• Journal of Dairy Science and Biotechnology
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• v.33 no.2
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• pp.111-118
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• 2015

Probiotic, prebiotic, and synbiotic substances as well as microorganisms were added to infant formula in an attempt to influence the intestinal microflora with an aim to stimulate the growth of lactic acid bacteria, especially bifidobacteria and lactobacilli. Over the last 10 years, new synbiotic infant formulas containing probiotics and prebiotics have been proposed in order to simulate the effect of breast-feeding on the intestinal microflora. Owing to their synergistic effect, the new synbiotics are expected to be more helpful than using probiotics and prebiotics individually. Maintenance of the viability of the probiotics during food processing and the passage through the gastrointestinal tract should be the most important consideration, since a sufficient number of bacteria ($10^8cfu/g$) should reach the intended location to have a positive effect on the host. Storage conditions and the processing technology used for the manufacture of products such as infant formula adversely affect the viability of the probiotics. When an appropriate and cost-effective microencapsulation methodology using the generally recognized as safe (GRAS) status and substances with high biological value are developed, the quality of infant formulas would improve. The effect of probiotics may be called a double-effect, where one is an immunomodulatory effect, induced by live probiotics that advantageously alter the gastrointestinal microflora, and the other comprises anti-inflammatory responses elicited by dead cells. At present, a new terminology is required to define the dead microorganisms or crude microbial fractions that positively affect health. The term "paraprobiotics" (or ghost probiotics) has been proposed to define dead microbial cells (not damaged or broken) or crude cell extracts (i.e., cell extracts with complex chemical composition) that are beneficial to humans and animals when a sufficient amount is orally or topically administered. The fecal microflora of bottle-fed infants is altered when the milk-based infant formula is supplemented with probiotics or prebiotics. Thus, by increasing the proportion of beneficial bacteria such as bifidobacteria and lactobacilli, prebiotics modify the fecal microbial composition and accordingly regulate the activity of the immune system. Therefore, considerable attention has been focused on the improvement of infant formula quality such that its beneficial effects are comparable to those of human milk, using prebiotics such as inulin and oligosaccharides and potential specific probiotics such as bifidobacteria, which selectively stimulate the proliferation of beneficial bacteria in the microflora and the indigenous intestinal metabolic activity of the microflora.

• Korean Journal of Agricultural and Forest Meteorology
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• v.14 no.3
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• pp.108-118
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• 2012

To investigate the responses of yellow poplar (Liriodendron tulipifera L.) seedlings to the interactive effects of the elevated atmospheric $CO_2$ level and nitrogen addition, we measured biomass, photosynthetic pigments, photosynthesis, and the contents of nitrogen (N) and carbon (C) from the seedlings after 16 weeks of the treatments. Yellow poplar seedlings were grown under the ambient ($400{\mu}mol\;mol^{-1}$) and the elevated (560 and $720{\mu}mol\;mol^{-1}$) CO2 concentratoins with three different N addition levels (1.2, 2.4, and $3.6g\;kg^{-1}$) in the Open Top Chambers (OTC). The dry weight of the seedlings enhanced with the increased N levels under the elevated $CO_2$ concentrations and the increment of the dry weight differed among the different N levels. Photosynthetic pigment content of the yellow poplar leaves also increased with the increase of the $CO_2$ concentration levels. The effects of the N levels on the photosynthetic pigment content, however, were significantly different among the $CO_2$ levels. Photosynthetic rates were affected by the levels of $CO_2$ and N concentrations. Stomatal conductance and transpiration rates increased with increasing $CO_2$ concentration. The carboxylation efficiency of the seedlings without N addition increased under the higher $CO_2$ concentrations whereas that with N addition decreased under the elevated $CO_2$ concentrations. Nitrogen and carbon uptake in leaf, stem, and root increased with the elevated $CO_2$ concentration level and N addition. In conclusion, under the elevated $CO_2$ concentrations, physiological characteristics and carbon uptake of the yellow poplar seedling were improved and increased with N addition.

