• Annals of Pediatric Endocrinology and Metabolism
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• v.23 no.4
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• pp.176-181
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• 2018

Noonan syndrome (NS) is an autosomal dominant disorder that involves multiple organ systems, with short stature as the most common presentation (>70%). Possible mechanisms of short stature in NS include growth hormone (GH) deficiency, neurosecretory dysfunction, and GH resistance. Accordingly, GH therapy has been carried out for NS patients over the last three decades, and multiple studies have reported acceleration of growth velocity (GV) and increase of height standard deviation score (SDS) in both prepubertal and pubertal NS patients upon GH therapy. One year of GH therapy resulted in almost doubling of GV compared with baseline; afterwards, the increase in GV gradually decreased in the following years, showing that the effect of GH therapy wanes over time. After four years of GH therapy, ~70% of NS patients reached normal height considering their age and sex. Early initiation, long duration of GH therapy, and higher height SDS at the onset of puberty were associated with improved final height, whereas gender, dosage of GH, and the clinical severity did not show significant association with final height. Studies have reported no significant adverse events of GH therapy regarding progression of hypertrophic cardiomyopathy, alteration of metabolism, and tumor development. Therefore, GH therapy is effective for improving height and GV of NS patients; nevertheless, concerns on possible malignancy remains, which necessitates continuous monitoring of NS patients receiving GH therapy.

• Journal of Yeungnam Medical Science
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• v.38 no.1
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• pp.47-52
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• 2021

Background: Short stature is defined as a height below the 3rd percentile or more than two standard deviations below the mean for a given age, sex, and population. There have been inconsistent results regarding craniofacial morphology in short-statured children. This study aimed to analyze the differences between short-statured children with growth hormone deficiency, idiopathic short-statured children, and normal children. Methods: Thirty-one short-statured children with growth hormone deficiency, 32 idiopathic short-statured children, and 32 healthy children were enrolled in this study. The measurements of their craniofacial structures from lateral cephalograms were evaluated. Results: There were statistically significant differences among the three groups seven variables (anterior cranial base length, posterior cranial base length, total cranial base length, upper posterior facial height, posterior total facial height, mandibular ramus length, and overall mandibular length) in the linear measurement and five variables (saddle angle, gonial angle, mandibular plane angle, position of mandible, and maxilla versus mandible) in the angular measurement. Conclusion: Compared to the control group, many linear and angular measurements of the craniofacial structures were significantly different in the two short-statured groups (p <0.05). Treatment plans by orthodontists should include these craniofacial structure characteristics.

• Journal of Korean Medicine for Obesity Research
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• v.5 no.1
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• pp.97-107
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• 2005

Objectives The purpose of this study was to investigate correlation between short stature and obese degree. And we also wanted to know the characteristics of patients visited clinic in the name of 'short stature'. Methods Height, body weight, BMI, fat mass, lean body mass, percent body fat were taken intended for 236 patients in the name of short stature. To all the patient questionnaire for growth clinic was drawn up, and ultrasound scan was taken through calcaneous of the right foot. The patients were classified to three groups - short, average, tall group - according to relative position of mid-parental height. It was analysed that the differences between groups in obese degree. Also was investigated correlation between position of short stature and obese degree, and between obese degree and bony maturity. Results & Conclusion 1. The average ages of patients in the name of 'short stature' were $12.69{\pm}3.93$ years old in boys, $10.66{\pm}3.67$ years old in girls. And it seemed to be just before second rapid maturing period. 2. The average BMI were $20.58{\pm}4.07kg/m^2$ in boys, $18.65{\pm}2.85kg/m^2$ in girls, and average percent body fat were $21.99{\pm}7.35%$ in boys, $26.01{\pm}6.35%$ in girls. 3. The numbers of obese children were 34(31.2%) in boys, 19(14.9%) in girls on the basis of BMI. And the numbers were 39(35.8%) in boys, 53(41.7%) in girls on the basis of percent body fat. There was a big difference in case of girls. 4. The numbers of AG(average group) were 48(44.0%) in boys, 60(47.2%) in girls, the numbers of SG(short group) were 35(32.1%) in boys, 31(24.4%) in girls, and numbers of TG(tall group) were 26(23.9%) in boys, 35(27.6%) in girls. 5. There were no significant differences among the groups in BMI, lean body mass, fat mass, percent body fat. Only significant difference in DI(disease index). 6. There were no significant correlation between PH(percent height) and BMI, leanbody mass, fat mass, percent body fat. Only significant correlation in DI(disease index). 7. There were no significant differences between DA(difference between bone age and chronorogical age) and BMI, leanbody mass, percent body fat. Only significant correlation in fat mass.

• Journal of the korean academy of Pediatric Dentistry
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• v.38 no.2
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• pp.161-169
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• 2011

Longitudinal serial cephalometric films in the every second year from fifty girls were used for the analysis of growth pattern of maxillary alveolar bone (MAE). Six parameters regarding MAB height were measured and were compared with stature and chronological age. Descriptive analysis. correlation coefficient test and linear regression analysis were done for the statistical analyses. 1. The height of MAE increased until 14 years although growth velocity was gradually decreased. which was different with stature growth pattern. 2. The correlation coefficients between chronological age and MAB height were high and had no statistical differences with those of stature and MAB height. In addition. the correlation coefficients between chronological age groups within each parameter of MAB were very high. 3. The growth amount of MAB could be predicted using linear regression analysis on the basis of chronological age data. The growth pattern between MAE and statue was quite different because of the growth pattern difference between skeletal and neuronal system. Therefore. growth pattern of Korean MAB must be considered in dental treatment of youth. Also. close relationship between chronological age and MAB height would be useful when clinicians want to predict growth amount of MAE for the dental implant treatment.

