according to the biplot analysis, Korean agri-food is strongly preferred for its appearance, but no country is strongly preferred as regards the level of freshness/safety that is expected by Chinese consumers. Conclusions - In this study, we analyzed the image of imported agri-food expected by Chinese consumers by reconstructing agri-food characteristics from the brand perspective. The research result shows that a Korean brand identity must be the ultimate goal for activities undertaken to enhance the image of Korean agri-food in the future. Additional research is needed because brand image can be formed through various channels.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8665-8670
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• 2016

Background and Aims: Hepatitis B virus (HBV) reactivation was reported to be induced by transcatheter arterial chemoembolization (TACE) in HBV-related hepatocellular carcinonma (HCC) patients with a high incidence. The effective strategy to reduce hepatitis flares due to HBV reactivation in this specific group of patients was limited to lamivudine. This retrospective study was aimed to investigate the efficacy of prophylactic entecavir in HCC patients receiving TACE. Methods: A consecutive series of 191 HBV-related HCC patients receiving TACE were analyzed including 44 patients received prophylactic entecavir. Virologic events, defined as an increase in serum HBV DNA level to more than 1 log10 copies/ml higher than nadir the level, and hepatitis flares due to HBV reactivation were the main endpoints. Results: Patients with or without prophylactic were similar in host factors and the majorities of characteristics regarding to tumor factors, HBV status, liver function and LMR. Notably, cycles of TACE were parallel between the groups. Ten (22.7%) patients receiving prophylactic entecavir reached virologic response. The patients receiving prophylactic entecavir presented significantly reduced virologic events (6.8% vs 54.4%, p=0.000) and hepatitis flares due to HBV reactivation (0.0% vs 11.6%, p=0.039) compared with patients without prophylaxis. Kaplan-Meier analysis illustrated that the patients in the entecavir group presented significantly improved virologic events free survival (p=0.000) and hepatitis flare free survival (p=0.017). Female and Eastern Cooperative Oncology Group (ECOG) performance status 2 was the only significant predictors for virological events in patients without prophylactic antiviral. Rescue antiviral therapy did not reduce the incidence of hepatitis flares due to HBV reactivation. Conclusion: Prophylactic entecavir presented promising efficacy in HBV-related cancer patients receiving TACE. Lower performance status and female gender might be the predictors for HBV reactivation in these patients.

• Journal of Korea Port Economic Association
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• v.29 no.1
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• pp.143-175
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• 2013

The purpose of this paper is to show the clustering trend by using the variable group benchmarking(VGB) and categorical variable(CV) models for 38 Asian ports during 9 years(2001-2009) with 4 inputs(birth length, depth, total area, and number of crane) and 1 output(container TEU). The main empirical results of this paper are as follows. First, clustering results by using VGB show that Shanghai, Qingdao, and Ningbo ports took the core role for clustering. Second, CV analysis focusing on the container throughputs indicated that Singapore, Keelong, Dubai, and Kaosiung ports except Chinese ports are appeared as the center ports of clustering. Third, Aqaba, Dubai, Hongkong, Shanghai, Guangzhou, and Ningbo ports are recommended as the efficient ports for the target of clustering. Fourth, when the ports are classified by the regional location, Dubai, Khor Fakkan, Shanghai, Hongkong, Keelong, Ningbo, and Singapore ports are the core ports for clustering. On the whole, other ports located in Asia should be clustered to Dubai, Khor Fakkan, Shanghai, Hongkong, Ningbo, and Singapore ports. The policy implication of this paper is that Korean port policy planner should introduce the VGB model, and CV model for clustering among the international ports for enhancing the efficiency of inputs and outputs.