• Journal of Korean Public Health Nursing
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• v.8 no.2
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• pp.35-56
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• 1994

This article was intended to survey whether Roy' Adapation model ('Roy Model') can be applied to family health assessment and to study whether application of the Roy Model to a Korean family is feasible. under the Roy Model, a family is viewed as an adaptation system having a series of process of input. process, feedback, and output. Further, the Roy Model indicates that a family contains Physiolosical, self-concept. role function and interdependent mode in respect of internal or external stimuli. In the event where the family health assessed, the adaptation mode of that family must be assess at the first stage. Then, the focal, contextual, residual stimuli affecting the family must be assessed. In 1984 Hanson suggested four types of family adaptation mode based upon the Roy Model and thereby enhanced the possibility for family health assessment. In order survey whether the Roy Model can be applied to the Korean family, the author of this article contracted adults of 169 who live in 'A' city to make open questions regarding family and then analyzed responses from them by utilizing Roy model. This study categorized family Adaptation mode based upon the' four types of family adaptation mode developed by Hanson. As a result of this study, family adaptation mode was categorized into 117 concepts. Those 117 concepts are consisted or Physiolosical mode of 47. self­concept mode of 56, role function mode of 9 and interdependent mode of 5. Further. stimuli affecting family were classified based upon Roy's definition as to three types of stimuli. Stimuli on a family are comprised focal stimuli concept of 19, contextual stimuli concepts of 19, one residual stimuli concept. this result implies that the Roy's Model can be applied to Korean family. Physiological mode shows meaning of survival. while self-concept mode reflects meaning of growth and emphasizes harmony among the family based on the familism. The role function mode shows continuity rather control of family member. By contrast, interdependent mode shows interaction with community to which the family belongs. but the degree of interaction does not appear too high. The analysis of family stimuli led this study to conclude that troubles within a family. changes in family structure and diease of family member generate stimuli. However, an application of the Roy Model contains the following problems: First, Roy argued that the family adaptation mode should be assessed at the first level family health assessment and then stimuli affecting family adaptation should be adaptation assessed at the second stage. To the belief of the author of this article. however, for checking family adaptation level. focal, contextual, residual stimuli should be confirmed by assessing stimuli at first stage. Then, the family adaptation mode in respect of such stimuli should be assessed. The rationale for this is that the family adaptation level is determined depending on degree of strength of focal. contextual. residual stimuli. Second. Whall (1991) raised a question 'Does one assess family adaptation mode and intervene in the stimuli?' 'Likewise, assessment of the family adaptation should be made in the following manner in order for family health to be enhanced. Third. Roy believes that additional stimuli (such as contextual and residual) are same as internal process (including nurturance. support, and socialization). However, the basis for this Roy's belief is not too clear. In spite of these problems which the author indicated above, it can be concluded that the Roy Model can serve as a good device for an assessment of family health and that the Roy Model can be applied to a Korean family. Finally, further research of family adaptation theory and family nursing theory is required for a development of these theories.

• Journal of Home Health Care Nursing
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• v.8 no.1
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• pp.5-24
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• 2001