• IE interfaces
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• v.13 no.2
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• pp.147-156
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• 2000

It is known that the human stature and its related dimensions generally increase until the late teens or early twenties, remain relatively constant throughout early adulthood, and decline from early-to-middle adulthood into old age. However, there is exception that the length of the human ears, which continue to grow throughout life. In this study, 600 Korean male and female subjects aging from 17 to 89 were selected. Four different points of external ears including Pinna length, ear connection point length, Concha length, and Lobule thickness were measured along with other relative subjects' demographic data(e.g., age, stature, weight) to determine the relationship among these obtained data. The results showed that the age, sex, and different ethnic populations were functions of ear dimensions similar to the human stature. For example, the Pinna length increases as the age increases(r= 0.689, p<0.00l). The primary objective of this study was thus to provide anthropometric dimensions of Korean ear for the product designers and recommend the appropriate product design solutions in relation to human ear. Based on the results of this study, it is suggested that the continuing growth of the human body parts should be considered in the application of anthropometric data to the design of the things especially for human use.

• Korean Journal of Social Welfare Studies
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• v.45 no.2
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• pp.173-202
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• 2014

This qualitative study is designed to explore parents' experiences with their children handicapped with restricted growth. The parents' unique reality and its essential meanings are elicited through in-depth interviews enabling to reflect the insider's perspective. "From the child unable to grow to the child able to grow" is identified as the main theme penetrating through the participants'parenting experiences unique to their reality. Embracing the shock and the disappointment related to their children 'unable to grow', they thrive to make their children able to grow. However, they eventually accept their children's handicap, in spite of never doing it easily, by getting confronted with the limits of making their children grow in stature, and the social stigma and the difficulty their children experience. Therefore, they get to take alternative perspectives not focusing on their children's stature unable to grow but on psycho-social growth able to grow. Social welfare plans to support the handicapped with restricted growth and their parents are suggested.

• Clinical and Experimental Pediatrics
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• v.52 no.2
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• pp.142-151
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• 2009

The incidence of small for gestational age (SGA) births is frequent, accounting for 2.3% to 8% of all live births. Several childhood and adult diseases are related to early postnatal growth and birth size, and 10% of children born SGA may have a short stature throughout postnatal life. Additionally, they may have abnormal growth hormone (GH)-insulin like growth factor axis, HPA axis, and gonadal function. Permanent changes are detrimental in an environment of nutritional abundance, and predispose SGA children to an array of diseases in adolescence and adulthood. Such changes may also cause premature pubarche, adrenarche, and precocious puberty. The varying results from clinical studies necessitate more prospective case control studies. Reproductive tract abnormalities and reproductive dysfunction are related to SGA births. GH treatment is required for SGA infants who do not experience catch-up growth.

• Clinical and Experimental Pediatrics
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• v.49 no.7
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• pp.703-709
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• 2006

Since the advent of growth hormone(GH), children with a wide variety of growth disorders have received GH treatment. In GH deficiency(GHD), Turner syndrome, chronic renal failure, children born small for gestational age, Prader-Willi syndrome, and idiopathic short stature, the therapeutic effects and safety profile of GH are reviewed. GH therapy has been clearly shown to improve height velocity and final adult height in a variety of pediatric conditions in which growth is compromised irrespective of GHD. Early initiation and individualization of GH treatment has the potential to normalize childhood growth. The supra-physiological doses of GH have been shown to increase height velocity during childhood and final height in non-GHD conditions. Adverse events during GH therapy are uncommon and often not drug related. However continued surveillance into adult life is crucial, especially in children receiving supra-physiological doses or whose underlying condition increases their risk of adverse effects.

• Journal of Dental Rehabilitation and Applied Science
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• v.30 no.2
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• pp.170-175
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• 2014

The growth disorder influences craniofacial development and early loss of permanent teeth. This case reports the importance of computerized tomography (CT) and surgical guide to identify horizontal bone loss, adjacent teeth and to guide drills when placing implants in a short stature patient. The patient has idiopathic short stature and the 3rd grade of intellectual disability. To recover posterior mandibular teeth, implant treatment was planned. CT images showed that the adjacent teeth were located markedly to the buccal side. A CT-based surgical guide was fabricated and implants was placed using flapless surgery. Bone dehiscence and fenestration may happen when the surgical guide was fabricated just based on adjacent clinical crowns. Thus, it is essential to analysis bone and teeth and to make surgical guide through CT, especially in atrophied bone on grow disorder patients. Furthermore, systematic researches are recommended to elucidate the relationship between growth disorder and tooth malposition.

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.1
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• pp.51-56
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• 2002

Russell-Silver syndrome is a type of intrauterine growth retardation, characterized by short stature noted at birth, hemiatrophy or asymmetry, variation in sexual development and other abnormalities, including cafe-aulait pigmentation and clinodactyly. Facial features commonly associated with this syndrome are a small triangular face, decreased facial height, down-turned corners of the mouth(shark's mouth), a small mandible, and occasionally asymmetry. The major intra-oral features of the syndrome that have been reported are a high-arched palate, delayed tooth eruption, microdontia, hypodontia, and crowding. These cases were diagnosed at birth as Russell-Silver syndrome by clinical features such as prenatal growth retardation, short stature, low body weight, et al., and have been treated with growth hormone. The purpose of this paper is to report the dental findings of two patients and review the pertinent literature through the two cases.