The purpose of this study was to develop a parenting intervention program and determine the efficacy of the program with low-birth weight infants and their mothers. Nine dyads for the experimental group and twelve dyads for the control group discharged from the Neonatal Intensive Care Unit of a University Hospital in Seoul were recruited for the study. For the intervention group, programmed education and support which focused on the maternal sensitivity of the infant's behavior. rearing environment. motherinfant interaction and infant care were given to each subject. Individual counseling and home visits were provided at discharge, one week after discharge. and one and three months of corrected age in every infant. Structured questionaires were administered and feeding interactions were videotaped and coded by a blinded certified observer. A Quasi-experimental design was conducted for this study. Postpartum depression, maternal self esteem. infant care burden, HOME. mother-infant interaction, and infant development were measured. Results were in favor of the intervention versus the control group. On the Beck depression inventory, intervention mothers showed decreasing trends in depressive symptom vs control mothers although, there were statistically no significant differences between the two groups at each time. The mean score of experimental group was 11.55(mild depression state) at discharge and became 8,6(normal state) at 1 month of corrected age. On the other hand, the mean score of the control group was 13.92(mild depression state) at discharge and became 14.0. Maternal self esteem in both groups improved over time. Infant care burden in both groups was also shown to increase over time. There was a significant difference between the two groups in HOME(p=.0340) at 3 months of corrected age. HOME scores of the experimental group and the control's were 31.10 and 25.58, respectively. Mothers' emotional and language responses were significantly high in the intervention group compared with the control group(p=.0155). Intervention group (53.33) showed a significantly high quality of motherinfant interaction compared with the in control group (42.80)(p =.0340). Intervention group mothers appeared have a better quality of mother-infant interaction behaviors. On the other hand, there was no statistical difference in the infant part between groups. Intervention group infants had higher trends in a general developmental quotient: although, there was no statistical difference between groups. The general developmental quotient of intervention infants was 102.56 and control's was 91.28. However, the developmental quotient of the domain of 'individuality-sociality' was higher in the intervention group infants compared with the control's(p=.0155). The concerns identified by parents revealed two domains of an infants' health management -knowledge and skills in caregiving of lowbirthweight-infants, characteristics of lowbirthweight infants, identifying a developmental milestone, coping with emergency situations and relaxation strategies of mothers from the infant care burden. Interview data with the mothers of low-birth weight infants can be used to develop intervention program contents. Limited intervention time and frequency due to time and cost limitations of this study should be modified. The intervention should be continuously implemented when low-birth weight infants become three years old. An NNNS demonstration appeared to be a very effective intervention for the mothers to improve the quality of mother-infant interactions. Therefore intervening in the mothers of low-birth weight infants as early after delivery as possible is desirable. This study has shown that home visit interventions are worthwhile for mothers only beyond the approach as an essential factor in ability of facilitating a growth fostering environment. In conclusion. the intervention program of this study was very effective in enhancing the parenting for the mothers of low-birth weight infants, resulting in health promotion of low-birth weight infants. The home-visit outreach intervention program of this study will contribute to the health delivery system in this country where there is a lack of continuous follow-up programs for low-birth weight infants after discharge from NICU, if it is activated as part of the home visit programs in community health systems.

• Journal of Intelligence and Information Systems
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• v.16 no.4
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• pp.1-19
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• 2010

In offline environment, unlike traditional advertising model through TV, newspaper, and radio, online advertising model draws instantaneous responses from potential consumers and it is convenient to assess. This kind of characteristics of Internet advertising model has driven the growth of advertising model among various Internet business models. There are, conventionally classified, CPM (Cost Per Mile), CPC (Cost Per Click), and CPS (Cost Per Sales) models as Internet advertising expenditure model. These can be examined in manners regarding risks that stakeholders should stand and degree of responsibility. CPM model that is based on number of advertisement exposure is mechanically exposed to users but not actually recognized by users resulting in risk of wasted expenditure by advertisers without any advertising effect. While on aspect of media, CPS model that is based on conversion action is the most risky model because of the conversion action such as product purchase is determined by capability of advertisers not that of media. In this regard, while there are issue of CPM and CPS models disadvantageously affecting only one side of Internet advertising business model value network, CPC model has been evaluated as reasonable both to advertisers and media, and occupied the largest segment of Internet advertising market. However, CPC model also can cause fraudulent behavior such as click fraud because of the competition or dishonest amount of advertising expenditure. On the user aspect, unintentionally accessed advertisements can lead to more inappropriate expenditure from advertisers. In this paper, we suggest "CPCD"(Cost Per Coupon Download) model. This goes beyond simple clicking of advertisements and advertising expenditure is exerted when users download a coupon from advertisers, which is a concept in between CPC and CPS models. To achieve the purpose, we describe the scenario of advertiser perspective, processes, participants and their benefits of CPCD model. Especially, we suggest the new value in online coupon; "possibility of storage" and "complement for delivery to the target group". We also analyze the working condition for advertiser by a comparison of CPC and CPCD models through advertising expenditure simulation. The result of simulation implies that the CPCD model suits more properly to advertisers with medium-low price products rather than that of high priced goods. This denotes that since most of advertisers in CPC model are dealing with medium-low priced products, the result is very interesting. At last, we contemplate applicability of CPCD model in ubiquitous environment.

• Korean Journal of Plant Resources
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• v.24 no.4
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• pp.413-418
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• 2011

This study was carried out to establish a proper cultivation site and diagnose the drought-tolerance of Aster scaber and Synurus deltoides leaves by using Pressure-volume curves. In order to measure pressure-volume (P-V) curves, Aster scaber and Synurus deltoides were cut off above ground part and the tip of the cutting were placed in water, which was covered with a plastic bag. Samples were kept overnight (about 12 hours) in darkness at room temperature (20~25$^{\circ}C$) to achieve maximal turgor (full saturation). The pressure in the chamber was gradually increased from 0.3MPa to 1.8MPa by nitrogen gas. After measured, leaf samples were dried at 80$^{\circ}C$ for 48 hours and dry weight of each samples were determined. The result of the original bulk osmotic potential at maximum turgor ${\Psi}^{sat}_o$ sat was lower -0.8 MPa in Aster scaber leaves than -0.7 MPa Synurus deltoides leaves. Also the osmotic potential at incipient plasmolysis ${\Psi}^{tlp}_o$ in Aster scaber leave was -0.9 MPa. In contrast, the value of maximum bulk modulus of elasticity $E_{max}$ of Aster scaber leaves were approximately two folds higher than that of Synurus deltoides leaves. The values of the relative water content at incipient plasmolysis $RWC^{tlp}$ are all above 90% showing that the function of osmoregulation is somewhat better, and Vo/DW, Vt/DW, Ns/DW of Synurus deltoides leaves were approximately 1~2 times higher than that of Aster scaber leaves. Thus, responses to water relations of Aster scaber and Synurus deltoides such as ${\Psi}^{sat}_o$, ${\Psi}^{tlp}_o$, $E_{max}$, ${\Psi}_{P,max}$, $RWC^{tl}$ were shown that the Aster scaber leaves was slightly higher drought-tolerance than Synurus deltoides leaves. However, in both of Aster scaber and Synurus deltoides, occurring incipient plasmolysis at the high water content, have a relatively lower drought-tolerance property indicating that growth of these plants are cultivated appropriate in high moisture soil sites.

• Journal of Life Science
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• v.19 no.7
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• pp.949-955
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• 2009

Mucosal epithelia sense external stress signals and transmit them to the intracellular cascade responses. Ribotoxic stress-producing chemicals such as deoxynivalenol (DON) or other trichothecene mycotoxins have been linked with gastrointestinal inflammatory diseases by Fusarium-contamination. The purpose of this study was to test the hypothesis that DON evokes the epithelial sentinel signals of RNA-dependent protein kinase (PKR) and early growth response gene 1 (EGR-1), which together contribute to the pro-inflammatory cytokine interleukin 8 (IL-8) in human intestinal epithelial cells. PKR suppression by the dominant negative PKR expression attenuated DON-stimulated interleukin-8 production. Moreover, 1L-8 transcriptional activation by DON was also reduced by PKR inhibition in the human intestinal epithelial cells. Treatment with the PKR inhibitor also suppressed EGR-1 promoter activity, mRNA and protein induction, although mitogen-activated protein (MAP) kinases such as extracellular signal-regulated protein kinases (ERK) 1/2, p38, c-Jun N-terminal Kinase (INK) were little affected or even enhanced in presence of a PKR inhibitor. These patterns were also compared in the EGR-1-suppressed cells, which showed much more suppressed production of 1L-8. All things taken into consideration, DON-activated sentinel signals of EGR-1 via PKR mediated interleukin-8 production in human intestinal epithelial cells, which provide insight into the possible general mechanism associated with mucosal inflammation as an intestinal toxic insult by ribotoxic trichothecene mycotoxins.

• Korean Journal of Soil Science and Fertilizer
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• v.27 no.1
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• pp.15-20
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• 1994

Lysimeter experiments were conducted to elucidate the behavior of $NO_3-N$ derived from urea applied at different rates and accompanying cations in soils and to further provide fundamental information of rational nitrogen-fertilizer management. Urea was applied at rates of 0, 7, 14, 21, 28 and 35kg N/10a to sandy loam pakced into PVC cylindrical lysimeter(vol. : $0.187m^2$, area $0.43m^2$). Leachates from the lysimeter with or without grass grown were collected periodically and analyzed for $NO_3$ and cations. Grass growth and yield responses to N fertilization were also examined. Dry matter yield and nitrogen uptake increased with the urea application rate. The amount of leachate from the lysimeter was negatively correlated with urea application ratesl($r=-0.95^{**}$). The nitrate leaching loss with grass grown was 230 g N/10a at the maximum rate of 35kg N/10a, but the highest leaching loss was observed as 1,607 g N/10a from the bare plot. Increase in urea application rates decreased significantly leaching losses of Ca, Mg, K and Na(>0.01). The highest leaching loss from the bare plot was observed for Ca but only 6.5% of exchangeable form and 14.0% for K from the grass plot respectively. Equivalent ratio of cations to nitrate leached were 3.2 % for the bare plot and the ratio for the grass plot increased with the urea application rate, ranging from 18.6 to 32.7%.

• Journal of The Korean Society of Grassland and Forage Science
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• v.10 no.3
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• pp.129-136
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• 1990

In the present report, two experiments were carried out with the purposes of knowing the differences of response among forage species to growing period and potassium level in culture solution, and investigating possible relation of the responses with occurence of grass tetany on grazing pasture. The results were as follows; (1) At 25 days after germination, fresh weight of top part as well as the sum of top and root parts of the forages increased rapidly. (2) Italian ryegrass was the highest in potassium (K) content but the lowest in magnesiurn(Mg) content among the three gramineous forages, while tall fescue showed the opposite result to it. And orchardgrass was intermediate of the two forage species (Experiment 1). (3) The K contents of forages generally increased, while Mg content became lower with the increase of K level in culture solution. The highest K contents of Italian ryegrass and orchardgrass were more than 3 times of the lowest values. The K contents of alfalfa and tall fescue increased in the narrower range. The decreases of Mg content of Italian ryegrass and orchardgrass were significant in the ranges of 5ppm to 25 or 50ppm KzO, while the content of the leguminous forages and tall fescue decreased up to 1000 level. (4) Fresh yield, water content and K content of the forages were significantly increased with the increase of K20 application levels up to 25 or 50ppm. (5) The K concentration of forage on a tissue water basis was higher at 50ppm than that at 5ppm $K_20$ level, especially for Italian ryegrass and orchardgrass with the value of 2.6times and 2.5times, respectively. However, the K concentration (tissue water) of leguminous forages increased gradually up to the level of lOOOppm (Experiment 2). It is suggested from the results that rapid changes of water content, Mg content and K concentration (tissue water) may occur to forage on a grazing pasture, when both growing period and K level in the soil affect the changes simultaneously. Under such conditions, plant water especially in Italian reyegrass and orchardgrass can function as toxic material to grazing ruminants.

• Journal of The Korean Society of Grassland and Forage Science
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• v.32 no.1
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• pp.39-48
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• 2012

This study was conducted to investigate effects of different levels of seleniferous whole crop barley (WCB) supplementation on performance, and blood characteristics as physiological responses in growing pigs. A total of 20 cross-bred pigs ((Landrace ${\times}$ Yorkshire) ${\times}$ Duroc) were divided into 4 treatments of 5 pigs each and experimental period lasted for 6 weeks. They were fed diets containing 0.1 (non-seleniferous WCB as controls), 0.2, 0.4, and 0.6 mg/kg levels of selenium (Se) by supplementing seleniferous WCB, and non-seleniferous or seleniferous WCB was formulated to 5% level in total ration. The diets were isonitrogenous (18% crude protein) and isocaloric (3,500 kcal/kg digestible energy) across treatments. Increasing levels of seleniferous WCB supplements did not affect feed intake and BW gain, and blood total protein concentration was (p<0.05) significantly higher for 0.2 mg/kg Se treatments than for controls. On d 14, blood albumin concentration was higher (p<0.05) for seleniferous WCB supplemented groups than for control group. Contrarily, blood glucose concentration was tended to be higher for controls than for seleniferous WCB groups. Blood total lipid concentration was significantly (p<0.05) lowered with increasing levels of seleniferous WCB. Serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase did not have any difference among treatments. It was tended that blood total cholesterol and triglyceride were lowered with increasing levels of seleniferous WCB. Blood Se concentration was significantly (p<0.05) increased with increasing levels of seleniferous WCB. The results indicate that Se present in seleniferous WCB had favorable effects on blood characteristics and blood Se increased by supplementing seleniferous WCB implies not only a good intestinal absorption of Se present in WCB but also the possibility of Se transfer into tissues.